PubMed:27860244
Annnotations
LitCoin-entities
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
11710 | 8-44 | GeneOrGeneProduct | denotes | protein arginine methyltransferase 5 | NCBIGene:10419 |
11711 | 48-60 | DiseaseOrPhenotypicFeature | denotes | inflammation | MESH:D007249 |
11712 | 110-130 | DiseaseOrPhenotypicFeature | denotes | rheumatoid arthritis | MESH:D001172 |
11713 | 153-189 | GeneOrGeneProduct | denotes | protein arginine methyltransferase 5 | NCBIGene:10419 |
11714 | 191-196 | GeneOrGeneProduct | denotes | PRMT5 | NCBIGene:10419 |
11715 | 212-224 | DiseaseOrPhenotypicFeature | denotes | inflammation | MESH:D007249 |
11716 | 313-321 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
11717 | 327-347 | DiseaseOrPhenotypicFeature | denotes | rheumatoid arthritis | MESH:D001172 |
11718 | 349-351 | DiseaseOrPhenotypicFeature | denotes | RA | MESH:D001172 |
11719 | 407-415 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
11720 | 421-423 | DiseaseOrPhenotypicFeature | denotes | RA | MESH:D001172 |
11721 | 428-442 | DiseaseOrPhenotypicFeature | denotes | osteoarthritis | MESH:D010003 |
11722 | 444-446 | DiseaseOrPhenotypicFeature | denotes | OA | MESH:D010003 |
11723 | 465-470 | GeneOrGeneProduct | denotes | PRMT5 | NCBIGene:10419 |
11724 | 472-481 | ChemicalEntity | denotes | EPZ015666 | MESH:C000599896 |
11725 | 526-531 | GeneOrGeneProduct | denotes | PRMT5 | NCBIGene:10419 |
11726 | 553-558 | GeneOrGeneProduct | denotes | PRMT5 | NCBIGene:10419 |
11727 | 687-699 | DiseaseOrPhenotypicFeature | denotes | inflammatory | MESH:D007249 |
11728 | 966-971 | GeneOrGeneProduct | denotes | PRMT5 | NCBIGene:10419 |
11729 | 1008-1016 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
11730 | 1022-1024 | DiseaseOrPhenotypicFeature | denotes | RA | MESH:D001172 |
11731 | 1029-1031 | DiseaseOrPhenotypicFeature | denotes | RA | MESH:D001172 |
11732 | 1051-1056 | GeneOrGeneProduct | denotes | PRMT5 | NCBIGene:10419 |
11733 | 1094-1099 | GeneOrGeneProduct | denotes | IL-1β | NCBIGene:3553 |
11734 | 1104-1109 | GeneOrGeneProduct | denotes | TNF-α | NCBIGene:7124 |
11735 | 1125-1130 | GeneOrGeneProduct | denotes | PRMT5 | NCBIGene:10419 |
11736 | 1134-1143 | ChemicalEntity | denotes | EPZ015666 | MESH:C000599896 |
11737 | 1181-1185 | GeneOrGeneProduct | denotes | IL-6 | NCBIGene:3569 |
11738 | 1190-1194 | GeneOrGeneProduct | denotes | IL-8 | NCBIGene:3576 |
11739 | 1228-1230 | DiseaseOrPhenotypicFeature | denotes | RA | MESH:D001172 |
11740 | 1264-1269 | GeneOrGeneProduct | denotes | PRMT5 | NCBIGene:10419 |
11741 | 1315-1317 | DiseaseOrPhenotypicFeature | denotes | RA | MESH:D001172 |
11742 | 1337-1346 | ChemicalEntity | denotes | EPZ015666 | MESH:C000599896 |
11743 | 1381-1392 | GeneOrGeneProduct | denotes | IκB kinaseβ | NCBIGene:3551 |
11744 | 1397-1401 | GeneOrGeneProduct | denotes | IκBα | NCBIGene:4792 |
11745 | 1440-1443 | GeneOrGeneProduct | denotes | p65 | NCBIGene:5970 |
11746 | 1455-1458 | GeneOrGeneProduct | denotes | AKT | NCBIGene:207 |
11747 | 1468-1473 | GeneOrGeneProduct | denotes | PRMT5 | NCBIGene:10419 |
11748 | 1502-1514 | DiseaseOrPhenotypicFeature | denotes | inflammatory | MESH:D007249 |
11749 | 1570-1572 | DiseaseOrPhenotypicFeature | denotes | RA | MESH:D001172 |
11750 | 1604-1609 | GeneOrGeneProduct | denotes | NF-κB | NCBIGene:5970 |
11751 | 1614-1617 | GeneOrGeneProduct | denotes | AKT | NCBIGene:207 |
11752 | 1662-1667 | GeneOrGeneProduct | denotes | PRMT5 | NCBIGene:10419 |
11753 | 1679-1700 | DiseaseOrPhenotypicFeature | denotes | synovial inflammation | MESH:D013585 |
