PubMed:8997164 JSONTXT

{"project":"bionlp-st-bb3-2016-training","denotations":[{"id":"T1","span":{"begin":0,"end":59},"obj":"Title"},{"id":"T2","span":{"begin":60,"end":1098},"obj":"Paragraph"},{"id":"T3","span":{"begin":0,"end":25},"obj":"Habitat"},{"id":"T4","span":{"begin":33,"end":58},"obj":"Habitat"},{"id":"T5","span":{"begin":33,"end":36},"obj":"Bacteria"},{"id":"T6","span":{"begin":37,"end":50},"obj":"Habitat"},{"id":"T7","span":{"begin":78,"end":81},"obj":"Habitat"},{"id":"T8","span":{"begin":86,"end":99},"obj":"Habitat"},{"id":"T9","span":{"begin":123,"end":154},"obj":"Habitat"},{"id":"T10","span":{"begin":156,"end":175},"obj":"Habitat"},{"id":"T11","span":{"begin":194,"end":206},"obj":"Bacteria"},{"id":"T12","span":{"begin":238,"end":251},"obj":"Bacteria"},{"id":"T13","span":{"begin":288,"end":307},"obj":"Habitat"},{"id":"T14","span":{"begin":370,"end":375},"obj":"Habitat"},{"id":"T15","span":{"begin":383,"end":396},"obj":"Habitat"},{"id":"T16","span":{"begin":441,"end":460},"obj":"Habitat"},{"id":"T17","span":{"begin":472,"end":486},"obj":"Habitat"},{"id":"T18","span":{"begin":472,"end":475},"obj":"Bacteria"},{"id":"T19","span":{"begin":531,"end":544},"obj":"Habitat"},{"id":"T20","span":{"begin":560,"end":584},"obj":"Habitat"},{"id":"T21","span":{"begin":560,"end":563},"obj":"Bacteria"},{"id":"T22","span":{"begin":564,"end":577},"obj":"Habitat"},{"id":"T23","span":{"begin":686,"end":705},"obj":"Habitat"},{"id":"T24","span":{"begin":743,"end":774},"obj":"Habitat"},{"id":"T25","span":{"begin":743,"end":746},"obj":"Bacteria"},{"id":"T26","span":{"begin":821,"end":840},"obj":"Habitat"},{"id":"T27","span":{"begin":868,"end":944},"obj":"Habitat"},{"id":"T28","span":{"begin":998,"end":1028},"obj":"Habitat"},{"id":"T29","span":{"begin":1048,"end":1061},"obj":"Habitat"},{"id":"T30","span":{"begin":1048,"end":1051},"obj":"Bacteria"}],"text":"Gamma/delta T lymphocytes in the BCG granulomatous lesions.\nRecent studies in man and animal models have demonstrated that TCR-gamma delta-bearing T cells (gamma delta T cells) are activated by mycobacteria and accumulate in the sites of mycobacterial infection. Although the function of gamma delta T cells remains unclear, some data suggest a potential role for these cells in the granulomatous immune response. To address the presence of gamma delta T cells within the BCG granulomas, we have characterized the TCR phenotype of T-lymphocytes present in the BCG granulomatous lesion immunohistochemically using a monoclonal antibody to TCR delta 1 and others. Fairly large numbers of gamma delta T cells were located at the periphery of the BCG granulomas without necrosis and most of them also expressed CD8. However, gamma delta T cells were rarely present in the granulomas with central caseous necrosis, calcification and fibrotic changes. With these results, it might be speculated that the CD8+ gamma delta T lymphocytes participate in the BCG granuloma formation mainly in the early stage."}