PubMed:9350434 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	50-60	protein	denotes	NF-kappa B
T2	83-91	DNA	denotes	inducers
T3	147-170	cell_line	denotes	T lymphocytic cell line
T4	172-175	cell_line	denotes	CEM
T5	226-236	protein	denotes	NF-kappa B
T6	383-410	protein	denotes	tumor necrosis factor-alpha
T7	412-421	protein	denotes	TNF-alpha
T8	476-486	protein	denotes	NF-kappa B
T9	553-563	protein	denotes	NF-kappa B
T10	721-730	protein	denotes	TNF-alpha

Id	Subject	Object	Predicate	Lexical cue
S1	0-92	Sentence	denotes	Involvement of different transduction pathways in NF-kappa B activation by several inducers.
S2	93-423	Sentence	denotes	Double-stimulation was used to demonstrate that, in a T lymphocytic cell line (CEM), phorbol myristate acetate (PMA) rapidly induced NF-kappa B through a signaling pathway which did not involve reactive oxygen species (ROS) and was different from the activation triggered by either H2O2 or tumor necrosis factor-alpha (TNF-alpha).
S3	424-740	Sentence	denotes	Since these latter compounds were known to activate NF-kappa B translocation in a redox-sensitive way, we have demonstrated that NF-kappa B activation by PMA was resistant to antioxidant N-acetyl-L-cysteine (NAC) and sensitive to kinase inhibitors staurosporine and H7 while activation by H2O2 or TNF-alpha were not.

Id	Subject	Object	Predicate	Lexical cue
C1	178-209	NP	denotes	phorbol myristate acetate (PMA)
C2	245-264	NP	denotes	a signaling pathway
C3	265-270	NP	denotes	which
C5	368-422	NP	denotes	either H2O2 or tumor necrosis factor-alpha (TNF-alpha)
C4	340-422	NP	denotes	the activation triggered by either H2O2 or tumor necrosis factor-alpha (TNF-alpha)
C6	430-452	NP	denotes	these latter compounds
C7	578-581	NP	denotes	PMA
C9	713-730	NP	denotes	H2O2 or TNF-alpha
C8	699-730	NP	denotes	activation by H2O2 or TNF-alpha
R1	C3	C2	coref-relat	which,a signaling pathway
R2	C6	C5	coref-ident	these latter compounds,either H2O2 or tumor necrosis factor-alpha (TNF-alpha)
R3	C7	C1	coref-ident	PMA,phorbol myristate acetate (PMA)
R4	C9	C6	coref-ident	H2O2 or TNF-alpha,these latter compounds
R5	C8	C4	coref-ident	activation by H2O2 or TNF-alpha,the activation triggered by either H2O2 or tumor necrosis factor-alpha (TNF-alpha)

Id	Subject	Object	Predicate	Lexical cue
T1	15-46	other_name	denotes	different transduction pathways
T2	50-60	protein_complex	denotes	NF-kappa B
T3	83-91	DNA_domain_or_region	denotes	inducers
T4	147-170	cell_line	denotes	T lymphocytic cell line
T5	172-175	cell_line	denotes	CEM
T6	178-203	other_organic_compound	denotes	phorbol myristate acetate
T7	205-208	other_organic_compound	denotes	PMA
T8	226-236	protein_complex	denotes	NF-kappa B
T9	247-264	other_name	denotes	signaling pathway
T10	287-310	inorganic	denotes	reactive oxygen species
T11	312-315	inorganic	denotes	ROS
T12	375-379	inorganic	denotes	H2O2
T13	383-410	protein_molecule	denotes	tumor necrosis factor-alpha
T14	412-421	protein_molecule	denotes	TNF-alpha
T15	476-486	protein_complex	denotes	NF-kappa B
T16	553-563	protein_complex	denotes	NF-kappa B
T17	578-581	other_organic_compound	denotes	PMA
T18	599-610	other_organic_compound	denotes	antioxidant
T19	611-630	other_organic_compound	denotes	N-acetyl-L-cysteine
T20	632-635	other_organic_compound	denotes	NAC
T21	672-685	other_organic_compound	denotes	staurosporine
T22	690-692	other_organic_compound	denotes	H7
T23	713-717	inorganic	denotes	H2O2
T24	721-730	protein_molecule	denotes	TNF-alpha