11754 | 1750-1752 | DiseaseOrPhenotypicFeature | denotes | RA | MESH:D001172 |
LitCoin-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-131 | Sentence | denotes | Role of protein arginine methyltransferase 5 in inflammation and migration of fibroblast-like synoviocytes in rheumatoid arthritis. |
T2 | 132-353 | Sentence | denotes | To probe the role of protein arginine methyltransferase 5 (PRMT5) in regulating inflammation, cell proliferation, migration and invasion of fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA). |
T3 | 354-448 | Sentence | denotes | FLSs were separated from synovial tissues (STs) from patients with RA and osteoarthritis (OA). |
T4 | 449-570 | Sentence | denotes | An inhibitor of PRMT5 (EPZ015666) and short interference RNA (siRNA) against PRMT5 were used to inhibit PRMT5 expression. |
T5 | 571-646 | Sentence | denotes | The standard of protein was measured by Western blot or immunofluorescence. |
T6 | 647-829 | Sentence | denotes | The excretion and genetic expression of inflammatory factors were, respectively, estimated by enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR). |
T7 | 830-900 | Sentence | denotes | Migration and invasion in vitro were detected by Boyden chamber assay. |
T8 | 901-955 | Sentence | denotes | FLSs proliferation was detected by BrdU incorporation. |
T9 | 956-1025 | Sentence | denotes | Increased PRMT5 was discovered in STs and FLSs from patients with RA. |
T10 | 1026-1110 | Sentence | denotes | In RA FLSs, the level of PRMT5 was up-regulated by stimulation with IL-1β and TNF-α. |
T11 | 1111-1236 | Sentence | denotes | Inhibition of PRMT5 by EPZ015666 and siRNA-mediated knockdown reduced IL-6 and IL-8 production, and proliferation of RA FLSs. |
T12 | 1237-1323 | Sentence | denotes | In addition, inhibition of PRMT5 decreased in vitro migration and invasion of RA FLSs. |
T13 | 1324-1467 | Sentence | denotes | Furthermore, EPZ015666 restrained the phosphorylation of IκB kinaseβ and IκBα, as well as nucleus transsituation of p65 as well as AKT in FLSs. |
T14 | 1468-1627 | Sentence | denotes | PRMT5 regulated the production of inflammatory factors, cell proliferation, migration and invasion of RA FLS, which was mediated by the NF-κB and AKT pathways. |
T15 | 1628-1753 | Sentence | denotes | Our data suggested that targeting PRMT5 to prevent synovial inflammation and destruction might be a promising therapy for RA. |
LitCoin_Mondo
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 110-130 | DiseaseOrPhenotypicFeature | denotes | rheumatoid arthritis | 0008383 |
T2 | 327-347 | DiseaseOrPhenotypicFeature | denotes | rheumatoid arthritis | 0008383 |
T3 | 428-442 | DiseaseOrPhenotypicFeature | denotes | osteoarthritis | 0005178 |
LitCoin-SeqVar
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 1128-1135 | SequenceVariant | denotes | T5 by E |
LitCoin-GeneOrGeneProduct-v2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 8-44 | GeneOrGeneProduct | denotes | protein arginine methyltransferase 5 |
T2 | 89-93 | GeneOrGeneProduct | denotes | like |
T3 | 153-189 | GeneOrGeneProduct | denotes | protein arginine methyltransferase 5 |
T4 | 191-196 | GeneOrGeneProduct | denotes | PRMT5 |
T5 | 226-230 | GeneOrGeneProduct | denotes | cell |
T6 | 283-287 | GeneOrGeneProduct | denotes | like |
T7 | 364-373 | GeneOrGeneProduct | denotes | separated |
T8 | 452-461 | GeneOrGeneProduct | denotes | inhibitor |
T9 | 465-470 | GeneOrGeneProduct | denotes | PRMT5 |
T10 | 526-531 | GeneOrGeneProduct | denotes | PRMT5 |
T11 | 553-558 | GeneOrGeneProduct | denotes | PRMT5 |
T12 | 587-594 | GeneOrGeneProduct | denotes | protein |
