> top > docs > PubMed:27860244 > annotations
TextAE configuration unavailable!

PubMed:27860244 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
11710 8-44 GeneOrGeneProduct denotes protein arginine methyltransferase 5 NCBIGene:10419
11711 48-60 DiseaseOrPhenotypicFeature denotes inflammation MESH:D007249
11712 110-130 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis MESH:D001172
11713 153-189 GeneOrGeneProduct denotes protein arginine methyltransferase 5 NCBIGene:10419
11714 191-196 GeneOrGeneProduct denotes PRMT5 NCBIGene:10419
11715 212-224 DiseaseOrPhenotypicFeature denotes inflammation MESH:D007249
11716 313-321 OrganismTaxon denotes patients NCBITaxon:9606
11717 327-347 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis MESH:D001172
11718 349-351 DiseaseOrPhenotypicFeature denotes RA MESH:D001172
11719 407-415 OrganismTaxon denotes patients NCBITaxon:9606
11720 421-423 DiseaseOrPhenotypicFeature denotes RA MESH:D001172
11721 428-442 DiseaseOrPhenotypicFeature denotes osteoarthritis MESH:D010003
11722 444-446 DiseaseOrPhenotypicFeature denotes OA MESH:D010003
11723 465-470 GeneOrGeneProduct denotes PRMT5 NCBIGene:10419
11724 472-481 ChemicalEntity denotes EPZ015666 MESH:C000599896
11725 526-531 GeneOrGeneProduct denotes PRMT5 NCBIGene:10419
11726 553-558 GeneOrGeneProduct denotes PRMT5 NCBIGene:10419
11727 687-699 DiseaseOrPhenotypicFeature denotes inflammatory MESH:D007249
11728 966-971 GeneOrGeneProduct denotes PRMT5 NCBIGene:10419
11729 1008-1016 OrganismTaxon denotes patients NCBITaxon:9606
11730 1022-1024 DiseaseOrPhenotypicFeature denotes RA MESH:D001172
11731 1029-1031 DiseaseOrPhenotypicFeature denotes RA MESH:D001172
11732 1051-1056 GeneOrGeneProduct denotes PRMT5 NCBIGene:10419
11733 1094-1099 GeneOrGeneProduct denotes IL-1β NCBIGene:3553
11734 1104-1109 GeneOrGeneProduct denotes TNF-α NCBIGene:7124
11735 1125-1130 GeneOrGeneProduct denotes PRMT5 NCBIGene:10419
11736 1134-1143 ChemicalEntity denotes EPZ015666 MESH:C000599896
11737 1181-1185 GeneOrGeneProduct denotes IL-6 NCBIGene:3569
11738 1190-1194 GeneOrGeneProduct denotes IL-8 NCBIGene:3576
11739 1228-1230 DiseaseOrPhenotypicFeature denotes RA MESH:D001172
11740 1264-1269 GeneOrGeneProduct denotes PRMT5 NCBIGene:10419
11741 1315-1317 DiseaseOrPhenotypicFeature denotes RA MESH:D001172
11742 1337-1346 ChemicalEntity denotes EPZ015666 MESH:C000599896
11743 1381-1392 GeneOrGeneProduct denotes IκB kinaseβ NCBIGene:3551
11744 1397-1401 GeneOrGeneProduct denotes IκBα NCBIGene:4792
11745 1440-1443 GeneOrGeneProduct denotes p65 NCBIGene:5970
11746 1455-1458 GeneOrGeneProduct denotes AKT NCBIGene:207
11747 1468-1473 GeneOrGeneProduct denotes PRMT5 NCBIGene:10419
11748 1502-1514 DiseaseOrPhenotypicFeature denotes inflammatory MESH:D007249
11749 1570-1572 DiseaseOrPhenotypicFeature denotes RA MESH:D001172
11750 1604-1609 GeneOrGeneProduct denotes NF-κB NCBIGene:5970
11751 1614-1617 GeneOrGeneProduct denotes AKT NCBIGene:207
11752 1662-1667 GeneOrGeneProduct denotes PRMT5 NCBIGene:10419
11753 1679-1700 DiseaseOrPhenotypicFeature denotes synovial inflammation MESH:D013585
11754 1750-1752 DiseaseOrPhenotypicFeature denotes RA MESH:D001172

