PubMed:9989503 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":26,"end":29},"obj":"protein"},{"id":"T2","span":{"begin":35,"end":40},"obj":"protein"},{"id":"T3","span":{"begin":45,"end":50},"obj":"protein"},{"id":"T4","span":{"begin":54,"end":58},"obj":"protein"},{"id":"T5","span":{"begin":64,"end":72},"obj":"protein"},{"id":"T6","span":{"begin":125,"end":131},"obj":"protein"},{"id":"T7","span":{"begin":207,"end":210},"obj":"protein"},{"id":"T8","span":{"begin":268,"end":273},"obj":"protein"},{"id":"T9","span":{"begin":307,"end":310},"obj":"protein"},{"id":"T10","span":{"begin":330,"end":335},"obj":"protein"},{"id":"T11","span":{"begin":343,"end":348},"obj":"protein"},{"id":"T12","span":{"begin":385,"end":389},"obj":"protein"},{"id":"T13","span":{"begin":394,"end":402},"obj":"protein"},{"id":"T14","span":{"begin":425,"end":428},"obj":"protein"},{"id":"T15","span":{"begin":438,"end":442},"obj":"protein"},{"id":"T16","span":{"begin":487,"end":496},"obj":"protein"},{"id":"T17","span":{"begin":513,"end":516},"obj":"protein"},{"id":"T18","span":{"begin":536,"end":569},"obj":"protein"},{"id":"T19","span":{"begin":580,"end":583},"obj":"protein"},{"id":"T20","span":{"begin":612,"end":641},"obj":"protein"},{"id":"T21","span":{"begin":647,"end":652},"obj":"protein"},{"id":"T22","span":{"begin":657,"end":662},"obj":"protein"},{"id":"T23","span":{"begin":682,"end":690},"obj":"protein"},{"id":"T24","span":{"begin":788,"end":791},"obj":"protein"},{"id":"T25","span":{"begin":807,"end":811},"obj":"protein"},{"id":"T26","span":{"begin":945,"end":984},"obj":"protein"}],"text":"Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.\nUsing the coiled-coil region of Stat5b as the bait in a yeast two-hybrid screen, we identified the association of Nmi, a protein of unknown function previously reported as an N-Myc interactor. We further show that Nmi interacts with all STATs except Stat2. We evaluated two cytokine systems, IL-2 and IFNgamma, and demonstrate that Nmi augments STAT-mediated transcription in response to these cytokines. Interestingly, Nmi lacks an intrinsic transcriptional activation domain; instead, Nmi enhances the association of CBP/p300 coactivator proteins with Stat1 and Stat5, and together with CBP/p300 can augment IL-2- and IFNgamma-dependent transcription. Therefore, our data not only reveal that Nmi can potentiate STAT-dependent transcription, but also suggest that it can augment coactivator protein recruitment to at least some members of a group of sequence-specific transcription factors."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":92},"obj":"Sentence"},{"id":"S2","span":{"begin":93,"end":285},"obj":"Sentence"},{"id":"S3","span":{"begin":286,"end":349},"obj":"Sentence"},{"id":"S4","span":{"begin":350,"end":497},"obj":"Sentence"},{"id":"S5","span":{"begin":498,"end":746},"obj":"Sentence"},{"id":"S6","span":{"begin":747,"end":985},"obj":"Sentence"}],"text":"Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.\nUsing the coiled-coil region of Stat5b as the bait in a yeast two-hybrid screen, we identified the association of Nmi, a protein of unknown function previously reported as an N-Myc interactor. We further show that Nmi interacts with all STATs except Stat2. We evaluated two cytokine systems, IL-2 and IFNgamma, and demonstrate that Nmi augments STAT-mediated transcription in response to these cytokines. Interestingly, Nmi lacks an intrinsic transcriptional activation domain; instead, Nmi enhances the association of CBP/p300 coactivator proteins with Stat1 and Stat5, and together with CBP/p300 can augment IL-2- and IFNgamma-dependent transcription. Therefore, our data not only reveal that Nmi can potentiate STAT-dependent transcription, but also suggest that it can augment coactivator protein recruitment to at least some members of a group of sequence-specific transcription factors."