PubMed:9350434 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":50,"end":60},"obj":"protein"},{"id":"T2","span":{"begin":83,"end":91},"obj":"DNA"},{"id":"T3","span":{"begin":147,"end":170},"obj":"cell_line"},{"id":"T4","span":{"begin":172,"end":175},"obj":"cell_line"},{"id":"T5","span":{"begin":226,"end":236},"obj":"protein"},{"id":"T6","span":{"begin":383,"end":410},"obj":"protein"},{"id":"T7","span":{"begin":412,"end":421},"obj":"protein"},{"id":"T8","span":{"begin":476,"end":486},"obj":"protein"},{"id":"T9","span":{"begin":553,"end":563},"obj":"protein"},{"id":"T10","span":{"begin":721,"end":730},"obj":"protein"}],"text":"Involvement of different transduction pathways in NF-kappa B activation by several inducers.\nDouble-stimulation was used to demonstrate that, in a T lymphocytic cell line (CEM), phorbol myristate acetate (PMA) rapidly induced NF-kappa B through a signaling pathway which did not involve reactive oxygen species (ROS) and was different from the activation triggered by either H2O2 or tumor necrosis factor-alpha (TNF-alpha). Since these latter compounds were known to activate NF-kappa B translocation in a redox-sensitive way, we have demonstrated that NF-kappa B activation by PMA was resistant to antioxidant N-acetyl-L-cysteine (NAC) and sensitive to kinase inhibitors staurosporine and H7 while activation by H2O2 or TNF-alpha were not."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":92},"obj":"Sentence"},{"id":"S2","span":{"begin":93,"end":423},"obj":"Sentence"},{"id":"S3","span":{"begin":424,"end":740},"obj":"Sentence"}],"text":"Involvement of different transduction pathways in NF-kappa B activation by several inducers.\nDouble-stimulation was used to demonstrate that, in a T lymphocytic cell line (CEM), phorbol myristate acetate (PMA) rapidly induced NF-kappa B through a signaling pathway which did not involve reactive oxygen species (ROS) and was different from the activation triggered by either H2O2 or tumor necrosis factor-alpha (TNF-alpha). Since these latter compounds were known to activate NF-kappa B translocation in a redox-sensitive way, we have demonstrated that NF-kappa B activation by PMA was resistant to antioxidant N-acetyl-L-cysteine (NAC) and sensitive to kinase inhibitors staurosporine and H7 while activation by H2O2 or TNF-alpha were not."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":178,"end":209},"obj":"NP"},{"id":"C2","span":{"begin":245,"end":264},"obj":"NP"},{"id":"C3","span":{"begin":265,"end":270},"obj":"NP"},{"id":"C5","span":{"begin":368,"end":422},"obj":"NP"},{"id":"C4","span":{"begin":340,"end":422},"obj":"NP"},{"id":"C6","span":{"begin":430,"end":452},"obj":"NP"},{"id":"C7","span":{"begin":578,"end":581},"obj":"NP"},{"id":"C9","span":{"begin":713,"end":730},"obj":"NP"},{"id":"C8","span":{"begin":699,"end":730},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-relat","subj":"C3","obj":"C2"},{"id":"R2","pred":"coref-ident","subj":"C6","obj":"C5"},{"id":"R3","pred":"coref-ident","subj":"C7","obj":"C1"},{"id":"R4","pred":"coref-ident","subj":"C9","obj":"C6"},{"id":"R5","pred":"coref-ident","subj":"C8","obj":"C4"}],"text":"Involvement of different transduction pathways in NF-kappa B activation by several inducers.\nDouble-stimulation was used to demonstrate that, in a T lymphocytic cell line (CEM), phorbol myristate acetate (PMA) rapidly induced NF-kappa B through a signaling pathway which did not involve reactive oxygen species (ROS) and was different from the activation triggered by either H2O2 or tumor necrosis factor-alpha (TNF-alpha). Since these latter compounds were known to activate NF-kappa B translocation in a redox-sensitive way, we have demonstrated that NF-kappa B activation by PMA was resistant to antioxidant N-acetyl-L-cysteine (NAC) and sensitive to kinase inhibitors staurosporine and H7 while activation by H2O2 or TNF-alpha were not."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":15,"end":46},"obj":"other_name"},{"id":"T2","span":{"begin":50,"end":60},"obj":"protein_complex"},{"id":"T3","span":{"begin":83,"end":91},"obj":"DNA_domain_or_region"},{"id":"T4","span":{"begin":147,"end":170},"obj":"cell_line"},{"id":"T5","span":{"begin":172,"end":175},"obj":"cell_line"},{"id":"T6","span":{"begin":178,"end":203},"obj":"other_organic_compound"},{"id":"T7","span":{"begin":205,"end":208},"obj":"other_organic_compound"},{"id":"T8","span":{"begin":226,"end":236},"obj":"protein_complex"},{"id":"T9","span":{"begin":247,"end":264},"obj":"other_name"},{"id":"T10","span":{"begin":287,"end":310},"obj":"inorganic"},{"id":"T11","span":{"begin":312,"end":315},"obj":"inorganic"},{"id":"T12","span":{"begin":375,"end":379},"obj":"inorganic"},{"id":"T13","span":{"begin":383,"end":410},"obj":"protein_molecule"},{"id":"T14","span":{"begin":412,"end":421},"obj":"protein_molecule"},{"id":"T15","span":{"begin":476,"end":486},"obj":"protein_complex"},{"id":"T16","span":{"begin":553,"end":563},"obj":"protein_complex"},{"id":"T17","span":{"begin":578,"end":581},"obj":"other_organic_compound"},{"id":"T18","span":{"begin":599,"end":610},"obj":"other_organic_compound"},{"id":"T19","span":{"begin":611,"end":630},"obj":"other_organic_compound"},{"id":"T20","span":{"begin":632,"end":635},"obj":"other_organic_compound"},{"id":"T21","span":{"begin":672,"end":685},"obj":"other_organic_compound"},{"id":"T22","span":{"begin":690,"end":692},"obj":"other_organic_compound"},{"id":"T23","span":{"begin":713,"end":717},"obj":"inorganic"},{"id":"T24","span":{"begin":721,"end":730},"obj":"protein_molecule"}],"text":"Involvement of different transduction pathways in NF-kappa B activation by several inducers.\nDouble-stimulation was used to demonstrate that, in a T lymphocytic cell line (CEM), phorbol myristate acetate (PMA) rapidly induced NF-kappa B through a signaling pathway which did not involve reactive oxygen species (ROS) and was different from the activation triggered by either H2O2 or tumor necrosis factor-alpha (TNF-alpha). Since these latter compounds were known to activate NF-kappa B translocation in a redox-sensitive way, we have demonstrated that NF-kappa B activation by PMA was resistant to antioxidant N-acetyl-L-cysteine (NAC) and sensitive to kinase inhibitors staurosporine and H7 while activation by H2O2 or TNF-alpha were not."}