> top > docs > PubMed:23603907 > annotations

PubMed:23603907 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density.
T2 96-320 Sentence denotes Forkhead transcription factor FOXO3 plays a critical role in suppressing tumor growth, in part, by increasing the cell cycle inhibitor p27kip1, and Foxo3 deficiency in mice results in marked colonic epithelial proliferation.
T3 321-501 Sentence denotes Here, we show in Foxo3-deficient colonic epithelial cells a striking increase in intracytoplasmic lipid droplets (LDs), a dynamic organelle recently observed in human tumor tissue.
T4 502-739 Sentence denotes Although the regulation and function of LDs in non-adipocytes is unclear, we hypothesize that the anti-proliferative effect of FOXO3 was dependent on lowering LD density, thus decreasing fuel energy in both normal and colon cancer cells.
T5 740-869 Sentence denotes In mouse colonic tumors, we found an increased expression of LD coat protein PLIN2 compared with normal colonic epithelial cells.
T6 870-1043 Sentence denotes Stimulation of LD density in human colon cancer cells led to a PI3K-dependent loss of FOXO3 and a decrease in the negative regulator of lipid metabolism in Sirtuin6 (SIRT6).
T7 1044-1171 Sentence denotes Foxo3 deficiency also led to a decrease in SIRT6, revealing the existence of LD and FOXO3 feedback regulation in colonic cells.
T8 1172-1315 Sentence denotes In parallel, LD-dependent loss of FOXO3 led to its dissociation from the promoter and decreased expression of the cell cycle inhibitor p27kip1.
T9 1316-1463 Sentence denotes Stimulation of LD density promoted proliferation in colon cancer cells, whereas silencing PLIN2 or overexpression of FOXO3 inhibited proliferation.
T10 1464-1566 Sentence denotes Taken together, FOXO3 and LDs might serve as new targets for therapeutic intervention of colon cancer.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 27-34 http://purl.obolibrary.org/obo/MAT_0000526 denotes colonic
T2 287-294 http://purl.obolibrary.org/obo/MAT_0000526 denotes colonic
T3 354-361 http://purl.obolibrary.org/obo/MAT_0000526 denotes colonic
T4 720-725 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T5 749-756 http://purl.obolibrary.org/obo/MAT_0000526 denotes colonic
T6 844-851 http://purl.obolibrary.org/obo/MAT_0000526 denotes colonic
T7 905-910 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T8 1157-1164 http://purl.obolibrary.org/obo/MAT_0000526 denotes colonic
T9 1368-1373 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T10 1553-1558 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon

DisGeNET

Id Subject Object Predicate Lexical cue
T0 629-634 gene:2309 denotes FOXO3
T1 720-732 disease:C0007102 denotes colon cancer
T2 629-634 gene:2309 denotes FOXO3
T3 720-732 disease:C0699790 denotes colon cancer
R1 T0 T1 associated_with FOXO3,colon cancer
R2 T2 T3 associated_with FOXO3,colon cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_23603907_2_0 419-433 expanded denotes lipid droplets
SS2_23603907_2_0 435-438 abbr denotes LDs
SS1_23603907_5_0 1026-1034 expanded denotes Sirtuin6
SS2_23603907_5_0 1036-1041 abbr denotes SIRT6
AE1_23603907_2_0 SS1_23603907_2_0 SS2_23603907_2_0 abbreviatedTo lipid droplets,LDs
AE1_23603907_5_0 SS1_23603907_5_0 SS2_23603907_5_0 abbreviatedTo Sirtuin6,SIRT6

