PubMed:23603907 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23603907","sourcedb":"PubMed","sourceid":"23603907","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23603907","text":"FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density.\nForkhead transcription factor FOXO3 plays a critical role in suppressing tumor growth, in part, by increasing the cell cycle inhibitor p27kip1, and Foxo3 deficiency in mice results in marked colonic epithelial proliferation. Here, we show in Foxo3-deficient colonic epithelial cells a striking increase in intracytoplasmic lipid droplets (LDs), a dynamic organelle recently observed in human tumor tissue. Although the regulation and function of LDs in non-adipocytes is unclear, we hypothesize that the anti-proliferative effect of FOXO3 was dependent on lowering LD density, thus decreasing fuel energy in both normal and colon cancer cells. In mouse colonic tumors, we found an increased expression of LD coat protein PLIN2 compared with normal colonic epithelial cells. Stimulation of LD density in human colon cancer cells led to a PI3K-dependent loss of FOXO3 and a decrease in the negative regulator of lipid metabolism in Sirtuin6 (SIRT6). Foxo3 deficiency also led to a decrease in SIRT6, revealing the existence of LD and FOXO3 feedback regulation in colonic cells. In parallel, LD-dependent loss of FOXO3 led to its dissociation from the promoter and decreased expression of the cell cycle inhibitor p27kip1. Stimulation of LD density promoted proliferation in colon cancer cells, whereas silencing PLIN2 or overexpression of FOXO3 inhibited proliferation. Taken together, FOXO3 and LDs might serve as new targets for therapeutic intervention of colon cancer.","tracks":[{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":95},"obj":"Sentence"},{"id":"T2","span":{"begin":96,"end":320},"obj":"Sentence"},{"id":"T3","span":{"begin":321,"end":501},"obj":"Sentence"},{"id":"T4","span":{"begin":502,"end":739},"obj":"Sentence"},{"id":"T5","span":{"begin":740,"end":869},"obj":"Sentence"},{"id":"T6","span":{"begin":870,"end":1043},"obj":"Sentence"},{"id":"T7","span":{"begin":1044,"end":1171},"obj":"Sentence"},{"id":"T8","span":{"begin":1172,"end":1315},"obj":"Sentence"},{"id":"T9","span":{"begin":1316,"end":1463},"obj":"Sentence"},{"id":"T10","span":{"begin":1464,"end":1566},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"}]},{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":27,"end":34},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T2","span":{"begin":287,"end":294},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T3","span":{"begin":354,"end":361},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T4","span":{"begin":720,"end":725},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T5","span":{"begin":749,"end":756},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T6","span":{"begin":844,"end":851},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T7","span":{"begin":905,"end":910},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T8","span":{"begin":1157,"end":1164},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T9","span":{"begin":1368,"end":1373},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T10","span":{"begin":1553,"end":1558},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"}],"attributes":[{"subj":"T1","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T2","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T3","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T4","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T5","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T6","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T7","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T8","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T9","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T10","pred":"source","obj":"Glycosmos6-MAT"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":629,"end":634},"obj":"gene:2309"},{"id":"T1","span":{"begin":720,"end":732},"obj":"disease:C0007102"},{"id":"T2","span":{"begin":629,"end":634},"obj":"gene:2309"},{"id":"T3","span":{"begin":720,"end":732},"obj":"disease:C0699790"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"}]},{"project":"Allie","denotations":[{"id":"SS1_23603907_2_0","span":{"begin":419,"end":433},"obj":"expanded"},{"id":"SS2_23603907_2_0","span":{"begin":435,"end":438},"obj":"abbr"},{"id":"SS1_23603907_5_0","span":{"begin":1026,"end":1034},"obj":"expanded"},{"id":"SS2_23603907_5_0","span":{"begin":1036,"end":1041},"obj":"abbr"}],"relations":[{"id":"AE1_23603907_2_0","pred":"abbreviatedTo","subj":"SS1_23603907_2_0","obj":"SS2_23603907_2_0"},{"id":"AE1_23603907_5_0","pred":"abbreviatedTo","subj":"SS1_23603907_5_0","obj":"SS2_23603907_5_0"}],"attributes":[{"subj":"SS1_23603907_2_0","pred":"source","obj":"Allie"},{"subj":"SS2_23603907_2_0","pred":"source","obj":"Allie"},{"subj":"SS1_23603907_5_0","pred":"source","obj":"Allie"},{"subj":"SS2_23603907_5_0","pred":"source","obj":"Allie"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":169,"end":174},"obj":"HP_0002664"},{"id":"T2","span":{"begin":488,"end":493},"obj":"HP_0002664"},{"id":"T3","span":{"begin":720,"end":732},"obj":"HP_0003003"},{"id":"T4","span":{"begin":720,"end":732},"obj":"HP_0100273"},{"id":"T5","span":{"begin":726,"end":732},"obj":"HP_0002664"},{"id":"T6","span":{"begin":749,"end":763},"obj":"HP_0003003"},{"id":"T7","span":{"begin":749,"end":763},"obj":"HP_0100273"},{"id":"T8","span":{"begin":757,"end":763},"obj":"HP_0002664"},{"id":"T9","span":{"begin":905,"end":917},"obj":"HP_0003003"},{"id":"T10","span":{"begin":905,"end":917},"obj":"HP_0100273"},{"id":"T11","span":{"begin":911,"end":917},"obj":"HP_0002664"},{"id":"T12","span":{"begin":1368,"end":1380},"obj":"HP_0003003"},{"id":"T13","span":{"begin":1368,"end":1380},"obj":"HP_0100273"},{"id":"T14","span":{"begin":1374,"end":1380},"obj":"HP_0002664"},{"id":"T15","span":{"begin":1553,"end":1565},"obj":"HP_0003003"},{"id":"T16","span":{"begin":1553,"end":1565},"obj":"HP_0100273"},{"id":"T17","span":{"begin":1559,"end":1565},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"},{"subj":"T6","pred":"source","obj":