CORD-19-Sentences  

CORD-19:c6b75757f2a356c2bbc3ec1d986d17a3d0048701 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-108 Sentence denotes The aetiology of pharyngotonsillitis in adolescents and adults - Fusobacterium necrophorum is commonly found
TextSentencer_T1 0-108 Sentence denotes The aetiology of pharyngotonsillitis in adolescents and adults - Fusobacterium necrophorum is commonly found
TextSentencer_T1 0-108 Sentence denotes The aetiology of pharyngotonsillitis in adolescents and adults - Fusobacterium necrophorum is commonly found
TextSentencer_T2 110-118 Sentence denotes Abstract
TextSentencer_T2 110-118 Sentence denotes Abstract
TextSentencer_T2 110-118 Sentence denotes Abstract
TextSentencer_T3 119-163 Sentence denotes Sore throat is common in primary healthcare.
TextSentencer_T3 119-163 Sentence denotes Sore throat is common in primary healthcare.
TextSentencer_T3 119-163 Sentence denotes Sore throat is common in primary healthcare.
TextSentencer_T4 164-247 Sentence denotes Aetiological studies have focused on the presence of a limited number of pathogens.
TextSentencer_T4 164-247 Sentence denotes Aetiological studies have focused on the presence of a limited number of pathogens.
TextSentencer_T4 164-247 Sentence denotes Aetiological studies have focused on the presence of a limited number of pathogens.
TextSentencer_T5 248-453 Sentence denotes The aim of the present study was to investigate the presence of a wide range of bacteria and viruses, including Fusobacterium necrophorum, in patients with pharyngotonsillitis and in asymptomatic controls.
TextSentencer_T5 248-453 Sentence denotes The aim of the present study was to investigate the presence of a wide range of bacteria and viruses, including Fusobacterium necrophorum, in patients with pharyngotonsillitis and in asymptomatic controls.
TextSentencer_T5 248-453 Sentence denotes The aim of the present study was to investigate the presence of a wide range of bacteria and viruses, including Fusobacterium necrophorum, in patients with pharyngotonsillitis and in asymptomatic controls.
TextSentencer_T6 454-551 Sentence denotes A prospective case control study was performed in primary healthcare in Kronoberg County, Sweden.
TextSentencer_T6 454-551 Sentence denotes A prospective case control study was performed in primary healthcare in Kronoberg County, Sweden.
TextSentencer_T6 454-551 Sentence denotes A prospective case control study was performed in primary healthcare in Kronoberg County, Sweden.
TextSentencer_T7 552-673 Sentence denotes Patients (n = 220) aged 15 to 45 years with a suspected acute pharyngotonsillitis, and controls (n = 128), were included.
TextSentencer_T7 552-673 Sentence denotes Patients (n = 220) aged 15 to 45 years with a suspected acute pharyngotonsillitis, and controls (n = 128), were included.
TextSentencer_T7 552-673 Sentence denotes Patients (n = 220) aged 15 to 45 years with a suspected acute pharyngotonsillitis, and controls (n = 128), were included.
TextSentencer_T8 674-846 Sentence denotes Nasopharyngeal and throat swabs were analysed for β-hemolytic streptococci, F. necrophorum, Mycoplasma pneumoniae, and Chlamydophila pneumoniae, and 13 respiratory viruses.
TextSentencer_T8 674-846 Sentence denotes Nasopharyngeal and throat swabs were analysed for β-hemolytic streptococci, F. necrophorum, Mycoplasma pneumoniae, and Chlamydophila pneumoniae, and 13 respiratory viruses.
TextSentencer_T8 674-846 Sentence denotes Nasopharyngeal and throat swabs were analysed for β-hemolytic streptococci, F. necrophorum, Mycoplasma pneumoniae, and Chlamydophila pneumoniae, and 13 respiratory viruses.
TextSentencer_T9 847-912 Sentence denotes Serum samples were analysed for antibodies to Epstein-Barr virus.
TextSentencer_T9 847-912 Sentence denotes Serum samples were analysed for antibodies to Epstein-Barr virus.
TextSentencer_T9 847-912 Sentence denotes Serum samples were analysed for antibodies to Epstein-Barr virus.
TextSentencer_T10 913-1010 Sentence denotes The patient history and symptoms, including Centor score, were analysed in relation to pathogens.
TextSentencer_T10 913-1010 Sentence denotes The patient history and symptoms, including Centor score, were analysed in relation to pathogens.
TextSentencer_T10 913-1010 Sentence denotes The patient history and symptoms, including Centor score, were analysed in relation to pathogens.
TextSentencer_T11 1011-1142 Sentence denotes In 155/220 (70.5%) of the patients, as compared to 26/128 (20.3%) of the controls (p <0.001), at least one microorganism was found.
TextSentencer_T11 1011-1142 Sentence denotes In 155/220 (70.5%) of the patients, as compared to 26/128 (20.3%) of the controls (p <0.001), at least one microorganism was found.
TextSentencer_T11 1011-1142 Sentence denotes In 155/220 (70.5%) of the patients, as compared to 26/128 (20.3%) of the controls (p <0.001), at least one microorganism was found.
TextSentencer_T12 1143-1350 Sentence denotes Group A streptococci, F. necrophorum, and influenza B virus were the three most common findings, and all significantly more common in patients than in controls (p <0.001, p 0.001, and p 0.002, respectively).
TextSentencer_T12 1143-1350 Sentence denotes Group A streptococci, F. necrophorum, and influenza B virus were the three most common findings, and all significantly more common in patients than in controls (p <0.001, p 0.001, and p 0.002, respectively).
TextSentencer_T12 1143-1350 Sentence denotes Group A streptococci, F. necrophorum, and influenza B virus were the three most common findings, and all significantly more common in patients than in controls (p <0.001, p 0.001, and p 0.002, respectively).
TextSentencer_T13 1351-1598 Sentence denotes Patients with F. necrophorum only (n = 14) displayed a lower Centor score than patients with Group A streptococcus only (n = 46), but a higher score than patients with influenza B, other viruses, or no potential pathogen (Kruskal-Wallis p <0.001).
TextSentencer_T13 1351-1598 Sentence denotes Patients with F. necrophorum only (n = 14) displayed a lower Centor score than patients with Group A streptococcus only (n = 46), but a higher score than patients with influenza B, other viruses, or no potential pathogen (Kruskal-Wallis p <0.001).
TextSentencer_T13 1351-1598 Sentence denotes Patients with F. necrophorum only (n = 14) displayed a lower Centor score than patients with Group A streptococcus only (n = 46), but a higher score than patients with influenza B, other viruses, or no potential pathogen (Kruskal-Wallis p <0.001).
TextSentencer_T14 1599-1737 Sentence denotes A pathogen was detected in 70% of the patients, displaying a wide range of pathogens contributing to the aetiology of pharyngotonsillitis.
TextSentencer_T14 1599-1737 Sentence denotes A pathogen was detected in 70% of the patients, displaying a wide range of pathogens contributing to the aetiology of pharyngotonsillitis.
TextSentencer_T14 1599-1737 Sentence denotes A pathogen was detected in 70% of the patients, displaying a wide range of pathogens contributing to the aetiology of pharyngotonsillitis.
TextSentencer_T15 1738-1854 Sentence denotes This study supports F. necrophorum as one of the pathogens to be considered in the aetiology of pharyngotonsillitis.
TextSentencer_T15 1738-1854 Sentence denotes This study supports F. necrophorum as one of the pathogens to be considered in the aetiology of pharyngotonsillitis.
TextSentencer_T15 1738-1854 Sentence denotes This study supports F. necrophorum as one of the pathogens to be considered in the aetiology of pharyngotonsillitis.
TextSentencer_T16 1855-1890 Sentence denotes Clinical Microbiology and Infection
TextSentencer_T16 1855-1890 Sentence denotes Clinical Microbiology and Infection
TextSentencer_T16 1855-1890 Sentence denotes Clinical Microbiology and Infection
TextSentencer_T17 1892-1961 Sentence denotes A sore throat is a common complaint in primary healthcare (PHC) [1] .
TextSentencer_T17 1892-1961 Sentence denotes A sore throat is a common complaint in primary healthcare (PHC) [1] .
TextSentencer_T17 1892-1961 Sentence denotes A sore throat is a common complaint in primary healthcare (PHC) [1] .
TextSentencer_T18 1962-2124 Sentence denotes The condition can be caused by a wide variety of infectious agents [2] , where the most common is Streptococcus pyogenes (Group A streptococci, GAS) [3] [4] [5] .
TextSentencer_T18 1962-2124 Sentence denotes The condition can be caused by a wide variety of infectious agents [2] , where the most common is Streptococcus pyogenes (Group A streptococci, GAS) [3] [4] [5] .
TextSentencer_T18 1962-2124 Sentence denotes The condition can be caused by a wide variety of infectious agents [2] , where the most common is Streptococcus pyogenes (Group A streptococci, GAS) [3] [4] [5] .
TextSentencer_T19 2125-2323 Sentence denotes Also, large colony variants of Streptococcus group C and G [6] , Mycoplasma pneumoniae [3] , Arcanobacterium haemolyticum [7] , and several viruses [3, 5, 8] have been associated with a sore throat.
TextSentencer_T19 2125-2323 Sentence denotes Also, large colony variants of Streptococcus group C and G [6] , Mycoplasma pneumoniae [3] , Arcanobacterium haemolyticum [7] , and several viruses [3, 5, 8] have been associated with a sore throat.
TextSentencer_T19 2125-2323 Sentence denotes Also, large colony variants of Streptococcus group C and G [6] , Mycoplasma pneumoniae [3] , Arcanobacterium haemolyticum [7] , and several viruses [3, 5, 8] have been associated with a sore throat.
TextSentencer_T20 2324-2565 Sentence denotes The aetiology has mainly been studied in children [9, 10] , and most studies have been performed with a focus on the presence of a limited number of pathogens [3, 5] , and studies covering both viral and bacterial aetiology are lacking [5] .
