PubMed:7892566 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":36,"end":54},"obj":"DNA"},{"id":"T2","span":{"begin":58,"end":71},"obj":"cell_type"},{"id":"T3","span":{"begin":85,"end":98},"obj":"cell_line"},{"id":"T4","span":{"begin":153,"end":166},"obj":"protein"},{"id":"T5","span":{"begin":178,"end":193},"obj":"protein"},{"id":"T6","span":{"begin":244,"end":257},"obj":"DNA"},{"id":"T7","span":{"begin":336,"end":340},"obj":"DNA"},{"id":"T8","span":{"begin":358,"end":378},"obj":"protein"},{"id":"T9","span":{"begin":379,"end":384},"obj":"protein"},{"id":"T10","span":{"begin":414,"end":422},"obj":"cell_line"},{"id":"T11","span":{"begin":463,"end":470},"obj":"cell_type"},{"id":"T12","span":{"begin":478,"end":489},"obj":"cell_line"},{"id":"T13","span":{"begin":495,"end":508},"obj":"DNA"},{"id":"T14","span":{"begin":526,"end":546},"obj":"protein"},{"id":"T15","span":{"begin":547,"end":553},"obj":"protein"},{"id":"T16","span":{"begin":576,"end":583},"obj":"cell_type"},{"id":"T17","span":{"begin":614,"end":621},"obj":"cell_line"},{"id":"T18","span":{"begin":687,"end":700},"obj":"DNA"}],"text":"[Regulation of transcription of the interleukin-2 gene in B-lymphocytes].\nSince most B cell clones immortalized with EBV virus can be induced to produce interleukin-2, a typical T cell cytokine, we studied the role of different elements of the IL-2 promoter in such clones by transfection. It was found, in particular, that the element TCEd, which binds the transcription factor NF-kB, is very active in all three B clones tested. This element has no activity in T cells of the Jurkat line. The NFATd element, which binds the transcription factor NFAT-1 and is very active in T cells, is only weakly active in one B clone and not at all in another. Different elements thus contribute to IL-2 promoter activity in different cells."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":32,"end":54},"obj":"NP"},{"id":"C2","span":{"begin":80,"end":126},"obj":"NP"},{"id":"C3","span":{"begin":153,"end":166},"obj":"NP"},{"id":"C4","span":{"begin":168,"end":193},"obj":"NP"},{"id":"C5","span":{"begin":261,"end":272},"obj":"NP"},{"id":"C6","span":{"begin":324,"end":340},"obj":"NP"},{"id":"C7","span":{"begin":342,"end":347},"obj":"NP"},{"id":"C8","span":{"begin":431,"end":443},"obj":"NP"},{"id":"C9","span":{"begin":463,"end":470},"obj":"NP"},{"id":"C10","span":{"begin":491,"end":508},"obj":"NP"},{"id":"C11","span":{"begin":510,"end":515},"obj":"NP"},{"id":"C12","span":{"begin":576,"end":583},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C3","obj":"C1"},{"id":"R2","pred":"coref-appos","subj":"C4","obj":"C3"},{"id":"R3","pred":"coref-ident","subj":"C5","obj":"C2"},{"id":"R4","pred":"coref-relat","subj":"C7","obj":"C6"},{"id":"R5","pred":"coref-ident","subj":"C8","obj":"C6"},{"id":"R6","pred":"coref-relat","subj":"C11","obj":"C10"},{"id":"R7","pred":"coref-ident","subj":"C12","obj":"C9"}],"text":"[Regulation of transcription of the interleukin-2 gene in B-lymphocytes].\nSince most B cell clones immortalized with EBV virus can be induced to produce interleukin-2, a typical T cell cytokine, we studied the role of different elements of the IL-2 promoter in such clones by transfection. It was found, in particular, that the element TCEd, which binds the transcription factor NF-kB, is very active in all three B clones tested. This element has no activity in T cells of the Jurkat line. The NFATd element, which binds the transcription factor NFAT-1 and is very active in T cells, is only weakly active in one B clone and not at all in another. Different elements thus contribute to IL-2 promoter activity in different cells."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":72},"obj":"Sentence"},{"id":"S2","span":{"begin":74,"end":289},"obj":"Sentence"},{"id":"S3","span":{"begin":290,"end":430},"obj":"Sentence"},{"id":"S4","span":{"begin":431,"end":490},"obj":"Sentence"},{"id":"S5","span":{"begin":491,"end":648},"obj":"Sentence"},{"id":"S6","span":{"begin":649,"end":729},"obj":"Sentence"}],"text":"[Regulation of transcription of the interleukin-2 gene in B-lymphocytes].\nSince most B cell clones immortalized with EBV virus can be induced to produce interleukin-2, a typical T cell cytokine, we studied the role of different elements of the IL-2 promoter in such clones by transfection. It was found, in particular, that the element TCEd, which binds the transcription factor NF-kB, is very active in all three B clones tested. This element has no activity in T cells of the Jurkat line. The NFATd element, which binds the transcription factor NFAT-1 and is very active in T cells, is only weakly active in one B clone and not at all in another. Different elements thus contribute to IL-2 promoter activity in different cells."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":15,"end":28},"obj":"other_name"},{"id":"T2","span":{"begin":36,"end":49},"obj":"protein_molecule"},{"id":"T3","span":{"begin":58,"end":71},"obj":"cell_type"},{"id":"T4","span":{"begin":85,"end":98},"obj":"cell_line"},{"id":"T5","span":{"begin":117,"end":126},"obj":"virus"},{"id":"T6","span":{"begin":153,"end":166},"obj":"protein_molecule"},{"id":"T7","span":{"begin":178,"end":193},"obj":"protein_molecule"},{"id":"T8","span":{"begin":244,"end":257},"obj":"DNA_domain_or_region"},{"id":"T9","span":{"begin":336,"end":340},"obj":"DNA_domain_or_region"},{"id":"T10","span":{"begin":358,"end":378},"obj":"protein_family_or_group"},{"id":"T11","span":{"begin":379,"end":384},"obj":"protein_molecule"},{"id":"T12","span":{"begin":414,"end":422},"obj":"cell_line"},{"id":"T13","span":{"begin":463,"end":470},"obj":"cell_type"},{"id":"T14","span":{"begin":478,"end":489},"obj":"cell_line"},{"id":"T15","span":{"begin":495,"end":508},"obj":"DNA_domain_or_region"},{"id":"T16","span":{"begin":526,"end":546},"obj":"protein_family_or_group"},{"id":"T17","span":{"begin":547,"end":553},"obj":"protein_molecule"},{"id":"T18","span":{"begin":576,"end":583},"obj":"cell_type"},{"id":"T19","span":{"begin":614,"end":621},"obj":"cell_line"},{"id":"T20","span":{"begin":687,"end":700},"obj":"DNA_domain_or_region"}],"text":"[Regulation of transcription of the interleukin-2 gene in B-lymphocytes].\nSince most B cell clones immortalized with EBV virus can be induced to produce interleukin-2, a typical T cell cytokine, we studied the role of different elements of the IL-2 promoter in such clones by transfection. It was found, in particular, that the element TCEd, which binds the transcription factor NF-kB, is very active in all three B clones tested. This element has no activity in T cells of the Jurkat line. The NFATd element, which binds the transcription factor NFAT-1 and is very active in T cells, is only weakly active in one B clone and not at all in another. Different elements thus contribute to IL-2 promoter activity in different cells."}