PubMed:9989503 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/9989503","sourcedb":"PubMed","sourceid":"9989503","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/9989503","text":"Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.\nUsing the coiled-coil region of Stat5b as the bait in a yeast two-hybrid screen, we identified the association of Nmi, a protein of unknown function previously reported as an N-Myc interactor. We further show that Nmi interacts with all STATs except Stat2. We evaluated two cytokine systems, IL-2 and IFNgamma, and demonstrate that Nmi augments STAT-mediated transcription in response to these cytokines. Interestingly, Nmi lacks an intrinsic transcriptional activation domain; instead, Nmi enhances the association of CBP/p300 coactivator proteins with Stat1 and Stat5, and together with CBP/p300 can augment IL-2- and IFNgamma-dependent transcription. 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