PubMed:24742750 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/24742750","sourcedb":"PubMed","sourceid":"24742750","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/24742750","text":"Availability of human induced pluripotent stem cell-derived cardiomyocytes in assessment of drug potential for QT prolongation.\nField potential duration (FPD) in human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), which can express QT interval in an electrocardiogram, is reported to be a useful tool to predict K(+) channel and Ca(2+) channel blocker effects on QT interval. However, there is no report showing that this technique can be used to predict multichannel blocker potential for QT prolongation. The aim of this study is to show that FPD from MEA (Multielectrode array) of hiPS-CMs can detect QT prolongation induced by multichannel blockers. hiPS-CMs were seeded onto MEA and FPD was measured for 2min every 10min for 30min after drug exposure for the vehicle and each drug concentration. IKr and IKs blockers concentration-dependently prolonged corrected FPD (FPDc), whereas Ca(2+) channel blockers concentration-dependently shortened FPDc. Also, the multichannel blockers Amiodarone, Paroxetine, Terfenadine and Citalopram prolonged FPDc in a concentration dependent manner. Finally, the IKr blockers, Terfenadine and Citalopram, which are reported to cause Torsade de Pointes (TdP) in clinical practice, produced early afterdepolarization (EAD). hiPS-CMs using MEA system and FPDc can predict the effects of drug candidates on QT interval. This study also shows that this assay can help detect EAD for drugs with TdP potential.","tracks":[{"project":"LitCoin-entities-OrganismTaxon-PD","denotations":[{"id":"T1","span":{"begin":16,"end":21},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":162,"end":167},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"NCBItxid:9606"},{"id":"A2","pred":"db_id","subj":"T2","obj":"NCBItxid:9606"},{"subj":"T1","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"},{"subj":"T2","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"}]},{"project":"LitCoin-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":127},"obj":"Sentence"},{"id":"T2","span":{"begin":128,"end":394},"obj":"Sentence"},{"id":"T3","span":{"begin":395,"end":525},"obj":"Sentence"},{"id":"T4","span":{"begin":526,"end":819},"obj":"Sentence"},{"id":"T5","span":{"begin":820,"end":972},"obj":"Sentence"},{"id":"T6","span":{"begin":973,"end":1107},"obj":"Sentence"},{"id":"T7","span":{"begin":1108,"end":1373},"obj":"Sentence"},{"id":"T8","span":{"begin":1374,"end":1461},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-sentences"},{"subj":"T2","pred":"source","obj":"LitCoin-sentences"},{"subj":"T3","pred":"source","obj":"LitCoin-sentences"},{"subj":"T4","pred":"source","obj":"LitCoin-sentences"},{"subj":"T5","pred":"source","obj":"LitCoin-sentences"},{"subj":"T6","pred":"source","obj":"LitCoin-sentences"},{"subj":"T7","pred":"source","obj":"LitCoin-sentences"},{"subj":"T8","pred":"source","obj":"LitCoin-sentences"}]},{"project":"LitCoin-entities","denotations":[{"id":"9878","span":{"begin":16,"end":21},"obj":"OrganismTaxon"},{"id":"9879","span":{"begin":111,"end":126},"obj":"DiseaseOrPhenotypicFeature"},{"id":"9880","span":{"begin":162,"end":167},"obj":"OrganismTaxon"},{"id":"9881","span":{"begin":331,"end":370},"obj":"ChemicalEntity"},{"id":"9882","span":{"begin":509,"end":524},"obj":"DiseaseOrPhenotypicFeature"},{"id":"9883","span":{"begin":623,"end":638},"obj":"DiseaseOrPhenotypicFeature"},{"id":"9884","span":{"begin":907,"end":930},"obj":"ChemicalEntity"},{"id":"9885","span":{"begin":1005,"end":1015},"obj":"ChemicalEntity"},{"id":"9886","span":{"begin":1017,"end":1027},"obj":"ChemicalEntity"},{"id":"9887","span":{"begin":1029,"end":1040},"obj":"ChemicalEntity"},{"id":"9888","span":{"begin":1045,"end":1055},"obj":"ChemicalEntity"},{"id":"9889","span":{"begin":1135,"end":1146},"obj":"ChemicalEntity"},{"id":"9890","span":{"begin":1151,"end":1161},"obj":"ChemicalEntity"},{"id":"9891","span":{"begin":1191,"end":1209},"obj":"DiseaseOrPhenotypicFeature"},{"id":"9892","span":{"begin":1211,"end":1214},"obj":"DiseaseOrPhenotypicFeature"},{"id":"9893","span":{"begin":1447,"end":1450},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"db_id","subj":"9878","obj":"NCBITaxon:9606"},{"id":"A2","pred":"db_id","subj":"9879","obj":"MESH:D008133"},{"id":"A3","pred":"db_id","subj":"9880","obj":"NCBITaxon:9606"},{"id":"A4","pred":"db_id","subj":"9881","obj":"MESH:D002121"},{"id":"A5","pred":"db_id","subj":"9881","obj":"MESH:D026902"},{"id":"A6","pred":"db_id","subj":"9882","obj":"MESH:D008133"},{"id":"A7","pred":"db_id","subj":"9883","obj":"MESH:D008133"},{"id":"A8","pred":"db_id","subj":"9884","obj":"MESH:D002121"},{"id":"A9","pred":"db_id","subj":"9885","obj":"MESH:D000638"},{"id":"A10","pred":"db_id","subj":"9886","obj":"MESH:D017374"},{"id":"A11","pred":"db_id","subj":"9887","obj":"MESH:D016593"},{"id":"A12","pred":"db_id","subj":"9888","obj":"MESH:D015283"},{"id":"A13","pred":"db_id","subj":"9889","obj":"MESH:D016593"},{"id":"A14","pred":"db_id","subj":"9890","obj":"MESH:D015283"},{"id":"A15","pred":"db_id","subj":"9891","obj":