"PubmedHPO"},{"subj":"T7","pred":"source","obj":"PubmedHPO"},{"subj":"T8","pred":"source","obj":"PubmedHPO"},{"subj":"T9","pred":"source","obj":"PubmedHPO"},{"subj":"T10","pred":"source","obj":"PubmedHPO"},{"subj":"T11","pred":"source","obj":"PubmedHPO"},{"subj":"T12","pred":"source","obj":"PubmedHPO"},{"subj":"T13","pred":"source","obj":"PubmedHPO"},{"subj":"T14","pred":"source","obj":"PubmedHPO"},{"subj":"T15","pred":"source","obj":"PubmedHPO"},{"subj":"T16","pred":"source","obj":"PubmedHPO"},{"subj":"T17","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"23603907-5#63#67#gene5290","span":{"begin":933,"end":937},"obj":"gene5290"},{"id":"23603907-5#63#67#gene5291","span":{"begin":933,"end":937},"obj":"gene5291"},{"id":"23603907-5#63#67#gene5293","span":{"begin":933,"end":937},"obj":"gene5293"},{"id":"23603907-5#63#67#gene5294","span":{"begin":933,"end":937},"obj":"gene5294"},{"id":"23603907-5#166#171#gene51548","span":{"begin":1036,"end":1041},"obj":"gene51548"},{"id":"23603907-5#35#47#diseaseC0007102","span":{"begin":905,"end":917},"obj":"diseaseC0007102"},{"id":"23603907-5#35#47#diseaseC0699790","span":{"begin":905,"end":917},"obj":"diseaseC0699790"},{"id":"23603907-5#35#47#diseaseC0007102","span":{"begin":905,"end":917},"obj":"diseaseC0007102"},{"id":"23603907-5#35#47#diseaseC0699790","span":{"begin":905,"end":917},"obj":"diseaseC0699790"},{"id":"23603907-5#35#47#diseaseC0007102","span":{"begin":905,"end":917},"obj":"diseaseC0007102"},{"id":"23603907-5#35#47#diseaseC0699790","span":{"begin":905,"end":917},"obj":"diseaseC0699790"},{"id":"23603907-5#35#47#diseaseC0007102","span":{"begin":905,"end":917},"obj":"diseaseC0007102"},{"id":"23603907-5#35#47#diseaseC0699790","span":{"begin":905,"end":917},"obj":"diseaseC0699790"},{"id":"23603907-5#35#47#diseaseC0007102","span":{"begin":905,"end":917},"obj":"diseaseC0007102"},{"id":"23603907-5#35#47#diseaseC0699790","span":{"begin":905,"end":917},"obj":"diseaseC0699790"},{"id":"23603907-9#16#21#gene2309","span":{"begin":1480,"end":1485},"obj":"gene2309"},{"id":"23603907-9#89#101#diseaseC0007102","span":{"begin":1553,"end":1565},"obj":"diseaseC0007102"},{"id":"23603907-9#89#101#diseaseC0699790","span":{"begin":1553,"end":1565},"obj":"diseaseC0699790"}],"relations":[{"id":"63#67#gene529035#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5290","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529035#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5290","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529035#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5290","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529035#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5290","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529035#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5290","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529035#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5290","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529035#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5290","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529035#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5290","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529035#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5290","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529035#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5290","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529135#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5291","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529135#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5291","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529135#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5291","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529135#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5291","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529135#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5291","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529135#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5291","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529135#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5291","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529135#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5291","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529135#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5291","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529135#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5291","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529335#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5293","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529335#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5293","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529335#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5293","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529335#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5293","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529335#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5293","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529335#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5293","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529335#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5293","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529335#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5293","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529335#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5293","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529335#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5293","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529435#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5294","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529435#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5294","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529435#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5294","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