TextSentencer_T20 2324-2565 Sentence denotes The aetiology has mainly been studied in children [9, 10] , and most studies have been performed with a focus on the presence of a limited number of pathogens [3, 5] , and studies covering both viral and bacterial aetiology are lacking [5] .
TextSentencer_T20 2324-2565 Sentence denotes The aetiology has mainly been studied in children [9, 10] , and most studies have been performed with a focus on the presence of a limited number of pathogens [3, 5] , and studies covering both viral and bacterial aetiology are lacking [5] .
TextSentencer_T21 2566-2605 Sentence denotes The criteria presented by Centor et al.
TextSentencer_T21 2566-2605 Sentence denotes The criteria presented by Centor et al.
TextSentencer_T21 2566-2605 Sentence denotes The criteria presented by Centor et al.
TextSentencer_T22 2606-2791 Sentence denotes 30 years ago were developed to predict the presence of GAS as the cause of the patients' symptoms, and thus predict the patients who were considered in need of antibiotic therapy [11] .
TextSentencer_T22 2606-2791 Sentence denotes 30 years ago were developed to predict the presence of GAS as the cause of the patients' symptoms, and thus predict the patients who were considered in need of antibiotic therapy [11] .
TextSentencer_T22 2606-2791 Sentence denotes 30 years ago were developed to predict the presence of GAS as the cause of the patients' symptoms, and thus predict the patients who were considered in need of antibiotic therapy [11] .
TextSentencer_T23 2792-2991 Sentence denotes In recent years, the anaerobic Gram-negative bacterium Fusobacterium necrophorum has been suggested as an important cause of acute pharyngotonsillitis in adolescents and young adults [12] [13] [14] .
TextSentencer_T23 2792-2991 Sentence denotes In recent years, the anaerobic Gram-negative bacterium Fusobacterium necrophorum has been suggested as an important cause of acute pharyngotonsillitis in adolescents and young adults [12] [13] [14] .
TextSentencer_T23 2792-2991 Sentence denotes In recent years, the anaerobic Gram-negative bacterium Fusobacterium necrophorum has been suggested as an important cause of acute pharyngotonsillitis in adolescents and young adults [12] [13] [14] .
TextSentencer_T24 2992-3124 Sentence denotes At the same time, some authors have noticed an increase of severe infections caused by F. necrophorum (Lemièrre syndrome) [15, 16] .
TextSentencer_T24 2992-3124 Sentence denotes At the same time, some authors have noticed an increase of severe infections caused by F. necrophorum (Lemièrre syndrome) [15, 16] .
TextSentencer_T24 2992-3124 Sentence denotes At the same time, some authors have noticed an increase of severe infections caused by F. necrophorum (Lemièrre syndrome) [15, 16] .
TextSentencer_T25 3125-3241 Sentence denotes This conclusion is not, however, generally accepted [17] , as the increase may be due to publication bias [18, 19] .
TextSentencer_T25 3125-3241 Sentence denotes This conclusion is not, however, generally accepted [17] , as the increase may be due to publication bias [18, 19] .
TextSentencer_T25 3125-3241 Sentence denotes This conclusion is not, however, generally accepted [17] , as the increase may be due to publication bias [18, 19] .
TextSentencer_T26 3242-3435 Sentence denotes The studies focusing on F. necrophorum as a throat pathogen have, so far, been based on routine clinical microbiology data and have focused on the presence of this bacterium only [12, 14, 15] .
TextSentencer_T26 3242-3435 Sentence denotes The studies focusing on F. necrophorum as a throat pathogen have, so far, been based on routine clinical microbiology data and have focused on the presence of this bacterium only [12, 14, 15] .
TextSentencer_T26 3242-3435 Sentence denotes The studies focusing on F. necrophorum as a throat pathogen have, so far, been based on routine clinical microbiology data and have focused on the presence of this bacterium only [12, 14, 15] .
TextSentencer_T27 3436-3731 Sentence denotes The aim of the present study was to investigate the presence of F. necrophorum together with β-hemolytic streptococci, Mycoplasma pneumoniae, Chlamydophila pneumoniae, and 14 respiratory viruses in adults attending PHC with the symptoms of pharyngotonsillitis, compared to asymptomatic controls.
TextSentencer_T27 3436-3731 Sentence denotes The aim of the present study was to investigate the presence of F. necrophorum together with β-hemolytic streptococci, Mycoplasma pneumoniae, Chlamydophila pneumoniae, and 14 respiratory viruses in adults attending PHC with the symptoms of pharyngotonsillitis, compared to asymptomatic controls.
TextSentencer_T27 3436-3731 Sentence denotes The aim of the present study was to investigate the presence of F. necrophorum together with β-hemolytic streptococci, Mycoplasma pneumoniae, Chlamydophila pneumoniae, and 14 respiratory viruses in adults attending PHC with the symptoms of pharyngotonsillitis, compared to asymptomatic controls.
TextSentencer_T28 3732-3900 Sentence denotes The second aim was to investigate the association of these pathogens to the patient's history and symptoms and signs, and in relation to the Centor score in particular.
TextSentencer_T28 3732-3900 Sentence denotes The second aim was to investigate the association of these pathogens to the patient's history and symptoms and signs, and in relation to the Centor score in particular.
TextSentencer_T28 3732-3900 Sentence denotes The second aim was to investigate the association of these pathogens to the patient's history and symptoms and signs, and in relation to the Centor score in particular.
TextSentencer_T29 3901-4026 Sentence denotes Setting A prospective case control study was conducted in five primary healthcare centres (PHCC) in Kronoberg County, Sweden.
TextSentencer_T29 3901-4026 Sentence denotes Setting A prospective case control study was conducted in five primary healthcare centres (PHCC) in Kronoberg County, Sweden.
TextSentencer_T29 3901-4026 Sentence denotes Setting A prospective case control study was conducted in five primary healthcare centres (PHCC) in Kronoberg County, Sweden.
TextSentencer_T30 4027-4128 Sentence denotes Data were collected between January 15 and April 30, 2011 and from October 1, 2011 to April 15, 2012.
TextSentencer_T30 4027-4128 Sentence denotes Data were collected between January 15 and April 30, 2011 and from October 1, 2011 to April 15, 2012.
TextSentencer_T30 4027-4128 Sentence denotes Data were collected between January 15 and April 30, 2011 and from October 1, 2011 to April 15, 2012.
TextSentencer_T31 4129-4138 Sentence denotes Patients.
TextSentencer_T31 4129-4138 Sentence denotes Patients.
TextSentencer_T31 4129-4138 Sentence denotes Patients.
TextSentencer_T32 4139-4364 Sentence denotes Patients aged 15 to 45 years with a suspected acute pharyngotonsillitis who contacted the PHCC and were considered in need of a consultation by the physician according to the national Swedish guidelines [20] , were recruited.
TextSentencer_T32 4139-4364 Sentence denotes Patients aged 15 to 45 years with a suspected acute pharyngotonsillitis who contacted the PHCC and were considered in need of a consultation by the physician according to the national Swedish guidelines [20] , were recruited.
TextSentencer_T32 4139-4364 Sentence denotes Patients aged 15 to 45 years with a suspected acute pharyngotonsillitis who contacted the PHCC and were considered in need of a consultation by the physician according to the national Swedish guidelines [20] , were recruited.
TextSentencer_T33 4365-4539 Sentence denotes According to standard procedures, all patients contacted the PHCC via telephone, and a nurse primarily assessed if the patient's symptoms called for a visit to the physician.
TextSentencer_T33 4365-4539 Sentence denotes According to standard procedures, all patients contacted the PHCC via telephone, and a nurse primarily assessed if the patient's symptoms called for a visit to the physician.
TextSentencer_T33 4365-4539 Sentence denotes According to standard procedures, all patients contacted the PHCC via telephone, and a nurse primarily assessed if the patient's symptoms called for a visit to the physician.
TextSentencer_T34 4540-4638 Sentence denotes Informed consent was obtained and the physician made the study assessment during the consultation.
TextSentencer_T34 4540-4638 Sentence denotes Informed consent was obtained and the physician made the study assessment during the consultation.
TextSentencer_T34 4540-4638 Sentence denotes Informed consent was obtained and the physician made the study assessment during the consultation.
TextSentencer_T35 4639-4922 Sentence denotes This included the Centor criteria, i.e. absence of cough, fever >38.5°C, tender lymphadenitis, and tonsillar coating, as well as potential confounders such as smoking habits, recent antibiotic treatment, history of sore throat, and the duration of symptoms prior to the consultation.
TextSentencer_T35 4639-4922 Sentence denotes This included the Centor criteria, i.e. absence of cough, fever >38.5°C, tender lymphadenitis, and tonsillar coating, as well as potential confounders such as smoking habits, recent antibiotic treatment, history of sore throat, and the duration of symptoms prior to the consultation.
TextSentencer_T35 4639-4922 Sentence denotes This included the Centor criteria, i.e. absence of cough, fever >38.5°C, tender lymphadenitis, and tonsillar coating, as well as potential confounders such as smoking habits, recent antibiotic treatment, history of sore throat, and the duration of symptoms prior to the consultation.
TextSentencer_T36 4923-5017 Sentence denotes Since the study did not interfere with the clinical management, the risk for bias was minimal.
TextSentencer_T36 4923-5017 Sentence denotes Since the study did not interfere with the clinical management, the risk for bias was minimal.
TextSentencer_T36 4923-5017 Sentence denotes Since the study did not interfere with the clinical management, the risk for bias was minimal.
TextSentencer_T37 5018-5027 Sentence denotes Controls.
TextSentencer_T37 5018-5027 Sentence denotes Controls.
TextSentencer_T37 5018-5027 Sentence denotes Controls.