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Role of protein arginine methyltransferase 5 in inflammation and migration of fibroblast-like synoviocytes in rheumatoid arthritis.
T2 132-353 Sentence denotes To probe the role of protein arginine methyltransferase 5 (PRMT5) in regulating inflammation, cell proliferation, migration and invasion of fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA).
T3 354-448 Sentence denotes FLSs were separated from synovial tissues (STs) from patients with RA and osteoarthritis (OA).
T4 449-570 Sentence denotes An inhibitor of PRMT5 (EPZ015666) and short interference RNA (siRNA) against PRMT5 were used to inhibit PRMT5 expression.
T5 571-646 Sentence denotes The standard of protein was measured by Western blot or immunofluorescence.
T6 647-829 Sentence denotes The excretion and genetic expression of inflammatory factors were, respectively, estimated by enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR).
T7 830-900 Sentence denotes Migration and invasion in vitro were detected by Boyden chamber assay.
T8 901-955 Sentence denotes FLSs proliferation was detected by BrdU incorporation.
T9 956-1025 Sentence denotes Increased PRMT5 was discovered in STs and FLSs from patients with RA.
T10 1026-1110 Sentence denotes In RA FLSs, the level of PRMT5 was up-regulated by stimulation with IL-1β and TNF-α.
T11 1111-1236 Sentence denotes Inhibition of PRMT5 by EPZ015666 and siRNA-mediated knockdown reduced IL-6 and IL-8 production, and proliferation of RA FLSs.
T12 1237-1323 Sentence denotes In addition, inhibition of PRMT5 decreased in vitro migration and invasion of RA FLSs.
T13 1324-1467 Sentence denotes Furthermore, EPZ015666 restrained the phosphorylation of IκB kinaseβ and IκBα, as well as nucleus transsituation of p65 as well as AKT in FLSs.
T14 1468-1627 Sentence denotes PRMT5 regulated the production of inflammatory factors, cell proliferation, migration and invasion of RA FLS, which was mediated by the NF-κB and AKT pathways.
T15 1628-1753 Sentence denotes Our data suggested that targeting PRMT5 to prevent synovial inflammation and destruction might be a promising therapy for RA.

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 110-130 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis 0008383
T2 327-347 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis 0008383
T3 428-442 DiseaseOrPhenotypicFeature denotes osteoarthritis 0005178

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 1128-1135 SequenceVariant denotes T5 by E

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 8-44 GeneOrGeneProduct denotes protein arginine methyltransferase 5
T2 89-93 GeneOrGeneProduct denotes like
T3 153-189 GeneOrGeneProduct denotes protein arginine methyltransferase 5
T4 191-196 GeneOrGeneProduct denotes PRMT5
T5 226-230 GeneOrGeneProduct denotes cell
T6 283-287 GeneOrGeneProduct denotes like
T7 364-373 GeneOrGeneProduct denotes separated
T8 452-461 GeneOrGeneProduct denotes inhibitor
T9 465-470 GeneOrGeneProduct denotes PRMT5
T10 526-531 GeneOrGeneProduct denotes PRMT5
T11 553-558 GeneOrGeneProduct denotes PRMT5
T12 587-594 GeneOrGeneProduct denotes protein
T13 619-623 GeneOrGeneProduct denotes blot
T14 741-747 GeneOrGeneProduct denotes enzyme
T15 787-796 GeneOrGeneProduct denotes real-time
T16 797-807 GeneOrGeneProduct denotes polymerase
T17 808-813 GeneOrGeneProduct denotes chain
T18 966-971 GeneOrGeneProduct denotes PRMT5
T19 1051-1056 GeneOrGeneProduct denotes PRMT5
T20 1094-1098 GeneOrGeneProduct denotes IL-1
T21 1125-1130 GeneOrGeneProduct denotes PRMT5
T22 1163-1172 GeneOrGeneProduct denotes knockdown
T23 1173-1180 GeneOrGeneProduct denotes reduced
T24 1181-1185 GeneOrGeneProduct denotes IL-6
T25 1190-1194 GeneOrGeneProduct denotes IL-8
T26 1264-1269 GeneOrGeneProduct denotes PRMT5
T27 1385-1391 GeneOrGeneProduct denotes kinase
T28 1414-1421 GeneOrGeneProduct denotes nucleus
T29 1468-1473 GeneOrGeneProduct denotes PRMT5
T30 1524-1528 GeneOrGeneProduct denotes cell
T31 1662-1667 GeneOrGeneProduct denotes PRMT5

