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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 863-870 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 863-870 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T3 1007-1014 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T4 1007-1014 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 76-89 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T2 184-197 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T3 329-341 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T4 329-333 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T5 342-357 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T6 359-361 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T7 427-431 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T8 473-488 Body_part denotes polysaccharides http://purl.org/sig/ont/fma/fma82746
T9 607-622 Body_part denotes polysaccharides http://purl.org/sig/ont/fma/fma82746
T10 624-640 Body_part denotes oligosaccharides http://purl.org/sig/ont/fma/fma82742
T11 863-870 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T12 1007-1014 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T13 1128-1136 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T14 1302-1310 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T15 1510-1525 Body_part denotes polysaccharides http://purl.org/sig/ont/fma/fma82746

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 59-67 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 167-175 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T3 314-322 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T4 392-400 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 677-685 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 843-851 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 934-942 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 1471-1479 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 1582-1590 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 14-22 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T2 209-214 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T3 329-333 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 427-431 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5 461-462 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 557-565 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T7 1032-1034 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T8 1126-1127 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 1182-1184 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T10 1189-1191 http://purl.obolibrary.org/obo/CLO_0002105 denotes C2
T11 1189-1191 http://purl.obolibrary.org/obo/CLO_0051742 denotes C2
T12 1192-1194 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T13 1241-1243 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T14 1300-1301 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 76-89 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T2 184-197 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T3 215-226 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T4 342-357 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T5 342-349 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T6 350-357 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T7 359-361 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T9 473-488 Chemical denotes polysaccharides http://purl.obolibrary.org/obo/CHEBI_18154
T10 607-622 Chemical denotes polysaccharides http://purl.obolibrary.org/obo/CHEBI_18154
T11 624-640 Chemical denotes oligosaccharides http://purl.obolibrary.org/obo/CHEBI_50699
T12 762-765 Chemical denotes D-S http://purl.obolibrary.org/obo/CHEBI_73454
T13 863-870 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T14 982-985 Chemical denotes D-S http://purl.obolibrary.org/obo/CHEBI_73454
T15 1007-1014 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T16 1106-1109 Chemical denotes D-S http://purl.obolibrary.org/obo/CHEBI_73454
T17 1189-1191 Chemical denotes C2 http://purl.obolibrary.org/obo/CHEBI_30083
T18 1510-1525 Chemical denotes polysaccharides http://purl.obolibrary.org/obo/CHEBI_18154

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 342-357 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T2 359-361 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
4 59-69 Species denotes SARS-CoV-2 Tax:2697049
5 95-110 Chemical denotes glucuronomannan MESH:C578162
6 124-136 Chemical denotes galactofucan
7 142-161 Species denotes Saccharina japonica Tax:88149
39 167-177 Species denotes SARS-CoV-2 Tax:2697049
40 209-214 Species denotes human Tax:9606
41 215-246 Gene denotes angiotensin converting enzyme 2 Gene:59272
42 248-252 Gene denotes ACE2 Gene:59272
43 314-322 Disease denotes COVID-19 MESH:C000657245
44 342-357 Chemical denotes heparan sulfate MESH:D006497
45 359-361 Chemical denotes HS MESH:D006497
46 392-402 Species denotes SARS-CoV-2 Tax:2697049
47 473-488 Chemical denotes polysaccharides MESH:D011134
48 494-513 Species denotes Saccharina japonica Tax:88149
49 607-622 Chemical denotes polysaccharides MESH:D011134
50 624-640 Chemical denotes oligosaccharides MESH:D009844
51 677-687 Species denotes SARS-CoV-2 Tax:2697049
52 698-702 Gene denotes ACE2 Gene:59272
53 745-757 Chemical denotes galactofucan
54 773-788 Chemical denotes glucuronomannan MESH:C578162
55 843-853 Species denotes SARS-CoV-2 Tax:2697049
56 863-870 Chemical denotes heparin MESH:D006493
57 934-944 Species denotes SARS-CoV-2 Tax:2697049
58 954-958 Gene denotes ACE2 Gene:59272
59 1007-1014 Chemical denotes heparin MESH:D006493
60 1152-1160 Chemical denotes α-L-Fucp
61 1211-1219 Chemical denotes α-L-Fucp
62 1293-1295 Chemical denotes Gn MESH:C578162
63 1326-1347 Chemical denotes 1, 4-linked β-D-GlcAp
64 1373-1381 Chemical denotes α-D-Manp
65 1405-1417 Chemical denotes galactofucan
66 1422-1437 Chemical denotes glucuronomannan MESH:C578162
67 1471-1481 Species denotes SARS-CoV-2 Tax:2697049
68 1510-1525 Chemical denotes polysaccharides MESH:D011134
69 1582-1592 Species denotes SARS-CoV-2 Tax:2697049

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-162 Sentence denotes The structure-activity relationship of the interactions of SARS-CoV-2 spike glycoproteins with glucuronomannan and sulfated galactofucan from Saccharina japonica.
T2 163-323 Sentence denotes The SARS-CoV-2 spike glycoproteins (SGPs) and human angiotensin converting enzyme 2 (ACE2) are the two key targets for the prevention and treatment of COVID-19.
T3 324-438 Sentence denotes Host cell surface heparan sulfate (HS) is believed to interact with SARS-CoV-2 SGPs to facilitate host cell entry.
T4 439-735 Sentence denotes In the current study, a series of polysaccharides from Saccharina japonica were prepared to investigate the structure-activity relationship on the binding abilities of polysaccharides (oligosaccharides) to pseudotype particles, including SARS-CoV-2 SGPs, and ACE2 using surface plasmon resonance.
T5 736-959 Sentence denotes Sulfated galactofucan (SJ-D-S-H) and glucuronomannan (Gn) displayed strongly inhibited interaction between SARS-CoV-2 SGPs and heparin while showing negligible inhibition of the interaction between SARS-CoV-2 SGPs and ACE2.
T6 960-1060 Sentence denotes The IC50 values of SJ-D-S-H and Gn in blocking heparin SGP binding were 27 and 231 nM, respectively.
T7 1061-1391 Sentence denotes NMR analysis showed that the structure of SJ-D-S-H featured with a backbone of 1, 3-linked α-L-Fucp residues sulfated at C4 and C2/C4 and 1, 3-linked α-L-Fucp residues sulfated at C4 and branched with 1, 6-linked β-D-galacto-biose; Gn had a backbone of alternating 1, 4-linked β-D-GlcAp residues and 1, 2-linked α-D-Manp residues.
T8 1392-1593 Sentence denotes The sulfated galactofucan and glucuronomannan showed strong binding ability to SARS-CoV-2 SGPs, suggesting that these polysaccharides might be good candidates for preventing and/or treating SARS-CoV-2.