PubMed:33164997 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":262,"end":278},"obj":"Body_part"},{"id":"T2","span":{"begin":273,"end":278},"obj":"Body_part"},{"id":"T3","span":{"begin":657,"end":662},"obj":"Body_part"},{"id":"T4","span":{"begin":671,"end":680},"obj":"Body_part"},{"id":"T5","span":{"begin":700,"end":706},"obj":"Body_part"},{"id":"T6","span":{"begin":714,"end":730},"obj":"Body_part"},{"id":"T7","span":{"begin":725,"end":730},"obj":"Body_part"},{"id":"T8","span":{"begin":864,"end":869},"obj":"Body_part"},{"id":"T9","span":{"begin":894,"end":899},"obj":"Body_part"},{"id":"T10","span":{"begin":997,"end":1007},"obj":"Body_part"},{"id":"T11","span":{"begin":1003,"end":1007},"obj":"Body_part"},{"id":"T12","span":{"begin":1130,"end":1139},"obj":"Body_part"},{"id":"T13","span":{"begin":1149,"end":1165},"obj":"Body_part"},{"id":"T14","span":{"begin":1160,"end":1165},"obj":"Body_part"},{"id":"T15","span":{"begin":1204,"end":1220},"obj":"Body_part"},{"id":"T16","span":{"begin":1215,"end":1220},"obj":"Body_part"},{"id":"T17","span":{"begin":1301,"end":1307},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma84382"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma9637"}],"text":"Inflammatory endotypes of CRSwNP and responses to COVID-19.\nPURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly become a great public health hazard globally. Nasal epithelial cells are an important site for SARS-CoV-2 infection and replication. The purpose of this review is to summarize recent findings on the endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) and the potential impact of SARS-CoV-2 infection.\nRECENT FINDINGS: Endotypes of CRSwNP are characterized by type 1, type 2 and type 3 inflammation according to patterns of inflammatory cells and the cytokines expressed in nasal tissue. Nasal epithelial cells show the highest expression of angiotensin-converting enzyme 2 (ACE2), the receptor for attachment and entry of SARS-CoV-2 into host cells, among all investigated cells in the respiratory tree. SARS-CoV-2 infection likely leads to increased activation of T-helper-1 (Th1) cell responses. Recent studies further suggest that ACE2 may be upregulated by type 1 and downregulated by type 2 inflammatory cytokines in nasal epithelial cells.\nSUMMARY: Expression of ACE2 in nasal epithelial cells is influenced by inflammatory endotypes of CRSwNP. Type 1 inflammation in nasal tissue may increase the risk of SARS-CoV-2 infection by upregulating ACE2 expression. However, clinical association between CRSwNP and COVID-19 is still unclear."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":700,"end":706},"obj":"Body_part"},{"id":"T2","span":{"begin":1301,"end":1307},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Inflammatory endotypes of CRSwNP and responses to COVID-19.\nPURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly become a great public health hazard globally. Nasal epithelial cells are an important site for SARS-CoV-2 infection and replication. The purpose of this review is to summarize recent findings on the endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) and the potential impact of SARS-CoV-2 infection.\nRECENT FINDINGS: Endotypes of CRSwNP are characterized by type 1, type 2 and type 3 inflammation according to patterns of inflammatory cells and the cytokines expressed in nasal tissue. Nasal epithelial cells show the highest expression of angiotensin-converting enzyme 2 (ACE2), the receptor for attachment and entry of SARS-CoV-2 into host cells, among all investigated cells in the respiratory tree. SARS-CoV-2 infection likely leads to increased activation of T-helper-1 (Th1) cell responses. Recent studies further suggest that ACE2 may be upregulated by type 1 and downregulated by type 2 inflammatory cytokines in nasal epithelial cells.\nSUMMARY: Expression of ACE2 in nasal epithelial cells is influenced by inflammatory endotypes of CRSwNP. Type 1 inflammation in nasal tissue may increase the risk of SARS-CoV-2 infection by upregulating ACE2 expression. However, clinical association between CRSwNP and COVID-19 is still unclear."