PubMed:27860244
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/27860244","sourcedb":"PubMed","sourceid":"27860244","text":"Role of protein arginine methyltransferase 5 in inflammation and migration of fibroblast-like synoviocytes in rheumatoid arthritis.\nTo probe the role of protein arginine methyltransferase 5 (PRMT5) in regulating inflammation, cell proliferation, migration and invasion of fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA). FLSs were separated from synovial tissues (STs) from patients with RA and osteoarthritis (OA). An inhibitor of PRMT5 (EPZ015666) and short interference RNA (siRNA) against PRMT5 were used to inhibit PRMT5 expression. The standard of protein was measured by Western blot or immunofluorescence. The excretion and genetic expression of inflammatory factors were, respectively, estimated by enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR). Migration and invasion in vitro were detected by Boyden chamber assay. FLSs proliferation was detected by BrdU incorporation. Increased PRMT5 was discovered in STs and FLSs from patients with RA. In RA FLSs, the level of PRMT5 was up-regulated by stimulation with IL-1β and TNF-α. Inhibition of PRMT5 by EPZ015666 and siRNA-mediated knockdown reduced IL-6 and IL-8 production, and proliferation of RA FLSs. In addition, inhibition of PRMT5 decreased in vitro migration and invasion of RA FLSs. Furthermore, EPZ015666 restrained the phosphorylation of IκB kinaseβ and IκBα, as well as nucleus transsituation of p65 as well as AKT in FLSs. PRMT5 regulated the production of inflammatory factors, cell proliferation, migration and invasion of RA FLS, which was mediated by the NF-κB and AKT pathways. Our data suggested that targeting PRMT5 to prevent synovial inflammation and destruction might be a promising therapy for RA.","tracks":[{"project":"LitCoin-entities","denotations":[{"id":"11710","span":{"begin":8,"end":44},"obj":"GeneOrGeneProduct"},{"id":"11711","span":{"begin":48,"end":60},"obj":"DiseaseOrPhenotypicFeature"},{"id":"11712","span":{"begin":110,"end":130},"obj":"DiseaseOrPhenotypicFeature"},{"id":"11713","span":{"begin":153,"end":189},"obj":"GeneOrGeneProduct"},{"id":"11714","span":{"begin":191,"end":196},"obj":"GeneOrGeneProduct"},{"id":"11715","span":{"begin":212,"end":224},"obj":"DiseaseOrPhenotypicFeature"},{"id":"11716","span":{"begin":313,"end":321},"obj":"OrganismTaxon"},{"id":"11717","span":{"begin":327,"end":347},"obj":"DiseaseOrPhenotypicFeature"},{"id":"11718","span":{"begin":349,"end":351},"obj":"DiseaseOrPhenotypicFeature"},{"id":"11719","span":{"begin":407,"end":415},"obj":"OrganismTaxon"},{"id":"11720","span":{"begin":421,"end":423},"obj":"DiseaseOrPhenotypicFeature"},{"id":"11721","span":{"begin":428,"end":442},"obj":"DiseaseOrPhenotypicFeature"},{"id":"11722","span":{"begin":444,"end":446},"obj":"DiseaseOrPhenotypicFeature"},{"id":"11723","span":{"begin":465,"end":470},"obj":"GeneOrGeneProduct"},{"id":"11724","span":{"begin":472,"end":481},"obj":"ChemicalEntity"},{"id":"11725","span":{"begin":526,"end":531},"obj":"GeneOrGeneProduct"},{"id":"11726","span":{"begin":553,"end":558},"obj":"GeneOrGeneProduct"},{"id":"11727","span":{"begin":687,"end":699},"obj":"DiseaseOrPhenotypicFeature"},{"id":"11728","span":{"begin":966,"end":971},"obj":"GeneOrGeneProduct"},{"id":"11729","span":{"begin":1008,"end":1016},"obj":"OrganismTaxon"},{"id":"11730","span":{"begin":1022,"end":1024},"obj":"DiseaseOrPhenotypicFeature"},{"id":"11731","span":{"begin":1029,"end":1031},"obj":"DiseaseOrPhenotypicFeature"},{"id":"11732","span":{"begin":1051,"end":1056},"obj":"GeneOrGeneProduct"},{"id":"11733","span":{"begin":1094,"end":1099},"obj":"GeneOrGeneProduct"},{"id":"11734","span":{"begin":1104,"end":1109},"obj":"GeneOrGeneProduct"},{"id":"11735","span":{"begin":1125,"end":1130},"obj":"GeneOrGeneProduct"},{"id":"11736","span":{"begin":1134,"end":1143},"obj":"ChemicalEntity"},{"id":"11737","span":{"begin":1181,"end":1185},"obj":"GeneOrGeneProduct"},{"id":"11738","span":{"begin":1190,"end":1194},"obj":"GeneOrGeneProduct"},{"id":"11739","span":{"begin":1228,"end":1230},"obj":"DiseaseOrPhenotypicFeature"},{"id":"11740","span":{"begin":1264,"end":1269},"obj":"GeneOrGeneProduct"},{"id":"11741","span":{"begin":1315,"end":1317},"obj":"DiseaseOrPhenotypicFeature"},{"id":"11742","span":{"begin":1337,"end":1346},"obj":"ChemicalEntity"},{"id":"11743","span":{"begin":1381,"end":1392},"obj":"GeneOrGeneProduct"},{"id":"11744","span":{"begin":1397,"end":1401},"obj":"GeneOrGeneProduct"},{"id":"11745","span":{"begin":1440,"end":1443},"obj":"GeneOrGeneProduct"},{"id":"11746","span":{"begin":1455,"end":1458},"obj":"GeneOrGeneProduct"},{"id":"11747","span":{"begin":1468,"end":1473},"obj":"GeneOrGeneProduct"},{"id":"11748","span":{"begin":1502,"end":1514},"obj":"DiseaseOrPhenotypicFeature"},{"id":"11749","span":{"begin":1570,"end":1572},"obj":"DiseaseOrPhenotypicFeature"},{"id":"11750","span":{"begin":1604,"end":1609},"obj":"GeneOrGeneProduct"},{"id":"11751","span":{"begin":1614,"end":1617},"obj":"GeneOrGeneProduct"},{"id":"11752","span":{"begin":1662,"end":1667},"obj":"GeneOrGeneProduct"},{"id":"11753","span":{"begin":1679,"end":1700},"obj":"DiseaseOrPhenotypicFeature"},{"id":"11754","span":{"begin":1750,"end":1752},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A42","pred":"db_id","subj":"11751","obj":"NCBIGene:207"},{"id":"A4","pred":"db_id","subj":"11713","obj":"NCBIGene:10419"},{"id":"A25","pred":"db_id","subj":"11734","obj":"NCBIGene:7124"},{"id":"A14","pred":"db_id","subj":"11723","obj":"NCBIGene:10419"},{"id":"A11","pred":"db_id","subj":"11720","obj":"MESH:D001172"},{"id":"A19","pred":"db_id","subj":"11728","obj":"NCBIGene:10419"},{"id":"A35","pred":"db_id","subj":"11744","obj":"NCBIGene:4792"},{"id":"A13","pred":"db_id","subj":"11722","obj":"MESH:D010003"},{"id":"A23","pred":"db_id","subj":"11732","obj":"NCBIGene:10419"},{"id":"A8","pred":"db_id","subj":"11717","obj":"MESH:D001172"},{"id":"A30","pred":"db_id","subj":"11739","obj":"MESH:D001172"},{"id":"A28","pred":"db_id","subj":"11737","obj":"NCBIGene:3569"},{"id":"A6","pred":"db_id","subj":"11715","obj":"MESH:D007249"},{"id":"A20","pred":"db_id","subj":"11729","obj":"NCBITaxon:9606"},{"id":"A22","pred":"db_id","subj":"11731","obj":"MESH:D001172"},{"id":"A10","pred":"db_id","subj":"11719","obj":"NCBITaxon:9606"},{"id":"A26","pred":"db_id","subj":"11735","obj":"NCBIGene:10419"},{"id":"A1","pred":"db_id","subj":"11710","obj":"NCBIGene:10419"},{"id":"A39","pred":"db_id","subj":"11748","obj":"MESH:D007249"},{"id":"A36","pred":"db_id","subj":"11745","obj":"NCBIGene:5970"},{"id":"A17","pred":"db_id","subj":"11726","obj":"NCBIGene:10419"},{"id":"A9","pred":"db_id","subj":"11718","obj":"MESH:D001172"},{"id":"A24","pred":"db_id","subj":"11733","obj":"NCBIGene:3553"},{"id":"A44","pred":"db_id","subj":"11753","obj":"MESH:D013585"},{"id":"A34","pred":"db_id","subj":"11743","obj":"NCBIGene:3551"},{"id":"A43","pred":"db_id","subj":"11752","obj":"NCBIGene:10419"},{"id":"A27","pred":"db_id","subj":"11736","obj":"MESH:C000599896"},{"id":"A33","pred":"db_id","subj":"11742","obj":"MESH:C000599896"},{"id":"A40","pred":"db_id","subj":"11749","obj":"MESH:D001172"},{"id":"A7","pred":"db_id","subj":"11716","obj":"NCBITaxon:9606"},{"id":"A2","pred":"db_id","subj":"11711","obj":"MESH:D007249"},{"id":"A37","pred":"db_id","subj":"11746","obj":"NCBIGene:207"},{"id":"A38","pred":"db_id","subj":"11747","obj":"NCBIGene:10419"},{"id":"A15","pred":"db_id","subj":"11724","obj":"MESH:C000599896"},{"id":"A29","pred":"db_id","subj":"11738","obj":"NCBIGene:3576"},{"id":"A16","pred":"db_id","subj":"11725","obj":"NCBIGene:10419"},{"id":"A31","pred":"db_id","subj":"11740","obj":"NCBIGene:10419"},{"id":"A3","pred":"db_id","subj":"11712","obj":"MESH:D001172"},{"id":"A18","pred":"db_id","subj":"11727","obj":"MESH:D007249"},{"id":"A41","pred":"db_id","subj":"11750","obj":"NCBIGene:5970"},{"id":"A32","pred":"db_id","subj":"11741","obj":"MESH:D001172"},{"id":"A12","pred":"db_id","subj":"11721","obj":"MESH:D010003"},{"id":"A45","pred":"db_id","subj":"11754","obj":"MESH:D001172"},{"id":"A21","pred":"db_id","subj":"11730","obj":"MESH:D001172"},{"id":"A5","pred":"db_id","subj":"11714","obj":"NCBIGene:10419"},{"subj":"11710","pred":"source","obj":"LitCoin-entities"},{"subj":"11711","pred":"source","obj":"LitCoin-entities"},{"subj":"11712","pred":"source","obj":"LitCoin-entities"},{"subj":"11713","pred":"source","obj":"LitCoin-entities"},{"subj":"11714","pred":"source","obj":"LitCoin-entities"},{"subj":"11715","pred":"source","obj":"LitCoin-entities"},{"subj":"11716","pred":"source","obj":"LitCoin-entities"},{"subj":"11717","pred":"source","obj":"LitCoin-entities"},{"subj":"11718","pred":"source","obj":"LitCoin-entities"},{"subj":"11719","pred":"source","obj":"LitCoin-entities"},{"subj":"11720","pred":"source","obj":"LitCoin-entities"},{"subj":"11721","pred":"source","obj":"LitCoin-entities"},{"subj":"11722","pred":"source","obj":"LitCoin-entities"},{"subj":"11723","pred":"source","obj":"LitCoin-entities"},{"subj":"11724","pred":"source","obj":"LitCoin-entities"},{"subj":"11725","pred":"source","obj":"LitCoin-entities"},{"subj":"11726","pred":"source","obj":"LitCoin-entities"},{"subj":"11727","pred":"source","obj":"LitCoin-entities"},{"subj":"11728","pred":"source","obj":"LitCoin-entities"},{"subj":"11729","pred":"source","obj":"LitCoin-entities"},{"subj":"11730","pred":"source","obj":"LitCoin-entities"},{"subj":"11731","pred":"source","obj":"LitCoin-entities"},{"subj":"11732","pred":"source","obj":"LitCoin-entities"},{"subj":"11733","pred":"source","obj":"LitCoin-entities"},{"subj":"11734","pred":"source","obj":"LitCoin-entities"},{"subj":"11735","pred":"source","obj":"LitCoin-entities"},{"subj":"11736","pred":"source","obj":"LitCoin-entities"},{"subj":"11737","pred":"source","obj":"LitCoin-entities"},{"subj":"11738","pred":"source","obj":"LitCoin-entities"},{"subj":"11739","pred":"source","obj":"LitCoin-entities"},{"subj":"11740","pred":"source","obj":"LitCoin-entities"},{"subj":"11741","pred":"source","obj":"LitCoin-entities"},{"subj":"11742","pred":"source","obj":"LitCoin-entities"},{"subj":"11743","pred":"source","obj":"LitCoin-entities"},{"subj":"11744","pred":"source","obj":"LitCoin-entities"},{"subj":"11745","pred":"source","obj":"LitCoin-entities"},{"subj":"11746","pred":"source","obj":"LitCoin-entities"},{"subj":"11747","pred":"source","obj":"LitCoin-entities"},{"subj":"11748","pred":"source","obj":"LitCoin-entities"},{"subj":"11749","pred":"source","obj":"LitCoin-entities"},{"subj":"11750","pred":"source","obj":"LitCoin-entities"},{"subj":"11751","pred":"source","obj":"LitCoin-entities"},{"subj":"11752","pred":"source","obj":"LitCoin-entities"},{"subj":"11753","pred":"source","obj":"LitCoin-entities"},{"subj":"11754","pred":"source","obj":"LitCoin-entities"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}]},{"project":"LitCoin-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":131},"obj":"Sentence"},{"id":"T2","span":{"begin":132,"end":353},"obj":"Sentence"},{"id":"T3","span":{"begin":354,"end":448},"obj":"Sentence"},{"id":"T4","span":{"begin":449,"end":570},"obj":"Sentence"},{"id":"T5","span":{"begin":571,"end":646},"obj":"Sentence"},{"id":"T6","span":{"begin":647,"end":829},"obj":"Sentence"},{"id":"T7","span":{"begin":830,"end":900},"obj":"Sentence"},{"id":"T8","span":{"begin":901,"end":955},"obj":"Sentence"},{"id":"T9","span":{"begin":956,"end":1025},"obj":"Sentence"},{"id":"T10","span":{"begin":1026,"end":1110},"obj":"Sentence"},{"id":"T11","span":{"begin":1111,"end":1236},"obj":"Sentence"},{"id":"T12","span":{"begin":1237,"end":1323},"obj":"Sentence"},{"id":"T13","span":{"begin":1324,"end":1467},"obj":"Sentence"},{"id":"T14","span":{"begin":1468,"end":1