PubMed:7489741 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	0-13	protein	denotes	Interleukin-7
T2	43-48	protein	denotes	Jak 1
T3	50-55	protein	denotes	Jak 3
T4	60-75	protein	denotes	STAT 5 proteins
T5	86-93	cell_type	denotes	T cells
T6	113-143	protein	denotes	Janus protein tyrosine kinases
T7	145-148	protein	denotes	Jak
T8	154-218	protein	denotes	STAT (signal transducer and activator of transcription) proteins
T9	292-301	protein	denotes	cytokines
T10	303-307	protein	denotes	IL-7
T11	386-391	protein	denotes	Jak 1
T12	396-401	protein	denotes	Jak 3
T13	487-500	protein	denotes	STAT proteins
T14	506-519	protein	denotes	STAT proteins
T15	532-536	protein	denotes	IL-7
T16	572-576	protein	denotes	IL-2
T17	612-627	protein	denotes	STAT 5 isoforms
T18	661-672	protein	denotes	Jak 1 and 3
T19	678-684	protein	denotes	STAT 5
T20	751-755	protein	denotes	IL-7
T21	831-835	protein	denotes	IL-7

Id	Subject	Object	Predicate	Lexical cue
T1	0-13	protein_molecule	denotes	Interleukin-7
T2	43-48	protein_molecule	denotes	Jak 1
T3	50-55	protein_molecule	denotes	Jak 3
T4	60-75	protein_molecule	denotes	STAT 5 proteins
T5	86-93	cell_type	denotes	T cells
T6	113-126	protein_family_or_group	denotes	Janus protein
T7	127-135	amino_acid_monomer	denotes	tyrosine
T8	145-148	protein_family_or_group	denotes	Jak
T9	154-158	protein_family_or_group	denotes	STAT
T10	160-208	protein_family_or_group	denotes	signal transducer and activator of transcription
T11	292-301	protein_family_or_group	denotes	cytokines
T12	303-307	protein_molecule	denotes	IL-7
T13	343-357	other_name	denotes	dose-dependent
T14	358-366	amino_acid_monomer	denotes	tyrosine
T15	386-391	protein_molecule	denotes	Jak 1
T16	396-401	protein_molecule	denotes	Jak 3
T17	425-433	amino_acid_monomer	denotes	tyrosine
T18	454-474	other_name	denotes	DNA binding activity
T19	487-500	protein_family_or_group	denotes	STAT proteins
T20	506-519	protein_family_or_group	denotes	STAT proteins
T21	532-536	protein_molecule	denotes	IL-7
T22	572-576	protein_molecule	denotes	IL-2
T23	612-627	protein_family_or_group	denotes	STAT 5 isoforms
T24	678-684	protein_molecule	denotes	STAT 5
T25	723-747	other_name	denotes	growth-promoting effects
T26	751-755	protein_molecule	denotes	IL-7
T27	778-807	other_name	denotes	signal transduction mechanism
T28	831-835	protein_molecule	denotes	IL-7

Id	Subject	Object	Predicate	Lexical cue
C1	0-13	NP	denotes	Interleukin-7
C2	25-75	NP	denotes	the activation of Jak 1, Jak 3 and STAT 5 proteins
C3	95-218	NP	denotes	The activation of Janus protein tyrosine kinases (Jak) and STAT (signal transducer and activator of transcription) proteins
C4	247-301	NP	denotes	the signal transduction mechanism of several cytokines
C5	303-307	NP	denotes	IL-7
C6	386-401	NP	denotes	Jak 1 and Jak 3
C7	478-500	NP	denotes	multiple STAT proteins
C9	502-519	NP	denotes	The STAT proteins
C10	532-536	NP	denotes	IL-7
C8	502-536	NP	denotes	The STAT proteins utilized by IL-7
C11	555-560	NP	denotes	those
C12	656-672	NP	denotes	both Jak 1 and 3
C13	751-755	NP	denotes	IL-7
C14	773-807	NP	denotes	this signal transduction mechanism
R1	C3	C2	coref-ident	The activation of Janus protein tyrosine kinases (Jak) and STAT (signal transducer and activator of transcription) proteins,"the activation of Jak 1, Jak 3 and STAT 5 proteins"
R2	C5	C1	coref-ident	IL-7,Interleukin-7
R3	C10	C5	coref-ident	IL-7,IL-7
R4	C8	C7	coref-ident	The STAT proteins utilized by IL-7,multiple STAT proteins
R5	C11	C9	coref-pron	those,The STAT proteins
R6	C12	C6	coref-ident	both Jak 1 and 3,Jak 1 and Jak 3
R7	C13	C10	coref-ident	IL-7,IL-7
R8	C14	C4	coref-ident	this signal transduction mechanism,the signal transduction mechanism of several cytokines

Id	Subject	Object	Predicate	Lexical cue
S1	0-94	Sentence	denotes	Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells.
S2	95-302	Sentence	denotes	The activation of Janus protein tyrosine kinases (Jak) and STAT (signal transducer and activator of transcription) proteins has recently been linked to the signal transduction mechanism of several cytokines.
S3	303-501	Sentence	denotes	IL-7 was observed to induce a rapid and dose-dependent tyrosine phosphorylation of Jak 1 and Jak 3 and concomitantly, the tyrosine phosphorylation and DNA binding activity of multiple STAT proteins.
S4	502-628	Sentence	denotes	The STAT proteins utilized by IL-7 were identical to those induced by IL-2 and could be identified as various STAT 5 isoforms.
S5	629-858	Sentence	denotes	Moreover, the induction of both Jak 1 and 3, and STAT 5 activity strongly correlated with the growth-promoting effects of IL-7, suggesting that this signal transduction mechanism may play a key role in IL-7-induced proliferation.