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":450,"end":462},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0100582"}],"text":"Inflammatory endotypes of CRSwNP and responses to COVID-19.\nPURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly become a great public health hazard globally. Nasal epithelial cells are an important site for SARS-CoV-2 infection and replication. The purpose of this review is to summarize recent findings on the endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) and the potential impact of SARS-CoV-2 infection.\nRECENT FINDINGS: Endotypes of CRSwNP are characterized by type 1, type 2 and type 3 inflammation according to patterns of inflammatory cells and the cytokines expressed in nasal tissue. Nasal epithelial cells show the highest expression of angiotensin-converting enzyme 2 (ACE2), the receptor for attachment and entry of SARS-CoV-2 into host cells, among all investigated cells in the respiratory tree. SARS-CoV-2 infection likely leads to increased activation of T-helper-1 (Th1) cell responses. Recent studies further suggest that ACE2 may be upregulated by type 1 and downregulated by type 2 inflammatory cytokines in nasal epithelial cells.\nSUMMARY: Expression of ACE2 in nasal epithelial cells is influenced by inflammatory endotypes of CRSwNP. Type 1 inflammation in nasal tissue may increase the risk of SARS-CoV-2 infection by upregulating ACE2 expression. However, clinical association between CRSwNP and COVID-19 is still unclear."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":50,"end":58},"obj":"Disease"},{"id":"T2","span":{"begin":79,"end":103},"obj":"Disease"},{"id":"T3","span":{"begin":105,"end":113},"obj":"Disease"},{"id":"T4","span":{"begin":136,"end":183},"obj":"Disease"},{"id":"T5","span":{"begin":136,"end":169},"obj":"Disease"},{"id":"T6","span":{"begin":185,"end":193},"obj":"Disease"},{"id":"T7","span":{"begin":305,"end":313},"obj":"Disease"},{"id":"T8","span":{"begin":316,"end":325},"obj":"Disease"},{"id":"T9","span":{"begin":422,"end":444},"obj":"Disease"},{"id":"T10","span":{"begin":450,"end":462},"obj":"Disease"},{"id":"T11","span":{"begin":500,"end":508},"obj":"Disease"},{"id":"T12","span":{"begin":511,"end":520},"obj":"Disease"},{"id":"T13","span":{"begin":606,"end":618},"obj":"Disease"},{"id":"T14","span":{"begin":843,"end":851},"obj":"Disease"},{"id":"T15","span":{"begin":925,"end":933},"obj":"Disease"},{"id":"T16","span":{"begin":936,"end":945},"obj":"Disease"},{"id":"T17","span":{"begin":1279,"end":1291},"obj":"Disease"},{"id":"T18","span":{"begin":1333,"end":1341},"obj":"Disease"},{"id":"T19","span":{"begin":1344,"end":1353},"obj":"Disease"},{"id":"T20","span":{"begin":1436,"end":1444},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0006031"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0006314"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Inflammatory endotypes of CRSwNP and responses to COVID-19.\nPURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly become a great public health hazard globally. Nasal epithelial cells are an important site for SARS-CoV-2 infection and replication. The purpose of this review is to summarize recent findings on the endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) and the potential impact of SARS-CoV-2 infection.\nRECENT FINDINGS: Endotypes of CRSwNP are characterized by type 1, type 2 and type 3 inflammation according to patterns of inflammatory cells and the cytokines expressed in nasal tissue. Nasal epithelial cells show the highest expression of angiotensin-converting enzyme 2 (ACE2), the receptor for attachment and entry of SARS-CoV-2 into host cells, among all investigated cells in the respiratory tree. SARS-CoV-2 infection likely leads to increased activation of T-helper-1 (Th1) cell responses. Recent studies further suggest that ACE2 may be upregulated by type 1 and downregulated by type 2 inflammatory cytokines in nasal epithelial cells.\nSUMMARY: Expression of ACE2 in nasal epithelial cells is influenced by inflammatory endotypes of CRSwNP. Type 1 inflammation in nasal tissue may increase the risk of SARS-CoV-2 infection by upregulating ACE2 expression. However, clinical association between CRSwNP and COVID-19 is still unclear."