PubMed:8276880 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/8276880","sourcedb":"PubMed","sourceid":"8276880","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/8276880","text":"Regulation of neural cell adhesion molecule and L1 by the transforming growth factor-beta superfamily. Selective effects of the bone morphogenetic proteins.\nThe transforming growth factor-beta (TGF-beta) superfamily plays a role in embryogenesis and regeneration. We have reported that osteogenic protein-1 (OP-1) promotes cell aggregation and induces the expression of the neural cell adhesion molecules N-CAM and L1 in proliferating neuroblastoma x glioma hybrid NG108-15 cells (Perides, G., Safran, R. M., Rueger, D. C., and Charness, M. E. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 10326-10330; Perides, G., Hu, G., Rueger, D. C., and Charness, M. E. (1993) J. Biol. Chem. 268, 25197-25205). Here we show that the structurally homologous bone morphogenetic proteins (BMP) BMP-2 and BMP-4 are 10-50-fold more potent in these actions than the subfamily comprising BMP-5, BMP-6, and OP-1 (BMP-7). In contrast, members of the TGF-beta subfamily, activin-A, inhibin-A, and 29 additional growth factors and cytokines did not induce N-CAM. The addition of serum to cells growing in serum-free medium caused a concentration-dependent increase in N-CAM and L1 expression; however, serum did not potentiate the induction of N-CAM and L1 by 40 ng/ml OP-1. These findings suggest the presence in NG108-15 cells of a BMP-2/BMP-4 receptor that discriminates subtle differences in structure among homologous members of the TGF-beta superfamily. An endogenous ligand for this receptor may be present in serum.","tracks":[{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":102},"obj":"Sentence"},{"id":"T2","span":{"begin":103,"end":156},"obj":"Sentence"},{"id":"T3","span":{"begin":157,"end":263},"obj":"Sentence"},{"id":"T4","span":{"begin":264,"end":504},"obj":"Sentence"},{"id":"T5","span":{"begin":505,"end":519},"obj":"Sentence"},{"id":"T6","span":{"begin":520,"end":540},"obj":"Sentence"},{"id":"T7","span":{"begin":541,"end":556},"obj":"Sentence"},{"id":"T8","span":{"begin":557,"end":562},"obj":"Sentence"},{"id":"T9","span":{"begin":563,"end":568},"obj":"Sentence"},{"id":"T10","span":{"begin":569,"end":573},"obj":"Sentence"},{"id":"T11","span":{"begin":574,"end":580},"obj":"Sentence"},{"id":"T12","span":{"begin":581,"end":629},"obj":"Sentence"},{"id":"T13","span":{"begin":630,"end":650},"obj":"Sentence"},{"id":"T14","span":{"begin":651,"end":663},"obj":"Sentence"},{"id":"T15","span":{"begin":664,"end":669},"obj":"Sentence"},{"id":"T16","span":{"begin":670,"end":675},"obj":"Sentence"},{"id":"T17","span":{"begin":676,"end":694},"obj":"Sentence"},{"id":"T18","span":{"begin":695,"end":896},"obj":"Sentence"},{"id":"T19","span":{"begin":897,"end":1035},"obj":"Sentence"},{"id":"T20","span":{"begin":1036,"end":1247},"obj":"Sentence"},{"id":"T21","span":{"begin":1248,"end":1432},"obj":"Sentence"},{"id":"T22","span":{"begin":1433,"end":1496},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":102},"obj":"Sentence"},{"id":"T2","span":{"begin":103,"end":156},"obj":"Sentence"},{"id":"T3","span":{"begin":157,"end":263},"obj":"Sentence"},{"id":"T4","span":{"begin":264,"end":504},"obj":"Sentence"},{"id":"T5","span":{"begin":505,"end":519},"obj":"Sentence"},{"id":"T6","span":{"begin":520,"end":540},"obj":"Sentence"},{"id":"T7","span":{"begin":541,"end":556},"obj":"Sentence"},{"id":"T8","span":{"begin":557,"end":562},"obj":"Sentence"},{"id":"T9","span":{"begin":563,"end":568},"obj":"Sentence"},{"id":"T10","span":{"begin":569,"end":573},"obj":"Sentence"},{"id":"T11","span":{"begin":574,"end":580},"obj":"Sentence"},{"id":"T12","span":{"begin":581,"end":629},"obj":"Sentence"},{"id":"T13","span":{"begin":630,"end":650},"obj":"Sentence"},{"id":"T14","span":{"begin":651,"end":663},"obj":"Sentence"},{"id":"T15","span":{"begin":664,"end":669},"obj":"Sentence"},{"id":"T16","span":{"begin":670,"end":675},"obj":"Sentence"},{"id":"T17","span":{"begin":676,"end":694},"obj":"Sentence"},{"id":"T18","span":{"begin":695,"end":896},"obj":"Sentence"},{"id":"T19","span":{"begin":897,"end":1035},"obj":"Sentence