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PubMed:24742750 JSONTXT

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LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 16-21 OrganismTaxon denotes human NCBItxid:9606
T2 162-167 OrganismTaxon denotes human NCBItxid:9606

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-127 Sentence denotes Availability of human induced pluripotent stem cell-derived cardiomyocytes in assessment of drug potential for QT prolongation.
T2 128-394 Sentence denotes Field potential duration (FPD) in human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), which can express QT interval in an electrocardiogram, is reported to be a useful tool to predict K(+) channel and Ca(2+) channel blocker effects on QT interval.
T3 395-525 Sentence denotes However, there is no report showing that this technique can be used to predict multichannel blocker potential for QT prolongation.
T4 526-819 Sentence denotes The aim of this study is to show that FPD from MEA (Multielectrode array) of hiPS-CMs can detect QT prolongation induced by multichannel blockers. hiPS-CMs were seeded onto MEA and FPD was measured for 2min every 10min for 30min after drug exposure for the vehicle and each drug concentration.
T5 820-972 Sentence denotes IKr and IKs blockers concentration-dependently prolonged corrected FPD (FPDc), whereas Ca(2+) channel blockers concentration-dependently shortened FPDc.
T6 973-1107 Sentence denotes Also, the multichannel blockers Amiodarone, Paroxetine, Terfenadine and Citalopram prolonged FPDc in a concentration dependent manner.
T7 1108-1373 Sentence denotes Finally, the IKr blockers, Terfenadine and Citalopram, which are reported to cause Torsade de Pointes (TdP) in clinical practice, produced early afterdepolarization (EAD). hiPS-CMs using MEA system and FPDc can predict the effects of drug candidates on QT interval.
T8 1374-1461 Sentence denotes This study also shows that this assay can help detect EAD for drugs with TdP potential.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
9878 16-21 OrganismTaxon denotes human NCBITaxon:9606
9879 111-126 DiseaseOrPhenotypicFeature denotes QT prolongation MESH:D008133
9880 162-167 OrganismTaxon denotes human NCBITaxon:9606
9881 331-370 ChemicalEntity denotes K(+) channel and Ca(2+) channel blocker MESH:D002121|MESH:D026902
9882 509-524 DiseaseOrPhenotypicFeature denotes QT prolongation MESH:D008133
9883 623-638 DiseaseOrPhenotypicFeature denotes QT prolongation MESH:D008133
9884 907-930 ChemicalEntity denotes Ca(2+) channel blockers MESH:D002121
9885 1005-1015 ChemicalEntity denotes Amiodarone MESH:D000638
9886 1017-1027 ChemicalEntity denotes Paroxetine MESH:D017374
9887 1029-1040 ChemicalEntity denotes Terfenadine MESH:D016593
9888 1045-1055 ChemicalEntity denotes Citalopram MESH:D015283
9889 1135-1146 ChemicalEntity denotes Terfenadine MESH:D016593
9890 1151-1161 ChemicalEntity denotes Citalopram MESH:D015283
9891 1191-1209 DiseaseOrPhenotypicFeature denotes Torsade de Pointes MESH:D016171
9892 1211-1214 DiseaseOrPhenotypicFeature denotes TdP MESH:D016171
9893 1447-1450 DiseaseOrPhenotypicFeature denotes TdP MESH:D016171

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 1191-1209 DiseaseOrPhenotypicFeature denotes Torsade de Pointes 0005478

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 47-51 GeneOrGeneProduct denotes cell
T2 193-197 GeneOrGeneProduct denotes cell
T3 331-343 GeneOrGeneProduct denotes K(+) channel
T4 348-362 GeneOrGeneProduct denotes Ca(2+) channel
T5 363-370 GeneOrGeneProduct denotes blocker
T6 487-494 GeneOrGeneProduct denotes blocker
T7 907-921 GeneOrGeneProduct denotes Ca(2+) channel
T8 1247-1252 GeneOrGeneProduct denotes early