T13 | 619-623 | GeneOrGeneProduct | denotes | blot |
T14 | 741-747 | GeneOrGeneProduct | denotes | enzyme |
T15 | 787-796 | GeneOrGeneProduct | denotes | real-time |
T16 | 797-807 | GeneOrGeneProduct | denotes | polymerase |
T17 | 808-813 | GeneOrGeneProduct | denotes | chain |
T18 | 966-971 | GeneOrGeneProduct | denotes | PRMT5 |
T19 | 1051-1056 | GeneOrGeneProduct | denotes | PRMT5 |
T20 | 1094-1098 | GeneOrGeneProduct | denotes | IL-1 |
T21 | 1125-1130 | GeneOrGeneProduct | denotes | PRMT5 |
T22 | 1163-1172 | GeneOrGeneProduct | denotes | knockdown |
T23 | 1173-1180 | GeneOrGeneProduct | denotes | reduced |
T24 | 1181-1185 | GeneOrGeneProduct | denotes | IL-6 |
T25 | 1190-1194 | GeneOrGeneProduct | denotes | IL-8 |
T26 | 1264-1269 | GeneOrGeneProduct | denotes | PRMT5 |
T27 | 1385-1391 | GeneOrGeneProduct | denotes | kinase |
T28 | 1414-1421 | GeneOrGeneProduct | denotes | nucleus |
T29 | 1468-1473 | GeneOrGeneProduct | denotes | PRMT5 |
T30 | 1524-1528 | GeneOrGeneProduct | denotes | cell |
T31 | 1662-1667 | GeneOrGeneProduct | denotes | PRMT5 |
LitCoin-GeneOrGeneProduct-v0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 8-44 | GeneOrGeneProduct | denotes | protein arginine methyltransferase 5 |
T2 | 89-93 | GeneOrGeneProduct | denotes | like |
T3 | 153-189 | GeneOrGeneProduct | denotes | protein arginine methyltransferase 5 |
T4 | 191-196 | GeneOrGeneProduct | denotes | PRMT5 |
T5 | 201-211 | GeneOrGeneProduct | denotes | regulating |
T6 | 226-230 | GeneOrGeneProduct | denotes | cell |
T7 | 283-287 | GeneOrGeneProduct | denotes | like |
T8 | 364-373 | GeneOrGeneProduct | denotes | separated |
T9 | 452-461 | GeneOrGeneProduct | denotes | inhibitor |
T10 | 465-470 | GeneOrGeneProduct | denotes | PRMT5 |
T11 | 526-531 | GeneOrGeneProduct | denotes | PRMT5 |
T12 | 553-558 | GeneOrGeneProduct | denotes | PRMT5 |
T13 | 587-594 | GeneOrGeneProduct | denotes | protein |
T14 | 619-623 | GeneOrGeneProduct | denotes | blot |
T15 | 700-707 | GeneOrGeneProduct | denotes | factors |
T16 | 741-747 | GeneOrGeneProduct | denotes | enzyme |
T17 | 748-754 | GeneOrGeneProduct | denotes | linked |
T18 | 787-796 | GeneOrGeneProduct | denotes | real-time |
T19 | 797-807 | GeneOrGeneProduct | denotes | polymerase |
T20 | 808-813 | GeneOrGeneProduct | denotes | chain |
T21 | 966-971 | GeneOrGeneProduct | denotes | PRMT5 |
T22 | 1022-1031 | GeneOrGeneProduct | denotes | RA. In RA |
T23 | 1051-1056 | GeneOrGeneProduct | denotes | PRMT5 |
T24 | 1064-1073 | GeneOrGeneProduct | denotes | regulated |
T25 | 1094-1098 | GeneOrGeneProduct | denotes | IL-1 |
T26 | 1125-1130 | GeneOrGeneProduct | denotes | PRMT5 |
T27 | 1154-1162 | GeneOrGeneProduct | denotes | mediated |
T28 | 1163-1172 | GeneOrGeneProduct | denotes | knockdown |
T29 | 1173-1180 | GeneOrGeneProduct | denotes | reduced |
T30 | 1181-1185 | GeneOrGeneProduct | denotes | IL-6 |
T31 | 1190-1194 | GeneOrGeneProduct | denotes | IL-8 |
T32 | 1195-1205 | GeneOrGeneProduct | denotes | production |
T33 | 1264-1269 | GeneOrGeneProduct | denotes | PRMT5 |
T34 | 1385-1391 | GeneOrGeneProduct | denotes | kinase |
T35 | 1414-1421 | GeneOrGeneProduct | denotes | nucleus |
T36 | 1468-1473 | GeneOrGeneProduct | denotes | PRMT5 |
T37 | 1474-1483 | GeneOrGeneProduct | denotes | regulated |
T38 | 1488-1498 | GeneOrGeneProduct | denotes | production |
T39 | 1515-1522 | GeneOrGeneProduct | denotes | factors |
T40 | 1524-1528 | GeneOrGeneProduct | denotes | cell |
T41 | 1588-1596 | GeneOrGeneProduct | denotes | mediated |
T42 | 1662-1667 | GeneOrGeneProduct | denotes | PRMT5 |
LitCoin-Disease-MeSH
