PubMed:24581344 / 111-729
Annnotations
PubMed_Structured_Abstracts
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-618 | BACKGROUND | denotes | Extracellular matrix (ECM) disarray is found in calcific aortic valvular disease (CAVD), yet much remains to be learned about the role of individual ECM components in valvular interstitial cell (VIC) function and dysfunction. Previous clinical analyses have shown that calcification is associated with decreased collagen content, while previous in vitro work has suggested that the presence of collagen attenuates the responsiveness of VICs to pro-calcific stimuli. The current study uses whole leaflet cultures to examine the contributions of endogenous collagen in regulating the phenotype and calcification of VICs. |
Goldhamster2_Cellosaurus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 359-362 | CVCL_6758|Undefined_cell_line_type|Cricetulus griseus | denotes | has |
| T2 | 359-362 | CVCL_E689|Transformed_cell_line|Homo sapiens | denotes | has |
| T3 | 444-447 | CVCL_N817|Cancer_cell_line|Homo sapiens | denotes | pro |
GoldHamster
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T10 | 0-20 | GO:0031012 | denotes | Extracellular matrix |
| T11 | 14-20 | UBERON:0027368 | denotes | matrix |
| T12 | 22-25 | PR:Q13201 | denotes | ECM |
| T14 | 22-25 | PR:000010492 | denotes | ECM |
| T13 | 22-25 | UBERON:4000022 | denotes | ECM |
| T15 | 73-80 | D004194 | denotes | disease |
| T16 | 73-80 | D004194 | denotes | disease |
| T17 | 82-86 | C535984 | denotes | CAVD |
| T18 | 149-152 | PR:Q13201 | denotes | ECM |
| T20 | 149-152 | PR:000010492 | denotes | ECM |
| T19 | 149-152 | UBERON:4000022 | denotes | ECM |
| T21 | 176-193 | CL:0000178 | denotes | interstitial cell |
| T22 | 195-198 | PR:000006898 | denotes | VIC |
| T23 | 195-198 | P23943 | denotes | VIC |
| T24 | 195-198 | P22389 | denotes | VIC |
| T26 | 312-320 | 2714 | denotes | collagen |
| T27 | 312-320 | D003094 | denotes | collagen |
| T28 | 312-320 | CHEBI:3815 | denotes | collagen |
| T25 | 312-320 | GO:0005202 | denotes | collagen |
| T30 | 394-402 | 2714 | denotes | collagen |
| T31 | 394-402 | D003094 | denotes | collagen |
| T32 | 394-402 | CHEBI:3815 | denotes | collagen |
| T29 | 394-402 | GO:0005202 | denotes | collagen |
| T33 | 436-440 | GO:0120095 | denotes | VICs |
| T38 | 444-447 | SO:0001439 | denotes | pro |
| T34 | 444-447 | CVCL_N817 | denotes | pro |
| T35 | 444-447 | CHEBI:32871 | denotes | pro |
| T36 | 444-447 | CHEBI:32865 | denotes | pro |
| T37 | 444-447 | CHEBI:50342 | denotes | pro |
| T39 | 444-447 | CHEBI:32866 | denotes | pro |
| T41 | 555-563 | 2714 | denotes | collagen |
| T42 | 555-563 | D003094 | denotes | collagen |
| T43 | 555-563 | CHEBI:3815 | denotes | collagen |
| T40 | 555-563 | GO:0005202 | denotes | collagen |
| T44 | 613-617 | GO:0120095 | denotes | VICs |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_24581344_2_0 | 0-20 | expanded | denotes | Extracellular matrix |
| SS2_24581344_2_0 | 22-25 | abbr | denotes | ECM |
| SS1_24581344_2_1 | 48-80 | expanded | denotes | calcific aortic valvular disease |
| SS2_24581344_2_1 | 82-86 | abbr | denotes | CAVD |
| SS1_24581344_2_2 | 167-193 | expanded | denotes | valvular interstitial cell |
| SS2_24581344_2_2 | 195-198 | abbr | denotes | VIC |
| AE1_24581344_2_0 | SS1_24581344_2_0 | SS2_24581344_2_0 | abbreviatedTo | Extracellular matrix,ECM |
| AE1_24581344_2_1 | SS1_24581344_2_1 | SS2_24581344_2_1 | abbreviatedTo | calcific aortic valvular disease,CAVD |
| AE1_24581344_2_2 | SS1_24581344_2_2 | SS2_24581344_2_2 | abbreviatedTo | valvular interstitial cell,VIC |