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":116,"end":117},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T2","span":{"begin":198,"end":201},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T3","span":{"begin":217,"end":218},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T4","span":{"begin":262,"end":272},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T5","span":{"begin":273,"end":278},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T6","span":{"begin":657,"end":662},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T7","span":{"begin":714,"end":724},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T8","span":{"begin":725,"end":730},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T9","span":{"begin":864,"end":869},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T10","span":{"begin":894,"end":899},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T11","span":{"begin":972,"end":982},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T12","span":{"begin":1003,"end":1007},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T13","span":{"begin":1149,"end":1159},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T14","span":{"begin":1160,"end":1165},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T15","span":{"begin":1204,"end":1214},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T16","span":{"begin":1215,"end":1220},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Inflammatory endotypes of CRSwNP and responses to COVID-19.\nPURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly become a great public health hazard globally. Nasal epithelial cells are an important site for SARS-CoV-2 infection and replication. The purpose of this review is to summarize recent findings on the endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) and the potential impact of SARS-CoV-2 infection.\nRECENT FINDINGS: Endotypes of CRSwNP are characterized by type 1, type 2 and type 3 inflammation according to patterns of inflammatory cells and the cytokines expressed in nasal tissue. Nasal epithelial cells show the highest expression of angiotensin-converting enzyme 2 (ACE2), the receptor for attachment and entry of SARS-CoV-2 into host cells, among all investigated cells in the respiratory tree. SARS-CoV-2 infection likely leads to increased activation of T-helper-1 (Th1) cell responses. Recent studies further suggest that ACE2 may be upregulated by type 1 and downregulated by type 2 inflammatory cytokines in nasal epithelial cells.\nSUMMARY: Expression of ACE2 in nasal epithelial cells is influenced by inflammatory endotypes of CRSwNP. Type 1 inflammation in nasal tissue may increase the risk of SARS-CoV-2 infection by upregulating ACE2 expression. However, clinical association between CRSwNP and COVID-19 is still unclear."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":762,"end":773},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"}],"text":"Inflammatory endotypes of CRSwNP and responses to COVID-19.\nPURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly become a great public health hazard globally. Nasal epithelial cells are an important site for SARS-CoV-2 infection and replication. The purpose of this review is to summarize recent findings on the endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) and the potential impact of SARS-CoV-2 infection.\nRECENT FINDINGS: Endotypes of CRSwNP are characterized by type 1, type 2 and type 3 inflammation according to patterns of inflammatory cells and the cytokines expressed in nasal tissue. Nasal epithelial cells show the highest expression of angiotensin-converting enzyme 2 (ACE2), the receptor for attachment and entry of SARS-CoV-2 into host cells, among all investigated cells in the respiratory tree. SARS-CoV-2 infection likely leads to increased activation of T-helper-1 (Th1) cell responses. Recent studies further suggest that ACE2 may be upregulated by type 1 and downregulated by type 2 inflammatory cytokines in nasal epithelial cells.