PubMed:24742750
Annnotations
LitCoin-entities-OrganismTaxon-PD
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 16-21 | OrganismTaxon | denotes | human | NCBItxid:9606 |
| T2 | 162-167 | OrganismTaxon | denotes | human | NCBItxid:9606 |
LitCoin-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-127 | Sentence | denotes | Availability of human induced pluripotent stem cell-derived cardiomyocytes in assessment of drug potential for QT prolongation. |
| T2 | 128-394 | Sentence | denotes | Field potential duration (FPD) in human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), which can express QT interval in an electrocardiogram, is reported to be a useful tool to predict K(+) channel and Ca(2+) channel blocker effects on QT interval. |
| T3 | 395-525 | Sentence | denotes | However, there is no report showing that this technique can be used to predict multichannel blocker potential for QT prolongation. |
| T4 | 526-819 | Sentence | denotes | The aim of this study is to show that FPD from MEA (Multielectrode array) of hiPS-CMs can detect QT prolongation induced by multichannel blockers. hiPS-CMs were seeded onto MEA and FPD was measured for 2min every 10min for 30min after drug exposure for the vehicle and each drug concentration. |
| T5 | 820-972 | Sentence | denotes | IKr and IKs blockers concentration-dependently prolonged corrected FPD (FPDc), whereas Ca(2+) channel blockers concentration-dependently shortened FPDc. |
| T6 | 973-1107 | Sentence | denotes | Also, the multichannel blockers Amiodarone, Paroxetine, Terfenadine and Citalopram prolonged FPDc in a concentration dependent manner. |
| T7 | 1108-1373 | Sentence | denotes | Finally, the IKr blockers, Terfenadine and Citalopram, which are reported to cause Torsade de Pointes (TdP) in clinical practice, produced early afterdepolarization (EAD). hiPS-CMs using MEA system and FPDc can predict the effects of drug candidates on QT interval. |
| T8 | 1374-1461 | Sentence | denotes | This study also shows that this assay can help detect EAD for drugs with TdP potential. |
LitCoin-entities
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 9878 | 16-21 | OrganismTaxon | denotes | human | NCBITaxon:9606 |
| 9879 | 111-126 | DiseaseOrPhenotypicFeature | denotes | QT prolongation | MESH:D008133 |
| 9880 | 162-167 | OrganismTaxon | denotes | human | NCBITaxon:9606 |
| 9881 | 331-370 | ChemicalEntity | denotes | K(+) channel and Ca(2+) channel blocker | MESH:D002121|MESH:D026902 |
| 9882 | 509-524 | DiseaseOrPhenotypicFeature | denotes | QT prolongation | MESH:D008133 |
| 9883 | 623-638 | DiseaseOrPhenotypicFeature | denotes | QT prolongation | MESH:D008133 |
| 9884 | 907-930 | ChemicalEntity | denotes | Ca(2+) channel blockers | MESH:D002121 |
| 9885 | 1005-1015 | ChemicalEntity | denotes | Amiodarone | MESH:D000638 |
| 9886 | 1017-1027 | ChemicalEntity | denotes | Paroxetine | MESH:D017374 |
| 9887 | 1029-1040 | ChemicalEntity | denotes | Terfenadine | MESH:D016593 |
| 9888 | 1045-1055 | ChemicalEntity | denotes | Citalopram | MESH:D015283 |
| 9889 | 1135-1146 | ChemicalEntity | denotes | Terfenadine | MESH:D016593 |
| 9890 | 1151-1161 | ChemicalEntity | denotes | Citalopram | MESH:D015283 |
| 9891 | 1191-1209 | DiseaseOrPhenotypicFeature | denotes | Torsade de Pointes | MESH:D016171 |