TextSentencer_T38 5028-5184 Sentence denotes Patients 15 to 45 years old visiting the PHCC for any medical reason other than an infection were recruited as a control group during the same time periods.
TextSentencer_T38 5028-5184 Sentence denotes Patients 15 to 45 years old visiting the PHCC for any medical reason other than an infection were recruited as a control group during the same time periods.
TextSentencer_T38 5028-5184 Sentence denotes Patients 15 to 45 years old visiting the PHCC for any medical reason other than an infection were recruited as a control group during the same time periods.
TextSentencer_T39 5185-5245 Sentence denotes Informed consent was obtained before sampling was performed.
TextSentencer_T39 5185-5245 Sentence denotes Informed consent was obtained before sampling was performed.
TextSentencer_T39 5185-5245 Sentence denotes Informed consent was obtained before sampling was performed.
TextSentencer_T40 5246-5414 Sentence denotes A questionnaire including questions about potential confounders such as recurrent sore throat, smoking habits, and antibiotic treatment in the last month was completed.
TextSentencer_T40 5246-5414 Sentence denotes A questionnaire including questions about potential confounders such as recurrent sore throat, smoking habits, and antibiotic treatment in the last month was completed.
TextSentencer_T40 5246-5414 Sentence denotes A questionnaire including questions about potential confounders such as recurrent sore throat, smoking habits, and antibiotic treatment in the last month was completed.
TextSentencer_T41 5415-5464 Sentence denotes All sampling was performed by staff at the PHCCs.
TextSentencer_T41 5415-5464 Sentence denotes All sampling was performed by staff at the PHCCs.
TextSentencer_T41 5415-5464 Sentence denotes All sampling was performed by staff at the PHCCs.
TextSentencer_T42 5465-5666 Sentence denotes A swab for the culture of β-hemolytic streptococci and F. necrophorum was obtained by rolling the swab on the tonsils at both sides and placing it in Amies medium with charcoal (Copan, Brescia, Italy).
TextSentencer_T42 5465-5666 Sentence denotes A swab for the culture of β-hemolytic streptococci and F. necrophorum was obtained by rolling the swab on the tonsils at both sides and placing it in Amies medium with charcoal (Copan, Brescia, Italy).
TextSentencer_T42 5465-5666 Sentence denotes A swab for the culture of β-hemolytic streptococci and F. necrophorum was obtained by rolling the swab on the tonsils at both sides and placing it in Amies medium with charcoal (Copan, Brescia, Italy).
TextSentencer_T43 5667-5918 Sentence denotes Two samples for the analyses of respiratory viruses Mycoplasma pneumoniae and Chlamydophila pneumoniae were obtained using flocked swabs transported in 3 mL of Universal Transport Medium (UTM; Copan), one from the pharynx and one from the nasopharynx.
TextSentencer_T43 5667-5918 Sentence denotes Two samples for the analyses of respiratory viruses Mycoplasma pneumoniae and Chlamydophila pneumoniae were obtained using flocked swabs transported in 3 mL of Universal Transport Medium (UTM; Copan), one from the pharynx and one from the nasopharynx.
TextSentencer_T43 5667-5918 Sentence denotes Two samples for the analyses of respiratory viruses Mycoplasma pneumoniae and Chlamydophila pneumoniae were obtained using flocked swabs transported in 3 mL of Universal Transport Medium (UTM; Copan), one from the pharynx and one from the nasopharynx.
TextSentencer_T44 5919-6044 Sentence denotes In the patient group, a capillary blood sample was obtained for the analysis of Epstein-Barr virus (EBV)-specific antibodies.
TextSentencer_T44 5919-6044 Sentence denotes In the patient group, a capillary blood sample was obtained for the analysis of Epstein-Barr virus (EBV)-specific antibodies.
TextSentencer_T44 5919-6044 Sentence denotes In the patient group, a capillary blood sample was obtained for the analysis of Epstein-Barr virus (EBV)-specific antibodies.
TextSentencer_T45 6045-6203 Sentence denotes According to the procedures used in the county at the time of the study, the result of the culture for β-hemolytic streptococci was reported to the physician.
TextSentencer_T45 6045-6203 Sentence denotes According to the procedures used in the county at the time of the study, the result of the culture for β-hemolytic streptococci was reported to the physician.
TextSentencer_T45 6045-6203 Sentence denotes According to the procedures used in the county at the time of the study, the result of the culture for β-hemolytic streptococci was reported to the physician.
TextSentencer_T46 6204-6330 Sentence denotes All samples were stored in a refrigerator and transported to the Department of Clinical Microbiology, Central Hospital, Växjö.
TextSentencer_T46 6204-6330 Sentence denotes All samples were stored in a refrigerator and transported to the Department of Clinical Microbiology, Central Hospital, Växjö.
TextSentencer_T46 6204-6330 Sentence denotes All samples were stored in a refrigerator and transported to the Department of Clinical Microbiology, Central Hospital, Växjö.
TextSentencer_T47 6331-6709 Sentence denotes Throat swabs were cultured for the recovery of β-hemolytic streptococci (Lancefield group A, C, and G), using a doublelayered agar (Columbia agar (Oxoid, Basingstokes, UK) covered with sheep blood agar, blood agar base (Merck, Darmstadt, Germany) with 5% sheep blood (SVA, Uppsala, Sweden), and 5 mg/mL methyl violet (Merck, Darmstadt, Germany) with a bacitracin disc (0.2 IU)).
TextSentencer_T47 6331-6709 Sentence denotes Throat swabs were cultured for the recovery of β-hemolytic streptococci (Lancefield group A, C, and G), using a doublelayered agar (Columbia agar (Oxoid, Basingstokes, UK) covered with sheep blood agar, blood agar base (Merck, Darmstadt, Germany) with 5% sheep blood (SVA, Uppsala, Sweden), and 5 mg/mL methyl violet (Merck, Darmstadt, Germany) with a bacitracin disc (0.2 IU)).
TextSentencer_T47 6331-6709 Sentence denotes Throat swabs were cultured for the recovery of β-hemolytic streptococci (Lancefield group A, C, and G), using a doublelayered agar (Columbia agar (Oxoid, Basingstokes, UK) covered with sheep blood agar, blood agar base (Merck, Darmstadt, Germany) with 5% sheep blood (SVA, Uppsala, Sweden), and 5 mg/mL methyl violet (Merck, Darmstadt, Germany) with a bacitracin disc (0.2 IU)).
TextSentencer_T48 6710-7035 Sentence denotes For F. necrophorum, a selective anaerobic plate (fastidious anaerobe agar (Lab M) with 5% horse blood (SVA) supplemented with vancomycin 2.5 mg/L (ICN Biomedicals, Irvine, CA, USA) and nalidixic acid 5.0 mg/L (MP Biomedicals, Santa Ana, CA, USA)), and with a kanamycin tablet 500 μg (Rosco, Taastrup, Denmark) was used [21] .
TextSentencer_T48 6710-7035 Sentence denotes For F. necrophorum, a selective anaerobic plate (fastidious anaerobe agar (Lab M) with 5% horse blood (SVA) supplemented with vancomycin 2.5 mg/L (ICN Biomedicals, Irvine, CA, USA) and nalidixic acid 5.0 mg/L (MP Biomedicals, Santa Ana, CA, USA)), and with a kanamycin tablet 500 μg (Rosco, Taastrup, Denmark) was used [21] .
TextSentencer_T48 6710-7035 Sentence denotes For F. necrophorum, a selective anaerobic plate (fastidious anaerobe agar (Lab M) with 5% horse blood (SVA) supplemented with vancomycin 2.5 mg/L (ICN Biomedicals, Irvine, CA, USA) and nalidixic acid 5.0 mg/L (MP Biomedicals, Santa Ana, CA, USA)), and with a kanamycin tablet 500 μg (Rosco, Taastrup, Denmark) was used [21] .
TextSentencer_T49 7036-7136 Sentence denotes The agar plates were incubated under anaerobic conditions in 35-37°C for 1 and 4 days, respectively.
TextSentencer_T49 7036-7136 Sentence denotes The agar plates were incubated under anaerobic conditions in 35-37°C for 1 and 4 days, respectively.
TextSentencer_T49 7036-7136 Sentence denotes The agar plates were incubated under anaerobic conditions in 35-37°C for 1 and 4 days, respectively.
TextSentencer_T50 7137-7328 Sentence denotes For species identification, Streptex (Remel Europe Ltd., Dartford, England) and MALDI-TOF (Microflex mass-spectrometer and Biotyper 3.1 software, Bruker Daltonics, Bremen, Germany) were used.
TextSentencer_T50 7137-7328 Sentence denotes For species identification, Streptex (Remel Europe Ltd., Dartford, England) and MALDI-TOF (Microflex mass-spectrometer and Biotyper 3.1 software, Bruker Daltonics, Bremen, Germany) were used.
TextSentencer_T50 7137-7328 Sentence denotes For species identification, Streptex (Remel Europe Ltd., Dartford, England) and MALDI-TOF (Microflex mass-spectrometer and Biotyper 3.1 software, Bruker Daltonics, Bremen, Germany) were used.
TextSentencer_T51 7329-7523 Sentence denotes All samples transported in UTM were stored in −80°C until shipped on dry ice to the Department of Clinical Microbiology, Sahlgrenska University Hospital, Gothenburg, Sweden for further analyses.
TextSentencer_T51 7329-7523 Sentence denotes All samples transported in UTM were stored in −80°C until shipped on dry ice to the Department of Clinical Microbiology, Sahlgrenska University Hospital, Gothenburg, Sweden for further analyses.
TextSentencer_T51 7329-7523 Sentence denotes All samples transported in UTM were stored in −80°C until shipped on dry ice to the Department of Clinical Microbiology, Sahlgrenska University Hospital, Gothenburg, Sweden for further analyses.