627},"obj":"Sentence"},{"id":"T15","span":{"begin":1628,"end":1753},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-sentences"},{"subj":"T2","pred":"source","obj":"LitCoin-sentences"},{"subj":"T3","pred":"source","obj":"LitCoin-sentences"},{"subj":"T4","pred":"source","obj":"LitCoin-sentences"},{"subj":"T5","pred":"source","obj":"LitCoin-sentences"},{"subj":"T6","pred":"source","obj":"LitCoin-sentences"},{"subj":"T7","pred":"source","obj":"LitCoin-sentences"},{"subj":"T8","pred":"source","obj":"LitCoin-sentences"},{"subj":"T9","pred":"source","obj":"LitCoin-sentences"},{"subj":"T10","pred":"source","obj":"LitCoin-sentences"},{"subj":"T11","pred":"source","obj":"LitCoin-sentences"},{"subj":"T12","pred":"source","obj":"LitCoin-sentences"},{"subj":"T13","pred":"source","obj":"LitCoin-sentences"},{"subj":"T14","pred":"source","obj":"LitCoin-sentences"},{"subj":"T15","pred":"source","obj":"LitCoin-sentences"}]},{"project":"LitCoin_Mondo","denotations":[{"id":"T1","span":{"begin":110,"end":130},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":327,"end":347},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":428,"end":442},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0008383"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0008383"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0005178"},{"subj":"T1","pred":"source","obj":"LitCoin_Mondo"},{"subj":"T2","pred":"source","obj":"LitCoin_Mondo"},{"subj":"T3","pred":"source","obj":"LitCoin_Mondo"}]},{"project":"LitCoin-SeqVar","denotations":[{"id":"T1","span":{"begin":1128,"end":1135},"obj":"SequenceVariant"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-SeqVar"}]},{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T1","span":{"begin":8,"end":44},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":89,"end":93},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":153,"end":189},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":191,"end":196},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":226,"end":230},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":283,"end":287},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":364,"end":373},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":452,"end":461},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":465,"end":470},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":526,"end":531},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":553,"end":558},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":587,"end":594},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":619,"end":623},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":741,"end":747},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":787,"end":796},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":797,"end":807},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":808,"end":813},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":966,"end":971},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":1051,"end":1056},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":1094,"end":1098},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":1125,"end":1130},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":1163,"end":1172},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":1173,"end":1180},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":1181,"end":1185},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":1190,"end":1194},"obj":"GeneOrGeneProduct"},{"id":"T26","span":{"begin":1264,"end":1269},"obj":"GeneOrGeneProduct"},{"id":"T27","span":{"begin":1385,"end":1391},"obj":"GeneOrGeneProduct"},{"id":"T28","span":{"begin":1414,"end":1421},"obj":"GeneOrGeneProduct"},{"id":"T29","span":{"begin":1468,"end":1473},"obj":"GeneOrGeneProduct"},{"id":"T30","span":{"begin":1524,"end":1528},"obj":"GeneOrGeneProduct"},{"id":"T31","span":{"begin":1662,"end":1667},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T16","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T17","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T18","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T19","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T20","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T21","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T22","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T23","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T24","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T25","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T26","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T27","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T28","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T29","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T30","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T31","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"}]},{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T1","span":{"begin":8,"end":44},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":89,"end":93},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":153,"end":189},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":191,"end":196},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":201,"end":211},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":226,"end":230},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":283,"end":287},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":364,"end":373},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":452,"end":461},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":465,"end":470},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":526,"end":531},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":553,"end":558},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":587,"end":594},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":619,"end":623},