"MESH:D016171"},{"id":"A16","pred":"db_id","subj":"9892","obj":"MESH:D016171"},{"id":"A17","pred":"db_id","subj":"9893","obj":"MESH:D016171"},{"subj":"9878","pred":"source","obj":"LitCoin-entities"},{"subj":"9879","pred":"source","obj":"LitCoin-entities"},{"subj":"9880","pred":"source","obj":"LitCoin-entities"},{"subj":"9881","pred":"source","obj":"LitCoin-entities"},{"subj":"9882","pred":"source","obj":"LitCoin-entities"},{"subj":"9883","pred":"source","obj":"LitCoin-entities"},{"subj":"9884","pred":"source","obj":"LitCoin-entities"},{"subj":"9885","pred":"source","obj":"LitCoin-entities"},{"subj":"9886","pred":"source","obj":"LitCoin-entities"},{"subj":"9887","pred":"source","obj":"LitCoin-entities"},{"subj":"9888","pred":"source","obj":"LitCoin-entities"},{"subj":"9889","pred":"source","obj":"LitCoin-entities"},{"subj":"9890","pred":"source","obj":"LitCoin-entities"},{"subj":"9891","pred":"source","obj":"LitCoin-entities"},{"subj":"9892","pred":"source","obj":"LitCoin-entities"},{"subj":"9893","pred":"source","obj":"LitCoin-entities"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}]},{"project":"LitCoin_Mondo","denotations":[{"id":"T1","span":{"begin":1191,"end":1209},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0005478"},{"subj":"T1","pred":"source","obj":"LitCoin_Mondo"}]},{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T1","span":{"begin":47,"end":51},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":193,"end":197},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":331,"end":343},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":348,"end":362},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":363,"end":370},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":487,"end":494},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":907,"end":921},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":1247,"end":1252},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"}]},{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T1","span":{"begin":0,"end":12},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":22,"end":29},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":47,"end":51},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":154,"end":157},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":168,"end":175},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":193,"end":197},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":323,"end":330},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":331,"end":343},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":348,"end":362},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":363,"end":370},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":466,"end":473},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":487,"end":494},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":564,"end":567},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":639,"end":646},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":663,"end":671},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":707,"end":710},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":832,"end":840},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":887,"end":890},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":907,"end":921},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":922,"end":930},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":996,"end":1004},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":1071,"end":1075},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":1125,"end":1133},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":1202,"end":1209},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":1247,"end":1252},"obj":"GeneOrGeneProduct"},{"id":"T26","span":{"begin":1319,"end":1326},"obj":"GeneOrGeneProduct"},{"id":"T27","span":{"begin":1416,"end":1420},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T2","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T3","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T4","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T5","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T6","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T7","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T8","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T9","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T10","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T11","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T12","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T13","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T14","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T15","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T16","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T17","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T18","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T19","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T20","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T21","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T22","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T23","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T24","