CORD-19:28795222c143e94145c975f044b72550370f1cbf JSONTXT 7 Projects

Abstract Fourteen diverse biological and pharmacological activities exhibited by various azetidin-2-ones (blactams) are comprehensively reviewed with numerous figures and references giving ideas of their structural diversity and immense biological potential. Membrane damaging activity of a maslinic acid analog pp. 1-6 Bianka Siewert and René Csuk* Incubation of human ovarian cancer cells A2780 with 4-oxa-4-phenylbutyl 2,3-dihydroxy-olean-12-en-28-oate (1) resulted in an incorporation of 1 into the cell's membrane followed by an extrusion of cholesterol from the lipid rafts. Shuang Han, Fei-Fei Zhang, Xin Xie and Jian-Zhong Chen* Pharmacophore-oriented 1,2,4-triazolones were designed and synthesized to have CB1 receptor antagonistic potency. Docking simulations were performed to predict the interaction modes of 1,2,4-triazolones binding to both CB1 and CB2 receptors. 8-Trifluoromethylquinoline based 1,2,3-triazoles derivatives were synthesized, characterized by spectral studies and X-ray analysis. Among the synthesized compounds 5c, 6b, 8b, 11 and 12 showed good antimicrobial activity. Synthesis and evaluation of anti-tubercular activity of 6-(4-substitutedpiperazin-1-yl) phenanthridine analogues pp. 333-339 Hunsur Nagendra Nagesh, Narva Suresh, Kalaga Mahalakshmi Naidu, Boyineni Arun, Jonnalagadda Padma Sridevi, Dharmarajan Sriram, Perumal Yogeeswari and Kondapalli Venkata Gowri Chandra Sekhar* In this communication, we revealed three 6-(4-substitutedpiperazin-1-yl)phenanthridine derivatives as promising anti-tubercular agents against Mycobacterium tuberculosis H 37 Rv. Further, structure of compound 5k is substantiated by X-ray crystallographic study.