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c_corpus

Id Subject Object Predicate Lexical cue
T2 0-8 Q17391 denotes Cullin-3
T3 0-8 PR:000006048 denotes Cullin-3
T4 0-8 Q09760 denotes Cullin-3
T5 0-8 P53202 denotes Cullin-3
T6 0-8 Q9JLV5 denotes Cullin-3
T7 0-8 Q13618 denotes Cullin-3
T8 0-8 Q54NZ5 denotes Cullin-3
T9 0-8 B5DF89 denotes Cullin-3
T10 0-8 A4IHP4 denotes Cullin-3
T15 9-16 SO:0000104 denotes protein
T14 9-16 PR:000000001 denotes protein
T11 9-16 GO:0003675 denotes protein
T12 9-16 CHEBI:36080 denotes protein
T13 9-16 CHEBI:11122 denotes protein
T16 50-56 UBERON:0000310 denotes breast
T17 50-63 D001943 denotes breast cancer
T18 50-63 D001943 denotes breast cancer
T19 108-114 PR:000000013 denotes Cullin
T20 120-129 P68197 denotes ubiquitin
T21 120-129 P84589 denotes ubiquitin
T22 120-129 P19848 denotes ubiquitin
T24 120-129 Q8SWD4 denotes ubiquitin
T25 120-129 P62975 denotes ubiquitin
T26 120-129 P69310 denotes ubiquitin
T27 120-129 PR:000035728 denotes ubiquitin
T28 120-129 P69317 denotes ubiquitin
T29 120-129 Q865C5 denotes ubiquitin
T31 120-129 P69313 denotes ubiquitin
T33 120-129 P69326 denotes ubiquitin
T30 120-129 D025801 denotes ubiquitin
T32 120-129 CHEBI:17471 denotes ubiquitin
T23 120-129 GO:0031386 denotes ubiquitin
T37 138-141 CVCL_YD58 denotes CRL
T34 138-141 PR:Q9FI46 denotes CRL
T35 138-141 PR:000022332 denotes CRL
T36 138-141 PR:P24251 denotes CRL
T42 192-199 SO:0000104 denotes protein
T41 192-199 PR:000000001 denotes protein
T38 192-199 GO:0003675 denotes protein
T39 192-199 CHEBI:36080 denotes protein
T40 192-199 CHEBI:11122 denotes protein
T43 192-211 GO:0030163 denotes protein degradation
T46 229-237 Q17391 denotes Cullin-3
T47 229-237 PR:000006048 denotes Cullin-3
T48 229-237 Q09760 denotes Cullin-3
T49 229-237 P53202 denotes Cullin-3
T50 229-237 Q9JLV5 denotes Cullin-3
T51 229-237 Q13618 denotes Cullin-3
T52 229-237 Q54NZ5 denotes Cullin-3
T53 229-237 B5DF89 denotes Cullin-3
T54 229-237 A4IHP4 denotes Cullin-3
T55 270-275 D006801 denotes human
T56 276-283 D009369 denotes cancers
T57 276-283 D009369 denotes cancers
T59 305-313 Q17391 denotes Cullin-3
T60 305-313 PR:000006048 denotes Cullin-3
T61 305-313 Q09760 denotes Cullin-3
T62 305-313 P53202 denotes Cullin-3
T63 305-313 Q9JLV5 denotes Cullin-3
T64 305-313 Q13618 denotes Cullin-3
T65 305-313 Q54NZ5 denotes Cullin-3
T66 305-313 B5DF89 denotes Cullin-3
T67 305-313 A4IHP4 denotes Cullin-3
T68 317-322 D009369 denotes tumor
T69 317-322 D009369 denotes tumor
T72 381-394 CVCL_5552 denotes MCF10DCIS.com
T73 386-390 D002285 denotes DCIS
T75 386-390 D002285 denotes DCIS
T77 391-394 CHEBI:17905 denotes com
T78 395-400 D006801 denotes human
T79 401-407 UBERON:0000310 denotes breast
T80 401-414 D001943 denotes breast cancer
T81 401-414 D001943 denotes breast cancer
T83 445-453 Q17391 denotes Cullin-3
T84 445-453 PR:000006048 denotes Cullin-3
T85 445-453 Q09760 denotes Cullin-3
T86 445-453 P53202 denotes Cullin-3
T87 445-453 Q9JLV5 denotes Cullin-3
T88 445-453 Q13618 denotes Cullin-3
T89 445-453 Q54NZ5 denotes Cullin-3
T90 445-453 B5DF89 denotes Cullin-3
T91 445-453 A4IHP4 denotes Cullin-3
T94 511-535 D002285 denotes ductal carcinoma in situ
T95 511-535 D002285 denotes ductal carcinoma in situ
T101 537-541 CVCL_5552 denotes DCIS
T100 537-541 D002285 denotes DCIS