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T25","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T26","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T27","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"}]},{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T1","span":{"begin":111,"end":126},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":509,"end":524},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":623,"end":638},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1191,"end":1209},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":1211,"end":1214},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":1447,"end":1450},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"originalLabel","subj":"T1","obj":"DISEASE"},{"id":"A2","pred":"originalLabel","subj":"T2","obj":"DISEASE"},{"id":"A3","pred":"originalLabel","subj":"T3","obj":"DISEASE"},{"id":"A4","pred":"originalLabel","subj":"T4","obj":"D016171"},{"id":"A5","pred":"originalLabel","subj":"T5","obj":"D016171"},{"id":"A6","pred":"originalLabel","subj":"T6","obj":"D016171"},{"subj":"T1","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T2","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T3","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T4","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T5","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T6","pred":"source","obj":"LitCoin-Disease-MeSH"}]},{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T1","span":{"begin":331,"end":343},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"}]},{"project":"LitCoin_Mondo_095","denotations":[{"id":"T1","span":{"begin":239,"end":242},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":451,"end":454},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":612,"end":615},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1274,"end":1277},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":1315,"end":1318},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":1412,"end":1415},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1428,"end":1431},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0012833"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0012833"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0012833"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0011281"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0012833"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0012833"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0011281"},{"subj":"T1","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T2","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T3","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T4","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T5","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T6","pred":"source","obj":"LitCoin_Mondo_095"},{"subj":"T7","pred":"source","obj":"LitCoin_Mondo_095"}]},{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T1","span":{"begin":111,"end":126},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":509,"end":524},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":623,"end":638},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1191,"end":1209},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":1211,"end":1214},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":1447,"end":1450},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"DISEASE"},{"id":"A2","pred":"ID:","subj":"T2","obj":"DISEASE"},{"id":"A3","pred":"ID:","subj":"T3","obj":"DISEASE"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D016171"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D016171"},{"id":"A6","pred":"ID:","subj":"T6","obj":"D016171"},{"subj":"T1","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T2","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T3","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T4","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T5","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T6","pred":"source","obj":"LitCoin-MeSH-Disease-2"}]},{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T1","span":{"begin":111,"end":126},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":509,"end":524},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":623,"end":638},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1191,"end":1209},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":1211,"end":1214},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":1447,"end":1450},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"#label","subj":"T1","obj":"DISEASE"},{"id":"A2","pred":"#label","subj":"T2","obj":"DISEASE"},{"id":"A3","pred":"#label","subj":"T3","obj":"DISEASE"},{"id":"A4","pred":"#label","subj":"T4","obj":"D016171"},{"id":"A5","pred":"#label","subj":"T5","obj":"D016171"},{"id":"A6","pred":"#label","subj":"T6","obj":"D016171"},{"subj":"T1","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T2","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T3","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T4","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T5","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T6","pred":"source","