\nSUMMARY: Expression of ACE2 in nasal epithelial cells is influenced by inflammatory endotypes of CRSwNP. Type 1 inflammation in nasal tissue may increase the risk of SARS-CoV-2 infection by upregulating ACE2 expression. However, clinical association between CRSwNP and COVID-19 is still unclear."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":606,"end":618},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T2","span":{"begin":1279,"end":1291},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Inflammatory endotypes of CRSwNP and responses to COVID-19.\nPURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly become a great public health hazard globally. Nasal epithelial cells are an important site for SARS-CoV-2 infection and replication. The purpose of this review is to summarize recent findings on the endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) and the potential impact of SARS-CoV-2 infection.\nRECENT FINDINGS: Endotypes of CRSwNP are characterized by type 1, type 2 and type 3 inflammation according to patterns of inflammatory cells and the cytokines expressed in nasal tissue. Nasal epithelial cells show the highest expression of angiotensin-converting enzyme 2 (ACE2), the receptor for attachment and entry of SARS-CoV-2 into host cells, among all investigated cells in the respiratory tree. SARS-CoV-2 infection likely leads to increased activation of T-helper-1 (Th1) cell responses. Recent studies further suggest that ACE2 may be upregulated by type 1 and downregulated by type 2 inflammatory cytokines in nasal epithelial cells.\nSUMMARY: Expression of ACE2 in nasal epithelial cells is influenced by inflammatory endotypes of CRSwNP. Type 1 inflammation in nasal tissue may increase the risk of SARS-CoV-2 infection by upregulating ACE2 expression. However, clinical association between CRSwNP and COVID-19 is still unclear."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1","span":{"begin":50,"end":58},"obj":"Disease"},{"id":"20","span":{"begin":79,"end":103},"obj":"Disease"},{"id":"21","span":{"begin":105,"end":113},"obj":"Disease"},{"id":"22","span":{"begin":136,"end":183},"obj":"Species"},{"id":"23","span":{"begin":185,"end":195},"obj":"Species"},{"id":"24","span":{"begin":310,"end":325},"obj":"Disease"},{"id":"25","span":{"begin":430,"end":462},"obj":"Disease"},{"id":"26","span":{"begin":500,"end":520},"obj":"Disease"},{"id":"27","span":{"begin":606,"end":618},"obj":"Disease"},{"id":"28","span":{"begin":762,"end":793},"obj":"Gene"},{"id":"29","span":{"begin":795,"end":799},"obj":"Gene"},{"id":"30","span":{"begin":843,"end":853},"obj":"Species"},{"id":"31","span":{"begin":925,"end":945},"obj":"Disease"},{"id":"32","span":{"begin":1055,"end":1059},"obj":"Gene"},{"id":"33","span":{"begin":1190,"end":1194},"obj":"Gene"},{"id":"34","span":{"begin":1279,"end":1291},"obj":"Disease"},{"id":"35","span":{"begin":1333,"end":1353},"obj":"Disease"},{"id":"36","span":{"begin":1370,"end":1374},"obj":"Gene"},{"id":"37","span":{"begin":1436,"end":1444},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"tao:has_database_id","subj":"1","obj":"MESH:C000657245"},{"id":"A20","pred":"tao:has_database_id","subj":"20","obj":"MESH:C000657245"},{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"MESH:C000657245"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"Tax:2697049"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Tax:2697049"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"MESH:C000657245"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"MESH:D009298"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"MESH:C000657245"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"MESH:D007249"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"Gene:59272"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"Gene:59272"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"Tax:2697049"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"MESH:C000657245"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"Gene:59272"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"Gene:59272"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"MESH:D007249"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"MESH:C000657245"},{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"Gene:59272"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Inflammatory endotypes of CRSwNP and responses to COVID-19.\nPURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly become a great public health hazard globally. Nasal epithelial cells are an important site for SARS-CoV-2 infection and replication. The purpose of this review is to summarize recent findings on the endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) and the potential impact of SARS-CoV-2 infection.\nRECENT FINDINGS: Endotypes of CRSwNP are characterized by type 1, type 2 and type 3 inflammation according to patterns of inflammatory cells and the cytokines expressed in nasal tissue. Nasal epithelial cells show the highest expression of angiotensin-converting enzyme 2 (ACE2), the receptor for attachment and entry of SARS-CoV-2 into host cells, among all investigated cells in the respiratory tree. SARS-CoV-2 infection likely leads to increased activation of T-helper-1 (Th1) cell responses. Recent studies further suggest that ACE2 may be upregulated by type 1 and downregulated by type 2 inflammatory cytokines in nasal epithelial cells.\nSUMMARY: Expression of ACE2 in nasal epithelial cells is influenced by inflammatory endotypes of CRSwNP. Type 1 inflammation in nasal tissue may increase the risk of SARS-CoV-2 infection by upregulating ACE2 expression. However, clinical association between CRSwNP and COVID-19 is still unclear."}

{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":59},"obj":"Sentence"},{"id":"T2","span":{"begin":60,"end":78},"obj":"Sentence"},{"id":"T3","span":{"begin":79,"end":255},"obj":"Sentence"},{"id":"T4","span":{"begin":256,"end":342},"obj":"Sentence"},{"id":"T5","span":{"begin":343,"end":521},"obj":"Sentence"},{"id":"T6","span":{"begin":522,"end":538},"obj":"Sentence"},{"id":"T7","span":{"begin":539,"end":707},"obj":"Sentence"},{"id":"T8","span":{"begin":708,"end":924},"obj":"Sentence"},{"id":"T9","span":{"begin":925,"end":1018},"obj":"Sentence"},{"id":"T10","span":{"begin":1019,"end":1166},"obj":"Sentence"},{"id":"T11","span":{"begin":1167,"end":1175},"obj":"Sentence"},{"id":"T12","span":{"begin":1176,"end":1271},"obj":"Sentence"},{"id":"T13","span":{"begin":1272,"end":1386},"obj":"Sentence"},{"id":"T14","span":{"begin":1387,"end":1462},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":59},"obj":"Sentence"},{"id":"T2","span":{"begin":60,"end":78},"obj":"Sentence"},{"id":"T3","span":{"begin":79,"end":255},"obj":"Sentence"},{"id":"T4","span":{"begin":256,"end":342},"obj":"Sentence"},{"id":"T5","span":{"begin":343,"end":521},"obj":"Sentence"},{"id":"T6","span":{"begin":522,"end":538},"obj":"Sentence"},{"id":"T7","span":{"begin":539,"end":707},"obj":"Sentence"},{"id":"T8","span":{"begin":708,"end":924},"obj":"Sentence"},{"id":"T9","span":{"begin":925,"end":1018},"obj":"Sentence"},{"id":"T10","span":{"begin":1019,"end":1166},"obj":"Sentence"},{"id":"T11","span":{"begin":1167,"end":1175},"obj":"Sentence"},{"id":"T12","span":{"begin":1176,"end":1271},"obj":"Sentence"},{"id":"T13","span":{"begin":1272,"end":1386},"obj":"Sentence"},{"id":"T14","span":{"begin":1387,"end":1462},"obj":"Sentence"}],"text":"Inflammatory endotypes of CRSwNP and responses to COVID-19.\nPURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly become a great public health hazard globally. Nasal epithelial cells are an important site for SARS-CoV-2 infection and replication. The purpose of this review is to summarize recent findings on the endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) and the potential impact of SARS-CoV-2 infection.\nRECENT FINDINGS: Endotypes of CRSwNP are characterized by type 1, type 2 and type 3 inflammation according to patterns of inflammatory cells and the cytokines expressed in nasal tissue. Nasal epithelial cells show the highest expression of angiotensin-converting enzyme 2 (ACE2), the receptor for attachment and entry of SARS-CoV-2 into host cells, among all investigated cells in the respiratory tree. SARS-CoV-2 infection likely leads to increased activation of T-helper-1 (Th1) cell responses. Recent studies further suggest that ACE2 may be upregulated by type 1 and downregulated by type 2 inflammatory cytokines in nasal epithelial cells.\nSUMMARY: Expression of ACE2 in nasal epithelial cells is influenced by inflammatory endotypes of CRSwNP. Type 1 inflammation in nasal tissue may increase the risk of SARS-CoV-2 infection by upregulating ACE2 expression. However, clinical association between CRSwNP and COVID-19 is still unclear."}