TextSentencer_T52 7524-7697 Sentence denotes All samples were analysed using multiplexed PCRs for 13 respiratory viruses and the two intracellular bacteria M. pneumoniae and C. pneumoniae as previously described [22] .
TextSentencer_T52 7524-7697 Sentence denotes All samples were analysed using multiplexed PCRs for 13 respiratory viruses and the two intracellular bacteria M. pneumoniae and C. pneumoniae as previously described [22] .
TextSentencer_T52 7524-7697 Sentence denotes All samples were analysed using multiplexed PCRs for 13 respiratory viruses and the two intracellular bacteria M. pneumoniae and C. pneumoniae as previously described [22] .
TextSentencer_T53 7698-7755 Sentence denotes Any detected DNA or RNA was considered a positive result.
TextSentencer_T53 7698-7755 Sentence denotes Any detected DNA or RNA was considered a positive result.
TextSentencer_T53 7698-7755 Sentence denotes Any detected DNA or RNA was considered a positive result.
TextSentencer_T54 7756-7883 Sentence denotes The blood samples were centrifuged at 3000 rpm for 10 minutes, and the sera were stored in −20°C until analyses were performed.
TextSentencer_T54 7756-7883 Sentence denotes The blood samples were centrifuged at 3000 rpm for 10 minutes, and the sera were stored in −20°C until analyses were performed.
TextSentencer_T54 7756-7883 Sentence denotes The blood samples were centrifuged at 3000 rpm for 10 minutes, and the sera were stored in −20°C until analyses were performed.
TextSentencer_T55 7884-8059 Sentence denotes All samples were screened for the presence of Epstein-Barr virus nucleic antigenantibodies (EBNA) (Novagnost EBV-EBNA IgG; Siemens, Tarrytown, NY, USA) on a BEP2000 (Siemens).
TextSentencer_T55 7884-8059 Sentence denotes All samples were screened for the presence of Epstein-Barr virus nucleic antigenantibodies (EBNA) (Novagnost EBV-EBNA IgG; Siemens, Tarrytown, NY, USA) on a BEP2000 (Siemens).
TextSentencer_T55 7884-8059 Sentence denotes All samples were screened for the presence of Epstein-Barr virus nucleic antigenantibodies (EBNA) (Novagnost EBV-EBNA IgG; Siemens, Tarrytown, NY, USA) on a BEP2000 (Siemens).
TextSentencer_T56 8060-8229 Sentence denotes Samples negative for EBNA were analysed with EBV IgM (Enzygnost Anti-EBV/IgM II; Siemens) and EBV-Viral Capsid Antigen IgG (VCA IgG, (Enzygnost Anti-EBV/ IgG; Siemens)).
TextSentencer_T56 8060-8229 Sentence denotes Samples negative for EBNA were analysed with EBV IgM (Enzygnost Anti-EBV/IgM II; Siemens) and EBV-Viral Capsid Antigen IgG (VCA IgG, (Enzygnost Anti-EBV/ IgG; Siemens)).
TextSentencer_T56 8060-8229 Sentence denotes Samples negative for EBNA were analysed with EBV IgM (Enzygnost Anti-EBV/IgM II; Siemens) and EBV-Viral Capsid Antigen IgG (VCA IgG, (Enzygnost Anti-EBV/ IgG; Siemens)).
TextSentencer_T57 8230-8333 Sentence denotes Patients with positive EBV IgM with or without VCA IgG were considered to have a primary EBV infection.
TextSentencer_T57 8230-8333 Sentence denotes Patients with positive EBV IgM with or without VCA IgG were considered to have a primary EBV infection.
TextSentencer_T57 8230-8333 Sentence denotes Patients with positive EBV IgM with or without VCA IgG were considered to have a primary EBV infection.
TextSentencer_T58 8334-8536 Sentence denotes Sampling strategies and detection techniques for the routine diagnostics of β-hemolytic streptococci (culture), influenza A and B (PCR), and M. pneumoniae (PCR) were not changed during the study period.
TextSentencer_T58 8334-8536 Sentence denotes Sampling strategies and detection techniques for the routine diagnostics of β-hemolytic streptococci (culture), influenza A and B (PCR), and M. pneumoniae (PCR) were not changed during the study period.
TextSentencer_T58 8334-8536 Sentence denotes Sampling strategies and detection techniques for the routine diagnostics of β-hemolytic streptococci (culture), influenza A and B (PCR), and M. pneumoniae (PCR) were not changed during the study period.
TextSentencer_T59 8537-8837 Sentence denotes All samples analysed for these pathogens were retrieved from the LIS system (ADBakt, Autonik AB, Sköldinge, Sweden) at the Department of Clinical Microbiology, Växjö from August 2010 to July 2012, and the proportion of positive samples were analysed on a monthly basis and compared to the study data.
TextSentencer_T59 8537-8837 Sentence denotes All samples analysed for these pathogens were retrieved from the LIS system (ADBakt, Autonik AB, Sköldinge, Sweden) at the Department of Clinical Microbiology, Växjö from August 2010 to July 2012, and the proportion of positive samples were analysed on a monthly basis and compared to the study data.
TextSentencer_T59 8537-8837 Sentence denotes All samples analysed for these pathogens were retrieved from the LIS system (ADBakt, Autonik AB, Sköldinge, Sweden) at the Department of Clinical Microbiology, Växjö from August 2010 to July 2012, and the proportion of positive samples were analysed on a monthly basis and compared to the study data.
TextSentencer_T60 8838-9026 Sentence denotes To be able to detect a 10% difference in the presence of F. necrophorum between the patients and the controls, 180 patients had to be included given a power of 0.80 and an α value of 0.05.
TextSentencer_T60 8838-9026 Sentence denotes To be able to detect a 10% difference in the presence of F. necrophorum between the patients and the controls, 180 patients had to be included given a power of 0.80 and an α value of 0.05.
TextSentencer_T60 8838-9026 Sentence denotes To be able to detect a 10% difference in the presence of F. necrophorum between the patients and the controls, 180 patients had to be included given a power of 0.80 and an α value of 0.05.
TextSentencer_T61 9027-9119 Sentence denotes The statistical analyses were performed using the SPSS 20.0 software (IBM, Armonk, NY, USA).
TextSentencer_T61 9027-9119 Sentence denotes The statistical analyses were performed using the SPSS 20.0 software (IBM, Armonk, NY, USA).
TextSentencer_T61 9027-9119 Sentence denotes The statistical analyses were performed using the SPSS 20.0 software (IBM, Armonk, NY, USA).
TextSentencer_T62 9120-9188 Sentence denotes For descriptive statistics, median values and proportions were used.
TextSentencer_T62 9120-9188 Sentence denotes For descriptive statistics, median values and proportions were used.
TextSentencer_T62 9120-9188 Sentence denotes For descriptive statistics, median values and proportions were used.
TextSentencer_T63 9189-9367 Sentence denotes Comparisons between proportions of categorical variables in two independent groups were performed using the χ 2 test or Fisher's exact test, when expected frequencies were small.
TextSentencer_T63 9189-9367 Sentence denotes Comparisons between proportions of categorical variables in two independent groups were performed using the χ 2 test or Fisher's exact test, when expected frequencies were small.
TextSentencer_T63 9189-9367 Sentence denotes Comparisons between proportions of categorical variables in two independent groups were performed using the χ 2 test or Fisher's exact test, when expected frequencies were small.
TextSentencer_T64 9368-9497 Sentence denotes Multiple logistic regressions were used to model the relationship between the outcome variable and several independent variables.
TextSentencer_T64 9368-9497 Sentence denotes Multiple logistic regressions were used to model the relationship between the outcome variable and several independent variables.
TextSentencer_T64 9368-9497 Sentence denotes Multiple logistic regressions were used to model the relationship between the outcome variable and several independent variables.
TextSentencer_T65 9498-9578 Sentence denotes The Kruskal-Wallis test was used when comparing medians in more than two groups.
TextSentencer_T65 9498-9578 Sentence denotes The Kruskal-Wallis test was used when comparing medians in more than two groups.
TextSentencer_T65 9498-9578 Sentence denotes The Kruskal-Wallis test was used when comparing medians in more than two groups.
TextSentencer_T66 9579-9698 Sentence denotes Missing data were <2% for all variables among the patients except for tonsillar coating, where 6% (14/220) was missing.
TextSentencer_T66 9579-9698 Sentence denotes Missing data were <2% for all variables among the patients except for tonsillar coating, where 6% (14/220) was missing.
TextSentencer_T66 9579-9698 Sentence denotes Missing data were <2% for all variables among the patients except for tonsillar coating, where 6% (14/220) was missing.
TextSentencer_T67 9699-9782 Sentence denotes Among the controls, background data were missing for 3% (4/120) of the individuals.
TextSentencer_T67 9699-9782 Sentence denotes Among the controls, background data were missing for 3% (4/120) of the individuals.
TextSentencer_T67 9699-9782 Sentence denotes Among the controls, background data were missing for 3% (4/120) of the individuals.
TextSentencer_T68 9783-9861 Sentence denotes The study was approved by the regional ethics board in Linköping, Sweden, Drn:
TextSentencer_T68 9783-9861 Sentence denotes The study was approved by the regional ethics board in Linköping, Sweden, Drn:
TextSentencer_T68 9783-9861 Sentence denotes The study was approved by the regional ethics board in Linköping, Sweden, Drn:
TextSentencer_T69 9862-9874 Sentence denotes 2010/267-31.
TextSentencer_T69 9862-9874 Sentence denotes 2010/267-31.
TextSentencer_T69 9862-9874 Sentence denotes 2010/267-31.
TextSentencer_T70 9875-9974 Sentence denotes All patients and controls received written information about the study before seeing the physician.
TextSentencer_T70 9875-9974 Sentence denotes All patients and controls received written information about the study before seeing the physician.
TextSentencer_T70 9875-9974 Sentence denotes All patients and controls received written information about the study before seeing the physician.