obj":"LitCoin-MONDO_bioort2019"}]},{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T1","span":{"begin":348,"end":370},"obj":"ChemicalEntity"},{"id":"T2","span":{"begin":573,"end":576},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":699,"end":702},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":907,"end":930},"obj":"ChemicalEntity"},{"id":"T7","span":{"begin":1005,"end":1015},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":1017,"end":1027},"obj":"ChemicalEntity"},{"id":"T9","span":{"begin":1029,"end":1040},"obj":"ChemicalEntity"},{"id":"T10","span":{"begin":1045,"end":1055},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":1135,"end":1146},"obj":"ChemicalEntity"},{"id":"T12","span":{"begin":1151,"end":1161},"obj":"ChemicalEntity"},{"id":"T13","span":{"begin":1295,"end":1298},"obj":"ChemicalEntity"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"ChemicalEntity"},{"id":"A2","pred":"ID:","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_17141"},{"id":"A3","pred":"ID:","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_16000"},{"id":"A4","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_17141"},{"id":"A5","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_16000"},{"id":"A6","pred":"ID:","subj":"T6","obj":"ChemicalEntity"},{"id":"A7","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_2663"},{"id":"A8","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_7936"},{"id":"A9","pred":"ID:","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_9453"},{"id":"A10","pred":"ID:","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_3723"},{"id":"A11","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_9453"},{"id":"A12","pred":"ID:","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_3723"},{"id":"A13","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_17141"},{"id":"A14","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_16000"},{"subj":"T1","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T6","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T7","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T8","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T9","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T10","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T11","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T12","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"},{"subj":"T13","pred":"source","obj":"LitCoin-Chemical-MeSH-CHEBI"}]},{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":16,"end":21},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":162,"end":167},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":573,"end":576},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":699,"end":702},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":1295,"end":1298},"obj":"OrganismTaxon"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T2","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T3","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T4","pred":"source","obj":"LitCoin-NCBITaxon-2"},{"subj":"T5","pred":"source","obj":"LitCoin-NCBITaxon-2"}]},{"project":"LitCoin-training-merged","denotations":[{"id":"T13","span":{"begin":1295,"end":1298},"obj":"ChemicalEntity"},{"id":"T12","span":{"begin":1151,"end":1161},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":1135,"end":1146},"obj":"ChemicalEntity"},{"id":"T2","span":{"begin":573,"end":576},"obj":"ChemicalEntity"},{"id":"T10","span":{"begin":1045,"end":1055},"obj":"ChemicalEntity"},{"id":"T9","span":{"begin":1029,"end":1040},"obj":"ChemicalEntity"},{"id":"T8","span":{"begin":1017,"end":1027},"obj":"ChemicalEntity"},{"id":"T7","span":{"begin":1005,"end":1015},"obj":"ChemicalEntity"},{"id":"T6","span":{"begin":907,"end":930},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":699,"end":702},"obj":"ChemicalEntity"},{"id":"T1","span":{"begin":348,"end":370},"obj":"ChemicalEntity"},{"id":"T82412","span":{"begin":331,"end":343},"obj":"GeneOrGeneProduct"},{"id":"T41537","span":{"begin":1447,"end":1450},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":1211,"end":1214},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T55776","span":{"begin":1191,"end":1209},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":623,"end":638},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11229","span":{"begin":509,"end":524},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T35311","span":{"begin":111,"end":126},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T93091","span":{"begin":1295,"end":1298},"obj":"OrganismTaxon"},{"id":"T79209","span":{"begin":699,"end":702},"obj":"OrganismTaxon"},{"id":"T74729","span":{"begin":573,"end":576},"obj":"OrganismTaxon"},{"id":"T14865","span":{"begin":162,"end":167},"obj":"OrganismTaxon"},{"id":"T8106","span":{"begin":16,"end":21},"obj":"OrganismTaxon"}],"attributes":[{"id":"A14","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_16000"},{"id":"A13","pred":"ID:","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_17141"},{"id":"A12","pred":"ID:","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_3723"},{"id":"A11","pred":"ID:","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_9453"},{"id":