PubMed:7892566 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	36-54	DNA	denotes	interleukin-2 gene
T2	58-71	cell_type	denotes	B-lymphocytes
T3	85-98	cell_line	denotes	B cell clones
T4	153-166	protein	denotes	interleukin-2
T5	178-193	protein	denotes	T cell cytokine
T6	244-257	DNA	denotes	IL-2 promoter
T7	336-340	DNA	denotes	TCEd
T8	358-378	protein	denotes	transcription factor
T9	379-384	protein	denotes	NF-kB
T10	414-422	cell_line	denotes	B clones
T11	463-470	cell_type	denotes	T cells
T12	478-489	cell_line	denotes	Jurkat line
T13	495-508	DNA	denotes	NFATd element
T14	526-546	protein	denotes	transcription factor
T15	547-553	protein	denotes	NFAT-1
T16	576-583	cell_type	denotes	T cells
T17	614-621	cell_line	denotes	B clone
T18	687-700	DNA	denotes	IL-2 promoter

Id	Subject	Object	Predicate	Lexical cue
C1	32-54	NP	denotes	the interleukin-2 gene
C2	80-126	NP	denotes	most B cell clones immortalized with EBV virus
C3	153-166	NP	denotes	interleukin-2
C4	168-193	NP	denotes	a typical T cell cytokine
C5	261-272	NP	denotes	such clones
C6	324-340	NP	denotes	the element TCEd
C7	342-347	NP	denotes	which
C8	431-443	NP	denotes	This element
C9	463-470	NP	denotes	T cells
C10	491-508	NP	denotes	The NFATd element
C11	510-515	NP	denotes	which
C12	576-583	NP	denotes	T cells
R1	C3	C1	coref-ident	interleukin-2,the interleukin-2 gene
R2	C4	C3	coref-appos	a typical T cell cytokine,interleukin-2
R3	C5	C2	coref-ident	such clones,most B cell clones immortalized with EBV virus
R4	C7	C6	coref-relat	which,the element TCEd
R5	C8	C6	coref-ident	This element,the element TCEd
R6	C11	C10	coref-relat	which,The NFATd element
R7	C12	C9	coref-ident	T cells,T cells

Id	Subject	Object	Predicate	Lexical cue
S1	0-72	Sentence	denotes	[Regulation of transcription of the interleukin-2 gene in B-lymphocytes]
S2	74-289	Sentence	denotes	Since most B cell clones immortalized with EBV virus can be induced to produce interleukin-2, a typical T cell cytokine, we studied the role of different elements of the IL-2 promoter in such clones by transfection.
S3	290-430	Sentence	denotes	It was found, in particular, that the element TCEd, which binds the transcription factor NF-kB, is very active in all three B clones tested.
S4	431-490	Sentence	denotes	This element has no activity in T cells of the Jurkat line.
S5	491-648	Sentence	denotes	The NFATd element, which binds the transcription factor NFAT-1 and is very active in T cells, is only weakly active in one B clone and not at all in another.
S6	649-729	Sentence	denotes	Different elements thus contribute to IL-2 promoter activity in different cells.

Id	Subject	Object	Predicate	Lexical cue
T1	15-28	other_name	denotes	transcription
T2	36-49	protein_molecule	denotes	interleukin-2
T3	58-71	cell_type	denotes	B-lymphocytes
T4	85-98	cell_line	denotes	B cell clones
T5	117-126	virus	denotes	EBV virus
T6	153-166	protein_molecule	denotes	interleukin-2
T7	178-193	protein_molecule	denotes	T cell cytokine
T8	244-257	DNA_domain_or_region	denotes	IL-2 promoter
T9	336-340	DNA_domain_or_region	denotes	TCEd
T10	358-378	protein_family_or_group	denotes	transcription factor
T11	379-384	protein_molecule	denotes	NF-kB
T12	414-422	cell_line	denotes	B clones
T13	463-470	cell_type	denotes	T cells
T14	478-489	cell_line	denotes	Jurkat line
T15	495-508	DNA_domain_or_region	denotes	NFATd element
T16	526-546	protein_family_or_group	denotes	transcription factor
T17	547-553	protein_molecule	denotes	NFAT-1
T18	576-583	cell_type	denotes	T cells
T19	614-621	cell_line	denotes	B clone
T20	687-700	DNA_domain_or_region	denotes	IL-2 promoter