asco@alo33:161997 JSONTXT

Background: Despite groing numbers of older people ith cancer, treatment decisions are often challenging, since evidence-based survival data according to staging and treatment progressively declines ith increasing age, particularly among the oldest old. The aim of this study as to describe the association of increasing age and disease staging at presentation, on survival among omen aged over 65 years, diagnosed ith breast cancer. Methods: This as a nested case control study, comparing 3,270 patients ith breast cancer to 13,163 non-cancer age-matched controls. Baseline characteristics and cancer data folloed up from 2000-2011 ere gathered from the Israeli Central Bureau of Statistics 1995 census and the Israel Cancer Registry. Survival curves and Hazards Ratios adjusted for ethnicity and socioeconomic status ere stratified for 5-year age groups. Results: The poor survival of metastatic cancer progressively deteriorated ith increasing age; among patients age 80 years old and more, the median survival in the upper quartile as less than a year. On the other hand, omen ith early stage cancer had similar survival compared to the non-cancer controls, even shoing a trend to improved survival among the oldest old. Similarly, the magnitude of the decreased survival among intermediate stage cancer as seen to attenuate beyond the age of 80. Compared to non-cancer controls, early breast cancer subjects had a non-significant decreased risk of death throughout follo-up, hich actually achieved a borderline significance beyond age 85 ith an adjusted HR = 0.60 95 percentCI:0.358-1.009 . The increased risk of death associated ith Intermediate stage breast cancer gradually declined ith rising age, falling from adjusted HR 3.26 95 percentCI: 2.58-4.12 at age 65-69, to an adjusted HR of 1.20 95 percentCI: 1.22-2.09 at age 80-84, slightly rising again beyond age 85. Metastatic disease as strongly associated ith mortality at all ages. Conclusions: Elderly omen ith breast cancer presenting ith localized disease have a comparable expectancy of life compared to non-cancer healthy controls irrespective of advancing age. In contrast, the poor prognosis of patients diagnosed ith metastatic disease as seen to deteriorate ith advancing age.,J Clin Oncol 34, 2016 suppl; abstr 10035 00:00.0,Patient and Survivor Care