TextSentencer_T71 9975-10078 Sentence denotes The patients had the opportunity to ask questions about the study before informed consent was obtained.
TextSentencer_T71 9975-10078 Sentence denotes The patients had the opportunity to ask questions about the study before informed consent was obtained.
TextSentencer_T71 9975-10078 Sentence denotes The patients had the opportunity to ask questions about the study before informed consent was obtained.
TextSentencer_T72 10079-10266 Sentence denotes The sampling methods used in this study were well established and familiar to the personnel performing the sampling, and thus were regarded as safe for the included patients and controls.
TextSentencer_T72 10079-10266 Sentence denotes The sampling methods used in this study were well established and familiar to the personnel performing the sampling, and thus were regarded as safe for the included patients and controls.
TextSentencer_T72 10079-10266 Sentence denotes The sampling methods used in this study were well established and familiar to the personnel performing the sampling, and thus were regarded as safe for the included patients and controls.
TextSentencer_T73 10267-10322 Sentence denotes In total, 220 patients and 128 controls were recruited.
TextSentencer_T73 10267-10322 Sentence denotes In total, 220 patients and 128 controls were recruited.
TextSentencer_T73 10267-10322 Sentence denotes In total, 220 patients and 128 controls were recruited.
TextSentencer_T74 10323-10446 Sentence denotes The median age was 33 years (range 15-48 years) in the patient group and 31 years (range 16-46 years) in the control group.
TextSentencer_T74 10323-10446 Sentence denotes The median age was 33 years (range 15-48 years) in the patient group and 31 years (range 16-46 years) in the control group.
TextSentencer_T74 10323-10446 Sentence denotes The median age was 33 years (range 15-48 years) in the patient group and 31 years (range 16-46 years) in the control group.
TextSentencer_T75 10447-10513 Sentence denotes Characteristics of the study population are presented in Table 1 .
TextSentencer_T75 10447-10513 Sentence denotes Characteristics of the study population are presented in Table 1 .
TextSentencer_T75 10447-10513 Sentence denotes Characteristics of the study population are presented in Table 1 .
TextSentencer_T76 10514-10607 Sentence denotes All patients were evaluated according to the symptoms and signs building up the Centor score.
TextSentencer_T76 10514-10607 Sentence denotes All patients were evaluated according to the symptoms and signs building up the Centor score.
TextSentencer_T76 10514-10607 Sentence denotes All patients were evaluated according to the symptoms and signs building up the Centor score.
TextSentencer_T77 10608-10756 Sentence denotes The median Centor score was 2 (14.1% presented with Centor score 4, 24.5 % with a score of 3, 31.4% score 2, 22.7% score 1, and 7.3 % with score 0).
TextSentencer_T77 10608-10756 Sentence denotes The median Centor score was 2 (14.1% presented with Centor score 4, 24.5 % with a score of 3, 31.4% score 2, 22.7% score 1, and 7.3 % with score 0).
TextSentencer_T77 10608-10756 Sentence denotes The median Centor score was 2 (14.1% presented with Centor score 4, 24.5 % with a score of 3, 31.4% score 2, 22.7% score 1, and 7.3 % with score 0).
TextSentencer_T78 10757-10820 Sentence denotes The detection of bacteria and viruses in patients and controls.
TextSentencer_T78 10757-10820 Sentence denotes The detection of bacteria and viruses in patients and controls.
TextSentencer_T78 10757-10820 Sentence denotes The detection of bacteria and viruses in patients and controls.
TextSentencer_T79 10821-10958 Sentence denotes In 155/220 (70.5%) of the patients, as compared to 26/128 (20.3%) of the controls, (p <0.001), at least one bacterium or virus was found.
TextSentencer_T79 10821-10958 Sentence denotes In 155/220 (70.5%) of the patients, as compared to 26/128 (20.3%) of the controls, (p <0.001), at least one bacterium or virus was found.
TextSentencer_T79 10821-10958 Sentence denotes In 155/220 (70.5%) of the patients, as compared to 26/128 (20.3%) of the controls, (p <0.001), at least one bacterium or virus was found.
TextSentencer_T80 10959-11238 Sentence denotes The corresponding figures for viruses, independent of the presence of bacteria, were 70 (31.8%) and 11 (8.6%) (p <0.001), respectively, while at least one bacterium, with or without the presence of viruses, was found in 103 (46.8%) patients and in 17 (13.3%) controls (p <0.001).
TextSentencer_T80 10959-11238 Sentence denotes The corresponding figures for viruses, independent of the presence of bacteria, were 70 (31.8%) and 11 (8.6%) (p <0.001), respectively, while at least one bacterium, with or without the presence of viruses, was found in 103 (46.8%) patients and in 17 (13.3%) controls (p <0.001).
TextSentencer_T80 10959-11238 Sentence denotes The corresponding figures for viruses, independent of the presence of bacteria, were 70 (31.8%) and 11 (8.6%) (p <0.001), respectively, while at least one bacterium, with or without the presence of viruses, was found in 103 (46.8%) patients and in 17 (13.3%) controls (p <0.001).
TextSentencer_T81 11239-11301 Sentence denotes In 58 (26.4%) patients, more than one microorganism was found.
TextSentencer_T81 11239-11301 Sentence denotes In 58 (26.4%) patients, more than one microorganism was found.
TextSentencer_T81 11239-11301 Sentence denotes In 58 (26.4%) patients, more than one microorganism was found.
TextSentencer_T82 11302-11394 Sentence denotes Two bacteria or viruses were found in 20.9%, three in 4.1% and four in 1.4% of the patients.
TextSentencer_T82 11302-11394 Sentence denotes Two bacteria or viruses were found in 20.9%, three in 4.1% and four in 1.4% of the patients.
TextSentencer_T82 11302-11394 Sentence denotes Two bacteria or viruses were found in 20.9%, three in 4.1% and four in 1.4% of the patients.
TextSentencer_T83 11395-11459 Sentence denotes The most common combination was GAS and F. necrophorum (n = 11).
TextSentencer_T83 11395-11459 Sentence denotes The most common combination was GAS and F. necrophorum (n = 11).
TextSentencer_T83 11395-11459 Sentence denotes The most common combination was GAS and F. necrophorum (n = 11).
TextSentencer_T84 11460-11526 Sentence denotes Six of the controls were positive for more than one microorganism.
TextSentencer_T84 11460-11526 Sentence denotes Six of the controls were positive for more than one microorganism.
TextSentencer_T84 11460-11526 Sentence denotes Six of the controls were positive for more than one microorganism.
TextSentencer_T85 11527-11613 Sentence denotes The distribution of the bacteria and viruses found is presented (see Results section).
TextSentencer_T85 11527-11613 Sentence denotes The distribution of the bacteria and viruses found is presented (see Results section).
TextSentencer_T85 11527-11613 Sentence denotes The distribution of the bacteria and viruses found is presented (see Results section).
TextSentencer_T86 11614-11830 Sentence denotes GAS (p <0.001), F. necrophorum (p 0.001), and influenza B (p <0.002) were significantly more commonly found among the patients than among controls, and represented the three most common findings in the patient group.
TextSentencer_T86 11614-11830 Sentence denotes GAS (p <0.001), F. necrophorum (p 0.001), and influenza B (p <0.002) were significantly more commonly found among the patients than among controls, and represented the three most common findings in the patient group.
TextSentencer_T86 11614-11830 Sentence denotes GAS (p <0.001), F. necrophorum (p 0.001), and influenza B (p <0.002) were significantly more commonly found among the patients than among controls, and represented the three most common findings in the patient group.
TextSentencer_T87 11831-11912 Sentence denotes Bacteria and viruses found in patients with the suspicion of pharyngotonsillitis.
TextSentencer_T87 11831-11912 Sentence denotes Bacteria and viruses found in patients with the suspicion of pharyngotonsillitis.
TextSentencer_T87 11831-11912 Sentence denotes Bacteria and viruses found in patients with the suspicion of pharyngotonsillitis.
TextSentencer_T88 11913-12006 Sentence denotes Except for C. pneumoniae, all tested bacteria and viruses were found in at least one patient.
TextSentencer_T88 11913-12006 Sentence denotes Except for C. pneumoniae, all tested bacteria and viruses were found in at least one patient.
TextSentencer_T88 11913-12006 Sentence denotes Except for C. pneumoniae, all tested bacteria and viruses were found in at least one patient.
TextSentencer_T89 12007-12184 Sentence denotes Of the 103 (46.8%) patients positive for bacteria, 15 (14.6%) were infected with more than one bacterial species, and 16 (15.5%) had a concomitant finding of at least one virus.
TextSentencer_T89 12007-12184 Sentence denotes Of the 103 (46.8%) patients positive for bacteria, 15 (14.6%) were infected with more than one bacterial species, and 16 (15.5%) had a concomitant finding of at least one virus.
TextSentencer_T89 12007-12184 Sentence denotes Of the 103 (46.8%) patients positive for bacteria, 15 (14.6%) were infected with more than one bacterial species, and 16 (15.5%) had a concomitant finding of at least one virus.
TextSentencer_T90 12185-12381 Sentence denotes GAS was the most common finding (n = 66), followed by F. necrophorum (n = 33), influenza B virus (n = 16), and rhinoviruses (n = 14) ( Importance of the sampling site for the detection of viruses.
TextSentencer_T90 12185-12381 Sentence denotes GAS was the most common finding (n = 66), followed by F. necrophorum (n = 33), influenza B virus (n = 16), and rhinoviruses (n = 14) ( Importance of the sampling site for the detection of viruses.
TextSentencer_T90 12185-12381 Sentence denotes GAS was the most common finding (n = 66), followed by F. necrophorum (n = 33), influenza B virus (n = 16), and rhinoviruses (n = 14) ( Importance of the sampling site for the detection of viruses.