| 9892 | 1211-1214 | DiseaseOrPhenotypicFeature | denotes | TdP | MESH:D016171 |
| 9893 | 1447-1450 | DiseaseOrPhenotypicFeature | denotes | TdP | MESH:D016171 |
LitCoin_Mondo
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1191-1209 | DiseaseOrPhenotypicFeature | denotes | Torsade de Pointes | 0005478 |
LitCoin-GeneOrGeneProduct-v2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 47-51 | GeneOrGeneProduct | denotes | cell |
| T2 | 193-197 | GeneOrGeneProduct | denotes | cell |
| T3 | 331-343 | GeneOrGeneProduct | denotes | K(+) channel |
| T4 | 348-362 | GeneOrGeneProduct | denotes | Ca(2+) channel |
| T5 | 363-370 | GeneOrGeneProduct | denotes | blocker |
| T6 | 487-494 | GeneOrGeneProduct | denotes | blocker |
| T7 | 907-921 | GeneOrGeneProduct | denotes | Ca(2+) channel |
| T8 | 1247-1252 | GeneOrGeneProduct | denotes | early |
LitCoin-GeneOrGeneProduct-v0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-12 | GeneOrGeneProduct | denotes | Availability |
| T2 | 22-29 | GeneOrGeneProduct | denotes | induced |
| T3 | 47-51 | GeneOrGeneProduct | denotes | cell |
| T4 | 154-157 | GeneOrGeneProduct | denotes | FPD |
| T5 | 168-175 | GeneOrGeneProduct | denotes | induced |
| T6 | 193-197 | GeneOrGeneProduct | denotes | cell |
| T7 | 323-330 | GeneOrGeneProduct | denotes | predict |
| T8 | 331-343 | GeneOrGeneProduct | denotes | K(+) channel |
| T9 | 348-362 | GeneOrGeneProduct | denotes | Ca(2+) channel |
| T10 | 363-370 | GeneOrGeneProduct | denotes | blocker |
| T11 | 466-473 | GeneOrGeneProduct | denotes | predict |
| T12 | 487-494 | GeneOrGeneProduct | denotes | blocker |
| T13 | 564-567 | GeneOrGeneProduct | denotes | FPD |
| T14 | 639-646 | GeneOrGeneProduct | denotes | induced |
| T15 | 663-671 | GeneOrGeneProduct | denotes | blockers |
| T16 | 707-710 | GeneOrGeneProduct | denotes | FPD |
| T17 | 832-840 | GeneOrGeneProduct | denotes | blockers |
| T18 | 887-890 | GeneOrGeneProduct | denotes | FPD |
| T19 | 907-921 | GeneOrGeneProduct | denotes | Ca(2+) channel |
| T20 | 922-930 | GeneOrGeneProduct | denotes | blockers |
| T21 | 996-1004 | GeneOrGeneProduct | denotes | blockers |
| T22 | 1071-1075 | GeneOrGeneProduct | denotes | in a |
| T23 | 1125-1133 | GeneOrGeneProduct | denotes | blockers |
| T24 | 1202-1209 | GeneOrGeneProduct | denotes | Pointes |
| T25 | 1247-1252 | GeneOrGeneProduct | denotes | early |
| T26 | 1319-1326 | GeneOrGeneProduct | denotes | predict |
| T27 | 1416-1420 | GeneOrGeneProduct | denotes | help |
LitCoin-Disease-MeSH
| Id | Subject | Object | Predicate | Lexical cue | originalLabel |
|---|---|---|---|---|---|
| T1 | 111-126 | DiseaseOrPhenotypicFeature | denotes | QT prolongation | DISEASE |
| T2 | 509-524 | DiseaseOrPhenotypicFeature | denotes | QT prolongation | DISEASE |
| T3 | 623-638 | DiseaseOrPhenotypicFeature | denotes | QT prolongation | DISEASE |
| T4 | 1191-1209 | DiseaseOrPhenotypicFeature | denotes | Torsade de Pointes | D016171 |
| T5 | 1211-1214 | DiseaseOrPhenotypicFeature | denotes | TdP | D016171 |
| T6 | 1447-1450 | DiseaseOrPhenotypicFeature | denotes | TdP | D016171 |
LitCoin-GeneOrGeneProduct-v3
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 331-343 | GeneOrGeneProduct | denotes | K(+) channel |
LitCoin_Mondo_095
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 239-242 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
