PubMed:24581344 / 111-729 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/24581344","sourcedb":"PubMed","sourceid":"24581344","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/24581344","text":"Extracellular matrix (ECM) disarray is found in calcific aortic valvular disease (CAVD), yet much remains to be learned about the role of individual ECM components in valvular interstitial cell (VIC) function and dysfunction. Previous clinical analyses have shown that calcification is associated with decreased collagen content, while previous in vitro work has suggested that the presence of collagen attenuates the responsiveness of VICs to pro-calcific stimuli. The current study uses whole leaflet cultures to examine the contributions of endogenous collagen in regulating the phenotype and calcification of VICs.","tracks":[{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T1","span":{"begin":0,"end":618},"obj":"BACKGROUND"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubMed_Structured_Abstracts"}]},{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T1","span":{"begin":359,"end":362},"obj":"CVCL_6758|Undefined_cell_line_type|Cricetulus griseus"},{"id":"T2","span":{"begin":359,"end":362},"obj":"CVCL_E689|Transformed_cell_line|Homo sapiens"},{"id":"T3","span":{"begin":444,"end":447},"obj":"CVCL_N817|Cancer_cell_line|Homo sapiens"}],"attributes":[{"subj":"T1","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T2","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T3","pred":"source","obj":"Goldhamster2_Cellosaurus"}]},{"project":"GoldHamster","denotations":[{"id":"T10","span":{"begin":0,"end":20},"obj":"GO:0031012"},{"id":"T11","span":{"begin":14,"end":20},"obj":"UBERON:0027368"},{"id":"T12","span":{"begin":22,"end":25},"obj":"PR:Q13201"},{"id":"T14","span":{"begin":22,"end":25},"obj":"PR:000010492"},{"id":"T13","span":{"begin":22,"end":25},"obj":"UBERON:4000022"},{"id":"T15","span":{"begin":73,"end":80},"obj":"D004194"},{"id":"T16","span":{"begin":73,"end":80},"obj":"D004194"},{"id":"T17","span":{"begin":82,"end":86},"obj":"C535984"},{"id":"T18","span":{"begin":149,"end":152},"obj":"PR:Q13201"},{"id":"T20","span":{"begin":149,"end":152},"obj":"PR:000010492"},{"id":"T19","span":{"begin":149,"end":152},"obj":"UBERON:4000022"},{"id":"T21","span":{"begin":176,"end":193},"obj":"CL:0000178"},{"id":"T22","span":{"begin":195,"end":198},"obj":"PR:000006898"},{"id":"T23","span":{"begin":195,"end":198},"obj":"P23943"},{"id":"T24","span":{"begin":195,"end":198},"obj":"P22389"},{"id":"T26","span":{"begin":312,"end":320},"obj":"2714"},{"id":"T27","span":{"begin":312,"end":320},"obj":"D003094"},{"id":"T28","span":{"begin":312,"end":320},"obj":"CHEBI:3815"},{"id":"T25","span":{"begin":312,"end":320},"obj":"GO:0005202"},{"id":"T30","span":{"begin":394,"end":402},"obj":"2714"},{"id":"T31","span":{"begin":394,"end":402},"obj":"D003094"},{"id":"T32","span":{"begin":394,"end":402},"obj":"CHEBI:3815"},{"id":"T29","span":{"begin":394,"end":402},"obj":"GO:0005202"},{"id":"T33","span":{"begin":436,"end":440},"obj":"GO:0120095"},{"id":"T38","span":{"begin":444,"end":447},"obj":"SO:0001439"},{"id":"T34","span":{"begin":444,"end":447},"obj":"CVCL_N817"},{"id":"T35","span":{"begin":444,"end":447},"obj":"CHEBI:32871"},{"id":"T36","span":{"begin":444,"end":447},"obj":"CHEBI:32865"},{"id":"T37","span":{"begin":444,"end":447},"obj":"CHEBI:50342"},{"id":"T39","span":{"begin":444,"end":447},"obj":"CHEBI:32866"},{"id":"T41","span