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 8-44 GeneOrGeneProduct denotes protein arginine methyltransferase 5
T2 89-93 GeneOrGeneProduct denotes like
T3 153-189 GeneOrGeneProduct denotes protein arginine methyltransferase 5
T4 191-196 GeneOrGeneProduct denotes PRMT5
T5 201-211 GeneOrGeneProduct denotes regulating
T6 226-230 GeneOrGeneProduct denotes cell
T7 283-287 GeneOrGeneProduct denotes like
T8 364-373 GeneOrGeneProduct denotes separated
T9 452-461 GeneOrGeneProduct denotes inhibitor
T10 465-470 GeneOrGeneProduct denotes PRMT5
T11 526-531 GeneOrGeneProduct denotes PRMT5
T12 553-558 GeneOrGeneProduct denotes PRMT5
T13 587-594 GeneOrGeneProduct denotes protein
T14 619-623 GeneOrGeneProduct denotes blot
T15 700-707 GeneOrGeneProduct denotes factors
T16 741-747 GeneOrGeneProduct denotes enzyme
T17 748-754 GeneOrGeneProduct denotes linked
T18 787-796 GeneOrGeneProduct denotes real-time
T19 797-807 GeneOrGeneProduct denotes polymerase
T20 808-813 GeneOrGeneProduct denotes chain
T21 966-971 GeneOrGeneProduct denotes PRMT5
T22 1022-1031 GeneOrGeneProduct denotes RA. In RA
T23 1051-1056 GeneOrGeneProduct denotes PRMT5
T24 1064-1073 GeneOrGeneProduct denotes regulated
T25 1094-1098 GeneOrGeneProduct denotes IL-1
T26 1125-1130 GeneOrGeneProduct denotes PRMT5
T27 1154-1162 GeneOrGeneProduct denotes mediated
T28 1163-1172 GeneOrGeneProduct denotes knockdown
T29 1173-1180 GeneOrGeneProduct denotes reduced
T30 1181-1185 GeneOrGeneProduct denotes IL-6
T31 1190-1194 GeneOrGeneProduct denotes IL-8
T32 1195-1205 GeneOrGeneProduct denotes production
T33 1264-1269 GeneOrGeneProduct denotes PRMT5
T34 1385-1391 GeneOrGeneProduct denotes kinase
T35 1414-1421 GeneOrGeneProduct denotes nucleus
T36 1468-1473 GeneOrGeneProduct denotes PRMT5
T37 1474-1483 GeneOrGeneProduct denotes regulated
T38 1488-1498 GeneOrGeneProduct denotes production
T39 1515-1522 GeneOrGeneProduct denotes factors
T40 1524-1528 GeneOrGeneProduct denotes cell
T41 1588-1596 GeneOrGeneProduct denotes mediated
T42 1662-1667 GeneOrGeneProduct denotes PRMT5

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 48-60 DiseaseOrPhenotypicFeature denotes inflammation D007249
T2 110-130 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172
T3 212-224 DiseaseOrPhenotypicFeature denotes inflammation D007249
T4 327-347 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172
T5 349-351 DiseaseOrPhenotypicFeature denotes RA D001172
T6 421-423 DiseaseOrPhenotypicFeature denotes RA D001172
T7 428-442 DiseaseOrPhenotypicFeature denotes osteoarthritis D010003
T8 444-446 DiseaseOrPhenotypicFeature denotes OA D010003
T9 687-699 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T10 1022-1024 DiseaseOrPhenotypicFeature denotes RA D001172
T11 1029-1031 DiseaseOrPhenotypicFeature denotes RA D001172
T12 1228-1230 DiseaseOrPhenotypicFeature denotes RA D001172
T13 1315-1317 DiseaseOrPhenotypicFeature denotes RA D001172
T14 1502-1514 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T15 1570-1572 DiseaseOrPhenotypicFeature denotes RA D001172
T16 1688-1700 DiseaseOrPhenotypicFeature denotes inflammation D007249
T17 1750-1752 DiseaseOrPhenotypicFeature denotes RA D001172

