PubMed:8997164 / 60-1098 JSONTXT

{"project":"bionlp-st-bb3-2016-training","denotations":[{"id":"T2","span":{"begin":0,"end":1038},"obj":"Paragraph"},{"id":"T7","span":{"begin":18,"end":21},"obj":"Habitat"},{"id":"T8","span":{"begin":26,"end":39},"obj":"Habitat"},{"id":"T9","span":{"begin":63,"end":94},"obj":"Habitat"},{"id":"T10","span":{"begin":96,"end":115},"obj":"Habitat"},{"id":"T11","span":{"begin":134,"end":146},"obj":"Bacteria"},{"id":"T12","span":{"begin":178,"end":191},"obj":"Bacteria"},{"id":"T13","span":{"begin":228,"end":247},"obj":"Habitat"},{"id":"T14","span":{"begin":310,"end":315},"obj":"Habitat"},{"id":"T15","span":{"begin":323,"end":336},"obj":"Habitat"},{"id":"T16","span":{"begin":381,"end":400},"obj":"Habitat"},{"id":"T17","span":{"begin":412,"end":426},"obj":"Habitat"},{"id":"T18","span":{"begin":412,"end":415},"obj":"Bacteria"},{"id":"T19","span":{"begin":471,"end":484},"obj":"Habitat"},{"id":"T20","span":{"begin":500,"end":524},"obj":"Habitat"},{"id":"T21","span":{"begin":500,"end":503},"obj":"Bacteria"},{"id":"T22","span":{"begin":504,"end":517},"obj":"Habitat"},{"id":"T23","span":{"begin":626,"end":645},"obj":"Habitat"},{"id":"T24","span":{"begin":683,"end":714},"obj":"Habitat"},{"id":"T25","span":{"begin":683,"end":686},"obj":"Bacteria"},{"id":"T26","span":{"begin":761,"end":780},"obj":"Habitat"},{"id":"T27","span":{"begin":808,"end":884},"obj":"Habitat"},{"id":"T28","span":{"begin":938,"end":968},"obj":"Habitat"},{"id":"T29","span":{"begin":988,"end":1001},"obj":"Habitat"},{"id":"T30","span":{"begin":988,"end":991},"obj":"Bacteria"}],"text":"Recent studies in man and animal models have demonstrated that TCR-gamma delta-bearing T cells (gamma delta T cells) are activated by mycobacteria and accumulate in the sites of mycobacterial infection. Although the function of gamma delta T cells remains unclear, some data suggest a potential role for these cells in the granulomatous immune response. To address the presence of gamma delta T cells within the BCG granulomas, we have characterized the TCR phenotype of T-lymphocytes present in the BCG granulomatous lesion immunohistochemically using a monoclonal antibody to TCR delta 1 and others. Fairly large numbers of gamma delta T cells were located at the periphery of the BCG granulomas without necrosis and most of them also expressed CD8. However, gamma delta T cells were rarely present in the granulomas with central caseous necrosis, calcification and fibrotic changes. With these results, it might be speculated that the CD8+ gamma delta T lymphocytes participate in the BCG granuloma formation mainly in the early stage."}