PubMed:8997164 / 60-1098 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/8997164","sourcedb":"PubMed","sourceid":"8997164","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/8997164","text":"Recent studies in man and animal models have demonstrated that TCR-gamma delta-bearing T cells (gamma delta T cells) are activated by mycobacteria and accumulate in the sites of mycobacterial infection. Although the function of gamma delta T cells remains unclear, some data suggest a potential role for these cells in the granulomatous immune response. To address the presence of gamma delta T cells within the BCG granulomas, we have characterized the TCR phenotype of T-lymphocytes present in the BCG granulomatous lesion immunohistochemically using a monoclonal antibody to TCR delta 1 and others. Fairly large numbers of gamma delta T cells were located at the periphery of the BCG granulomas without necrosis and most of them also expressed CD8. However, gamma delta T cells were rarely present in the granulomas with central caseous necrosis, calcification and fibrotic changes. With these results, it might be speculated that the CD8+ gamma delta T lymphocytes participate in the BCG granuloma formation mainly in the early stage.","tracks":[{"project":"bionlp-st-bb3-2016-training","denotations":[{"id":"T2","span":{"begin":0,"end":1038},"obj":"Paragraph"},{"id":"T7","span":{"begin":18,"end":21},"obj":"Habitat"},{"id":"T8","span":{"begin":26,"end":39},"obj":"Habitat"},{"id":"T9","span":{"begin":63,"end":94},"obj":"Habitat"},{"id":"T10","span":{"begin":96,"end":115},"obj":"Habitat"},{"id":"T11","span":{"begin":134,"end":146},"obj":"Bacteria"},{"id":"T12","span":{"begin":178,"end":191},"obj":"Bacteria"},{"id":"T13","span":{"begin":228,"end":247},"obj":"Habitat"},{"id":"T14","span":{"begin":310,"end":315},"obj":"Habitat"},{"id":"T15","span":{"begin":323,"end":336},"obj":"Habitat"},{"id":"T16","span":{"begin":381,"end":400},"obj":"Habitat"},{"id":"T17","span":{"begin":412,"end":426},"obj":"Habitat"},{"id":"T18","span":{"begin":412,"end":415},"obj":"Bacteria"},{"id":"T19","span":{"begin":471,"end":484},"obj":"Habitat"},{"id":"T20","span":{"begin":500,"end":524},"obj":"Habitat"},{"id":"T21","span":{"begin":500,"end":503},"obj":"Bacteria"},{"id":"T22","span":{"begin":504,"end":517},"obj":"Habitat"},{"id":"T23","span":{"begin":626,"end":645},"obj":"Habitat"},{"id":"T24","span":{"begin":683,"end":714},"obj":"Habitat"},{"id":"T25","span":{"begin":683,"end":686},"obj":"Bacteria"},{"id":"T26","span":{"begin":761,"end":780},"obj":"Habitat"},{"id":"T27","span":{"begin":808,"end":884},"obj":"Habitat"},{"id":"T28","span":{"begin":938,"end":968},"obj":"Habitat"},{"id":"T29","span":{"begin":988,"end":1001},"obj":"Habitat"},{"id":"T30","span":{"begin":988,"end":991},"obj":"Bacteria"}],"attributes":[{"subj":"T2","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T7","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T8","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T9","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T10","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T11","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T12","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T13","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T14","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T15","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T16","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T17","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T18","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T19","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T20","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T21","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T22","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T23","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T24","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T25","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T26","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T27","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T28","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T29","pred":"source","obj":"bionlp-st-bb3-2016-training"},{"subj":"T30","pred":"source","obj":"bionlp-st-bb3-2016-training"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"bionlp-st-bb3-2016-training","color":"#9bec93","default":true}]}]}}