| T2 | 451-454 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
| T3 | 612-615 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
| T4 | 1274-1277 | DiseaseOrPhenotypicFeature | denotes | EAD | 0011281 |
| T5 | 1315-1318 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
| T6 | 1412-1415 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
| T7 | 1428-1431 | DiseaseOrPhenotypicFeature | denotes | EAD | 0011281 |
LitCoin-MeSH-Disease-2
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 111-126 | DiseaseOrPhenotypicFeature | denotes | QT prolongation | DISEASE |
| T2 | 509-524 | DiseaseOrPhenotypicFeature | denotes | QT prolongation | DISEASE |
| T3 | 623-638 | DiseaseOrPhenotypicFeature | denotes | QT prolongation | DISEASE |
| T4 | 1191-1209 | DiseaseOrPhenotypicFeature | denotes | Torsade de Pointes | D016171 |
| T5 | 1211-1214 | DiseaseOrPhenotypicFeature | denotes | TdP | D016171 |
| T6 | 1447-1450 | DiseaseOrPhenotypicFeature | denotes | TdP | D016171 |
LitCoin-MONDO_bioort2019
| Id | Subject | Object | Predicate | Lexical cue | #label |
|---|---|---|---|---|---|
| T1 | 111-126 | DiseaseOrPhenotypicFeature | denotes | QT prolongation | DISEASE |
| T2 | 509-524 | DiseaseOrPhenotypicFeature | denotes | QT prolongation | DISEASE |
| T3 | 623-638 | DiseaseOrPhenotypicFeature | denotes | QT prolongation | DISEASE |
| T4 | 1191-1209 | DiseaseOrPhenotypicFeature | denotes | Torsade de Pointes | D016171 |
| T5 | 1211-1214 | DiseaseOrPhenotypicFeature | denotes | TdP | D016171 |
| T6 | 1447-1450 | DiseaseOrPhenotypicFeature | denotes | TdP | D016171 |
LitCoin-Chemical-MeSH-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 348-370 | ChemicalEntity | denotes | Ca(2+) channel blocker | ChemicalEntity |
| T2 | 573-576 | ChemicalEntity | denotes | MEA | http://purl.obolibrary.org/obo/CHEBI_17141|http://purl.obolibrary.org/obo/CHEBI_16000 |
| T4 | 699-702 | ChemicalEntity | denotes | MEA | http://purl.obolibrary.org/obo/CHEBI_17141|http://purl.obolibrary.org/obo/CHEBI_16000 |
| T6 | 907-930 | ChemicalEntity | denotes | Ca(2+) channel blockers | ChemicalEntity |
| T7 | 1005-1015 | ChemicalEntity | denotes | Amiodarone | http://purl.obolibrary.org/obo/CHEBI_2663 |
| T8 | 1017-1027 | ChemicalEntity | denotes | Paroxetine | http://purl.obolibrary.org/obo/CHEBI_7936 |
| T9 | 1029-1040 | ChemicalEntity | denotes | Terfenadine | http://purl.obolibrary.org/obo/CHEBI_9453 |
| T10 | 1045-1055 | ChemicalEntity | denotes | Citalopram | http://purl.obolibrary.org/obo/CHEBI_3723 |
| T11 | 1135-1146 | ChemicalEntity | denotes | Terfenadine | http://purl.obolibrary.org/obo/CHEBI_9453 |
| T12 | 1151-1161 | ChemicalEntity | denotes | Citalopram | http://purl.obolibrary.org/obo/CHEBI_3723 |
| T13 | 1295-1298 | ChemicalEntity | denotes | MEA | http://purl.obolibrary.org/obo/CHEBI_17141|http://purl.obolibrary.org/obo/CHEBI_16000 |
LitCoin-NCBITaxon-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 16-21 | OrganismTaxon | denotes | human |
| T2 | 162-167 | OrganismTaxon | denotes | human |
| T3 | 573-576 | OrganismTaxon | denotes | MEA |
| T4 | 699-702 | OrganismTaxon | denotes | MEA |
| T5 | 1295-1298 | OrganismTaxon | denotes | MEA |
LitCoin-training-merged
| Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
|---|---|---|---|---|---|---|