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":700,"end":707},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":741,"end":747},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":748,"end":754},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":787,"end":796},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":797,"end":807},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":808,"end":813},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":966,"end":971},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":1022,"end":1031},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":1051,"end":1056},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":1064,"end":1073},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":1094,"end":1098},"obj":"GeneOrGeneProduct"},{"id":"T26","span":{"begin":1125,"end":1130},"obj":"GeneOrGeneProduct"},{"id":"T27","span":{"begin":1154,"end":1162},"obj":"GeneOrGeneProduct"},{"id":"T28","span":{"begin":1163,"end":1172},"obj":"GeneOrGeneProduct"},{"id":"T29","span":{"begin":1173,"end":1180},"obj":"GeneOrGeneProduct"},{"id":"T30","span":{"begin":1181,"end":1185},"obj":"GeneOrGeneProduct"},{"id":"T31","span":{"begin":1190,"end":1194},"obj":"GeneOrGeneProduct"},{"id":"T32","span":{"begin":1195,"end":1205},"obj":"GeneOrGeneProduct"},{"id":"T33","span":{"begin":1264,"end":1269},"obj":"GeneOrGeneProduct"},{"id":"T34","span":{"begin":1385,"end":1391},"obj":"GeneOrGeneProduct"},{"id":"T35","span":{"begin":1414,"end":1421},"obj":"GeneOrGeneProduct"},{"id":"T36","span":{"begin":1468,"end":1473},"obj":"GeneOrGeneProduct"},{"id":"T37","span":{"begin":1474,"end":1483},"obj":"GeneOrGeneProduct"},{"id":"T38","span":{"begin":1488,"end":1498},"obj":"GeneOrGeneProduct"},{"id":"T39","span":{"begin":1515,"end":1522},"obj":"GeneOrGeneProduct"},{"id":"T40","span":{"begin":1524,"end":1528},"obj":"GeneOrGeneProduct"},{"id":"T41","span":{"begin":1588,"end":1596},"obj":"GeneOrGeneProduct"},{"id":"T42","span":{"begin":1662,"end":1667},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T16","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T17","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T18","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T19","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T20","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T21","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T22","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T23","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T24","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T25","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T26","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T27","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T28","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T29","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T30","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T31","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T32","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T33","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T34","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T35","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T36","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T37","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T38","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T39","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T40","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T41","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T42","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"}]},{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T1","span":{"begin":48,"end":60},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":110,"end":130},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":212,"end":224},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":327,"end":347},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":349,"end":351},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":421,"end":423},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":428,"end":442},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":444,"end":446},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":687,"end":699},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":1022,"end":1024},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":1029,"end":1031},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":1228,"end":1230},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":1315,"end":1317},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":1502,"end":1514},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T15","span":{"begin":1570,"end":1572},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T16","span":{"begin":1688,"end":1700},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T17","span":{"begin":1750,"end":1752},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A17","pred":"originalLabel","subj":"T17","obj":"D001172"},{"id":"A15","pred":"originalLabel","subj":"T15","obj":"D001172"},{"id":"A7","pred":"originalLabel","subj":"T7","obj":"D010003"},{"id":"A10","pred":"originalLabel","subj":"T10","obj":"D001172"},{"id":"A11","pred":"originalLabel","subj":"T11","obj":"D001172"},{"id":"A16","pred":"originalLabel","subj":"T16","obj":"D007249"},{"id":"A12","pred":"originalLabel","subj":"T12","obj":"D001172"},{"id":"A14","pred":"originalLabel","subj":"T14","obj":"DISEASE"},{"id":"A9","pred":"originalLabel","subj":"T9","obj":"DISEASE"},{"id":"A1","pred":"originalLabel","subj":"T1","obj":"D007249"},{"id":"A3","pred":"originalLabel","subj":"T3","obj":"D007249"},{"id":"A2","pred":"originalLabel","subj":"T2","obj":"D001172"},{"id":"A5","pred":"originalLabel","subj":"T5","obj":"D001172"},{"id":"A13","pred":"originalLabel","subj":"T13","obj":"D001172"},{"id":"A8","pred":"