PubMed:7489741 JSONTXT

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{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":13},"obj":"protein_molecule"},{"id":"T2","span":{"begin":43,"end":48},"obj":"protein_molecule"},{"id":"T3","span":{"begin":50,"end":55},"obj":"protein_molecule"},{"id":"T4","span":{"begin":60,"end":75},"obj":"protein_molecule"},{"id":"T5","span":{"begin":86,"end":93},"obj":"cell_type"},{"id":"T6","span":{"begin":113,"end":126},"obj":"protein_family_or_group"},{"id":"T7","span":{"begin":127,"end":135},"obj":"amino_acid_monomer"},{"id":"T8","span":{"begin":145,"end":148},"obj":"protein_family_or_group"},{"id":"T9","span":{"begin":154,"end":158},"obj":"protein_family_or_group"},{"id":"T10","span":{"begin":160,"end":208},"obj":"protein_family_or_group"},{"id":"T11","span":{"begin":292,"end":301},"obj":"protein_family_or_group"},{"id":"T12","span":{"begin":303,"end":307},"obj":"protein_molecule"},{"id":"T13","span":{"begin":343,"end":357},"obj":"other_name"},{"id":"T14","span":{"begin":358,"end":366},"obj":"amino_acid_monomer"},{"id":"T15","span":{"begin":386,"end":391},"obj":"protein_molecule"},{"id":"T16","span":{"begin":396,"end":401},"obj":"protein_molecule"},{"id":"T17","span":{"begin":425,"end":433},"obj":"amino_acid_monomer"},{"id":"T18","span":{"begin":454,"end":474},"obj":"other_name"},{"id":"T19","span":{"begin":487,"end":500},"obj":"protein_family_or_group"},{"id":"T20","span":{"begin":506,"end":519},"obj":"protein_family_or_group"},{"id":"T21","span":{"begin":532,"end":536},"obj":"protein_molecule"},{"id":"T22","span":{"begin":572,"end":576},"obj":"protein_molecule"},{"id":"T23","span":{"begin":612,"end":627},"obj":"protein_family_or_group"},{"id":"T24","span":{"begin":678,"end":684},"obj":"protein_molecule"},{"id":"T25","span":{"begin":723,"end":747},"obj":"other_name"},{"id":"T26","span":{"begin":751,"end":755},"obj":"protein_molecule"},{"id":"T27","span":{"begin":778,"end":807},"obj":"other_name"},{"id":"T28","span":{"begin":831,"end":835},"obj":"protein_molecule"}],"text":"Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells.\nThe activation of Janus protein tyrosine kinases (Jak) and STAT (signal transducer and activator of transcription) proteins has recently been linked to the signal transduction mechanism of several cytokines. IL-7 was observed to induce a rapid and dose-dependent tyrosine phosphorylation of Jak 1 and Jak 3 and concomitantly, the tyrosine phosphorylation and DNA binding activity of multiple STAT proteins. The STAT proteins utilized by IL-7 were identical to those induced by IL-2 and could be identified as various STAT 5 isoforms. Moreover, the induction of both Jak 1 and 3, and STAT 5 activity strongly correlated with the growth-promoting effects of IL-7, suggesting that this signal transduction mechanism may play a key role in IL-7-induced proliferation."}

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{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":94},"obj":"Sentence"},{"id":"S2","span":{"begin":95,"end":302},"obj":"Sentence"},{"id":"S3","span":{"begin":303,"end":501},"obj":"Sentence"},{"id":"S4","span":{"begin":502,"end":628},"obj":"Sentence"},{"id":"S5","span":{"begin":629,"end":858},"obj":"Sentence"}],"text":"Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells.\nThe activation of Janus protein tyrosine kinases (Jak) and STAT (signal transducer and activator of transcription) proteins has recently been linked to the signal transduction mechanism of several cytokines. IL-7 was observed to induce a rapid and dose-dependent tyrosine phosphorylation of Jak 1 and Jak 3 and concomitantly, the tyrosine phosphorylation and DNA binding activity of multiple STAT proteins. The STAT proteins utilized by IL-7 were identical to those induced by IL-2 and could be identified as various STAT 5 isoforms. Moreover, the induction of both Jak 1 and 3, and STAT 5 activity strongly correlated with the growth-promoting effects of IL-7, suggesting that this signal transduction mechanism may play a key role in IL-7-induced proliferation."}