| T13 | 1295-1298 | ChemicalEntity | denotes | MEA | http://purl.obolibrary.org/obo/CHEBI_16000|http://purl.obolibrary.org/obo/CHEBI_17141 | |
| T12 | 1151-1161 | ChemicalEntity | denotes | Citalopram | http://purl.obolibrary.org/obo/CHEBI_3723 | |
| T11 | 1135-1146 | ChemicalEntity | denotes | Terfenadine | http://purl.obolibrary.org/obo/CHEBI_9453 | |
| T2 | 573-576 | ChemicalEntity | denotes | MEA | http://purl.obolibrary.org/obo/CHEBI_16000|http://purl.obolibrary.org/obo/CHEBI_17141 | |
| T10 | 1045-1055 | ChemicalEntity | denotes | Citalopram | http://purl.obolibrary.org/obo/CHEBI_3723 | |
| T9 | 1029-1040 | ChemicalEntity | denotes | Terfenadine | http://purl.obolibrary.org/obo/CHEBI_9453 | |
| T8 | 1017-1027 | ChemicalEntity | denotes | Paroxetine | http://purl.obolibrary.org/obo/CHEBI_7936 | |
| T7 | 1005-1015 | ChemicalEntity | denotes | Amiodarone | http://purl.obolibrary.org/obo/CHEBI_2663 | |
| T6 | 907-930 | ChemicalEntity | denotes | Ca(2+) channel blockers | ChemicalEntity | |
| T4 | 699-702 | ChemicalEntity | denotes | MEA | http://purl.obolibrary.org/obo/CHEBI_16000|http://purl.obolibrary.org/obo/CHEBI_17141 | |
| T1 | 348-370 | ChemicalEntity | denotes | Ca(2+) channel blocker | ChemicalEntity | |
| T82412 | 331-343 | GeneOrGeneProduct | denotes | K(+) channel | ||
| T41537 | 1447-1450 | DiseaseOrPhenotypicFeature | denotes | TdP | D016171 | |
| T5 | 1211-1214 | DiseaseOrPhenotypicFeature | denotes | TdP | D016171 | |
| T55776 | 1191-1209 | DiseaseOrPhenotypicFeature | denotes | Torsade de Pointes | D016171 | |
| T3 | 623-638 | DiseaseOrPhenotypicFeature | denotes | QT prolongation | DISEASE | |
| T11229 | 509-524 | DiseaseOrPhenotypicFeature | denotes | QT prolongation | DISEASE | |
| T35311 | 111-126 | DiseaseOrPhenotypicFeature | denotes | QT prolongation | DISEASE | |
| T93091 | 1295-1298 | OrganismTaxon | denotes | MEA | ||
| T79209 | 699-702 | OrganismTaxon | denotes | MEA | ||
| T74729 | 573-576 | OrganismTaxon | denotes | MEA | ||
| T14865 | 162-167 | OrganismTaxon | denotes | human | ||
| T8106 | 16-21 | OrganismTaxon | denotes | human |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_24742750_1_0 | 128-152 | expanded | denotes | Field potential duration |
| SS2_24742750_1_0 | 154-157 | abbr | denotes | FPD |
| SS1_24742750_1_1 | 162-220 | expanded | denotes | human-induced pluripotent stem cell-derived cardiomyocytes |
| SS2_24742750_1_1 | 222-230 | abbr | denotes | hiPS-CMs |
| SS1_24742750_4_0 | 892-896 | expanded | denotes | FPDc |
| SS2_24742750_4_0 | 887-890 | abbr | denotes | FPD |
| SS1_24742750_6_0 | 1191-1209 | expanded | denotes | Torsade de Pointes |
| SS2_24742750_6_0 | 1211-1214 | abbr | denotes | TdP |
| SS1_24742750_6_1 | 1247-1272 | expanded | denotes | early afterdepolarization |
| SS2_24742750_6_1 | 1274-1277 | abbr | denotes | EAD |
| AE1_24742750_1_0 | SS1_24742750_1_0 | SS2_24742750_1_0 | abbreviatedTo | Field potential duration,FPD |
| AE1_24742750_1_1 | SS1_24742750_1_1 | SS2_24742750_1_1 | abbreviatedTo | human-induced pluripotent stem cell-derived cardiomyocytes,hiPS-CMs |
| AE1_24742750_4_0 | SS1_24742750_4_0 | SS2_24742750_4_0 | abbreviatedTo | FPDc,FPD |
| AE1_24742750_6_0 | SS1_24742750_6_0 | SS2_24742750_6_0 | abbreviatedTo | Torsade de Pointes,TdP |
| AE1_24742750_6_1 | SS1_24742750_6_1 | SS2_24742750_6_1 | abbreviatedTo | early afterdepolarization,EAD |