Id | Subject | Object | Predicate | Lexical cue | originalLabel |
---|---|---|---|---|---|
T1 | 48-60 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 |
T2 | 110-130 | DiseaseOrPhenotypicFeature | denotes | rheumatoid arthritis | D001172 |
T3 | 212-224 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 |
T4 | 327-347 | DiseaseOrPhenotypicFeature | denotes | rheumatoid arthritis | D001172 |
T5 | 349-351 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T6 | 421-423 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T7 | 428-442 | DiseaseOrPhenotypicFeature | denotes | osteoarthritis | D010003 |
T8 | 444-446 | DiseaseOrPhenotypicFeature | denotes | OA | D010003 |
T9 | 687-699 | DiseaseOrPhenotypicFeature | denotes | inflammatory | DISEASE |
T10 | 1022-1024 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T11 | 1029-1031 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T12 | 1228-1230 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T13 | 1315-1317 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T14 | 1502-1514 | DiseaseOrPhenotypicFeature | denotes | inflammatory | DISEASE |
T15 | 1570-1572 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T16 | 1688-1700 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 |
T17 | 1750-1752 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
LitCoin-GeneOrGeneProduct-v3
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 8-44 | GeneOrGeneProduct | denotes | protein arginine methyltransferase 5 |
T2 | 153-189 | GeneOrGeneProduct | denotes | protein arginine methyltransferase 5 |
T3 | 191-196 | GeneOrGeneProduct | denotes | PRMT5 |
T4 | 364-373 | GeneOrGeneProduct | denotes | separated |
T5 | 465-470 | GeneOrGeneProduct | denotes | PRMT5 |
T6 | 526-531 | GeneOrGeneProduct | denotes | PRMT5 |
T7 | 553-558 | GeneOrGeneProduct | denotes | PRMT5 |
T8 | 966-971 | GeneOrGeneProduct | denotes | PRMT5 |
T9 | 1051-1056 | GeneOrGeneProduct | denotes | PRMT5 |
T10 | 1094-1098 | GeneOrGeneProduct | denotes | IL-1 |
T11 | 1125-1130 | GeneOrGeneProduct | denotes | PRMT5 |
T12 | 1181-1185 | GeneOrGeneProduct | denotes | IL-6 |
T13 | 1190-1194 | GeneOrGeneProduct | denotes | IL-8 |
T14 | 1264-1269 | GeneOrGeneProduct | denotes | PRMT5 |
T15 | 1468-1473 | GeneOrGeneProduct | denotes | PRMT5 |
T16 | 1662-1667 | GeneOrGeneProduct | denotes | PRMT5 |
LitCoin_Mondo_095
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 110-130 | DiseaseOrPhenotypicFeature | denotes | rheumatoid arthritis | 0008383 |
T2 | 327-347 | DiseaseOrPhenotypicFeature | denotes | rheumatoid arthritis | 0008383 |
T3 | 349-351 | DiseaseOrPhenotypicFeature | denotes | RA | 0008383|0005272 |
T5 | 421-423 | DiseaseOrPhenotypicFeature | denotes | RA | 0008383|0005272 |
T7 | 428-442 | DiseaseOrPhenotypicFeature | denotes | osteoarthritis | 0005178 |
T8 | 444-446 | DiseaseOrPhenotypicFeature | denotes | OA | 0005178 |
T9 | 1022-1024 | DiseaseOrPhenotypicFeature | denotes | RA | 0008383|0005272 |
T11 | 1029-1031 | DiseaseOrPhenotypicFeature | denotes | RA | 0008383|0005272 |
T13 | 1228-1230 | DiseaseOrPhenotypicFeature | denotes | RA | 0008383|0005272 |
T15 | 1315-1317 | DiseaseOrPhenotypicFeature | denotes | RA | 0008383|0005272 |
T17 | 1570-1572 | DiseaseOrPhenotypicFeature | denotes | RA | 0008383|0005272 |
T19 | 1750-1752 | DiseaseOrPhenotypicFeature | denotes | RA | 0008383|0005272 |
LitCoin-MeSH-Disease-2
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 48-60 | DiseaseOrPhenotypicFeature | denotes | inflammation | DISEASE|D007249 |
T3 | 110-130 | DiseaseOrPhenotypicFeature | denotes | rheumatoid arthritis | D001172 |