":{"begin":555,"end":563},"obj":"2714"},{"id":"T42","span":{"begin":555,"end":563},"obj":"D003094"},{"id":"T43","span":{"begin":555,"end":563},"obj":"CHEBI:3815"},{"id":"T40","span":{"begin":555,"end":563},"obj":"GO:0005202"},{"id":"T44","span":{"begin":613,"end":617},"obj":"GO:0120095"}],"attributes":[{"subj":"T10","pred":"source","obj":"GoldHamster"},{"subj":"T11","pred":"source","obj":"GoldHamster"},{"subj":"T12","pred":"source","obj":"GoldHamster"},{"subj":"T14","pred":"source","obj":"GoldHamster"},{"subj":"T13","pred":"source","obj":"GoldHamster"},{"subj":"T15","pred":"source","obj":"GoldHamster"},{"subj":"T16","pred":"source","obj":"GoldHamster"},{"subj":"T17","pred":"source","obj":"GoldHamster"},{"subj":"T18","pred":"source","obj":"GoldHamster"},{"subj":"T20","pred":"source","obj":"GoldHamster"},{"subj":"T19","pred":"source","obj":"GoldHamster"},{"subj":"T21","pred":"source","obj":"GoldHamster"},{"subj":"T22","pred":"source","obj":"GoldHamster"},{"subj":"T23","pred":"source","obj":"GoldHamster"},{"subj":"T24","pred":"source","obj":"GoldHamster"},{"subj":"T26","pred":"source","obj":"GoldHamster"},{"subj":"T27","pred":"source","obj":"GoldHamster"},{"subj":"T28","pred":"source","obj":"GoldHamster"},{"subj":"T25","pred":"source","obj":"GoldHamster"},{"subj":"T30","pred":"source","obj":"GoldHamster"},{"subj":"T31","pred":"source","obj":"GoldHamster"},{"subj":"T32","pred":"source","obj":"GoldHamster"},{"subj":"T29","pred":"source","obj":"GoldHamster"},{"subj":"T33","pred":"source","obj":"GoldHamster"},{"subj":"T38","pred":"source","obj":"GoldHamster"},{"subj":"T34","pred":"source","obj":"GoldHamster"},{"subj":"T35","pred":"source","obj":"GoldHamster"},{"subj":"T36","pred":"source","obj":"GoldHamster"},{"subj":"T37","pred":"source","obj":"GoldHamster"},{"subj":"T39","pred":"source","obj":"GoldHamster"},{"subj":"T41","pred":"source","obj":"GoldHamster"},{"subj":"T42","pred":"source","obj":"GoldHamster"},{"subj":"T43","pred":"source","obj":"GoldHamster"},{"subj":"T40","pred":"source","obj":"GoldHamster"},{"subj":"T44","pred":"source","obj":"GoldHamster"}]},{"project":"Allie","denotations":[{"id":"SS1_24581344_2_0","span":{"begin":0,"end":20},"obj":"expanded"},{"id":"SS2_24581344_2_0","span":{"begin":22,"end":25},"obj":"abbr"},{"id":"SS1_24581344_2_1","span":{"begin":48,"end":80},"obj":"expanded"},{"id":"SS2_24581344_2_1","span":{"begin":82,"end":86},"obj":"abbr"},{"id":"SS1_24581344_2_2","span":{"begin":167,"end":193},"obj":"expanded"},{"id":"SS2_24581344_2_2","span":{"begin":195,"end":198},"obj":"abbr"}],"relations":[{"id":"AE1_24581344_2_0","pred":"abbreviatedTo","subj":"SS1_24581344_2_0","obj":"SS2_24581344_2_0"},{"id":"AE1_24581344_2_1","pred":"abbreviatedTo","subj":"SS1_24581344_2_1","obj":"SS2_24581344_2_1"},{"id":"AE1_24581344_2_2","pred":"abbreviatedTo","subj":"SS1_24581344_2_2","obj":"SS2_24581344_2_2"}],"attributes":[{"subj":"SS1_24581344_2_0","pred":"source","obj":"Allie"},{"subj":"SS2_24581344_2_0","pred":"source","obj":"Allie"},{"subj":"SS1_24581344_2_1","pred":"source","obj":"Allie"},{"subj":"SS2_24581344_2_1","pred":"source","obj":"Allie"},{"subj":"SS1_24581344_2_2","pred":"source","obj":"Allie"},{"subj":"SS2_24581344_2_2","pred":"source","obj":"Allie"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubMed_Structured_Abstracts","color":"#ec93da","default":true},{"id":"Goldhamster2_Cellosaurus","color":"#93ece4"},{"id":"GoldHamster","color":"#ecca93"},{"id":"Allie","color":"#b093ec"}]}]}}