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 8-44 GeneOrGeneProduct denotes protein arginine methyltransferase 5
T2 153-189 GeneOrGeneProduct denotes protein arginine methyltransferase 5
T3 191-196 GeneOrGeneProduct denotes PRMT5
T4 364-373 GeneOrGeneProduct denotes separated
T5 465-470 GeneOrGeneProduct denotes PRMT5
T6 526-531 GeneOrGeneProduct denotes PRMT5
T7 553-558 GeneOrGeneProduct denotes PRMT5
T8 966-971 GeneOrGeneProduct denotes PRMT5
T9 1051-1056 GeneOrGeneProduct denotes PRMT5
T10 1094-1098 GeneOrGeneProduct denotes IL-1
T11 1125-1130 GeneOrGeneProduct denotes PRMT5
T12 1181-1185 GeneOrGeneProduct denotes IL-6
T13 1190-1194 GeneOrGeneProduct denotes IL-8
T14 1264-1269 GeneOrGeneProduct denotes PRMT5
T15 1468-1473 GeneOrGeneProduct denotes PRMT5
T16 1662-1667 GeneOrGeneProduct denotes PRMT5

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 110-130 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis 0008383
T2 327-347 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis 0008383
T3 349-351 DiseaseOrPhenotypicFeature denotes RA 0008383|0005272
T5 421-423 DiseaseOrPhenotypicFeature denotes RA 0008383|0005272
T7 428-442 DiseaseOrPhenotypicFeature denotes osteoarthritis 0005178
T8 444-446 DiseaseOrPhenotypicFeature denotes OA 0005178
T9 1022-1024 DiseaseOrPhenotypicFeature denotes RA 0008383|0005272
T11 1029-1031 DiseaseOrPhenotypicFeature denotes RA 0008383|0005272
T13 1228-1230 DiseaseOrPhenotypicFeature denotes RA 0008383|0005272
T15 1315-1317 DiseaseOrPhenotypicFeature denotes RA 0008383|0005272
T17 1570-1572 DiseaseOrPhenotypicFeature denotes RA 0008383|0005272
T19 1750-1752 DiseaseOrPhenotypicFeature denotes RA 0008383|0005272

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 48-60 DiseaseOrPhenotypicFeature denotes inflammation DISEASE|D007249
T3 110-130 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172
T4 212-224 DiseaseOrPhenotypicFeature denotes inflammation DISEASE|D007249
T6 327-347 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172
T7 349-351 DiseaseOrPhenotypicFeature denotes RA D001172
T8 421-423 DiseaseOrPhenotypicFeature denotes RA D001172
T9 428-442 DiseaseOrPhenotypicFeature denotes osteoarthritis D010003
T10 444-446 DiseaseOrPhenotypicFeature denotes OA D010003
T11 687-699 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T12 1022-1024 DiseaseOrPhenotypicFeature denotes RA D001172
T13 1029-1031 DiseaseOrPhenotypicFeature denotes RA D001172
T14 1228-1230 DiseaseOrPhenotypicFeature denotes RA D001172
T15 1315-1317 DiseaseOrPhenotypicFeature denotes RA D001172
T16 1502-1514 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T17 1570-1572 DiseaseOrPhenotypicFeature denotes RA D001172
T18 1688-1700 DiseaseOrPhenotypicFeature denotes inflammation DISEASE|D007249
T20 1750-1752 DiseaseOrPhenotypicFeature denotes RA D001172

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 48-60 DiseaseOrPhenotypicFeature denotes inflammation D007249
T2 110-130 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172
T3 212-224 DiseaseOrPhenotypicFeature denotes inflammation D007249
T4 327-347 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172
T5 349-351 DiseaseOrPhenotypicFeature denotes RA D001172
T6 421-423 DiseaseOrPhenotypicFeature denotes RA D001172
T7 428-442 DiseaseOrPhenotypicFeature denotes osteoarthritis D010003
T8 444-446 DiseaseOrPhenotypicFeature denotes OA D010003
T9 1022-1024 DiseaseOrPhenotypicFeature denotes RA D001172
T10 1029-1031 DiseaseOrPhenotypicFeature denotes RA D001172
T11 1228-1230 DiseaseOrPhenotypicFeature denotes RA D001172
T12 1315-1317 DiseaseOrPhenotypicFeature denotes RA D001172
T13 1570-1572 DiseaseOrPhenotypicFeature denotes RA D001172
T14 1688-1700 DiseaseOrPhenotypicFeature denotes inflammation D007249
T15 1750-1752 DiseaseOrPhenotypicFeature denotes RA D001172