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":26,"end":29},"obj":"NP"},{"id":"C2","span":{"begin":35,"end":50},"obj":"NP"},{"id":"C3","span":{"begin":207,"end":210},"obj":"NP"},{"id":"C4","span":{"begin":212,"end":284},"obj":"NP"},{"id":"C5","span":{"begin":307,"end":310},"obj":"NP"},{"id":"C6","span":{"begin":363,"end":383},"obj":"NP"},{"id":"C7","span":{"begin":385,"end":402},"obj":"NP"},{"id":"C8","span":{"begin":425,"end":428},"obj":"NP"},{"id":"C9","span":{"begin":481,"end":496},"obj":"NP"},{"id":"C10","span":{"begin":513,"end":516},"obj":"NP"},{"id":"C11","span":{"begin":580,"end":583},"obj":"NP"},{"id":"C12","span":{"begin":612,"end":641},"obj":"NP"},{"id":"C13","span":{"begin":647,"end":662},"obj":"NP"},{"id":"C14","span":{"begin":682,"end":690},"obj":"NP"},{"id":"C15","span":{"begin":788,"end":791},"obj":"NP"},{"id":"C16","span":{"begin":859,"end":861},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C3","obj":"C1"},{"id":"R2","pred":"coref-appos","subj":"C4","obj":"C3"},{"id":"R3","pred":"coref-ident","subj":"C5","obj":"C3"},{"id":"R4","pred":"coref-appos","subj":"C7","obj":"C6"},{"id":"R5","pred":"coref-ident","subj":"C8","obj":"C5"},{"id":"R6","pred":"coref-ident","subj":"C9","obj":"C6"},{"id":"R7","pred":"coref-ident","subj":"C10","obj":"C8"},{"id":"R8","pred":"coref-ident","subj":"C11","obj":"C10"},{"id":"R9","pred":"coref-ident","subj":"C13","obj":"C2"},{"id":"R10","pred":"coref-ident","subj":"C14","obj":"C12"},{"id":"R11","pred":"coref-ident","subj":"C15","obj":"C11"},{"id":"R12","pred":"coref-pron","subj":"C16","obj":"C15"}],"text":"Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.\nUsing the coiled-coil region of Stat5b as the bait in a yeast two-hybrid screen, we identified the association of Nmi, a protein of unknown function previously reported as an N-Myc interactor. We further show that Nmi interacts with all STATs except Stat2. We evaluated two cytokine systems, IL-2 and IFNgamma, and demonstrate that Nmi augments STAT-mediated transcription in response to these cytokines. Interestingly, Nmi lacks an intrinsic transcriptional activation domain; instead, Nmi enhances the association of CBP/p300 coactivator proteins with Stat1 and Stat5, and together with CBP/p300 can augment IL-2- and IFNgamma-dependent transcription. Therefore, our data not only reveal that Nmi can potentiate STAT-dependent transcription, but also suggest that it can augment coactivator protein recruitment to at least some members of a group of sequence-specific transcription factors."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":26,"end":29},"obj":"protein_molecule"},{"id":"T2","span":{"begin":35,"end":40},"obj":"protein_molecule"},{"id":"T3","span":{"begin":45,"end":50},"obj":"protein_molecule"},{"id":"T4","span":{"begin":54,"end":58},"obj":"protein_molecule"},{"id":"T5","span":{"begin":64,"end":72},"obj":"protein_molecule"},{"id":"T6","span":{"begin":125,"end":131},"obj":"protein_molecule"},{"id":"T7","span":{"begin":149,"end":154},"obj":"mono_cell"},{"id":"T8","span":{"begin":207,"end":210},"obj":"protein_molecule"},{"id":"T9","span":{"begin":268,"end":273},"obj":"protein_molecule"},{"id":"T10","span":{"begin":307,"end":310},"obj":"protein_molecule"},{"id":"T11","span":{"begin":330,"end":335},"obj":"protein_family_or_group"},{"id":"T12","span":{"begin":343,"end":348},"obj":"protein_molecule"},{"id":"T13","span":{"begin":385,"end":389},"obj":"protein_molecule"},{"id":"T14","span":{"begin":394,"end":402},"obj":"protein_molecule"},{"id":"T15","span":{"begin":425,"end":428},"obj":"protein_molecule"},{"id":"T16","span":{"begin":438,"end":442},"obj":"protein_family_or_group"},{"id":"T17","span":{"begin":487,"end":496},"obj":"protein_family_or_group"},{"id":"T18","span":{"begin":513,"end":516},"obj":"protein_molecule"},{"id":"T19","span":{"begin":536,"end":569},"obj":"protein_domain_or_region"},{"id":"T20","span":{"begin":580,"end":583},"obj":"protein_molecule"},{"id":"T21","span":{"begin":612,"end":641},"obj":"protein_family_or_group"},{"id":"T22","span":{"begin":647,"end":652},"obj":"protein_molecule"},{"id":"T23","span":{"begin":657,"end":662},"obj":"protein_molecule"},{"id":"T24","span":{"begin":682,"end":690},"obj":"protein_molecule"},{"id":"T25","span":{"begin":788,"end":791},"obj":"protein_molecule"},{"id":"T26","span":{"begin":807,"end":811},"obj":"protein_family_or_group"},{"id":"T27","span":{"begin":945,"end":984},"obj":"protein_family_or_group"}],"text":"Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.