PubMed:31129139 / 1052-1572
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/31129139","sourcedb":"PubMed","sourceid":"31129139","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/31129139","text":"Morphological and biochemical assessments clearly demonstrated that HO could alleviate APAP-induced liver damage. The hepatoprotective effect of HO was positively associated with the reduction of APAP-protein adducts. Further investigation suggested that HO induced inhibition of CYP 2E1 and CYP2A1 as well as upregulation of GSH co-contributed to the reduction of APAP-protein adducts. 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