PubMed:28068934 / 415-779 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/28068934","sourcedb":"PubMed","sourceid":"28068934","text":"We examined five hotspot mutations in the PIK3CA gene (E542K, E545K, E546K, H1047R, and H1047L) in formalin-fixed and paraffin-embedded tissue sections of paired endoscopic biopsy and surgically resected specimens from 181 patients undergoing curative resection for ESCC between 2000 and 2011 using a Luminex technology-based multiplex gene mutation detection kit.","tracks":[{"project":"PubTator4TogoVar","denotations":[{"id":"28068934_0","span":{"begin":76,"end":82},"obj":"ProteinMutation"},{"id":"28068934_1","span":{"begin":88,"end":94},"obj":"ProteinMutation"}],"attributes":[{"id":"28068934_0_ProteinMutation","pred":"proteinmutation","subj":"28068934_0","obj":"rs121913279"},{"id":"28068934_1_ProteinMutation","pred":"proteinmutation","subj":"28068934_1","obj":"rs121913279"},{"subj":"28068934_0","pred":"source","obj":"PubTator4TogoVar"},{"subj":"28068934_1","pred":"source","obj":"PubTator4TogoVar"}]},{"project":"LitCoin-sentences","denotations":[{"id":"T5","span":{"begin":0,"end":364},"obj":"Sentence"}],"attributes":[{"subj":"T5","pred":"source","obj":"LitCoin-sentences"}]},{"project":"LitCoin-entities","denotations":[{"id":"12043","span":{"begin":42,"end":48},"obj":"GeneOrGeneProduct"},{"id":"12044","span":{"begin":55,"end":60},"obj":"SequenceVariant"},{"id":"12045","span":{"begin":62,"end":67},"obj":"SequenceVariant"},{"id":"12046","span":{"begin":69,"end":74},"obj":"SequenceVariant"},{"id":"12047","span":{"begin":76,"end":82},"obj":"SequenceVariant"},{"id":"12048","span":{"begin":88,"end":94},"obj":"SequenceVariant"},{"id":"12049","span":{"begin":99,"end":107},"obj":"ChemicalEntity"},{"id":"12050","span":{"begin":118,"end":126},"obj":"ChemicalEntity"},{"id":"12051","span":{"begin":223,"end":231},"obj":"OrganismTaxon"},{"id":"12052","span":{"begin":266,"end":270},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A7","pred":"db_id","subj":"12043","obj":"NCBIGene:5290"},{"id":"A8","pred":"db_id","subj":"12044","obj":"DBSNP:rs121913273"},{"id":"A9","pred":"db_id","subj":"12045","obj":"DBSNP:rs104886003"},{"id":"A10","pred":"db_id","subj":"12046","obj":"p|SUB|E|546|K"},{"id":"A11","pred":"db_id","subj":"12047","obj":"DBSNP:rs121913279"},{"id":"A12","pred":"db_id","subj":"12048","obj":"DBSNP:rs121913279"},{"id":"A13","pred":"db_id","subj":"12049","obj":"MESH:D005557"},{"id":"A14","pred":"db_id","subj":"12050","obj":"MESH:D010232"},{"id":"A15","pred":"db_id","subj":"12051","obj":"NCBITaxon:9606"},{"id":"A16","pred":"db_id","subj":"12052","obj":"MESH:D000077277"},{"subj":"12043","pred":"source","obj":"LitCoin-entities"},{"subj":"12044","pred":"source","obj":"LitCoin-entities"},{"subj":"12045","pred":"source","obj":"LitCoin-entities"},{"subj":"12046","pred":"source","obj":"LitCoin-entities"},{"subj":"12047","pred":"source","obj":"LitCoin-entities"},{"subj":"12048","pred":"source","obj":"LitCoin-entities"},{"subj":"12049","pred":"source","obj":"LitCoin-entities"},{"subj":"12050","pred":"source","obj":"LitCoin-entities"},{"subj":"12051","pred":"source","obj":"LitCoin-entities"},{"subj":"12052","pred":"source","obj":"LitCoin-entities"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}]},{"project":"LitCoin-SeqVar","denotations":[{"id":"T1","span":{"begin":55,"end":60},"obj":"SequenceVariant"},{"id":"T2","span":{"begin":62,"end":67},"obj":"SequenceVariant"},{"id":"T3","span":{"begin":69,"end":74},"obj":"SequenceVariant"},{"id":"T4","span":{"begin":76,"end":82},"obj":"SequenceVariant"},{"id":"T5","span":{"begin":88,"end":94},"obj":"SequenceVariant"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-SeqVar"},{"subj":"T2","pred":"source","obj":"LitCoin-SeqVar"},{"subj":"T3","pred":"source","obj":"LitCoin-SeqVar"},{"subj":"T4","pred":"source","obj":"LitCoin-SeqVar"},{"subj":"T5","pred":"source","obj":"LitCoin-SeqVar"}]},{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T11","span":{"begin":25,"end":34},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":42,"end":48},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":155,"end":161},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":266,"end":270},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":320,"end":325},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":341,"end":349},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