PubMed:31129139 / 0-573 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/31129139","sourcedb":"PubMed","sourceid":"31129139","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/31129139","text":"Honokiol alleviates acetaminophen-induced hepatotoxicity via decreasing generation of acetaminophen-protein adducts in liver.\nAIM: Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver damage. Magnolia officinalis is a traditional hepatoprotective Chinese medicine and Honokiol (HO) is the major active constituent. The present study was to investigate the effect of HO on APAP-induced hepatotoxicity and related mechanisms.\nMAIN METHODS: Four groups of mice were subjected to treatment as vehicle, APAP, APAP + HO and APAP + HO + NRF2 inhibitor. 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