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 313-321 OrganismTaxon denotes patients
T2 407-415 OrganismTaxon denotes patients
T3 1008-1016 OrganismTaxon denotes patients

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 8-42 ChemicalEntity denotes protein arginine methyltransferase D011484
T2 153-187 ChemicalEntity denotes protein arginine methyltransferase D011484
T3 472-481 ChemicalEntity denotes EPZ015666 C000599896|ChemicalEntity
T5 936-940 ChemicalEntity denotes BrdU http://purl.obolibrary.org/obo/CHEBI_472552
T6 1134-1143 ChemicalEntity denotes EPZ015666 C000599896|ChemicalEntity
T8 1337-1346 ChemicalEntity denotes EPZ015666 C000599896|ChemicalEntity

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T8 1337-1346 ChemicalEntity denotes EPZ015666 ChemicalEntity|C000599896
T6 1134-1143 ChemicalEntity denotes EPZ015666 ChemicalEntity|C000599896
T5 936-940 ChemicalEntity denotes BrdU http://purl.obolibrary.org/obo/CHEBI_472552
T3 472-481 ChemicalEntity denotes EPZ015666 ChemicalEntity|C000599896
T2 153-187 ChemicalEntity denotes protein arginine methyltransferase D011484
T1 8-42 ChemicalEntity denotes protein arginine methyltransferase D011484
T16 1662-1667 GeneOrGeneProduct denotes PRMT5
T15 1468-1473 GeneOrGeneProduct denotes PRMT5
T14 1264-1269 GeneOrGeneProduct denotes PRMT5
T13 1190-1194 GeneOrGeneProduct denotes IL-8
T12 1181-1185 GeneOrGeneProduct denotes IL-6
T11 1125-1130 GeneOrGeneProduct denotes PRMT5
T10 1094-1098 GeneOrGeneProduct denotes IL-1
T9 1051-1056 GeneOrGeneProduct denotes PRMT5
T49596 966-971 GeneOrGeneProduct denotes PRMT5
T7 553-558 GeneOrGeneProduct denotes PRMT5
T27320 526-531 GeneOrGeneProduct denotes PRMT5
T70212 465-470 GeneOrGeneProduct denotes PRMT5
T4 364-373 GeneOrGeneProduct denotes separated
T59672 191-196 GeneOrGeneProduct denotes PRMT5
T34029 153-189 GeneOrGeneProduct denotes protein arginine methyltransferase 5
T66908 8-44 GeneOrGeneProduct denotes protein arginine methyltransferase 5
T7305 1750-1752 DiseaseOrPhenotypicFeature denotes RA D001172
T3952 1688-1700 DiseaseOrPhenotypicFeature denotes inflammation D007249
T45963 1570-1572 DiseaseOrPhenotypicFeature denotes RA D001172
T79435 1315-1317 DiseaseOrPhenotypicFeature denotes RA D001172
T13416 1228-1230 DiseaseOrPhenotypicFeature denotes RA D001172
T75692 1029-1031 DiseaseOrPhenotypicFeature denotes RA D001172
T36732 1022-1024 DiseaseOrPhenotypicFeature denotes RA D001172
T97804 444-446 DiseaseOrPhenotypicFeature denotes OA D010003
T51768 428-442 DiseaseOrPhenotypicFeature denotes osteoarthritis D010003
T39796 421-423 DiseaseOrPhenotypicFeature denotes RA D001172
T30244 349-351 DiseaseOrPhenotypicFeature denotes RA D001172
T74568 327-347 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172
T65270 212-224 DiseaseOrPhenotypicFeature denotes inflammation D007249
T2527 110-130 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis D001172
T83949 48-60 DiseaseOrPhenotypicFeature denotes inflammation D007249
T76135 1008-1016 OrganismTaxon denotes patients
T53948 407-415 OrganismTaxon denotes patients
T86187 313-321 OrganismTaxon denotes patients
T53708 1128-1135 SequenceVariant denotes T5 by E

