PubMed:9350434 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/9350434","sourcedb":"PubMed","sourceid":"9350434","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/9350434","text":"Involvement of different transduction pathways in NF-kappa B activation by several inducers.\nDouble-stimulation was used to demonstrate that, in a T lymphocytic cell line (CEM), phorbol myristate acetate (PMA) rapidly induced NF-kappa B through a signaling pathway which did not involve reactive oxygen species (ROS) and was different from the activation triggered by either H2O2 or tumor necrosis factor-alpha (TNF-alpha). Since these latter compounds were known to activate NF-kappa B translocation in a redox-sensitive way, we have demonstrated that NF-kappa B activation by PMA was resistant to antioxidant N-acetyl-L-cysteine (NAC) and sensitive to kinase inhibitors staurosporine and H7 while activation by H2O2 or TNF-alpha were 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