originalLabel","subj":"T8","obj":"D010003"},{"id":"A4","pred":"originalLabel","subj":"T4","obj":"D001172"},{"id":"A6","pred":"originalLabel","subj":"T6","obj":"D001172"},{"subj":"T1","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T2","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T3","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T4","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T5","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T6","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T7","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T8","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T9","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T10","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T11","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T12","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T13","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T14","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T15","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T16","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T17","pred":"source","obj":"LitCoin-Disease-MeSH"}]},{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T1","span":{"begin":8,"end":44},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":153,"end":189},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":191,"end":196},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":364,"end":373},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":465,"end":470},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":526,"end":531},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":553,"end":558},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":966,"end":971},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":1051,"end":1056},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":1094,"end":1098},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":1125,"end":1130},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":1181,"end":1185},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":1190,"end":1194},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":1264,"end":1269},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":1468,"end":1473},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":1662,"end":1667},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T16","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"}]},{"project":"LitCoin_Mondo_095","denotations":[{"id":"T1","span":{"begin":110,"end":130},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":327,"end":347},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":349,"end":351},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":421,"end":423},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":428,"end":442},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":444,"end":446},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1022,"end":1024},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":1029,"end":1031},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":1228,"end":1230},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T15","span":{"begin":1315,"end":1317},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T17","span":{"begin":1570,"end":1572},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T19","span":{"begin":1750,"end":1752},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0005178"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0008383"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"0008383"},{"id":"A18","pred":"mondo_id","subj":"T17","obj":"0005272"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"0008383"},{"id":"A20","pred":"mondo_id","subj":"T19","obj":"0005272"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"0008383"},{"id":"A12","pred":"mondo_id","subj":"T11","obj":"0005272"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"0008383"},{"id":"A14","pred":"mondo_id","subj":"T13","obj":"0005272"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"0008383"},{"id":"A16","pred":"mondo_id","subj":"T15","obj":"0005272"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0008383"},{"id":"A4","pred":"mondo_id","subj":"T3","obj":"0005272"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0008383"},{"id":"A10","pred":"mondo_id","subj":"T9","obj":"0005272"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0008383"},{"id":"A6","pred":"mondo_id","subj":"T5","obj":"0005272"},{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0008383"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0005178"},{"subj":"T1","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T2","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T3","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T5","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T7","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T8","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T9","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T11","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T13","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T15","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T17","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T19","pred":"source","obj":"LitCoin_Mondo_095"}]},{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T1","span":{"begin":48,"end":60},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":110,"end":130},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":212,"end":224},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":327,"end":347},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":349,"end":351},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":421,"end":423},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":428,"end":442},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":444,"end":446},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