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 169-174 HP_0002664 denotes tumor
T2 488-493 HP_0002664 denotes tumor
T3 720-732 HP_0003003 denotes colon cancer
T4 720-732 HP_0100273 denotes colon cancer
T5 726-732 HP_0002664 denotes cancer
T6 749-763 HP_0003003 denotes colonic tumors
T7 749-763 HP_0100273 denotes colonic tumors
T8 757-763 HP_0002664 denotes tumors
T9 905-917 HP_0003003 denotes colon cancer
T10 905-917 HP_0100273 denotes colon cancer
T11 911-917 HP_0002664 denotes cancer
T12 1368-1380 HP_0003003 denotes colon cancer
T13 1368-1380 HP_0100273 denotes colon cancer
T14 1374-1380 HP_0002664 denotes cancer
T15 1553-1565 HP_0003003 denotes colon cancer
T16 1553-1565 HP_0100273 denotes colon cancer
T17 1559-1565 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23603907-5#63#67#gene5290 933-937 gene5290 denotes PI3K
23603907-5#63#67#gene5291 933-937 gene5291 denotes PI3K
23603907-5#63#67#gene5293 933-937 gene5293 denotes PI3K
23603907-5#63#67#gene5294 933-937 gene5294 denotes PI3K
23603907-5#166#171#gene51548 1036-1041 gene51548 denotes SIRT6
23603907-5#35#47#diseaseC0007102 905-917 diseaseC0007102 denotes colon cancer
23603907-5#35#47#diseaseC0699790 905-917 diseaseC0699790 denotes colon cancer
23603907-5#35#47#diseaseC0007102 905-917 diseaseC0007102 denotes colon cancer
23603907-5#35#47#diseaseC0699790 905-917 diseaseC0699790 denotes colon cancer
23603907-5#35#47#diseaseC0007102 905-917 diseaseC0007102 denotes colon cancer
23603907-5#35#47#diseaseC0699790 905-917 diseaseC0699790 denotes colon cancer
23603907-5#35#47#diseaseC0007102 905-917 diseaseC0007102 denotes colon cancer
23603907-5#35#47#diseaseC0699790 905-917 diseaseC0699790 denotes colon cancer
23603907-5#35#47#diseaseC0007102 905-917 diseaseC0007102 denotes colon cancer
23603907-5#35#47#diseaseC0699790 905-917 diseaseC0699790 denotes colon cancer
23603907-9#16#21#gene2309 1480-1485 gene2309 denotes FOXO3
23603907-9#89#101#diseaseC0007102 1553-1565 diseaseC0007102 denotes colon cancer
23603907-9#89#101#diseaseC0699790 1553-1565 diseaseC0699790 denotes colon cancer
63#67#gene529035#47#diseaseC0007102 23603907-5#63#67#gene5290 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529035#47#diseaseC0699790 23603907-5#63#67#gene5290 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529035#47#diseaseC0007102 23603907-5#63#67#gene5290 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529035#47#diseaseC0699790 23603907-5#63#67#gene5290 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529035#47#diseaseC0007102 23603907-5#63#67#gene5290 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529035#47#diseaseC0699790 23603907-5#63#67#gene5290 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529035#47#diseaseC0007102 23603907-5#63#67#gene5290 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529035#47#diseaseC0699790 23603907-5#63#67#gene5290 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529035#47#diseaseC0007102 23603907-5#63#67#gene5290 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529035#47#diseaseC0699790 23603907-5#63#67#gene5290 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529135#47#diseaseC0007102 23603907-5#63#67#gene5291 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529135#47#diseaseC0699790 23603907-5#63#67#gene5291 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529135#47#diseaseC0007102 23603907-5#63#67#gene5291 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529135#47#diseaseC0699790 23603907-5#63#67#gene5291 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529135#47#diseaseC0007102 23603907-5#63#67#gene5291 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529135#47#diseaseC0699790 23603907-5#63#67#gene5291 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529135#47#diseaseC0007102 23603907-5#63#67#gene5291 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529135#47#diseaseC0699790 23603907-5#63#67#gene5291 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529135#47#diseaseC0007102 23603907-5#63#67#gene5291 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529135#47#diseaseC0699790 23603907-5#63#67#gene5291 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529335#47#diseaseC0007102 23603907-5#63#67#gene5293 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529335#47#diseaseC0699790 23603907-5#63#67#gene5293 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529335#47#diseaseC0007102 23603907-5#63#67#gene5293 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529335#47#diseaseC0699790 23603907-5#63#67#gene5293 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529335#47#diseaseC0007102 23603907-5#63#67#gene5293 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529335#47#diseaseC0699790 23603907-5#63#67#gene5293 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529335#47#diseaseC0007102 23603907-5#63#67#gene5293 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529335#47#diseaseC0699790 23603907-5#63#67#gene5293 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529335#47#diseaseC0007102 23603907-5#63#67#gene5293 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529335#47#diseaseC0699790 23603907-5#63#67#gene5293 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529435#47#diseaseC0007102 23603907-5#63#67#gene5294 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529435#47#diseaseC0699790 23603907-5#63#67#gene5294 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529435#47#diseaseC0007102 23603907-5#63#67#gene5294 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529435#47#diseaseC0699790 23603907-5#63#67#gene5294 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529435#47#diseaseC0007102 23603907-5#63#67#gene5294 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529435#47#diseaseC0699790 23603907-5#63#67#gene5294 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529435#47#diseaseC0007102 23603907-5#63#67#gene5294 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529435#47#diseaseC0699790 23603907-5#63#67#gene5294 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
63#67#gene529435#47#diseaseC0007102 23603907-5#63#67#gene5294 23603907-5#35#47#diseaseC0007102 associated_with PI3K,colon cancer
63#67#gene529435#47#diseaseC0699790 23603907-5#63#67#gene5294 23603907-5#35#47#diseaseC0699790 associated_with PI3K,colon cancer
166#171#gene5154835#47#diseaseC0007102 23603907-5#166#171#gene51548 23603907-5#35#47#diseaseC0007102 associated_with SIRT6,colon cancer
166#171#gene5154835#47#diseaseC0699790 23603907-5#166#171#gene51548 23603907-5#35#47#diseaseC0699790 associated_with SIRT6,colon cancer
166#171#gene5154835#47#diseaseC0007102 23603907-5#166#171#gene51548 23603907-5#35#47#diseaseC0007102 associated_with SIRT6,colon cancer
166#171#gene5154835#47#diseaseC0699790 23603907-5#166#171#gene51548 23603907-5#35#47#diseaseC0699790 associated_with SIRT6,colon cancer
166#171#gene5154835#47#diseaseC0007102 23603907-5#166#171#gene51548 23603907-5#35#47#diseaseC0007102 associated_with SIRT6,colon cancer
166#171#gene5154835#47#diseaseC0699790 23603907-5#166#171#gene51548 23603907-5#35#47#diseaseC0699790 associated_with SIRT6,colon cancer
166#171#gene5154835#47#diseaseC0007102 23603907-5#166#171#gene51548 23603907-5#35#47#diseaseC0007102 associated_with SIRT6,colon cancer
166#171#gene5154835#47#diseaseC0699790 23603907-5#166#171#gene51548 23603907-5#35#47#diseaseC0699790 associated_with SIRT6,colon cancer
166#171#gene5154835#47#diseaseC0007102 23603907-5#166#171#gene51548 23603907-5#35#47#diseaseC0007102 associated_with SIRT6,colon cancer
166#171#gene5154835#47#diseaseC0699790 23603907-5#166#171#gene51548 23603907-5#35#47#diseaseC0699790 associated_with SIRT6,colon cancer
16#21#gene230989#101#diseaseC0007102 23603907-9#16#21#gene2309 23603907-9#89#101#diseaseC0007102 associated_with FOXO3,colon cancer
16#21#gene230989#101#diseaseC0699790 23603907-9#16#21#gene2309 23603907-9#89#101#diseaseC0699790 associated_with FOXO3,colon cancer

