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Background: Volumetric parameters of positron emission tomography-computed tomography using 18F-fludeoxyglucose 18F-FDG PETCT that comprehensively reflect both metabolic activity and tumor burden are capable of predicting survival in several cancers. The aim of this study as to investigate the predictive performance of metabolic tumor burden measured by 18F-FDG PETCT in ovarian cancer patients ho received platinum-based adjuvant chemotherapy after cytoreductive surgery. Methods: Included in this study ere 37 epithelial ovarian cancer patients. Metabolic tumor burden in terms of metabolic tumor volume MTV and total lesion glycolysis TLG , clinical stage, histological type, residual tumor after primary cytoreductive surgery, baseline serum carbohydrate antigen 125 CA125 level, and the maximum standardized uptake value SUVmax ere determined, and compared for their performance in predicting progression-free survival PFS . Results: MTV correlated ith CA125 r = 0.547, Plt 0.001 , and TLG correlated ith SUVmax and CA125 SUVmax : r = 0.437, P= 0.007; CA125: r = 0.593, Plt 0.001 . Kaplan-Meier analysis shoed a significant difference in PFS beteen the groups categorized by TLG P= 0.043; log-rank test . Univariate analysis indicated that TLG as a statistically significant risk factor for poor PFS. Multivariate analysis adjusted according to the clinicopathological features as performed for MTV, TLG, SUVmax , tumor size and CA125. Only TLG shoed a significant difference P= 0.038 , and a 3.915-fold increase in the hazard ratio of PFS. Conclusions: MTV and TLG especially TLG could serve as potential surrogate biomarkers for recurrence in patients ho undergo primary cytoreductive surgery folloed by platinum-based chemotherapy, and could identify patients at high risk of recurrence ho need more aggressive treatment.,J Clin Oncol 34, 2016 suppl; abstr e17100 ,Publication Only Gynecologic Cancer