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Role of protein arginine methyltransferase 5 in inflammation and migration of fibroblast-like synoviocytes in rheumatoid arthritis.
T2 132-353 Sentence denotes To probe the role of protein arginine methyltransferase 5 (PRMT5) in regulating inflammation, cell proliferation, migration and invasion of fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA).
T3 354-448 Sentence denotes FLSs were separated from synovial tissues (STs) from patients with RA and osteoarthritis (OA).
T4 449-570 Sentence denotes An inhibitor of PRMT5 (EPZ015666) and short interference RNA (siRNA) against PRMT5 were used to inhibit PRMT5 expression.
T5 571-646 Sentence denotes The standard of protein was measured by Western blot or immunofluorescence.
T6 647-829 Sentence denotes The excretion and genetic expression of inflammatory factors were, respectively, estimated by enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR).
T7 830-900 Sentence denotes Migration and invasion in vitro were detected by Boyden chamber assay.
T8 901-955 Sentence denotes FLSs proliferation was detected by BrdU incorporation.
T9 956-1025 Sentence denotes Increased PRMT5 was discovered in STs and FLSs from patients with RA.
T10 1026-1110 Sentence denotes In RA FLSs, the level of PRMT5 was up-regulated by stimulation with IL-1β and TNF-α.
T11 1111-1236 Sentence denotes Inhibition of PRMT5 by EPZ015666 and siRNA-mediated knockdown reduced IL-6 and IL-8 production, and proliferation of RA FLSs.
T12 1237-1323 Sentence denotes In addition, inhibition of PRMT5 decreased in vitro migration and invasion of RA FLSs.
T13 1324-1467 Sentence denotes Furthermore, EPZ015666 restrained the phosphorylation of IκB kinaseβ and IκBα, as well as nucleus transsituation of p65 as well as AKT in FLSs.
T14 1468-1627 Sentence denotes PRMT5 regulated the production of inflammatory factors, cell proliferation, migration and invasion of RA FLS, which was mediated by the NF-κB and AKT pathways.
T15 1628-1753 Sentence denotes Our data suggested that targeting PRMT5 to prevent synovial inflammation and destruction might be a promising therapy for RA.
T1 0-131 Sentence denotes Role of protein arginine methyltransferase 5 in inflammation and migration of fibroblast-like synoviocytes in rheumatoid arthritis.
T2 132-353 Sentence denotes To probe the role of protein arginine methyltransferase 5 (PRMT5) in regulating inflammation, cell proliferation, migration and invasion of fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA).
T3 354-448 Sentence denotes FLSs were separated from synovial tissues (STs) from patients with RA and osteoarthritis (OA).
T4 449-570 Sentence denotes An inhibitor of PRMT5 (EPZ015666) and short interference RNA (siRNA) against PRMT5 were used to inhibit PRMT5 expression.
T5 571-646 Sentence denotes The standard of protein was measured by Western blot or immunofluorescence.
T6 647-829 Sentence denotes The excretion and genetic expression of inflammatory factors were, respectively, estimated by enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR).
T7 830-900 Sentence denotes Migration and invasion in vitro were detected by Boyden chamber assay.
T8 901-955 Sentence denotes FLSs proliferation was detected by BrdU incorporation.
T9 956-1025 Sentence denotes Increased PRMT5 was discovered in STs and FLSs from patients with RA.
T10 1026-1110 Sentence denotes In RA FLSs, the level of PRMT5 was up-regulated by stimulation with IL-1β and TNF-α.
T11 1111-1236 Sentence denotes Inhibition of PRMT5 by EPZ015666 and siRNA-mediated knockdown reduced IL-6 and IL-8 production, and proliferation of RA FLSs.
T12 1237-1323 Sentence denotes In addition, inhibition of PRMT5 decreased in vitro migration and invasion of RA FLSs.
T13 1324-1467 Sentence denotes Furthermore, EPZ015666 restrained the phosphorylation of IκB kinaseβ and IκBα, as well as nucleus transsituation of p65 as well as AKT in FLSs.
T14 1468-1627 Sentence denotes PRMT5 regulated the production of inflammatory factors, cell proliferation, migration and invasion of RA FLS, which was mediated by the NF-κB and AKT pathways.
T15 1628-1753 Sentence denotes Our data suggested that targeting PRMT5 to prevent synovial inflammation and destruction might be a promising therapy for RA.