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 169-174 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 488-493 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T3 720-732 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T4 749-763 Disease denotes colonic tumors http://purl.obolibrary.org/obo/MONDO_0002278|http://purl.obolibrary.org/obo/MONDO_0005401
T6 905-917 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T7 1368-1380 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T8 1553-1565 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 27-34 Body_part denotes colonic http://purl.obolibrary.org/obo/MAT_0000526
T2 287-294 Body_part denotes colonic http://purl.obolibrary.org/obo/MAT_0000526
T3 354-361 Body_part denotes colonic http://purl.obolibrary.org/obo/MAT_0000526
T4 720-725 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526
T5 749-756 Body_part denotes colonic http://purl.obolibrary.org/obo/MAT_0000526
T6 844-851 Body_part denotes colonic http://purl.obolibrary.org/obo/MAT_0000526
T7 905-910 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526
T8 1157-1164 Body_part denotes colonic http://purl.obolibrary.org/obo/MAT_0000526
T9 1368-1373 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526
T10 1553-1558 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 264-268 OrganismTaxon denotes mice 10088
T2 482-487 OrganismTaxon denotes human 9606
T3 743-748 OrganismTaxon denotes mouse 10088|10090
T5 899-904 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 210-220 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T2 354-378 Body_part denotes colonic epithelial cells http://purl.obolibrary.org/obo/CL_0011108
T3 451-460 Body_part denotes organelle http://purl.obolibrary.org/obo/GO_0043226
T4 494-500 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T5 553-563 Body_part denotes adipocytes http://purl.obolibrary.org/obo/CL_0000136
T6 720-725 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T7 844-868 Body_part denotes colonic epithelial cells http://purl.obolibrary.org/obo/CL_0011108
T8 905-910 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T9 1286-1296 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T10 1368-1373 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T11 1553-1558 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 169-174 Phenotype denotes tumor HP:0002664
T2 488-493 Phenotype denotes tumor HP:0002664
T3 720-732 Phenotype denotes colon cancer HP:0003003
T4 905-917 Phenotype denotes colon cancer HP:0003003
T5 1368-1380 Phenotype denotes colon cancer HP:0003003
T6 1553-1565 Phenotype denotes colon cancer HP:0003003

Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 354-378 Cell denotes colonic epithelial cells http://purl.obolibrary.org/obo/CL:0011108
T2 553-563 Cell denotes adipocytes http://purl.obolibrary.org/obo/CL:0000136
T3 726-738 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T4 844-868 Cell denotes colonic epithelial cells http://purl.obolibrary.org/obo/CL:0011108
T5 911-923 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T6 1374-1386 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064