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PubMed:8997164 JSONTXT

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bionlp-st-bb3-2016-training

Id	Subject	Object	Predicate	Lexical cue
T1	0-59	Title	denotes	Gamma/delta T lymphocytes in the BCG granulomatous lesions.
T2	60-1098	Paragraph	denotes	Recent studies in man and animal models have demonstrated that TCR-gamma delta-bearing T cells (gamma delta T cells) are activated by mycobacteria and accumulate in the sites of mycobacterial infection. Although the function of gamma delta T cells remains unclear, some data suggest a potential role for these cells in the granulomatous immune response. To address the presence of gamma delta T cells within the BCG granulomas, we have characterized the TCR phenotype of T-lymphocytes present in the BCG granulomatous lesion immunohistochemically using a monoclonal antibody to TCR delta 1 and others. Fairly large numbers of gamma delta T cells were located at the periphery of the BCG granulomas without necrosis and most of them also expressed CD8. However, gamma delta T cells were rarely present in the granulomas with central caseous necrosis, calcification and fibrotic changes. With these results, it might be speculated that the CD8+ gamma delta T lymphocytes participate in the BCG granuloma formation mainly in the early stage.
T3	0-25	Habitat	denotes	Gamma/delta T lymphocytes
T4	33-58	Habitat	denotes	BCG granulomatous lesions
T5	33-36	Bacteria	denotes	BCG
T6	37-50	Habitat	denotes	granulomatous
T7	78-81	Habitat	denotes	man
T8	86-99	Habitat	denotes	animal models
T9	123-154	Habitat	denotes	TCR-gamma delta-bearing T cells
T10	156-175	Habitat	denotes	gamma delta T cells
T11	194-206	Bacteria	denotes	mycobacteria
T12	238-251	Bacteria	denotes	mycobacterial
T13	288-307	Habitat	denotes	gamma delta T cells
T14	370-375	Habitat	denotes	cells
T15	383-396	Habitat	denotes	granulomatous
T16	441-460	Habitat	denotes	gamma delta T cells
T17	472-486	Habitat	denotes	BCG granulomas
T18	472-475	Bacteria	denotes	BCG
T19	531-544	Habitat	denotes	T-lymphocytes
T20	560-584	Habitat	denotes	BCG granulomatous lesion
T21	560-563	Bacteria	denotes	BCG
T22	564-577	Habitat	denotes	granulomatous
T23	686-705	Habitat	denotes	gamma delta T cells
T24	743-774	Habitat	denotes	BCG granulomas without necrosis
T25	743-746	Bacteria	denotes	BCG
T26	821-840	Habitat	denotes	gamma delta T cells
T27	868-944	Habitat	denotes	granulomas with central caseous necrosis, calcification and fibrotic changes
T28	998-1028	Habitat	denotes	CD8+ gamma delta T lymphocytes
T29	1048-1061	Habitat	denotes	BCG granuloma
T30	1048-1051	Bacteria	denotes	BCG