Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-102 |
Sentence |
denotes |
Regulation of neural cell adhesion molecule and L1 by the transforming growth factor-beta superfamily. |
T2 |
103-156 |
Sentence |
denotes |
Selective effects of the bone morphogenetic proteins. |
T3 |
157-263 |
Sentence |
denotes |
The transforming growth factor-beta (TGF-beta) superfamily plays a role in embryogenesis and regeneration. |
T4 |
264-504 |
Sentence |
denotes |
We have reported that osteogenic protein-1 (OP-1) promotes cell aggregation and induces the expression of the neural cell adhesion molecules N-CAM and L1 in proliferating neuroblastoma x glioma hybrid NG108-15 cells (Perides, G., Safran, R. |
T5 |
505-519 |
Sentence |
denotes |
M., Rueger, D. |
T6 |
520-540 |
Sentence |
denotes |
C., and Charness, M. |
T7 |
541-556 |
Sentence |
denotes |
E. (1992) Proc. |
T8 |
557-562 |
Sentence |
denotes |
Natl. |
T9 |
563-568 |
Sentence |
denotes |
Acad. |
T10 |
569-573 |
Sentence |
denotes |
Sci. |
T11 |
574-580 |
Sentence |
denotes |
U.S.A. |
T12 |
581-629 |
Sentence |
denotes |
89, 10326-10330; Perides, G., Hu, G., Rueger, D. |
T13 |
630-650 |
Sentence |
denotes |
C., and Charness, M. |
T14 |
651-663 |
Sentence |
denotes |
E. (1993) J. |
T15 |
664-669 |
Sentence |
denotes |
Biol. |
T16 |
670-675 |
Sentence |
denotes |
Chem. |
T17 |
676-694 |
Sentence |
denotes |
268, 25197-25205). |
T18 |
695-896 |
Sentence |
denotes |
Here we show that the structurally homologous bone morphogenetic proteins (BMP) BMP-2 and BMP-4 are 10-50-fold more potent in these actions than the subfamily comprising BMP-5, BMP-6, and OP-1 (BMP-7). |
T19 |
897-1035 |
Sentence |
denotes |
In contrast, members of the TGF-beta subfamily, activin-A, inhibin-A, and 29 additional growth factors and cytokines did not induce N-CAM. |
T20 |
1036-1247 |
Sentence |
denotes |
The addition of serum to cells growing in serum-free medium caused a concentration-dependent increase in N-CAM and L1 expression; however, serum did not potentiate the induction of N-CAM and L1 by 40 ng/ml OP-1. |
T21 |
1248-1432 |
Sentence |
denotes |
These findings suggest the presence in NG108-15 cells of a BMP-2/BMP-4 receptor that discriminates subtle differences in structure among homologous members of the TGF-beta superfamily. |
T22 |
1433-1496 |
Sentence |
denotes |
An endogenous ligand for this receptor may be present in serum. |
T1 |
0-102 |
Sentence |
denotes |
Regulation of neural cell adhesion molecule and L1 by the transforming growth factor-beta superfamily. |
T2 |
103-156 |
Sentence |
denotes |
Selective effects of the bone morphogenetic proteins. |
T3 |
157-263 |
Sentence |
denotes |
The transforming growth factor-beta (TGF-beta) superfamily plays a role in embryogenesis and regeneration. |
T4 |
264-504 |
Sentence |
denotes |
We have reported that osteogenic protein-1 (OP-1) promotes cell aggregation and induces the expression of the neural cell adhesion molecules N-CAM and L1 in proliferating neuroblastoma x glioma hybrid NG108-15 cells (Perides, G., Safran, R. |
T5 |
505-519 |
Sentence |
denotes |
M., Rueger, D. |
T6 |
520-540 |
Sentence |
denotes |
C., and Charness, M. |
T7 |
541-556 |
Sentence |
denotes |
E. (1992) Proc. |
T8 |
557-562 |
Sentence |
denotes |
Natl. |
T9 |
563-568 |
Sentence |
denotes |
Acad. |
T10 |
569-573 |
Sentence |
denotes |
Sci. |
T11 |
574-580 |
Sentence |
denotes |
U.S.A. |
T12 |
581-629 |
Sentence |
denotes |
89, 10326-10330; Perides, G., Hu, G., Rueger, D. |
T13 |
630-650 |
Sentence |
denotes |
C., and Charness, M. |
T14 |
651-663 |
Sentence |
denotes |
E. (1993) J. |
T15 |
664-669 |
Sentence |
denotes |
Biol. |
T16 |
670-675 |
Sentence |
denotes |
Chem. |
T17 |
676-694 |
Sentence |
denotes |
268, 25197-25205). |
T18 |
695-896 |
Sentence |
denotes |
Here we show that the structurally homologous bone morphogenetic proteins (BMP) BMP-2 and BMP-4 are 10-50-fold more potent in these actions than the subfamily comprising BMP-5, BMP-6, and OP-1 (BMP-7). |
T19 |
897-1035 |
Sentence |
denotes |
In contrast, members of the TGF-beta subfamily, activin-A, inhibin-A, and 29 additional growth factors and cytokines did not induce N-CAM. |
T20 |
1036-1247 |
Sentence |
denotes |
The addition of serum to cells growing in serum-free medium caused a concentration-dependent increase in N-CAM and L1 expression; however, serum did not potentiate the induction of N-CAM and L1 by 40 ng/ml OP-1. |
T21 |
1248-1432 |
Sentence |
denotes |
These findings suggest the presence in NG108-15 cells of a BMP-2/BMP-4 receptor that discriminates subtle differences in structure among homologous members of the TGF-beta superfamily. |
T22 |
1433-1496 |
Sentence |
denotes |
An endogenous ligand for this receptor may be present in serum. |