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-12 GeneOrGeneProduct denotes Availability
T2 22-29 GeneOrGeneProduct denotes induced
T3 47-51 GeneOrGeneProduct denotes cell
T4 154-157 GeneOrGeneProduct denotes FPD
T5 168-175 GeneOrGeneProduct denotes induced
T6 193-197 GeneOrGeneProduct denotes cell
T7 323-330 GeneOrGeneProduct denotes predict
T8 331-343 GeneOrGeneProduct denotes K(+) channel
T9 348-362 GeneOrGeneProduct denotes Ca(2+) channel
T10 363-370 GeneOrGeneProduct denotes blocker
T11 466-473 GeneOrGeneProduct denotes predict
T12 487-494 GeneOrGeneProduct denotes blocker
T13 564-567 GeneOrGeneProduct denotes FPD
T14 639-646 GeneOrGeneProduct denotes induced
T15 663-671 GeneOrGeneProduct denotes blockers
T16 707-710 GeneOrGeneProduct denotes FPD
T17 832-840 GeneOrGeneProduct denotes blockers
T18 887-890 GeneOrGeneProduct denotes FPD
T19 907-921 GeneOrGeneProduct denotes Ca(2+) channel
T20 922-930 GeneOrGeneProduct denotes blockers
T21 996-1004 GeneOrGeneProduct denotes blockers
T22 1071-1075 GeneOrGeneProduct denotes in a
T23 1125-1133 GeneOrGeneProduct denotes blockers
T24 1202-1209 GeneOrGeneProduct denotes Pointes
T25 1247-1252 GeneOrGeneProduct denotes early
T26 1319-1326 GeneOrGeneProduct denotes predict
T27 1416-1420 GeneOrGeneProduct denotes help

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 111-126 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T2 509-524 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T3 623-638 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T4 1191-1209 DiseaseOrPhenotypicFeature denotes Torsade de Pointes D016171
T5 1211-1214 DiseaseOrPhenotypicFeature denotes TdP D016171
T6 1447-1450 DiseaseOrPhenotypicFeature denotes TdP D016171

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 331-343 GeneOrGeneProduct denotes K(+) channel

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 239-242 DiseaseOrPhenotypicFeature denotes can 0012833
T2 451-454 DiseaseOrPhenotypicFeature denotes can 0012833
T3 612-615 DiseaseOrPhenotypicFeature denotes can 0012833
T4 1274-1277 DiseaseOrPhenotypicFeature denotes EAD 0011281
T5 1315-1318 DiseaseOrPhenotypicFeature denotes can 0012833
T6 1412-1415 DiseaseOrPhenotypicFeature denotes can 0012833
T7 1428-1431 DiseaseOrPhenotypicFeature denotes EAD 0011281

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 111-126 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T2 509-524 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T3 623-638 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T4 1191-1209 DiseaseOrPhenotypicFeature denotes Torsade de Pointes D016171
T5 1211-1214 DiseaseOrPhenotypicFeature denotes TdP D016171
T6 1447-1450 DiseaseOrPhenotypicFeature denotes TdP D016171

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 111-126 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T2 509-524 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T3 623-638 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T4 1191-1209 DiseaseOrPhenotypicFeature denotes Torsade de Pointes D016171
T5 1211-1214 DiseaseOrPhenotypicFeature denotes TdP D016171
T6 1447-1450 DiseaseOrPhenotypicFeature denotes TdP D016171

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 348-370 ChemicalEntity denotes Ca(2+) channel blocker ChemicalEntity
T2 573-576 ChemicalEntity denotes MEA http://purl.obolibrary.org/obo/CHEBI_17141|http://purl.obolibrary.org/obo/CHEBI_16000
T4 699-702 ChemicalEntity denotes MEA http://purl.obolibrary.org/obo/CHEBI_17141|http://purl.obolibrary.org/obo/CHEBI_16000
T6 907-930 ChemicalEntity denotes Ca(2+) channel blockers ChemicalEntity
T7 1005-1015 ChemicalEntity denotes Amiodarone http://purl.obolibrary.org/obo/CHEBI_2663
T8 1017-1027 ChemicalEntity denotes Paroxetine http://purl.obolibrary.org/obo/CHEBI_7936
T9 1029-1040 ChemicalEntity denotes Terfenadine http://purl.obolibrary.org/obo/CHEBI_9453
T10 1045-1055 ChemicalEntity denotes Citalopram http://purl.obolibrary.org/obo/CHEBI_3723
T11 1135-1146 ChemicalEntity denotes Terfenadine http://purl.obolibrary.org/obo/CHEBI_9453
T12 1151-1161 ChemicalEntity denotes Citalopram http://purl.obolibrary.org/obo/CHEBI_3723
T13 1295-1298 ChemicalEntity denotes MEA http://purl.obolibrary.org/obo/CHEBI_17141|http://purl.obolibrary.org/obo/CHEBI_16000

