PubMed:31129139 / 0-573 JSONTXT

{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T1","span":{"begin":131,"end":449},"obj":"OBJECTIVE"}],"text":"Honokiol alleviates acetaminophen-induced hepatotoxicity via decreasing generation of acetaminophen-protein adducts in liver.\nAIM: Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver damage. Magnolia officinalis is a traditional hepatoprotective Chinese medicine and Honokiol (HO) is the major active constituent. The present study was to investigate the effect of HO on APAP-induced hepatotoxicity and related mechanisms.\nMAIN METHODS: Four groups of mice were subjected to treatment as vehicle, APAP, APAP + HO and APAP + HO + NRF2 inhibitor. T"}

{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T1","span":{"begin":242,"end":243},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T2","span":{"begin":304,"end":306},"obj":"CVCL_M698|Cancer_cell_line|Homo sapiens"},{"id":"T3","span":{"begin":321,"end":327},"obj":"CVCL_C410|Hybridoma|Mus musculus"},{"id":"T4","span":{"begin":392,"end":394},"obj":"CVCL_M698|Cancer_cell_line|Homo sapiens"}],"text":"Honokiol alleviates acetaminophen-induced hepatotoxicity via decreasing generation of acetaminophen-protein adducts in liver.\nAIM: Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver damage. Magnolia officinalis is a traditional hepatoprotective Chinese medicine and Honokiol (HO) is the major active constituent. The present study was to investigate the effect of HO on APAP-induced hepatotoxicity and related mechanisms.\nMAIN METHODS: Four groups of mice were subjected to treatment as vehicle, APAP, APAP + HO and APAP + HO + NRF2 inhibitor. T"}

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