529435#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5294","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529435#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5294","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529435#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5294","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529435#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5294","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529435#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5294","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"63#67#gene529435#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#63#67#gene5294","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"63#67#gene529435#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#63#67#gene5294","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"166#171#gene5154835#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#166#171#gene51548","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"166#171#gene5154835#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#166#171#gene51548","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"166#171#gene5154835#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#166#171#gene51548","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"166#171#gene5154835#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#166#171#gene51548","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"166#171#gene5154835#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#166#171#gene51548","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"166#171#gene5154835#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#166#171#gene51548","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"166#171#gene5154835#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#166#171#gene51548","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"166#171#gene5154835#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#166#171#gene51548","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"166#171#gene5154835#47#diseaseC0007102","pred":"associated_with","subj":"23603907-5#166#171#gene51548","obj":"23603907-5#35#47#diseaseC0007102"},{"id":"166#171#gene5154835#47#diseaseC0699790","pred":"associated_with","subj":"23603907-5#166#171#gene51548","obj":"23603907-5#35#47#diseaseC0699790"},{"id":"16#21#gene230989#101#diseaseC0007102","pred":"associated_with","subj":"23603907-9#16#21#gene2309","obj":"23603907-9#89#101#diseaseC0007102"},{"id":"16#21#gene230989#101#diseaseC0699790","pred":"associated_with","subj":"23603907-9#16#21#gene2309","obj":"23603907-9#89#101#diseaseC0699790"}],"attributes":[{"subj":"23603907-5#63#67#gene5290","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23603907-5#63#67#gene5291","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23603907-5#63#67#gene5293","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23603907-5#63#67#gene5294","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23603907-5#166#171#gene51548","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23603907-5#35#47#diseaseC0007102","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23603907-5#35#47#diseaseC0699790","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23603907-5#35#47#diseaseC0007102","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23603907-5#35#47#diseaseC0699790","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23603907-5#35#47#diseaseC0007102","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23603907-5#35#47#diseaseC0699790","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23603907-5#35#47#diseaseC0007102","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23603907-5#35#47#diseaseC0699790","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23603907-5#35#47#diseaseC0007102","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23603907-5#35#47#diseaseC0699790","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23603907-9#16#21#gene2309","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23603907-9#89#101#diseaseC0007102","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"23603907-9#89#101#diseaseC0699790","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":169,"end":174},"obj":"Disease"},{"id":"T2","span":{"begin":488,"end":493},"obj":"Disease"},{"id":"T3","span":{"begin":720,"end":732},"obj":"Disease"},{"id":"T4","span":{"begin":749,"end":763},"obj":"Disease"},{"id":"T6","span":{"begin":905,"end":917},"obj":"Disease"},{"id":"T7","span":{"begin":1368,"end":1380},"obj":"Disease"},{"id":"T8","span":{"begin":1553,"end":1565},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0021063"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0002278"},{"id":"A5","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005401"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0021063"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0021063"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0021063"},{"subj":"T1","pred":"source","obj":"mondo_disease"},{"subj":"T2","pred":"source","obj":"mondo_disease"},{"subj":"T3","pred":"source","obj":"mondo_disease"},{"subj":"T4","pred":"source","obj":"mondo_disease"},{"subj":"T6","pred":"source","obj":"mondo_disease"},{"subj":"T7","pred":"source","obj":"mondo_disease"},{"subj":"T8","pred":"source","obj":"mondo_disease"}]},{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":27,"end":34},"obj":"Body_part"},{"id":"T2","span":{"begin":287,"end":294},"obj":"Body_part"},{"id":"T3","span":{"begin":354,"end":361},"obj":"Body_part"},{"id":"T4","span":{"begin":720,"end":725},"obj":"Body_part"},{"id":"T5","span":{"begin":749,"end":756},"obj":"Body_part"},{"id":"T6","span":{"begin":844,"end":851},"obj":"Body_part"},{"id":"T7","span":{"begin":905,"end":910},"obj":"Body_part"},{"id":"T8","span":{"begin":1157,"end":1164},"obj":"Body_part"},{"id":"T9","span":{"begin":1368,"end":1373},"obj":"Body_part"},{"id":"T10","span":{"begin":1553,"end":1558},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"A2","pred":"mat_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"A3","pred":"mat_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"A4","pred":"mat_