T4 | 212-224 | DiseaseOrPhenotypicFeature | denotes | inflammation | DISEASE|D007249 |
T6 | 327-347 | DiseaseOrPhenotypicFeature | denotes | rheumatoid arthritis | D001172 |
T7 | 349-351 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T8 | 421-423 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T9 | 428-442 | DiseaseOrPhenotypicFeature | denotes | osteoarthritis | D010003 |
T10 | 444-446 | DiseaseOrPhenotypicFeature | denotes | OA | D010003 |
T11 | 687-699 | DiseaseOrPhenotypicFeature | denotes | inflammatory | DISEASE |
T12 | 1022-1024 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T13 | 1029-1031 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T14 | 1228-1230 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T15 | 1315-1317 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T16 | 1502-1514 | DiseaseOrPhenotypicFeature | denotes | inflammatory | DISEASE |
T17 | 1570-1572 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T18 | 1688-1700 | DiseaseOrPhenotypicFeature | denotes | inflammation | DISEASE|D007249 |
T20 | 1750-1752 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
LitCoin-MONDO_bioort2019
Id | Subject | Object | Predicate | Lexical cue | #label |
---|---|---|---|---|---|
T1 | 48-60 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 |
T2 | 110-130 | DiseaseOrPhenotypicFeature | denotes | rheumatoid arthritis | D001172 |
T3 | 212-224 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 |
T4 | 327-347 | DiseaseOrPhenotypicFeature | denotes | rheumatoid arthritis | D001172 |
T5 | 349-351 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T6 | 421-423 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T7 | 428-442 | DiseaseOrPhenotypicFeature | denotes | osteoarthritis | D010003 |
T8 | 444-446 | DiseaseOrPhenotypicFeature | denotes | OA | D010003 |
T9 | 1022-1024 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T10 | 1029-1031 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T11 | 1228-1230 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T12 | 1315-1317 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T13 | 1570-1572 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
T14 | 1688-1700 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 |
T15 | 1750-1752 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 |
LitCoin-NCBITaxon-2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 313-321 | OrganismTaxon | denotes | patients |
T2 | 407-415 | OrganismTaxon | denotes | patients |
T3 | 1008-1016 | OrganismTaxon | denotes | patients |
LitCoin-Chemical-MeSH-CHEBI
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 8-42 | ChemicalEntity | denotes | protein arginine methyltransferase | D011484 |
T2 | 153-187 | ChemicalEntity | denotes | protein arginine methyltransferase | D011484 |
T3 | 472-481 | ChemicalEntity | denotes | EPZ015666 | C000599896|ChemicalEntity |
T5 | 936-940 | ChemicalEntity | denotes | BrdU | http://purl.obolibrary.org/obo/CHEBI_472552 |
T6 | 1134-1143 | ChemicalEntity | denotes | EPZ015666 | C000599896|ChemicalEntity |
T8 | 1337-1346 | ChemicalEntity | denotes | EPZ015666 | C000599896|ChemicalEntity |
LitCoin-training-merged
Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
---|---|---|---|---|---|---|
T8 | 1337-1346 | ChemicalEntity | denotes | EPZ015666 | ChemicalEntity|C000599896 | |
T6 | 1134-1143 | ChemicalEntity | denotes | EPZ015666 | ChemicalEntity|C000599896 | |
T5 | 936-940 | ChemicalEntity | denotes | BrdU | http://purl.obolibrary.org/obo/CHEBI_472552 | |
T3 | 472-481 | ChemicalEntity | denotes | EPZ015666 | ChemicalEntity|C000599896 | |