TextSentencer_T91 12382-12491 Sentence denotes Most viruses were found either in the throat sample or in the nasopharyngeal sample (Supplementary Table 2 ).
TextSentencer_T91 12382-12491 Sentence denotes Most viruses were found either in the throat sample or in the nasopharyngeal sample (Supplementary Table 2 ).
TextSentencer_T91 12382-12491 Sentence denotes Most viruses were found either in the throat sample or in the nasopharyngeal sample (Supplementary Table 2 ).
TextSentencer_T92 12492-12753 Sentence denotes There was no significant difference in the cycle threshold values (± 1 cycle threshold) between the different sampling sites, or between patients with only a virus found or in combination with bacteria, thus indicating similar amounts of viruses in the samples.
TextSentencer_T92 12492-12753 Sentence denotes There was no significant difference in the cycle threshold values (± 1 cycle threshold) between the different sampling sites, or between patients with only a virus found or in combination with bacteria, thus indicating similar amounts of viruses in the samples.
TextSentencer_T92 12492-12753 Sentence denotes There was no significant difference in the cycle threshold values (± 1 cycle threshold) between the different sampling sites, or between patients with only a virus found or in combination with bacteria, thus indicating similar amounts of viruses in the samples.
TextSentencer_T93 12754-12859 Sentence denotes For several pathogens, the detection rate in the patient group was unevenly distributed during the study.
TextSentencer_T93 12754-12859 Sentence denotes For several pathogens, the detection rate in the patient group was unevenly distributed during the study.
TextSentencer_T93 12754-12859 Sentence denotes For several pathogens, the detection rate in the patient group was unevenly distributed during the study.
TextSentencer_T94 12860-13089 Sentence denotes Adenoviruses (first inclusion period), rhinoviruses (second period), and influenza B (first period) were found during separate time frames of the study, while GAS and F. necrophorum were isolated throughout the inclusion periods.
TextSentencer_T94 12860-13089 Sentence denotes Adenoviruses (first inclusion period), rhinoviruses (second period), and influenza B (first period) were found during separate time frames of the study, while GAS and F. necrophorum were isolated throughout the inclusion periods.
TextSentencer_T94 12860-13089 Sentence denotes Adenoviruses (first inclusion period), rhinoviruses (second period), and influenza B (first period) were found during separate time frames of the study, while GAS and F. necrophorum were isolated throughout the inclusion periods.
TextSentencer_T95 13090-13254 Sentence denotes For influenza B and GAS, the relative prevalence in the study population at a given time was in relation to the detection rate in clinical samples (data not shown).
TextSentencer_T95 13090-13254 Sentence denotes For influenza B and GAS, the relative prevalence in the study population at a given time was in relation to the detection rate in clinical samples (data not shown).
TextSentencer_T95 13090-13254 Sentence denotes For influenza B and GAS, the relative prevalence in the study population at a given time was in relation to the detection rate in clinical samples (data not shown).
TextSentencer_T96 13255-13525 Sentence denotes The association of bacteria and viruses significantly associated with disease (i.e. only bacteria, only viruses, GAS, F. necrophorum, and influenza B virus) to background characteristics, the specific symptoms and signs and Centor score are presented in Tables 3 and 4 .
TextSentencer_T96 13255-13525 Sentence denotes The association of bacteria and viruses significantly associated with disease (i.e. only bacteria, only viruses, GAS, F. necrophorum, and influenza B virus) to background characteristics, the specific symptoms and signs and Centor score are presented in Tables 3 and 4 .
TextSentencer_T96 13255-13525 Sentence denotes The association of bacteria and viruses significantly associated with disease (i.e. only bacteria, only viruses, GAS, F. necrophorum, and influenza B virus) to background characteristics, the specific symptoms and signs and Centor score are presented in Tables 3 and 4 .
TextSentencer_T97 13526-13748 Sentence denotes Patients with only one or several bacteria found had a higher median Centor score (56.4% with Centor score 3, median 3) than patients with viruses only (25.0% with Centor score 3, median 2) (Mann-Whitney U test p <0.0001).
TextSentencer_T97 13526-13748 Sentence denotes Patients with only one or several bacteria found had a higher median Centor score (56.4% with Centor score 3, median 3) than patients with viruses only (25.0% with Centor score 3, median 2) (Mann-Whitney U test p <0.0001).
TextSentencer_T97 13526-13748 Sentence denotes Patients with only one or several bacteria found had a higher median Centor score (56.4% with Centor score 3, median 3) than patients with viruses only (25.0% with Centor score 3, median 2) (Mann-Whitney U test p <0.0001).
TextSentencer_T98 13749-13857 Sentence denotes In patients with no bacteria or viruses detected, 24.6% had a Centor score 3 with a median score value of 2.
TextSentencer_T98 13749-13857 Sentence denotes In patients with no bacteria or viruses detected, 24.6% had a Centor score 3 with a median score value of 2.
TextSentencer_T98 13749-13857 Sentence denotes In patients with no bacteria or viruses detected, 24.6% had a Centor score 3 with a median score value of 2.
TextSentencer_T99 13858-14071 Sentence denotes Patients with F. necrophorum only (n = 14) displayed a lower Centor score than GAS only (n = 46), but higher than patients with influenza B, other viruses, or no potential pathogen found (Kruskal-Wallis p <0.001).
TextSentencer_T99 13858-14071 Sentence denotes Patients with F. necrophorum only (n = 14) displayed a lower Centor score than GAS only (n = 46), but higher than patients with influenza B, other viruses, or no potential pathogen found (Kruskal-Wallis p <0.001).
TextSentencer_T99 13858-14071 Sentence denotes Patients with F. necrophorum only (n = 14) displayed a lower Centor score than GAS only (n = 46), but higher than patients with influenza B, other viruses, or no potential pathogen found (Kruskal-Wallis p <0.001).
TextSentencer_T100 14072-14246 Sentence denotes The multiple regression analysis revealed "being a smoker" and the presence of tonsillar coatings to be of importance for the likelihood of finding F. necrophorum (Table 5 ).
TextSentencer_T100 14072-14246 Sentence denotes The multiple regression analysis revealed "being a smoker" and the presence of tonsillar coatings to be of importance for the likelihood of finding F. necrophorum (Table 5 ).
TextSentencer_T100 14072-14246 Sentence denotes The multiple regression analysis revealed "being a smoker" and the presence of tonsillar coatings to be of importance for the likelihood of finding F. necrophorum (Table 5 ).
TextSentencer_T101 14247-14559 Sentence denotes This prospective case control study, analysing 20 potential causative agents of sore throat (6 bacteria and 14 viruses), could detect at least one of these in 70.5% of patients 15-45 years of age attending PHC with the suspicion of pharyngotonsillitis, compared to 20.3% in asymptomatic controls of the same age.
TextSentencer_T101 14247-14559 Sentence denotes This prospective case control study, analysing 20 potential causative agents of sore throat (6 bacteria and 14 viruses), could detect at least one of these in 70.5% of patients 15-45 years of age attending PHC with the suspicion of pharyngotonsillitis, compared to 20.3% in asymptomatic controls of the same age.
TextSentencer_T101 14247-14559 Sentence denotes This prospective case control study, analysing 20 potential causative agents of sore throat (6 bacteria and 14 viruses), could detect at least one of these in 70.5% of patients 15-45 years of age attending PHC with the suspicion of pharyngotonsillitis, compared to 20.3% in asymptomatic controls of the same age.
TextSentencer_T102 14560-14714 Sentence denotes GAS, F. necrophorum, and influenza B were significantly more common in the patients, and the highest level of Centor score was found in patients with GAS.
TextSentencer_T102 14560-14714 Sentence denotes GAS, F. necrophorum, and influenza B were significantly more common in the patients, and the highest level of Centor score was found in patients with GAS.
TextSentencer_T102 14560-14714 Sentence denotes GAS, F. necrophorum, and influenza B were significantly more common in the patients, and the highest level of Centor score was found in patients with GAS.
TextSentencer_T103 14715-14905 Sentence denotes Several viruses (influenza B, adeno-and rhinovirus) and GAS showed a marked seasonal variation and thus contributed differently to the aetiology of pharyngotonsillitis at a given time point.
TextSentencer_T103 14715-14905 Sentence denotes Several viruses (influenza B, adeno-and rhinovirus) and GAS showed a marked seasonal variation and thus contributed differently to the aetiology of pharyngotonsillitis at a given time point.
TextSentencer_T103 14715-14905 Sentence denotes Several viruses (influenza B, adeno-and rhinovirus) and GAS showed a marked seasonal variation and thus contributed differently to the aetiology of pharyngotonsillitis at a given time point.
TextSentencer_T104 14906-15149 Sentence denotes As far as we know, this is the first prospective study with a broad diagnostic approach, including both bacteria and viruses that relate to the reported signs and symptoms in patients aged 15-45 years with the suspicion of pharyngotonsillitis.
TextSentencer_T104 14906-15149 Sentence denotes As far as we know, this is the first prospective study with a broad diagnostic approach, including both bacteria and viruses that relate to the reported signs and symptoms in patients aged 15-45 years with the suspicion of pharyngotonsillitis.
TextSentencer_T104 14906-15149 Sentence denotes As far as we know, this is the first prospective study with a broad diagnostic approach, including both bacteria and viruses that relate to the reported signs and symptoms in patients aged 15-45 years with the suspicion of pharyngotonsillitis.
TextSentencer_T105 15150-15303 Sentence denotes The high quality of clinical data allowed us to perform analyses on the relationship between specific pathogens and patient history, symptoms, and signs.
TextSentencer_T105 15150-15303 Sentence denotes The high quality of clinical data allowed us to perform analyses on the relationship between specific pathogens and patient history, symptoms, and signs.
TextSentencer_T105 15150-15303 Sentence denotes The high quality of clinical data allowed us to perform analyses on the relationship between specific pathogens and patient history, symptoms, and signs.
