PubMed:6804019 JSONTXT 3 Projects

[Comparison of blood-brain barrier of various amino acids in 5, 12 and 21 day old rats]. The bolus injection technique described by Oldendorf has been modified in order to study the blood brain transport of amino acids in immature Rats. The brain uptake indices (BUI) of lysine, leucine, alanine, proline, glucose and glutamic acid have been compared at tracer dose and at 10 mM concentration in 5, 12 and 21 day-old Rats. At every time-period, the BUIs of proline, glycine and glutamic acid were not decreased by the 10 mM concentration and were similar to that of sucrose. Between day 5 to 21, the saturable fraction of the BUI of lysine decreased by 50% that of leucine increased by about 50% and that of alanine which represented only a small fraction of the total uptake decreased with time; the unsaturable fraction of the BUIs of these 3 amino acids was higher than the BUI of sucrose and declined progressively.