":687,"end":699},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":1022,"end":1024},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":1029,"end":1031},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":1228,"end":1230},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T15","span":{"begin":1315,"end":1317},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T16","span":{"begin":1502,"end":1514},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T17","span":{"begin":1570,"end":1572},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T18","span":{"begin":1688,"end":1700},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T20","span":{"begin":1750,"end":1752},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A6","pred":"ID:","subj":"T6","obj":"D001172"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D001172"},{"id":"A15","pred":"ID:","subj":"T15","obj":"D001172"},{"id":"A14","pred":"ID:","subj":"T14","obj":"D001172"},{"id":"A16","pred":"ID:","subj":"T16","obj":"DISEASE"},{"id":"A13","pred":"ID:","subj":"T13","obj":"D001172"},{"id":"A18","pred":"ID:","subj":"T18","obj":"DISEASE"},{"id":"A19","pred":"ID:","subj":"T18","obj":"D007249"},{"id":"A11","pred":"ID:","subj":"T11","obj":"DISEASE"},{"id":"A9","pred":"ID:","subj":"T9","obj":"D010003"},{"id":"A12","pred":"ID:","subj":"T12","obj":"D001172"},{"id":"A4","pred":"ID:","subj":"T4","obj":"DISEASE"},{"id":"A5","pred":"ID:","subj":"T4","obj":"D007249"},{"id":"A20","pred":"ID:","subj":"T20","obj":"D001172"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D001172"},{"id":"A1","pred":"ID:","subj":"T1","obj":"DISEASE"},{"id":"A2","pred":"ID:","subj":"T1","obj":"D007249"},{"id":"A10","pred":"ID:","subj":"T10","obj":"D010003"},{"id":"A17","pred":"ID:","subj":"T17","obj":"D001172"},{"id":"A8","pred":"ID:","subj":"T8","obj":"D001172"},{"subj":"T1","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T3","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T4","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T6","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T7","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T8","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T9","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T10","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T11","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T12","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T13","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T14","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T15","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T16","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T17","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T18","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T20","pred":"source","obj":"LitCoin-MeSH-Disease-2"}]},{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T1","span":{"begin":48,"end":60},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":110,"end":130},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":212,"end":224},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":327,"end":347},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":349,"end":351},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":421,"end":423},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":428,"end":442},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":444,"end":446},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1022,"end":1024},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":1029,"end":1031},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":1228,"end":1230},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":1315,"end":1317},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":1570,"end":1572},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T14","span":{"begin":1688,"end":1700},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T15","span":{"begin":1750,"end":1752},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A7","pred":"#label","subj":"T7","obj":"D010003"},{"id":"A10","pred":"#label","subj":"T10","obj":"D001172"},{"id":"A2","pred":"#label","subj":"T2","obj":"D001172"},{"id":"A9","pred":"#label","subj":"T9","obj":"D001172"},{"id":"A13","pred":"#label","subj":"T13","obj":"D001172"},{"id":"A15","pred":"#label","subj":"T15","obj":"D001172"},{"id":"A5","pred":"#label","subj":"T5","obj":"D001172"},{"id":"A8","pred":"#label","subj":"T8","obj":"D010003"},{"id":"A11","pred":"#label","subj":"T11","obj":"D001172"},{"id":"A14","pred":"#label","subj":"T14","obj":"D007249"},{"id":"A1","pred":"#label","subj":"T1","obj":"D007249"},{"id":"A3","pred":"#label","subj":"T3","obj":"D007249"},{"id":"A6","pred":"#label","subj":"T6","obj":"D001172"},{"id":"A4","pred":"#label","subj":"T4","obj":"D001172"},{"id":"A12","pred":"#label","subj":"T12","obj":"D001172"},{"subj":"T1","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T2","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T3","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T4","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T5","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T6","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T7","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T8","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T9","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T10","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T11","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T12","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T13","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T14","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T15","pred":"source","obj":"LitCoin-MONDO_bioort2019"}]},{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":313,"end":321},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":407,"