TextSentencer_T106 15304-15555 Sentence denotes The summer was considered a low season of pharyngotonsillitis and therefore not included, the overall Centor score was relatively low, and the clinical assessment of the patients was not guided, all of which can be considered limitations of the study.
TextSentencer_T106 15304-15555 Sentence denotes The summer was considered a low season of pharyngotonsillitis and therefore not included, the overall Centor score was relatively low, and the clinical assessment of the patients was not guided, all of which can be considered limitations of the study.
TextSentencer_T106 15304-15555 Sentence denotes The summer was considered a low season of pharyngotonsillitis and therefore not included, the overall Centor score was relatively low, and the clinical assessment of the patients was not guided, all of which can be considered limitations of the study.
TextSentencer_T107 15556-15664 Sentence denotes This, however, reflects the patient group and practice in Swedish PHCs and is therefore considered relevant.
TextSentencer_T107 15556-15664 Sentence denotes This, however, reflects the patient group and practice in Swedish PHCs and is therefore considered relevant.
TextSentencer_T107 15556-15664 Sentence denotes This, however, reflects the patient group and practice in Swedish PHCs and is therefore considered relevant.
TextSentencer_T108 15665-15828 Sentence denotes The study was powered to be able to detect a significant difference in the presence of F. necrophorum in pharyngotonsillitis patients, compared to a control group.
TextSentencer_T108 15665-15828 Sentence denotes The study was powered to be able to detect a significant difference in the presence of F. necrophorum in pharyngotonsillitis patients, compared to a control group.
TextSentencer_T108 15665-15828 Sentence denotes The study was powered to be able to detect a significant difference in the presence of F. necrophorum in pharyngotonsillitis patients, compared to a control group.
TextSentencer_T109 15829-15973 Sentence denotes Since the power was not calculated on the associations between bacteria and viruses and signs or symptoms, we may have missed some associations.
TextSentencer_T109 15829-15973 Sentence denotes Since the power was not calculated on the associations between bacteria and viruses and signs or symptoms, we may have missed some associations.
TextSentencer_T109 15829-15973 Sentence denotes Since the power was not calculated on the associations between bacteria and viruses and signs or symptoms, we may have missed some associations.
TextSentencer_T110 15974-16012 Sentence denotes This should encourage further studies.
TextSentencer_T110 15974-16012 Sentence denotes This should encourage further studies.
TextSentencer_T110 15974-16012 Sentence denotes This should encourage further studies.
TextSentencer_T111 16013-16079 Sentence denotes We could not identify a potential pathogen in 30% of the patients.
TextSentencer_T111 16013-16079 Sentence denotes We could not identify a potential pathogen in 30% of the patients.
TextSentencer_T111 16013-16079 Sentence denotes We could not identify a potential pathogen in 30% of the patients.
TextSentencer_T112 16080-16152 Sentence denotes This could be due to sampling, or the detection methods used [2, 3, 7] .
TextSentencer_T112 16080-16152 Sentence denotes This could be due to sampling, or the detection methods used [2, 3, 7] .
TextSentencer_T112 16080-16152 Sentence denotes This could be due to sampling, or the detection methods used [2, 3, 7] .
TextSentencer_T113 16153-16297 Sentence denotes However, the methods for sampling and analyses of the samples used here are the same that may be used in the clinical setting and thus relevant.
TextSentencer_T113 16153-16297 Sentence denotes However, the methods for sampling and analyses of the samples used here are the same that may be used in the clinical setting and thus relevant.
TextSentencer_T113 16153-16297 Sentence denotes However, the methods for sampling and analyses of the samples used here are the same that may be used in the clinical setting and thus relevant.
TextSentencer_T114 16298-16419 Sentence denotes Non-infectious causes of sore throat have also been reported by other authors [23] , but were not included in this study.
TextSentencer_T114 16298-16419 Sentence denotes Non-infectious causes of sore throat have also been reported by other authors [23] , but were not included in this study.
TextSentencer_T114 16298-16419 Sentence denotes Non-infectious causes of sore throat have also been reported by other authors [23] , but were not included in this study.
TextSentencer_T115 16420-16692 Sentence denotes Interestingly, the median Centor score in the group of patients with no bacterium or virus found (Centor score 2) were similar to the group with viruses found, indicating that there may be more infections due to viruses rather than bacteria being undetected in this group.
TextSentencer_T115 16420-16692 Sentence denotes Interestingly, the median Centor score in the group of patients with no bacterium or virus found (Centor score 2) were similar to the group with viruses found, indicating that there may be more infections due to viruses rather than bacteria being undetected in this group.
TextSentencer_T115 16420-16692 Sentence denotes Interestingly, the median Centor score in the group of patients with no bacterium or virus found (Centor score 2) were similar to the group with viruses found, indicating that there may be more infections due to viruses rather than bacteria being undetected in this group.
TextSentencer_T116 16693-16745 Sentence denotes As expected, GAS was the most common pathogen [24] .
TextSentencer_T116 16693-16745 Sentence denotes As expected, GAS was the most common pathogen [24] .
TextSentencer_T116 16693-16745 Sentence denotes As expected, GAS was the most common pathogen [24] .
TextSentencer_T117 16746-16916 Sentence denotes The Centor score for these patients was higher than for patients with non-GAS infections, supporting the continuous use of this score to predict the presence of GAS [5] .
TextSentencer_T117 16746-16916 Sentence denotes The Centor score for these patients was higher than for patients with non-GAS infections, supporting the continuous use of this score to predict the presence of GAS [5] .
TextSentencer_T117 16746-16916 Sentence denotes The Centor score for these patients was higher than for patients with non-GAS infections, supporting the continuous use of this score to predict the presence of GAS [5] .
TextSentencer_T118 16917-17133 Sentence denotes There was a large diversity of the viruses contributing to the aetiology, and the temporal variation resulted in influenza B (only period 1) being the most common viral cause of pharyngotonsillitis in this age group.
TextSentencer_T118 16917-17133 Sentence denotes There was a large diversity of the viruses contributing to the aetiology, and the temporal variation resulted in influenza B (only period 1) being the most common viral cause of pharyngotonsillitis in this age group.
TextSentencer_T118 16917-17133 Sentence denotes There was a large diversity of the viruses contributing to the aetiology, and the temporal variation resulted in influenza B (only period 1) being the most common viral cause of pharyngotonsillitis in this age group.
TextSentencer_T119 17134-17194 Sentence denotes Respiratory viruses were also detected in the control group.
TextSentencer_T119 17134-17194 Sentence denotes Respiratory viruses were also detected in the control group.
TextSentencer_T119 17134-17194 Sentence denotes Respiratory viruses were also detected in the control group.
TextSentencer_T120 17195-17300 Sentence denotes This might be seen as over-reporting of the presence of these viruses due to the high sensitivity of PCR.
TextSentencer_T120 17195-17300 Sentence denotes This might be seen as over-reporting of the presence of these viruses due to the high sensitivity of PCR.
TextSentencer_T120 17195-17300 Sentence denotes This might be seen as over-reporting of the presence of these viruses due to the high sensitivity of PCR.
TextSentencer_T121 17301-17408 Sentence denotes However, we would argue, rather, that it reflects asymptomatic infections or prolonged shedding of viruses.
TextSentencer_T121 17301-17408 Sentence denotes However, we would argue, rather, that it reflects asymptomatic infections or prolonged shedding of viruses.
TextSentencer_T121 17301-17408 Sentence denotes However, we would argue, rather, that it reflects asymptomatic infections or prolonged shedding of viruses.
TextSentencer_T122 17409-17584 Sentence denotes Despite the unbiased inclusion, as many as 15% of the patients were culturepositive for F. necrophorum, while only 3% of the healthy controls were positive for this bacterium.
TextSentencer_T122 17409-17584 Sentence denotes Despite the unbiased inclusion, as many as 15% of the patients were culturepositive for F. necrophorum, while only 3% of the healthy controls were positive for this bacterium.
TextSentencer_T122 17409-17584 Sentence denotes Despite the unbiased inclusion, as many as 15% of the patients were culturepositive for F. necrophorum, while only 3% of the healthy controls were positive for this bacterium.
TextSentencer_T123 17585-17843 Sentence denotes Previously, Aliyu et al. described patients, aged 5 months to 79 years, with a sore throat where a routine culture was obtained, and found F. necrophorum in 10% of these samples using PCR, but did not find any F. necrophorum among 100 healthy controls [12] .
TextSentencer_T123 17585-17843 Sentence denotes Previously, Aliyu et al. described patients, aged 5 months to 79 years, with a sore throat where a routine culture was obtained, and found F. necrophorum in 10% of these samples using PCR, but did not find any F. necrophorum among 100 healthy controls [12] .
TextSentencer_T123 17585-17843 Sentence denotes Previously, Aliyu et al. described patients, aged 5 months to 79 years, with a sore throat where a routine culture was obtained, and found F. necrophorum in 10% of these samples using PCR, but did not find any F. necrophorum among 100 healthy controls [12] .
TextSentencer_T124 17844-18025 Sentence denotes Amess reported 4.9% of routine throat cultures in the age group <1-88 years to be positive for F. necrophorum, with the highest prevalence in patients ages 11-25 years (9.8%) [14] .
TextSentencer_T124 17844-18025 Sentence denotes Amess reported 4.9% of routine throat cultures in the age group <1-88 years to be positive for F. necrophorum, with the highest prevalence in patients ages 11-25 years (9.8%) [14] .
TextSentencer_T124 17844-18025 Sentence denotes Amess reported 4.9% of routine throat cultures in the age group <1-88 years to be positive for F. necrophorum, with the highest prevalence in patients ages 11-25 years (9.8%) [14] .
TextSentencer_T125 18026-18228 Sentence denotes In patients 18-32 years of age with "non-streptococcal tonsillitis," Jensen et al. identified F. necrophorum with PCR in almost half of the samples, and in lower amounts among 21% of the controls [13] .