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"A5","pred":"mat_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"A6","pred":"mat_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"A7","pred":"mat_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"A8","pred":"mat_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"A9","pred":"mat_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"A10","pred":"mat_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"subj":"T1","pred":"source","obj":"Anatomy-MAT"},{"subj":"T2","pred":"source","obj":"Anatomy-MAT"},{"subj":"T3","pred":"source","obj":"Anatomy-MAT"},{"subj":"T4","pred":"source","obj":"Anatomy-MAT"},{"subj":"T5","pred":"source","obj":"Anatomy-MAT"},{"subj":"T6","pred":"source","obj":"Anatomy-MAT"},{"subj":"T7","pred":"source","obj":"Anatomy-MAT"},{"subj":"T8","pred":"source","obj":"Anatomy-MAT"},{"subj":"T9","pred":"source","obj":"Anatomy-MAT"},{"subj":"T10","pred":"source","obj":"Anatomy-MAT"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":264,"end":268},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":482,"end":487},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":743,"end":748},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":899,"end":904},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"10088"},{"id":"A2","pred":"db_id","subj":"T2","obj":"9606"},{"id":"A3","pred":"db_id","subj":"T3","obj":"10088"},{"id":"A4","pred":"db_id","subj":"T3","obj":"10090"},{"id":"A5","pred":"db_id","subj":"T5","obj":"9606"},{"subj":"T1","pred":"source","obj":"NCBITAXON"},{"subj":"T2","pred":"source","obj":"NCBITAXON"},{"subj":"T3","pred":"source","obj":"NCBITAXON"},{"subj":"T5","pred":"source","obj":"NCBITAXON"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":210,"end":220},"obj":"Body_part"},{"id":"T2","span":{"begin":354,"end":378},"obj":"Body_part"},{"id":"T3","span":{"begin":451,"end":460},"obj":"Body_part"},{"id":"T4","span":{"begin":494,"end":500},"obj":"Body_part"},{"id":"T5","span":{"begin":553,"end":563},"obj":"Body_part"},{"id":"T6","span":{"begin":720,"end":725},"obj":"Body_part"},{"id":"T7","span":{"begin":844,"end":868},"obj":"Body_part"},{"id":"T8","span":{"begin":905,"end":910},"obj":"Body_part"},{"id":"T9","span":{"begin":1286,"end":1296},"obj":"Body_part"},{"id":"T10","span":{"begin":1368,"end":1373},"obj":"Body_part"},{"id":"T11","span":{"begin":1553,"end":1558},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_2000098"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_0011108"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/GO_0043226"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL_0000136"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL_0011108"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_2000098"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T2","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T3","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T4","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T5","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T6","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T7","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T8","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T9","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T10","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T11","pred":"source","obj":"Anatomy-UBERON"}]},{"project":"GlyCosmos15-HP","denotations":[{"id":"T1","span":{"begin":169,"end":174},"obj":"Phenotype"},{"id":"T2","span":{"begin":488,"end":493},"obj":"Phenotype"},{"id":"T3","span":{"begin":720,"end":732},"obj":"Phenotype"},{"id":"T4","span":{"begin":905,"end":917},"obj":"Phenotype"},{"id":"T5","span":{"begin":1368,"end":1380},"obj":"Phenotype"},{"id":"T6","span":{"begin":1553,"end":1565},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0002664"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0002664"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"HP:0003003"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"HP:0003003"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"HP:0003003"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"HP:0003003"},{"subj":"T1","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T2","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T3","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T4","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T5","pred":"source","obj":"GlyCosmos15-HP"},{"subj":"T6","pred":"source","obj":"GlyCosmos15-HP"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]},{"project":"Glycosmos15-CL","denotations":[{"id":"T1","span":{"begin":354,"end":378},"obj":"Cell"},{"id":"T2","span":{"begin":553,"end":563},"obj":"Cell"},{"id":"T3","span":{"begin":726,"end":738},"obj":"Cell"},{"id":"T4","span":{"begin":844,"end":868},"obj":"Cell"},{"id":"T5","span":{"begin":911,"end":923},"obj":"Cell"},{"id":"T6","span":{"begin":1374,"end":1386},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0011108"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000136"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0001064"},{"id":"A4","pred":"cl_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL:0011108"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0001064"},{"id":"A6","pred":"cl_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL:0001064"},{"subj":"T1","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T2","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T3","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T4","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T5","pred":"source","obj":"Glycosmos15-CL"},{"subj":"T6","pred":"source","obj":"Glycosmos15-CL"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"sentences","color":"#af93ec","default":true},{"id":"Glycosmos6-MAT","color":"#93ec95"},{"id":"DisGeNET","color":"#ec93aa"},{"id":"Allie","color":"#93c4ec"},{"id":"PubmedHPO","color":"#deec93"},{"id":"DisGeNET5_gene_disease","color":"#e093ec"},{"id":"mondo_disease","color":"#93ecc6"},{"id":"Anatomy-MAT","color":"#ecac93"},{"id":"NCBITAXON","color":"#9394ec"},{"id":"Anatomy-UBERON","color":"#aeec93"},{"id":"GlyCosmos15-HP","color":"#ec93c8"},{"id":"Glycosmos15-CL","color":"#93e2ec"}]}]}}