end":415},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":1008,"end":1016},"obj":"OrganismTaxon"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T2","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T3","pred":"source","obj":"LitCoin-NCBITaxon-2"}]},{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":8,"end":42},"obj":"ChemicalEntity"},{"id":"T2","span":{"begin":153,"end":187},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":472,"end":481},"obj":"ChemicalEntity"},{"id":"T5","span":{"begin":936,"end":940},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":1134,"end":1143},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":1337,"end":1346},"obj":"ChemicalEntity"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"D011484"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D011484"},{"id":"A3","pred":"ID:","subj":"T3","obj":"C000599896"},{"id":"A4","pred":"ID:","subj":"T3","obj":"ChemicalEntity"},{"id":"A5","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_472552"},{"id":"A6","pred":"ID:","subj":"T6","obj":"C000599896"},{"id":"A7","pred":"ID:","subj":"T6","obj":"ChemicalEntity"},{"id":"A8","pred":"ID:","subj":"T8","obj":"C000599896"},{"id":"A9","pred":"ID:","subj":"T8","obj":"ChemicalEntity"},{"subj":"T1","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T5","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T6","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T8","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"}]},{"project":"LitCoin-training-merged","denotations":[{"id":"T8","span":{"begin":1337,"end":1346},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":1134,"end":1143},"obj":"ChemicalEntity"},{"id":"T5","span":{"begin":936,"end":940},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":472,"end":481},"obj":"ChemicalEntity"},{"id":"T2","span":{"begin":153,"end":187},"obj":"ChemicalEntity"},{"id":"T1","span":{"begin":8,"end":42},"obj":"ChemicalEntity"},{"id":"T16","span":{"begin":1662,"end":1667},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":1468,"end":1473},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":1264,"end":1269},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":1190,"end":1194},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":1181,"end":1185},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":1125,"end":1130},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":1094,"end":1098},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":1051,"end":1056},"obj":"GeneOrGeneProduct"},{"id":"T49596","span":{"begin":966,"end":971},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":553,"end":558},"obj":"GeneOrGeneProduct"},{"id":"T27320","span":{"begin":526,"end":531},"obj":"GeneOrGeneProduct"},{"id":"T70212","span":{"begin":465,"end":470},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":364,"end":373},"obj":"GeneOrGeneProduct"},{"id":"T59672","span":{"begin":191,"end":196},"obj":"GeneOrGeneProduct"},{"id":"T34029","span":{"begin":153,"end":189},"obj":"GeneOrGeneProduct"},{"id":"T66908","span":{"begin":8,"end":44},"obj":"GeneOrGeneProduct"},{"id":"T7305","span":{"begin":1750,"end":1752},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3952","span":{"begin":1688,"end":1700},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T45963","span":{"begin":1570,"end":1572},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T79435","span":{"begin":1315,"end":1317},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13416","span":{"begin":1228,"end":1230},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T75692","span":{"begin":1029,"end":1031},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T36732","span":{"begin":1022,"end":1024},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T97804","span":{"begin":444,"end":446},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T51768","span":{"begin":428,"end":442},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T39796","span":{"begin":421,"end":423},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T30244","span":{"begin":349,"end":351},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T74568","span":{"begin":327,"end":347},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T65270","span":{"begin":212,"end":224},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2527","span":{"begin":110,"end":130},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T83949","span":{"begin":48,"end":60},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T76135","span":{"begin":1008,"end":1016},"obj":"OrganismTaxon"},{"id":"T53948","span":{"begin":407,"end":415},"obj":"OrganismTaxon"},{"id":"T86187","span":{"begin":313,"end":321},"obj":"OrganismTaxon"},{"id":"T53708","span":{"begin":1128,"end":1135},"obj":"SequenceVariant"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"D011484"},{"id":"A15","pred":"#label","subj":"T7305","obj":"D001172"},{"id":"A55137","pred":"#label","subj":"T30244","obj":"D001172"},{"id":"A44292","pred":"#label","subj":"T97804","obj":"D010003"},{"id":"A95857","pred":"#label","subj":"T65270","obj":"D007249"},{"id":"A74670","pred":"#label","subj":"T39796","obj":"D001172"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D011484"},{"id":"A5","pred":"ID:","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_472552"},{"id":"A4318","pred":"#label","subj":"T36732","obj":"D001172"},{"id":"A9","pred":"ID:","subj":"T8","obj":"ChemicalEntity"},{"id":"A8","pred":"ID:","subj":"T8","obj":"C000599896"},{"id":"A13138","pred":"#label","subj":"T83949","obj":"D007249"},{"id":"A12","pred":"#label","subj":"T79435","obj":"D001172"},{"id":"A11","pred":"#label","subj":"T13416","obj":"D001172"},{"id":"A68751","pred":"#label","subj":"T51768","obj":"D010003"},{"id":"A63101","pred":"#label","subj":"T74568","obj":"D001172"},{"id":"A10","pred":"#label","subj":"T75692","obj":"D001172"},{"id":"A14","pred":"#label","subj