{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":59},"obj":"Sentence"},{"id":"T2","span":{"begin":60,"end":78},"obj":"Sentence"},{"id":"T3","span":{"begin":79,"end":255},"obj":"Sentence"},{"id":"T4","span":{"begin":256,"end":342},"obj":"Sentence"},{"id":"T5","span":{"begin":343,"end":521},"obj":"Sentence"},{"id":"T6","span":{"begin":522,"end":538},"obj":"Sentence"},{"id":"T7","span":{"begin":539,"end":707},"obj":"Sentence"},{"id":"T8","span":{"begin":708,"end":924},"obj":"Sentence"},{"id":"T9","span":{"begin":925,"end":1018},"obj":"Sentence"},{"id":"T10","span":{"begin":1019,"end":1166},"obj":"Sentence"},{"id":"T11","span":{"begin":1167,"end":1175},"obj":"Sentence"},{"id":"T12","span":{"begin":1176,"end":1271},"obj":"Sentence"},{"id":"T13","span":{"begin":1272,"end":1386},"obj":"Sentence"},{"id":"T14","span":{"begin":1387,"end":1462},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Inflammatory endotypes of CRSwNP and responses to COVID-19.\nPURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly become a great public health hazard globally. Nasal epithelial cells are an important site for SARS-CoV-2 infection and replication. The purpose of this review is to summarize recent findings on the endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) and the potential impact of SARS-CoV-2 infection.\nRECENT FINDINGS: Endotypes of CRSwNP are characterized by type 1, type 2 and type 3 inflammation according to patterns of inflammatory cells and the cytokines expressed in nasal tissue. Nasal epithelial cells show the highest expression of angiotensin-converting enzyme 2 (ACE2), the receptor for attachment and entry of SARS-CoV-2 into host cells, among all investigated cells in the respiratory tree. SARS-CoV-2 infection likely leads to increased activation of T-helper-1 (Th1) cell responses. Recent studies further suggest that ACE2 may be upregulated by type 1 and downregulated by type 2 inflammatory cytokines in nasal epithelial cells.\nSUMMARY: Expression of ACE2 in nasal epithelial cells is influenced by inflammatory endotypes of CRSwNP. Type 1 inflammation in nasal tissue may increase the risk of SARS-CoV-2 infection by upregulating ACE2 expression. However, clinical association between CRSwNP and COVID-19 is still unclear."}

{"project":"LitCovid_AGAC_only","denotations":[{"id":"p284353s19","span":{"begin":1370,"end":1374},"obj":"Gene"},{"id":"p284353s20","span":{"begin":1375,"end":1385},"obj":"MPA"}],"text":"Inflammatory endotypes of CRSwNP and responses to COVID-19.\nPURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly become a great public health hazard globally. Nasal epithelial cells are an important site for SARS-CoV-2 infection and replication. The purpose of this review is to summarize recent findings on the endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) and the potential impact of SARS-CoV-2 infection.\nRECENT FINDINGS: Endotypes of CRSwNP are characterized by type 1, type 2 and type 3 inflammation according to patterns of inflammatory cells and the cytokines expressed in nasal tissue. Nasal epithelial cells show the highest expression of angiotensin-converting enzyme 2 (ACE2), the receptor for attachment and entry of SARS-CoV-2 into host cells, among all investigated cells in the respiratory tree. SARS-CoV-2 infection likely leads to increased activation of T-helper-1 (Th1) cell responses. Recent studies further suggest that ACE2 may be upregulated by type 1 and downregulated by type 2 inflammatory cytokines in nasal epithelial cells.\nSUMMARY: Expression of ACE2 in nasal epithelial cells is influenced by inflammatory endotypes of CRSwNP. Type 1 inflammation in nasal tissue may increase the risk of SARS-CoV-2 infection by upregulating ACE2 expression. However, clinical association between CRSwNP and COVID-19 is still unclear."}