PubMed:31129139 / 1052-1572 JSONTXT

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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T3 0-520 RESULTS denotes Morphological and biochemical assessments clearly demonstrated that HO could alleviate APAP-induced liver damage. The hepatoprotective effect of HO was positively associated with the reduction of APAP-protein adducts. Further investigation suggested that HO induced inhibition of CYP 2E1 and CYP2A1 as well as upregulation of GSH co-contributed to the reduction of APAP-protein adducts. Furthermore, HO induced activations of NRF2 and its target enzymes, such as GCLC, GCLM and GST, gave rise to the upregulation of GSH.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T7 68-70 CVCL_M698|Cancer_cell_line|Homo sapiens denotes HO
T8 145-147 CVCL_M698|Cancer_cell_line|Homo sapiens denotes HO
T9 255-257 CVCL_M698|Cancer_cell_line|Homo sapiens denotes HO
T10 330-332 CVCL_J653|Cancer_cell_line|Homo sapiens denotes co
T11 400-402 CVCL_M698|Cancer_cell_line|Homo sapiens denotes HO
T12 411-422 CVCL_C410|Hybridoma|Mus musculus denotes activations

GoldHamster

Id Subject Object Predicate Lexical cue
T164 87-91 D000082 denotes APAP
T165 87-91 D000082 denotes APAP
T166 87-91 CHEBI:46195 denotes APAP
T167 100-105 UBERON:0002107 denotes liver
T168 183-192 MOP:0000569 denotes reduction
T169 196-200 D000082 denotes APAP
T170 196-200 D000082 denotes APAP
T171 196-200 CHEBI:46195 denotes APAP
T175 201-208 PR:000000001 denotes protein
T172 201-208 GO:0003675 denotes protein
T176 201-208 SO:0000104 denotes protein
T173 201-208 CHEBI:36080 denotes protein
T174 201-208 CHEBI:11122 denotes protein
T189 280-287 PR:P05182 denotes CYP 2E1
T190 280-287 PR:000006122 denotes CYP 2E1
T192 280-287 PR:Q05421 denotes CYP 2E1
T193 280-287 PR:P05181 denotes CYP 2E1
T191 280-287 D019392 denotes CYP 2E1
T202 292-297 C029009 denotes CYP2A
T203 292-298 PR:P11711 denotes CYP2A1
T204 295-298 CVCL_XG57 denotes 2A1
T205 295-298 CVCL_1930 denotes 2A1
T207 326-329 CHEBI:16856 denotes GSH
T206 326-329 C563177 denotes GSH
T208 352-361 MOP:0000569 denotes reduction
T209 365-369 D000082 denotes APAP
T210 365-369 D000082 denotes APAP
T211 365-369 CHEBI:46195 denotes APAP
T212 370-377 GO:0003675 denotes protein
T216 370-377 SO:0000104 denotes protein
T215 370-377 PR:000000001 denotes protein
T213 370-377 CHEBI:36080 denotes protein
T214 370-377 CHEBI:11122 denotes protein
T220 426-430 PR:Q60795 denotes NRF2
T221 426-430 PR:O54968 denotes NRF2
T222 426-430 PR:000011170 denotes NRF2
T223 426-430 Q16236 denotes NRF2
T224 426-430 PR:Q16236 denotes NRF2
T225 463-467 PR:Q9W3K5 denotes GCLC
T226 463-467 PR:000007897 denotes GCLC
T227 463-467 PR:P48506 denotes GCLC
T228 463-467 PR:P97494 denotes GCLC
T229 463-467 PR:P19468 denotes GCLC
T230 469-473 PR:000007898 denotes GCLM
T231 469-473 PR:P48507 denotes GCLM
T232 469-473 PR:O09172 denotes GCLM
T233 469-473 PR:P48508 denotes GCLM
T234 478-481 Q86UG4 denotes GST
T235 478-481 PR:P20432 denotes GST
T236 478-481 PR:000025821 denotes GST
T237 478-481 PR:Q7REH6 denotes GST
T239 516-519 CHEBI:16856 denotes GSH
T238 516-519 C563177 denotes GSH