PubMed:32979436 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32979436","sourcedb":"PubMed","sourceid":"32979436","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32979436","text":"The structure-activity relationship of the interactions of SARS-CoV-2 spike glycoproteins with glucuronomannan and sulfated galactofucan from Saccharina japonica.\nThe SARS-CoV-2 spike glycoproteins (SGPs) and human angiotensin converting enzyme 2 (ACE2) are the two key targets for the prevention and treatment of COVID-19. Host cell surface heparan sulfate (HS) is believed to interact with SARS-CoV-2 SGPs to facilitate host cell entry. In the current study, a series of polysaccharides from Saccharina japonica were prepared to investigate the structure-activity relationship on the binding abilities of polysaccharides (oligosaccharides) to pseudotype particles, including SARS-CoV-2 SGPs, and ACE2 using surface plasmon resonance. Sulfated galactofucan (SJ-D-S-H) and glucuronomannan (Gn) displayed strongly inhibited interaction between SARS-CoV-2 SGPs and heparin while showing negligible inhibition of the interaction between SARS-CoV-2 SGPs and ACE2. The IC50 values of SJ-D-S-H and Gn in blocking heparin SGP binding were 27 and 231 nM, respectively. NMR analysis showed that the structure of SJ-D-S-H featured with a backbone of 1, 3-linked α-L-Fucp residues sulfated at C4 and C2/C4 and 1, 3-linked α-L-Fucp residues sulfated at C4 and branched with 1, 6-linked β-D-galacto-biose; Gn had a backbone of alternating 1, 4-linked β-D-GlcAp residues and 1, 2-linked α-D-Manp residues. The sulfated galactofucan and glucuronomannan showed strong binding ability to SARS-CoV-2 SGPs, suggesting that these polysaccharides might be good candidates for preventing and/or treating SARS-CoV-2.","tracks":[{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":863,"end":870},"obj":"https://glytoucan.org/Structures/Glycans/G00021MO"},{"id":"T2","span":{"begin":863,"end":870},"obj":"https://glytoucan.org/Structures/Glycans/G54161DR"},{"id":"T3","span":{"begin":1007,"end":1014},"obj":"https://glytoucan.org/Structures/Glycans/G00021MO"},{"id":"T4","span":{"begin":1007,"end":1014},"obj":"https://glytoucan.org/Structures/Glycans/G54161DR"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T2","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T3","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T4","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":76,"end":89},"obj":"Body_part"},{"id":"T2","span":{"begin":184,"end":197},"obj":"Body_part"},{"id":"T3","span":{"begin":329,"end":341},"obj":"Body_part"},{"id":"T4","span":{"begin":329,"end":333},"obj":"Body_part"},{"id":"T5","span":{"begin":342,"end":357},"obj":"Body_part"},{"id":"T6","span":{"begin":359,"end":361},"obj":"Body_part"},{"id":"T7","span":{"begin":427,"end":431},"obj":"Body_part"},{"id":"T8","span":{"begin":473,"end":488},"obj":"Body_part"},{"id":"T9","span":{"begin":607,"end":622},"obj":"Body_part"},{"id":"T10","span":{"begin":624,"end":640},"obj":"Body_part"},{"id":"T11","span":{"begin":863,"end":870},"obj":"Body_part"},{"id":"T12","span":{"begin":1007,"end":1014},"obj":"Body_part"},{"id":"T13","span":{"begin":1128,"end":1136},"obj":"Body_part"},{"id":"T14","span":{"begin":1302,"end":1310},"obj":"Body_part"},{"id":"T15","span":{"begin":1510,"end":1525},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma82746"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma82746"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma82742"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma13478"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma13478"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma82746"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":59,"end":67},"obj":"Disease"},{"id":"T2","span":{"begin":167,"end":175},"obj":"Disease"},{"id":"T3","span":{"begin":314,"end":322},"obj":"Disease"},{"id":"T4","span":{"begin":392,"end":400},"obj":"Disease"},{"id":"T5","span":{"begin":677,"end":685},"obj":"Disease"},{"id":"T6","span":{"begin":843,"end":851},"obj":"Disease"},{"id":"T7","span":{"begin":934,"end":942},"obj":"Disease"},{"id":"T8","span":{"begin":1471,"end":1479},"obj":"Disease"},{"id":"T9","span":{"begin":1582,"end":1590},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A5","pred":"mondo_id","subj"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