TextSentencer_T125 18026-18228 Sentence denotes In patients 18-32 years of age with "non-streptococcal tonsillitis," Jensen et al. identified F. necrophorum with PCR in almost half of the samples, and in lower amounts among 21% of the controls [13] .
TextSentencer_T125 18026-18228 Sentence denotes In patients 18-32 years of age with "non-streptococcal tonsillitis," Jensen et al. identified F. necrophorum with PCR in almost half of the samples, and in lower amounts among 21% of the controls [13] .
TextSentencer_T126 18229-18422 Sentence denotes The use of samples from routine microbiology and "nonstreptococcal" samples will tend, contrary to the prospective open inclusion used in the present study, to over-report the pathogen studied.
TextSentencer_T126 18229-18422 Sentence denotes The use of samples from routine microbiology and "nonstreptococcal" samples will tend, contrary to the prospective open inclusion used in the present study, to over-report the pathogen studied.
TextSentencer_T126 18229-18422 Sentence denotes The use of samples from routine microbiology and "nonstreptococcal" samples will tend, contrary to the prospective open inclusion used in the present study, to over-report the pathogen studied.
TextSentencer_T127 18423-18497 Sentence denotes Fusobacterium necrophorum was the only microorganism found in 14 patients.
TextSentencer_T127 18423-18497 Sentence denotes Fusobacterium necrophorum was the only microorganism found in 14 patients.
TextSentencer_T127 18423-18497 Sentence denotes Fusobacterium necrophorum was the only microorganism found in 14 patients.
TextSentencer_T128 18498-18644 Sentence denotes These patients were not necessarily less ill than the patients with GAS only, but received a lower Centor score due to a higher presence of cough.
TextSentencer_T128 18498-18644 Sentence denotes These patients were not necessarily less ill than the patients with GAS only, but received a lower Centor score due to a higher presence of cough.
TextSentencer_T128 18498-18644 Sentence denotes These patients were not necessarily less ill than the patients with GAS only, but received a lower Centor score due to a higher presence of cough.
TextSentencer_T129 18645-18936 Sentence denotes Although the power of the study was not calculated to rule out associations between signs and symptoms, this study could not find any association between age [14] , recent primary EBV infection [25] , or recurrent sore throat [26] and the detection of F. necrophorum, as suggested by others.
TextSentencer_T129 18645-18936 Sentence denotes Although the power of the study was not calculated to rule out associations between signs and symptoms, this study could not find any association between age [14] , recent primary EBV infection [25] , or recurrent sore throat [26] and the detection of F. necrophorum, as suggested by others.
TextSentencer_T129 18645-18936 Sentence denotes Although the power of the study was not calculated to rule out associations between signs and symptoms, this study could not find any association between age [14] , recent primary EBV infection [25] , or recurrent sore throat [26] and the detection of F. necrophorum, as suggested by others.
TextSentencer_T130 18937-19034 Sentence denotes However, smoking and coating of the tonsils increased the likelihood of detecting F. necrophorum.
TextSentencer_T130 18937-19034 Sentence denotes However, smoking and coating of the tonsils increased the likelihood of detecting F. necrophorum.
TextSentencer_T130 18937-19034 Sentence denotes However, smoking and coating of the tonsils increased the likelihood of detecting F. necrophorum.
TextSentencer_T131 19035-19184 Sentence denotes Importantly, some of the controls were positive for F. necrophorum, and the presence of this bacterium is thus not strictly associated with symptoms.
TextSentencer_T131 19035-19184 Sentence denotes Importantly, some of the controls were positive for F. necrophorum, and the presence of this bacterium is thus not strictly associated with symptoms.
TextSentencer_T131 19035-19184 Sentence denotes Importantly, some of the controls were positive for F. necrophorum, and the presence of this bacterium is thus not strictly associated with symptoms.
TextSentencer_T132 19185-19310 Sentence denotes Among nearly twothirds of patients with a presence of F. necrophorum, another microorganism was found (both GAS and viruses).
TextSentencer_T132 19185-19310 Sentence denotes Among nearly twothirds of patients with a presence of F. necrophorum, another microorganism was found (both GAS and viruses).
TextSentencer_T132 19185-19310 Sentence denotes Among nearly twothirds of patients with a presence of F. necrophorum, another microorganism was found (both GAS and viruses).
TextSentencer_T133 19311-19439 Sentence denotes The growth, and possibly also the pathogenic potential of F. necrophorum, may thus be facilitated by an underlying inflammation.
TextSentencer_T133 19311-19439 Sentence denotes The growth, and possibly also the pathogenic potential of F. necrophorum, may thus be facilitated by an underlying inflammation.
TextSentencer_T133 19311-19439 Sentence denotes The growth, and possibly also the pathogenic potential of F. necrophorum, may thus be facilitated by an underlying inflammation.
TextSentencer_T134 19440-19603 Sentence denotes In conclusion, this study showed that GAS and several respiratory viruses, together with F. necrophorum, are of importance in the aetiology of pharyngotonsillitis.
TextSentencer_T134 19440-19603 Sentence denotes In conclusion, this study showed that GAS and several respiratory viruses, together with F. necrophorum, are of importance in the aetiology of pharyngotonsillitis.
TextSentencer_T134 19440-19603 Sentence denotes In conclusion, this study showed that GAS and several respiratory viruses, together with F. necrophorum, are of importance in the aetiology of pharyngotonsillitis.
TextSentencer_T135 19604-19722 Sentence denotes The exact distribution of each specific pathogen will, at a given time, be subjected to local and temporal variations.
TextSentencer_T135 19604-19722 Sentence denotes The exact distribution of each specific pathogen will, at a given time, be subjected to local and temporal variations.
TextSentencer_T135 19604-19722 Sentence denotes The exact distribution of each specific pathogen will, at a given time, be subjected to local and temporal variations.
TextSentencer_T136 19723-19898 Sentence denotes Both Centor and Bank et al. have suggested that a broad antibiotic treatment of tonsillitis could prevent the few cases of severe infection (i.e. Lemièrre syndrome) [27, 28] .
TextSentencer_T136 19723-19898 Sentence denotes Both Centor and Bank et al. have suggested that a broad antibiotic treatment of tonsillitis could prevent the few cases of severe infection (i.e. Lemièrre syndrome) [27, 28] .
TextSentencer_T136 19723-19898 Sentence denotes Both Centor and Bank et al. have suggested that a broad antibiotic treatment of tonsillitis could prevent the few cases of severe infection (i.e. Lemièrre syndrome) [27, 28] .
TextSentencer_T137 19899-20162 Sentence denotes We consider this suggestion premature, as the finding of F. necrophorum in a predisposing tonsillitis has not been shown to be of importance for the development of Lemièrre syndrome, and as the best treatment option of F. necrophorum has not yet been established.
TextSentencer_T137 19899-20162 Sentence denotes We consider this suggestion premature, as the finding of F. necrophorum in a predisposing tonsillitis has not been shown to be of importance for the development of Lemièrre syndrome, and as the best treatment option of F. necrophorum has not yet been established.
TextSentencer_T137 19899-20162 Sentence denotes We consider this suggestion premature, as the finding of F. necrophorum in a predisposing tonsillitis has not been shown to be of importance for the development of Lemièrre syndrome, and as the best treatment option of F. necrophorum has not yet been established.
TextSentencer_T138 20163-20403 Sentence denotes More studies are warranted to further define the importance of F. necrophorum in tonsillitis, establish a standard for how to handle the finding of F. necrophorum in pharyngotonsillitis, and determine whether antibiotic treatment is needed.
TextSentencer_T138 20163-20403 Sentence denotes More studies are warranted to further define the importance of F. necrophorum in tonsillitis, establish a standard for how to handle the finding of F. necrophorum in pharyngotonsillitis, and determine whether antibiotic treatment is needed.
TextSentencer_T138 20163-20403 Sentence denotes More studies are warranted to further define the importance of F. necrophorum in tonsillitis, establish a standard for how to handle the finding of F. necrophorum in pharyngotonsillitis, and determine whether antibiotic treatment is needed.
TextSentencer_T139 20404-20573 Sentence denotes We urge diagnostic laboratories to consider the methods needed to find this bacterium in throat swabs (i.e. PCR-based methodology or anaerobic culture for 4 days) [13] .
TextSentencer_T139 20404-20573 Sentence denotes We urge diagnostic laboratories to consider the methods needed to find this bacterium in throat swabs (i.e. PCR-based methodology or anaerobic culture for 4 days) [13] .
TextSentencer_T139 20404-20573 Sentence denotes We urge diagnostic laboratories to consider the methods needed to find this bacterium in throat swabs (i.e. PCR-based methodology or anaerobic culture for 4 days) [13] .
TextSentencer_T140 20574-20809 Sentence denotes The study was funded by unrestricted grants from The Kronoberg County Council, The Nordic Society of Clinical Microbiology and Infectious diseases (NSCMID), The South Swedish Region Council, and the Swedish Society of Physicians (SLS).
TextSentencer_T140 20574-20809 Sentence denotes The study was funded by unrestricted grants from The Kronoberg County Council, The Nordic Society of Clinical Microbiology and Infectious diseases (NSCMID), The South Swedish Region Council, and the Swedish Society of Physicians (SLS).
TextSentencer_T140 20574-20809 Sentence denotes The study was funded by unrestricted grants from The Kronoberg County Council, The Nordic Society of Clinical Microbiology and Infectious diseases (NSCMID), The South Swedish Region Council, and the Swedish Society of Physicians (SLS).
TextSentencer_T141 20810-20870 Sentence denotes The authors declare that they have no conflicts of interest.
TextSentencer_T141 20810-20870 Sentence denotes The authors declare that they have no conflicts of interest.
TextSentencer_T141 20810-20870 Sentence denotes The authors declare that they have no conflicts of interest.