\nUsing the coiled-coil region of Stat5b as the bait in a yeast two-hybrid screen, we identified the association of Nmi, a protein of unknown function previously reported as an N-Myc interactor. We further show that Nmi interacts with all STATs except Stat2. We evaluated two cytokine systems, IL-2 and IFNgamma, and demonstrate that Nmi augments STAT-mediated transcription in response to these cytokines. Interestingly, Nmi lacks an intrinsic transcriptional activation domain; instead, Nmi enhances the association of CBP/p300 coactivator proteins with Stat1 and Stat5, and together with CBP/p300 can augment IL-2- and IFNgamma-dependent transcription. Therefore, our data not only reveal that Nmi can potentiate STAT-dependent transcription, but also suggest that it can augment coactivator protein recruitment to at least some members of a group of sequence-specific transcription factors."}

{"project":"bionlp-st-gro-2013-development","denotations":[{"id":"T1","span":{"begin":26,"end":29},"obj":"Protein"},{"id":"T2","span":{"begin":35,"end":40},"obj":"Protein"},{"id":"T3","span":{"begin":45,"end":50},"obj":"Protein"},{"id":"T4","span":{"begin":54,"end":58},"obj":"Protein"},{"id":"T5","span":{"begin":64,"end":72},"obj":"Protein"},{"id":"T8","span":{"begin":125,"end":131},"obj":"Protein"},{"id":"T9","span":{"begin":207,"end":210},"obj":"Protein"},{"id":"T10","span":{"begin":214,"end":221},"obj":"Protein"},{"id":"T11","span":{"begin":268,"end":273},"obj":"Protein"},{"id":"T12","span":{"begin":307,"end":310},"obj":"Protein"},{"id":"T14","span":{"begin":330,"end":335},"obj":"Protein"},{"id":"T15","span":{"begin":367,"end":375},"obj":"Protein"},{"id":"T16","span":{"begin":385,"end":389},"obj":"Protein"},{"id":"T17","span":{"begin":394,"end":402},"obj":"Protein"},{"id":"T18","span":{"begin":425,"end":428},"obj":"Protein"},{"id":"T20","span":{"begin":438,"end":442},"obj":"Protein"},{"id":"T24","span":{"begin":487,"end":496},"obj":"Protein"},{"id":"T25","span":{"begin":513,"end":516},"obj":"Protein"},{"id":"T29","span":{"begin":580,"end":583},"obj":"Protein"},{"id":"T32","span":{"begin":612,"end":641},"obj":"TranscriptionCoactivator"},{"id":"T33","span":{"begin":647,"end":652},"obj":"Protein"},{"id":"T34","span":{"begin":657,"end":662},"obj":"Protein"},{"id":"T35","span":{"begin":682,"end":690},"obj":"Protein"},{"id":"T37","span":{"begin":703,"end":707},"obj":"Protein"},{"id":"T38","span":{"begin":713,"end":721},"obj":"Protein"},{"id":"T40","span":{"begin":788,"end":791},"obj":"Protein"},{"id":"T42","span":{"begin":807,"end":811},"obj":"Protein"},{"id":"T45","span":{"begin":874,"end":893},"obj":"TranscriptionCoactivator"},{"id":"T47","span":{"begin":963,"end":984},"obj":"TranscriptionFactor"},{"id":"T26","span":{"begin":536,"end":569},"obj":"ProteinDomain"},{"id":"E1","span":{"begin":73,"end":81},"obj":"RegulatoryProcess"},{"id":"E2","span":{"begin":82,"end":91},"obj":"SignalingPathway"},{"id":"E3","span":{"begin":311,"end":320},"obj":"BindingToProtein"},{"id":"E4","span":{"begin":429,"end":437},"obj":"PositiveRegulation"},{"id":"E5","span":{"begin":443,"end":451},"obj":"RegulatoryProcess"},{"id":"E6","span":{"begin":452,"end":465},"obj":"Transcription"},{"id":"E7","span":{"begin":469,"end":477},"obj":"ResponseProcess"},{"id":"E10","span":{"begin":584,"end":592},"obj":"PositiveRegulation"},{"id":"E11","span":{"begin":597,"end":608},"obj":"BindingToProtein"},{"id":"E12","span":{"begin":695,"end":702},"obj":"PositiveRegulation"},{"id":"E13","span":{"begin":732,"end":745},"obj":"Transcription"},{"id":"E14","span