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 16-21 OrganismTaxon denotes human
T2 162-167 OrganismTaxon denotes human
T3 573-576 OrganismTaxon denotes MEA
T4 699-702 OrganismTaxon denotes MEA
T5 1295-1298 OrganismTaxon denotes MEA

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T13 1295-1298 ChemicalEntity denotes MEA http://purl.obolibrary.org/obo/CHEBI_16000|http://purl.obolibrary.org/obo/CHEBI_17141
T12 1151-1161 ChemicalEntity denotes Citalopram http://purl.obolibrary.org/obo/CHEBI_3723
T11 1135-1146 ChemicalEntity denotes Terfenadine http://purl.obolibrary.org/obo/CHEBI_9453
T2 573-576 ChemicalEntity denotes MEA http://purl.obolibrary.org/obo/CHEBI_16000|http://purl.obolibrary.org/obo/CHEBI_17141
T10 1045-1055 ChemicalEntity denotes Citalopram http://purl.obolibrary.org/obo/CHEBI_3723
T9 1029-1040 ChemicalEntity denotes Terfenadine http://purl.obolibrary.org/obo/CHEBI_9453
T8 1017-1027 ChemicalEntity denotes Paroxetine http://purl.obolibrary.org/obo/CHEBI_7936
T7 1005-1015 ChemicalEntity denotes Amiodarone http://purl.obolibrary.org/obo/CHEBI_2663
T6 907-930 ChemicalEntity denotes Ca(2+) channel blockers ChemicalEntity
T4 699-702 ChemicalEntity denotes MEA http://purl.obolibrary.org/obo/CHEBI_16000|http://purl.obolibrary.org/obo/CHEBI_17141
T1 348-370 ChemicalEntity denotes Ca(2+) channel blocker ChemicalEntity
T82412 331-343 GeneOrGeneProduct denotes K(+) channel
T41537 1447-1450 DiseaseOrPhenotypicFeature denotes TdP D016171
T5 1211-1214 DiseaseOrPhenotypicFeature denotes TdP D016171
T55776 1191-1209 DiseaseOrPhenotypicFeature denotes Torsade de Pointes D016171
T3 623-638 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T11229 509-524 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T35311 111-126 DiseaseOrPhenotypicFeature denotes QT prolongation DISEASE
T93091 1295-1298 OrganismTaxon denotes MEA
T79209 699-702 OrganismTaxon denotes MEA
T74729 573-576 OrganismTaxon denotes MEA
T14865 162-167 OrganismTaxon denotes human
T8106 16-21 OrganismTaxon denotes human

Allie

Id Subject Object Predicate Lexical cue
SS1_24742750_1_0 128-152 expanded denotes Field potential duration
SS2_24742750_1_0 154-157 abbr denotes FPD
SS1_24742750_1_1 162-220 expanded denotes human-induced pluripotent stem cell-derived cardiomyocytes
SS2_24742750_1_1 222-230 abbr denotes hiPS-CMs
SS1_24742750_4_0 892-896 expanded denotes FPDc
SS2_24742750_4_0 887-890 abbr denotes FPD
SS1_24742750_6_0 1191-1209 expanded denotes Torsade de Pointes
SS2_24742750_6_0 1211-1214 abbr denotes TdP
SS1_24742750_6_1 1247-1272 expanded denotes early afterdepolarization
SS2_24742750_6_1 1274-1277 abbr denotes EAD
AE1_24742750_1_0 SS1_24742750_1_0 SS2_24742750_1_0 abbreviatedTo Field potential duration,FPD
AE1_24742750_1_1 SS1_24742750_1_1 SS2_24742750_1_1 abbreviatedTo human-induced pluripotent stem cell-derived cardiomyocytes,hiPS-CMs
AE1_24742750_4_0 SS1_24742750_4_0 SS2_24742750_4_0 abbreviatedTo FPDc,FPD
AE1_24742750_6_0 SS1_24742750_6_0 SS2_24742750_6_0 abbreviatedTo Torsade de Pointes,TdP
AE1_24742750_6_1 SS1_24742750_6_1 SS2_24742750_6_1 abbreviatedTo early afterdepolarization,EAD