T2 | 153-187 | ChemicalEntity | denotes | protein arginine methyltransferase | D011484 | |
T1 | 8-42 | ChemicalEntity | denotes | protein arginine methyltransferase | D011484 | |
T16 | 1662-1667 | GeneOrGeneProduct | denotes | PRMT5 | ||
T15 | 1468-1473 | GeneOrGeneProduct | denotes | PRMT5 | ||
T14 | 1264-1269 | GeneOrGeneProduct | denotes | PRMT5 | ||
T13 | 1190-1194 | GeneOrGeneProduct | denotes | IL-8 | ||
T12 | 1181-1185 | GeneOrGeneProduct | denotes | IL-6 | ||
T11 | 1125-1130 | GeneOrGeneProduct | denotes | PRMT5 | ||
T10 | 1094-1098 | GeneOrGeneProduct | denotes | IL-1 | ||
T9 | 1051-1056 | GeneOrGeneProduct | denotes | PRMT5 | ||
T49596 | 966-971 | GeneOrGeneProduct | denotes | PRMT5 | ||
T7 | 553-558 | GeneOrGeneProduct | denotes | PRMT5 | ||
T27320 | 526-531 | GeneOrGeneProduct | denotes | PRMT5 | ||
T70212 | 465-470 | GeneOrGeneProduct | denotes | PRMT5 | ||
T4 | 364-373 | GeneOrGeneProduct | denotes | separated | ||
T59672 | 191-196 | GeneOrGeneProduct | denotes | PRMT5 | ||
T34029 | 153-189 | GeneOrGeneProduct | denotes | protein arginine methyltransferase 5 | ||
T66908 | 8-44 | GeneOrGeneProduct | denotes | protein arginine methyltransferase 5 | ||
T7305 | 1750-1752 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 | |
T3952 | 1688-1700 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 | |
T45963 | 1570-1572 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 | |
T79435 | 1315-1317 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 | |
T13416 | 1228-1230 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 | |
T75692 | 1029-1031 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 | |
T36732 | 1022-1024 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 | |
T97804 | 444-446 | DiseaseOrPhenotypicFeature | denotes | OA | D010003 | |
T51768 | 428-442 | DiseaseOrPhenotypicFeature | denotes | osteoarthritis | D010003 | |
T39796 | 421-423 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 | |
T30244 | 349-351 | DiseaseOrPhenotypicFeature | denotes | RA | D001172 | |
T74568 | 327-347 | DiseaseOrPhenotypicFeature | denotes | rheumatoid arthritis | D001172 | |
T65270 | 212-224 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 | |
T2527 | 110-130 | DiseaseOrPhenotypicFeature | denotes | rheumatoid arthritis | D001172 | |
T83949 | 48-60 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 | |
T76135 | 1008-1016 | OrganismTaxon | denotes | patients | ||
T53948 | 407-415 | OrganismTaxon | denotes | patients | ||
T86187 | 313-321 | OrganismTaxon | denotes | patients | ||
T53708 | 1128-1135 | SequenceVariant | denotes | T5 by E |
Inflammaging
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-131 | Sentence | denotes | Role of protein arginine methyltransferase 5 in inflammation and migration of fibroblast-like synoviocytes in rheumatoid arthritis. |
T2 | 132-353 | Sentence | denotes | To probe the role of protein arginine methyltransferase 5 (PRMT5) in regulating inflammation, cell proliferation, migration and invasion of fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA). |
T3 | 354-448 | Sentence | denotes | FLSs were separated from synovial tissues (STs) from patients with RA and osteoarthritis (OA). |
T4 | 449-570 | Sentence | denotes | An inhibitor of PRMT5 (EPZ015666) and short interference RNA (siRNA) against PRMT5 were used to inhibit PRMT5 expression. |
T5 | 571-646 | Sentence | denotes | The standard of protein was measured by Western blot or immunofluorescence. |
T6 | 647-829 | Sentence | denotes | The excretion and genetic expression of inflammatory factors were, respectively, estimated by enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR). |