T16","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"}]},{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T6","span":{"begin":42,"end":48},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":155,"end":161},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"}]},{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T4","span":{"begin":266,"end":270},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A4","pred":"originalLabel","subj":"T4","obj":"D000077277"},{"subj":"T4","pred":"source","obj":"LitCoin-Disease-MeSH"}]},{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T4","span":{"begin":42,"end":48},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"}]},{"project":"LitCoin_Mondo_095","denotations":[{"id":"T4","span":{"begin":266,"end":270},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0005580"},{"subj":"T4","pred":"source","obj":"LitCoin_Mondo_095"}]},{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T4","span":{"begin":266,"end":270},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A4","pred":"ID:","subj":"T4","obj":"D000077277"},{"subj":"T4","pred":"source","obj":"LitCoin-MeSH-Disease-2"}]},{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":223,"end":231},"obj":"OrganismTaxon"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-NCBITaxon-2"}]},{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T4","span":{"begin":266,"end":270},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A4","pred":"#label","subj":"T4","obj":"D000077277"},{"subj":"T4","pred":"source","obj":"LitCoin-MONDO_bioort2019"}]},{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":99,"end":107},"obj":"ChemicalEntity"},{"id":"T2","span":{"begin":118,"end":126},"obj":"ChemicalEntity"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"D005557"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D010232"},{"id":"A3","pred":"ID:","subj":"T2","obj":"ChemicalEntity"},{"subj":"T1","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"}]},{"project":"LitCoin-training-merged","denotations":[{"id":"T2","span":{"begin":118,"end":126},"obj":"ChemicalEntity"},{"id":"T1","span":{"begin":99,"end":107},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":42,"end":48},"obj":"GeneOrGeneProduct"},{"id":"T76861","span":{"begin":266,"end":270},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T58424","span":{"begin":223,"end":231},"obj":"OrganismTaxon"},{"id":"T74027","span":{"begin":88,"end":94},"obj":"SequenceVariant"},{"id":"T42809","span":{"begin":76,"end":82},"obj":"SequenceVariant"},{"id":"T3154","span":{"begin":69,"end":74},"obj":"SequenceVariant"},{"id":"T72399","span":{"begin":62,"end":67},"obj":"SequenceVariant"},{"id":"T23816","span":{"begin":55,"end":60},"obj":"SequenceVariant"}],"attributes":[{"id":"A3","pred":"ID:","subj":"T2","obj":"ChemicalEntity"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D010232"},{"id":"A1","pred":"ID:","subj":"T1","obj":"D005557"},{"id":"A4","pred":"#label","subj":"T76861","obj":"D000077277"},{"subj":"T2","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T1","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T4","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T76861","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T58424","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T74027","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T42809","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T3154","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T72399","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T23816","pred":"source","obj":"LitCoin-training-merged"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubTator4TogoVar","color":"#9396ec","default":true},{"id":"LitCoin-sentences","color":"#b0ec93"},{"id":"LitCoin-entities","color":"#ec93ca"},{"id":"LitCoin-SeqVar","color":"#93e4ec"},{"id":"LitCoin-GeneOrGeneProduct-v0","color":"#ecda93"},{"id":"LitCoin-GeneOrGeneProduct-v2","color":"#c093ec"},{"id":"LitCoin-Disease-MeSH","color":"#93eca6"},{"id":"LitCoin-GeneOrGeneProduct-v3","color":"#ec9399"},{"id":"LitCoin_Mondo_095","color":"#93b3ec"},{"id":"LitCoin-MeSH-Disease-2","color":"#cdec93"},{"id":"LitCoin-NCBITaxon-2","color":"#ec93e7"},{"id":"LitCoin-MONDO_bioort2019","color":"#93ecd6"},{"id":"LitCoin-Chemical-MeSH-CHEBI","color":"#ecbc93"},{"id":"LitCoin-training-merged","color":"#a293ec"}]}]}}