PubMed:7892566 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/7892566","sourcedb":"PubMed","sourceid":"7892566","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/7892566","text":"[Regulation of transcription of the interleukin-2 gene in B-lymphocytes].\nSince most B cell clones immortalized with EBV virus can be induced to produce interleukin-2, a typical T cell cytokine, we studied the role of different elements of the IL-2 promoter in such clones by transfection. It was found, in particular, that the element TCEd, which binds the transcription factor NF-kB, is very active in all three B clones tested. This element has no activity in T cells of the Jurkat line. The NFATd element, which binds the transcription factor NFAT-1 and is very active in T cells, is only weakly active in one B clone and not at all in another. Different elements thus contribute to IL-2 promoter activity in different 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