"A10","pred":"ID:","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_3723"},{"id":"A9","pred":"ID:","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_9453"},{"id":"A8","pred":"ID:","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_7936"},{"id":"A7","pred":"ID:","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_2663"},{"id":"A6","pred":"ID:","subj":"T6","obj":"ChemicalEntity"},{"id":"A5","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_16000"},{"id":"A4","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_17141"},{"id":"A3","pred":"ID:","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_16000"},{"id":"A2","pred":"ID:","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_17141"},{"id":"A1","pred":"ID:","subj":"T1","obj":"ChemicalEntity"},{"id":"A80091","pred":"#label","subj":"T41537","obj":"D016171"},{"id":"A17097","pred":"#label","subj":"T5","obj":"D016171"},{"id":"A85572","pred":"#label","subj":"T55776","obj":"D016171"},{"id":"A85796","pred":"#label","subj":"T3","obj":"DISEASE"},{"id":"A13834","pred":"#label","subj":"T11229","obj":"DISEASE"},{"id":"A63857","pred":"#label","subj":"T35311","obj":"DISEASE"},{"subj":"T13","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T12","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T11","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T2","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T10","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T9","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T8","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T7","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T6","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T4","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T1","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T82412","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T41537","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T5","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T55776","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T3","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T11229","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T35311","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T93091","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T79209","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T74729","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T14865","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T8106","pred":"source","obj":"LitCoin-training-merged"}]},{"project":"Allie","denotations":[{"id":"SS1_24742750_1_0","span":{"begin":128,"end":152},"obj":"expanded"},{"id":"SS2_24742750_1_0","span":{"begin":154,"end":157},"obj":"abbr"},{"id":"SS1_24742750_1_1","span":{"begin":162,"end":220},"obj":"expanded"},{"id":"SS2_24742750_1_1","span":{"begin":222,"end":230},"obj":"abbr"},{"id":"SS1_24742750_4_0","span":{"begin":892,"end":896},"obj":"expanded"},{"id":"SS2_24742750_4_0","span":{"begin":887,"end":890},"obj":"abbr"},{"id":"SS1_24742750_6_0","span":{"begin":1191,"end":1209},"obj":"expanded"},{"id":"SS2_24742750_6_0","span":{"begin":1211,"end":1214},"obj":"abbr"},{"id":"SS1_24742750_6_1","span":{"begin":1247,"end":1272},"obj":"expanded"},{"id":"SS2_24742750_6_1","span":{"begin":1274,"end":1277},"obj":"abbr"}],"relations":[{"id":"AE1_24742750_1_0","pred":"abbreviatedTo","subj":"SS1_24742750_1_0","obj":"SS2_24742750_1_0"},{"id":"AE1_24742750_1_1","pred":"abbreviatedTo","subj":"SS1_24742750_1_1","obj":"SS2_24742750_1_1"},{"id":"AE1_24742750_4_0","pred":"abbreviatedTo","subj":"SS1_24742750_4_0","obj":"SS2_24742750_4_0"},{"id":"AE1_24742750_6_0","pred":"abbreviatedTo","subj":"SS1_24742750_6_0","obj":"SS2_24742750_6_0"},{"id":"AE1_24742750_6_1","pred":"abbreviatedTo","subj":"SS1_24742750_6_1","obj":"SS2_24742750_6_1"}],"attributes":[{"subj":"SS1_24742750_1_0","pred":"source","obj":"Allie"},{"subj":"SS2_24742750_1_0","pred":"source","obj":"Allie"},{"subj":"SS1_24742750_1_1","pred":"source","obj":"Allie"},{"subj":"SS2_24742750_1_1","pred":"source","obj":"Allie"},{"subj":"SS1_24742750_4_0","pred":"source","obj":"Allie"},{"subj":"SS2_24742750_4_0","pred":"source","obj":"Allie"},{"subj":"SS1_24742750_6_0","pred":"source","obj":"Allie"},{"subj":"SS2_24742750_6_0","pred":"source","obj":"Allie"},{"subj":"SS1_24742750_6_1","pred":"source","obj":"Allie"},{"subj":"SS2_24742750_6_1","pred":"source","obj":"Allie"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCoin-entities-OrganismTaxon-PD","color":"#9dec93","default":true},{"id":"LitCoin-sentences","color":"#ec93b7"},{"id":"LitCoin-entities","color":"#93d1ec"},{"id":"LitCoin_Mondo","color":"#ebec93"},{"id":"LitCoin-GeneOrGeneProduct-v2","color":"#d393ec"},{"id":"LitCoin-GeneOrGeneProduct-v0","color":"#93ecb9"},{"id":"LitCoin-Disease-MeSH","color":"#ec9f93"},{"id":"LitCoin-GeneOrGeneProduct-v3","color":"#93a1ec"},{"id":"LitCoin_Mondo_095","color":"#bbec93"},{"id":"LitCoin-MeSH-Disease-2","color":"#ec93d5"},{"id":"LitCoin-MONDO_bioort2019","color":"#93ece9"},{"id":"LitCoin-Chemical-MeSH-CHEBI","color":"#eccf93"},{"id":"LitCoin-NCBITaxon-2","color":"#b593ec"},{"id":"LitCoin-training-merged","color":"#93ec9b"},{"id":"Allie","color":"#ec93a4"}]}]}}