"},{"id":"T20","span":{"begin":1036,"end":1247},"obj":"Sentence"},{"id":"T21","span":{"begin":1248,"end":1432},"obj":"Sentence"},{"id":"T22","span":{"begin":1433,"end":1496},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"},{"subj":"T13","pred":"source","obj":"sentences"},{"subj":"T14","pred":"source","obj":"sentences"},{"subj":"T15","pred":"source","obj":"sentences"},{"subj":"T16","pred":"source","obj":"sentences"},{"subj":"T17","pred":"source","obj":"sentences"},{"subj":"T18","pred":"source","obj":"sentences"},{"subj":"T19","pred":"source","obj":"sentences"},{"subj":"T20","pred":"source","obj":"sentences"},{"subj":"T21","pred":"source","obj":"sentences"},{"subj":"T22","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"},{"subj":"T13","pred":"source","obj":"sentences"},{"subj":"T14","pred":"source","obj":"sentences"},{"subj":"T15","pred":"source","obj":"sentences"},{"subj":"T16","pred":"source","obj":"sentences"},{"subj":"T17","pred":"source","obj":"sentences"},{"subj":"T18","pred":"source","obj":"sentences"},{"subj":"T19","pred":"source","obj":"sentences"},{"subj":"T20","pred":"source","obj":"sentences"},{"subj":"T21","pred":"source","obj":"sentences"},{"subj":"T22","pred":"source","obj":"sentences"}]},{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":128,"end":132},"obj":"http://purl.obolibrary.org/obo/MAT_0000299"},{"id":"T2","span":{"begin":741,"end":745},"obj":"http://purl.obolibrary.org/obo/MAT_0000299"}],"attributes":[{"subj":"T1","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T2","pred":"source","obj":"Glycosmos6-MAT"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":435,"end":448},"obj":"Disease"},{"id":"T2","span":{"begin":451,"end":457},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005072"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0021042"},{"subj":"T1","pred":"source","obj":"mondo_disease"},{"subj":"T2","pred":"source","obj":"mondo_disease"}]},{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":128,"end":132},"obj":"Body_part"},{"id":"T2","span":{"begin":741,"end":745},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000299"},{"id":"A2","pred":"mat_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MAT_0000299"},{"subj":"T1","pred":"source","obj":"Anatomy-MAT"},{"subj":"T2","pred":"source","obj":"Anatomy-MAT"}]},{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":435,"end":448},"obj":"Phenotype"},{"id":"T2","span":{"begin":451,"end":457},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0003006"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0009733"},{"subj":"T1","pred":"source","obj":"HP-phenotype"},{"subj":"T2","pred":"source","obj":"HP-phenotype"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":14,"end":25},"obj":"Body_part"},{"id":"T2","span":{"begin":128,"end":132},"obj":"Body_part"},{"id":"T4","span":{"begin":374,"end":385},"obj":"Body_part"},{"id":"T5","span":{"begin":741,"end":745},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0002319"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0001474"},{"id":"A3","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0002481"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL_0002319"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0001474"},{"id":"A6","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0002481"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T2","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T4","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T5","pred":"source","obj":"Anatomy-UBERON"}]},{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":14,"end":25},"obj":"Cell"},{"id":"T2","span":{"begin":374,"end":385},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0002319"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0002319"},{"subj":"T1","pred":"source","obj":"CL-cell"},{"subj":"T2","pred":"source","obj":"CL-cell"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"sentences","color":"#ecc393","default":true},{"id":"Glycosmos6-MAT","color":"#a993ec"},{"id":"mondo_disease","color":"#96ec93"},{"id":"Anatomy-MAT","color":"#ec93b0"},{"id":"HP-phenotype","color":"#93caec"},{"id":"Anatomy-UBERON","color":"#e4ec93"},{"id":"CL-cell","color":"#da93ec"}]}]}}