PubMed:7489741 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/7489741","sourcedb":"PubMed","sourceid":"7489741","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/7489741","text":"Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells.\nThe activation of Janus protein tyrosine kinases (Jak) and STAT (signal transducer and activator of transcription) proteins has recently been linked to the signal transduction mechanism of several cytokines. IL-7 was observed to induce a rapid and dose-dependent tyrosine phosphorylation of Jak 1 and Jak 3 and concomitantly, the tyrosine phosphorylation and DNA binding activity of multiple STAT proteins. The STAT proteins utilized by IL-7 were identical to those induced by IL-2 and could be identified as various STAT 5 isoforms. Moreover, the induction of both Jak 1 and 3, and STAT 5 activity strongly correlated with the growth-promoting effects of IL-7, suggesting that this signal transduction mechanism may play a key role in IL-7-induced 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