T7 | 830-900 | Sentence | denotes | Migration and invasion in vitro were detected by Boyden chamber assay. |
T8 | 901-955 | Sentence | denotes | FLSs proliferation was detected by BrdU incorporation. |
T9 | 956-1025 | Sentence | denotes | Increased PRMT5 was discovered in STs and FLSs from patients with RA. |
T10 | 1026-1110 | Sentence | denotes | In RA FLSs, the level of PRMT5 was up-regulated by stimulation with IL-1β and TNF-α. |
T11 | 1111-1236 | Sentence | denotes | Inhibition of PRMT5 by EPZ015666 and siRNA-mediated knockdown reduced IL-6 and IL-8 production, and proliferation of RA FLSs. |
T12 | 1237-1323 | Sentence | denotes | In addition, inhibition of PRMT5 decreased in vitro migration and invasion of RA FLSs. |
T13 | 1324-1467 | Sentence | denotes | Furthermore, EPZ015666 restrained the phosphorylation of IκB kinaseβ and IκBα, as well as nucleus transsituation of p65 as well as AKT in FLSs. |
T14 | 1468-1627 | Sentence | denotes | PRMT5 regulated the production of inflammatory factors, cell proliferation, migration and invasion of RA FLS, which was mediated by the NF-κB and AKT pathways. |
T15 | 1628-1753 | Sentence | denotes | Our data suggested that targeting PRMT5 to prevent synovial inflammation and destruction might be a promising therapy for RA. |
T1 | 0-131 | Sentence | denotes | Role of protein arginine methyltransferase 5 in inflammation and migration of fibroblast-like synoviocytes in rheumatoid arthritis. |
T2 | 132-353 | Sentence | denotes | To probe the role of protein arginine methyltransferase 5 (PRMT5) in regulating inflammation, cell proliferation, migration and invasion of fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA). |
T3 | 354-448 | Sentence | denotes | FLSs were separated from synovial tissues (STs) from patients with RA and osteoarthritis (OA). |
T4 | 449-570 | Sentence | denotes | An inhibitor of PRMT5 (EPZ015666) and short interference RNA (siRNA) against PRMT5 were used to inhibit PRMT5 expression. |
T5 | 571-646 | Sentence | denotes | The standard of protein was measured by Western blot or immunofluorescence. |
T6 | 647-829 | Sentence | denotes | The excretion and genetic expression of inflammatory factors were, respectively, estimated by enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR). |
T7 | 830-900 | Sentence | denotes | Migration and invasion in vitro were detected by Boyden chamber assay. |
T8 | 901-955 | Sentence | denotes | FLSs proliferation was detected by BrdU incorporation. |
T9 | 956-1025 | Sentence | denotes | Increased PRMT5 was discovered in STs and FLSs from patients with RA. |
T10 | 1026-1110 | Sentence | denotes | In RA FLSs, the level of PRMT5 was up-regulated by stimulation with IL-1β and TNF-α. |
T11 | 1111-1236 | Sentence | denotes | Inhibition of PRMT5 by EPZ015666 and siRNA-mediated knockdown reduced IL-6 and IL-8 production, and proliferation of RA FLSs. |
T12 | 1237-1323 | Sentence | denotes | In addition, inhibition of PRMT5 decreased in vitro migration and invasion of RA FLSs. |
T13 | 1324-1467 | Sentence | denotes | Furthermore, EPZ015666 restrained the phosphorylation of IκB kinaseβ and IκBα, as well as nucleus transsituation of p65 as well as AKT in FLSs. |
T14 | 1468-1627 | Sentence | denotes | PRMT5 regulated the production of inflammatory factors, cell proliferation, migration and invasion of RA FLS, which was mediated by the NF-κB and AKT pathways. |
T15 | 1628-1753 | Sentence | denotes | Our data suggested that targeting PRMT5 to prevent synovial inflammation and destruction might be a promising therapy for RA. |