":"T3952","obj":"D007249"},{"id":"A7","pred":"ID:","subj":"T6","obj":"ChemicalEntity"},{"id":"A6","pred":"ID:","subj":"T6","obj":"C000599896"},{"id":"A4","pred":"ID:","subj":"T3","obj":"ChemicalEntity"},{"id":"A3","pred":"ID:","subj":"T3","obj":"C000599896"},{"id":"A13","pred":"#label","subj":"T45963","obj":"D001172"},{"id":"A98463","pred":"#label","subj":"T2527","obj":"D001172"},{"subj":"T8","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T6","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T5","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T3","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T2","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T1","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T16","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T15","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T14","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T13","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T12","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T11","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T10","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T9","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T49596","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T7","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T27320","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T70212","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T4","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T59672","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T34029","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T66908","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T7305","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T3952","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T45963","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T79435","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T13416","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T75692","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T36732","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T97804","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T51768","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T39796","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T30244","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T74568","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T65270","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T2527","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T83949","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T76135","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T53948","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T86187","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T53708","pred":"source","obj":"LitCoin-training-merged"}]},{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":131},"obj":"Sentence"},{"id":"T2","span":{"begin":132,"end":353},"obj":"Sentence"},{"id":"T3","span":{"begin":354,"end":448},"obj":"Sentence"},{"id":"T4","span":{"begin":449,"end":570},"obj":"Sentence"},{"id":"T5","span":{"begin":571,"end":646},"obj":"Sentence"},{"id":"T6","span":{"begin":647,"end":829},"obj":"Sentence"},{"id":"T7","span":{"begin":830,"end":900},"obj":"Sentence"},{"id":"T8","span":{"begin":901,"end":955},"obj":"Sentence"},{"id":"T9","span":{"begin":956,"end":1025},"obj":"Sentence"},{"id":"T10","span":{"begin":1026,"end":1110},"obj":"Sentence"},{"id":"T11","span":{"begin":1111,"end":1236},"obj":"Sentence"},{"id":"T12","span":{"begin":1237,"end":1323},"obj":"Sentence"},{"id":"T13","span":{"begin":1324,"end":1467},"obj":"Sentence"},{"id":"T14","span":{"begin":1468,"end":1627},"obj":"Sentence"},{"id":"T15","span":{"begin":1628,"end":1753},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":131},"obj":"Sentence"},{"id":"T2","span":{"begin":132,"end":353},"obj":"Sentence"},{"id":"T3","span":{"begin":354,"end":448},"obj":"Sentence"},{"id":"T4","span":{"begin":449,"end":570},"obj":"Sentence"},{"id":"T5","span":{"begin":571,"end":646},"obj":"Sentence"},{"id":"T6","span":{"begin":647,"end":829},"obj":"Sentence"},{"id":"T7","span":{"begin":830,"end":900},"obj":"Sentence"},{"id":"T8","span":{"begin":901,"end":955},"obj":"Sentence"},{"id":"T9","span":{"begin":956,"end":1025},"obj":"Sentence"},{"id":"T10","span":{"begin":1026,"end":1110},"obj":"Sentence"},{"id":"T11","span":{"begin":1111,"end":1236},"obj":"Sentence"},{"id":"T12","span":{"begin":1237,"end":1323},"obj":"Sentence"},{"id":"T13","span":{"begin":1324,"end":1467},"obj":"Sentence"},{"id":"T14","span":{"begin":1468,"end":1627},"obj":"Sentence"},{"id":"T15","span":{"begin":1628,"end":1753},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"},{"subj":"T13","pred":"source","obj":"Inflammaging"},{"subj":"T14","pred":"source","obj":"Inflammaging"},{"subj":"T15","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"},{"subj":"T13","pred":"source","obj":"Inflammaging"},{"subj":"T14","pred":"source","obj":"Inflammaging"},{"subj":"T15","pred":"source","obj":"Inflammaging"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCoin-entities","color":"#ec93ae","default":true},{"id":"LitCoin-sentences","color":"#93c8ec"},{"id":"LitCoin_Mondo","color":"#e2ec93"},{"id":"LitCoin-SeqVar","color":"#dc93ec"},{"id":"LitCoin-GeneOrGeneProduct-v2","color":"#93ecc2"},{"id":"LitCoin-GeneOrGeneProduct-v0","color":"#eca893"},{"id":"LitCoin-Disease-MeSH","color":"#9398ec"},{"id":"LitCoin-GeneOrGeneProduct-v3","color":"#b2ec93"},{"id":"LitCoin_Mondo_095","color":"#ec93cc"},{"id":"LitCoin-MeSH-Disease-2","color":"#93e6ec"},{"id":"LitCoin-MONDO_bioort2019","color":"#ecd893"},{"id":"LitCoin-NCBITaxon-2","color":"#be93ec"},{"id":"LitCoin-Chemical-MeSH-CHEBI","color":"#93eca4"},{"id":"LitCoin-training-merged","color":"#ec939b"},{"id":"Inflammaging","color":"#93b5ec"}]}]}}