PubMed:32712670 / 4702-5215 JSONTXT

{"project":"LitCovid-OGER-BB","denotations":[{"id":"T156","span":{"begin":81,"end":90},"obj":"CHEBI:31781"},{"id":"T157","span":{"begin":81,"end":90},"obj":"DG_23"},{"id":"T158","span":{"begin":81,"end":90},"obj":"CHEBI:31781"},{"id":"T159","span":{"begin":98,"end":107},"obj":"GO:0007565"},{"id":"T160","span":{"begin":126,"end":135},"obj":"CHEBI:31781"},{"id":"T161","span":{"begin":126,"end":135},"obj":"DG_23"},{"id":"T162","span":{"begin":126,"end":135},"obj":"CHEBI:31781"},{"id":"T163","span":{"begin":197,"end":206},"obj":"DG_13"},{"id":"T164","span":{"begin":256,"end":265},"obj":"GO:0007565"},{"id":"T165","span":{"begin":299,"end":307},"obj":"SP_7"},{"id":"T166","span":{"begin":318,"end":327},"obj":"CHEBI:31781"},{"id":"T167","span":{"begin":318,"end":327},"obj":"DG_23"},{"id":"T168","span":{"begin":318,"end":327},"obj":"CHEBI:31781"},{"id":"T169","span":{"begin":345,"end":349},"obj":"CHEBI:23888"},{"id":"T170","span":{"begin":345,"end":349},"obj":"CHEBI:23888"},{"id":"T171","span":{"begin":493,"end":504},"obj":"UBERON:0001004"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"text":"Our results highlight the need for reconsidering current guidelines recommending lopinavir use in pregnancy and indicate that lopinavir should be avoided especially in the first trimester, whereas darunavir is safe to use and should be the preferred PI in pregnancy.Further, in current times of the COVID-19 pandemic, lopinavir is among the top drug candidates which are being repurposed for inclusion in clinical trials world-over, to assess their therapeutic potential against the dangerous respiratory disease."}

{"project":"Inflammaging","denotations":[{"id":"T38","span":{"begin":0,"end":513},"obj":"Sentence"},{"id":"T38","span":{"begin":0,"end":513},"obj":"Sentence"}],"text":"Our results highlight the need for reconsidering current guidelines recommending lopinavir use in pregnancy and indicate that lopinavir should be avoided especially in the first trimester, whereas darunavir is safe to use and should be the preferred PI in pregnancy.Further, in current times of the COVID-19 pandemic, lopinavir is among the top drug candidates which are being repurposed for inclusion in clinical trials world-over, to assess their therapeutic potential against the dangerous respiratory disease."}