":{"begin":796,"end":806},"obj":"PositiveRegulation"},{"id":"E15","span":{"begin":822,"end":835},"obj":"Transcription"},{"id":"E16","span":{"begin":866,"end":873},"obj":"PositiveRegulation"},{"id":"E17","span":{"begin":894,"end":905},"obj":"Transport"},{"id":"E18","span":{"begin":192,"end":203},"obj":"BindingToProtein"},{"id":"E8","span":{"begin":73,"end":81},"obj":"RegulatoryProcess"}],"relations":[{"id":"R1","pred":"hasAgent","subj":"T4","obj":"E1"},{"id":"R2","pred":"hasPatient","subj":"E2","obj":"E1"},{"id":"R3","pred":"hasPatient","subj":"T14","obj":"E3"},{"id":"R4","pred":"hasPatient","subj":"T12","obj":"E3"},{"id":"R5","pred":"hasAgent","subj":"T18","obj":"E4"},{"id":"R6","pred":"hasPatient","subj":"E6","obj":"E4"},{"id":"R7","pred":"hasAgent","subj":"T20","obj":"E5"},{"id":"R8","pred":"hasPatient","subj":"E6","obj":"E5"},{"id":"R9","pred":"hasAgent","subj":"T24","obj":"E7"},{"id":"R10","pred":"hasAgent","subj":"T29","obj":"E10"},{"id":"R11","pred":"hasPatient","subj":"E11","obj":"E10"},{"id":"R12","pred":"hasPatient","subj":"T33","obj":"E11"},{"id":"R13","pred":"hasPatient","subj":"T34","obj":"E11"},{"id":"R14","pred":"hasPatient","subj":"T32","obj":"E11"},{"id":"R15","pred":"hasAgent","subj":"T35","obj":"E12"},{"id":"R16","pred":"hasPatient","subj":"E13","obj":"E12"},{"id":"R17","pred":"hasAgent","subj":"T40","obj":"E14"},{"id":"R18","pred":"hasPatient","subj":"E15","obj":"E14"},{"id":"R19","pred":"hasAgent","subj":"T40","obj":"E16"},{"id":"R20","pred":"hasPatient","subj":"E17","obj":"E16"},{"id":"R21","pred":"hasPatient","subj":"T45","obj":"E17"},{"id":"R22","pred":"hasPatient","subj":"T8","obj":"E18"},{"id":"R23","pred":"hasPatient","subj":"T9","obj":"E18"},{"id":"R24","pred":"hasAgent","subj":"T5","obj":"E8"},{"id":"R25","pred":"hasPatient","subj":"E2","obj":"E8"}],"text":"Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.\nUsing the coiled-coil region of Stat5b as the bait in a yeast two-hybrid screen, we identified the association of Nmi, a protein of unknown function previously reported as an N-Myc interactor. We further show that Nmi interacts with all STATs except Stat2. We evaluated two cytokine systems, IL-2 and IFNgamma, and demonstrate that Nmi augments STAT-mediated transcription in response to these cytokines. Interestingly, Nmi lacks an intrinsic transcriptional activation domain; instead, Nmi enhances the association of CBP/p300 coactivator proteins with Stat1 and Stat5, and together with CBP/p300 can augment IL-2- and IFNgamma-dependent transcription. Therefore, our data not only reveal that Nmi can potentiate STAT-dependent transcription, but also suggest that it can augment coactivator protein recruitment to at least some members of a group of sequence-specific transcription factors."}

{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":612,"end":615},"obj":"Disease"},{"id":"T2","span":{"begin":682,"end":685},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0010565"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0010565"}],"text":"Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.\nUsing the coiled-coil region of Stat5b as the bait in a yeast two-hybrid screen, we identified the association of Nmi, a protein of unknown function previously reported as an N-Myc interactor. We further show that Nmi interacts with all STATs except Stat2. We evaluated two cytokine systems, IL-2 and IFNgamma, and demonstrate that Nmi augments STAT-mediated transcription in response to these cytokines. Interestingly, Nmi lacks an intrinsic transcriptional activation domain; instead, Nmi enhances the association of CBP/p300 coactivator proteins with Stat1 and Stat5, and together with CBP/p300 can augment IL-2- and IFNgamma-dependent transcription. Therefore, our data not only reveal that Nmi can potentiate STAT-dependent transcription, but also suggest that it can augment coactivator protein recruitment to at least some members of a group of sequence-specific transcription factors."}