T102 537-541 D002285 denotes DCIS
T103 555-565 D002277 denotes carcinomas
T104 555-565 D002277 denotes carcinomas
T106 567-575 Q17391 denotes Cullin-3
T107 567-575 PR:000006048 denotes Cullin-3
T108 567-575 Q09760 denotes Cullin-3
T109 567-575 P53202 denotes Cullin-3
T110 567-575 Q9JLV5 denotes Cullin-3
T111 567-575 Q13618 denotes Cullin-3
T112 567-575 Q54NZ5 denotes Cullin-3
T113 567-575 B5DF89 denotes Cullin-3
T114 567-575 A4IHP4 denotes Cullin-3
T119 576-583 SO:0000104 denotes protein
T118 576-583 PR:000000001 denotes protein
T115 576-583 GO:0003675 denotes protein
T116 576-583 CHEBI:36080 denotes protein
T117 576-583 CHEBI:11122 denotes protein
T121 648-652 CVCL_5552 denotes DCIS
T120 648-652 D002285 denotes DCIS
T122 648-652 D002285 denotes DCIS
T123 653-659 D009369 denotes tumors
T124 653-659 D009369 denotes tumors
T125 704-711 D009369 denotes cancers
T126 704-711 D009369 denotes cancers
T127 729-739 D009362 denotes metastasis
T128 729-739 D009362 denotes metastasis
T130 767-775 Q17391 denotes Cullin-3
T131 767-775 PR:000006048 denotes Cullin-3
T132 767-775 Q09760 denotes Cullin-3
T133 767-775 P53202 denotes Cullin-3
T134 767-775 Q9JLV5 denotes Cullin-3
T135 767-775 Q13618 denotes Cullin-3
T136 767-775 Q54NZ5 denotes Cullin-3
T137 767-775 B5DF89 denotes Cullin-3
T138 767-775 A4IHP4 denotes Cullin-3
T139 796-800 UBERON:0002048 denotes lung
T141 820-828 Q17391 denotes Cullin-3
T142 820-828 PR:000006048 denotes Cullin-3
T143 820-828 Q09760 denotes Cullin-3
T144 820-828 P53202 denotes Cullin-3
T145 820-828 Q9JLV5 denotes Cullin-3
T146 820-828 Q13618 denotes Cullin-3
T147 820-828 Q54NZ5 denotes Cullin-3
T148 820-828 B5DF89 denotes Cullin-3
T149 820-828 A4IHP4 denotes Cullin-3
T150 853-858 D006801 denotes human
T151 859-865 UBERON:0000310 denotes breast
T152 859-872 D001943 denotes breast cancer
T153 859-872 D001943 denotes breast cancer
T154 896-902 UBERON:0000310 denotes breast
T155 963-968 D009369 denotes tumor
T156 963-968 D009369 denotes tumor
T158 1000-1008 Q17391 denotes Cullin-3
T159 1000-1008 PR:000006048 denotes Cullin-3
T160 1000-1008 Q09760 denotes Cullin-3
T161 1000-1008 P53202 denotes Cullin-3
T162 1000-1008 Q9JLV5 denotes Cullin-3
T163 1000-1008 Q13618 denotes Cullin-3
T164 1000-1008 Q54NZ5 denotes Cullin-3
T165 1000-1008 B5DF89 denotes Cullin-3
T166 1000-1008 A4IHP4 denotes Cullin-3
T167 1039-1044 D009369 denotes tumor
T168 1039-1044 D009369 denotes tumor
T170 1062-1066 CVCL_5552 denotes DCIS
T169 1062-1066 D002285 denotes DCIS
T171 1062-1066 D002285 denotes DCIS
T172 1105-1114 CHEBI:59163 denotes biomarker
T173 1147-1153 UBERON:0000310 denotes breast
T174 1147-1160 D001943 denotes breast cancer
T175 1147-1160 D001943 denotes breast cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_22825334_1_0 108-136 expanded denotes Cullin-Ring ubiquitin ligase
SS2_22825334_1_0 138-141 abbr denotes CRL
SS1_22825334_3_0 511-535 expanded denotes ductal carcinoma in situ
SS2_22825334_3_0 537-541 abbr denotes DCIS
AE1_22825334_1_0 SS1_22825334_1_0 SS2_22825334_1_0 abbreviatedTo Cullin-Ring ubiquitin ligase,CRL
AE1_22825334_3_0 SS1_22825334_3_0 SS2_22825334_3_0 abbreviatedTo ductal carcinoma in situ,DCIS

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-76 DRI_Outcome denotes Cullin-3 protein expression levels correlate with breast cancer progression.
T2 77-212 DRI_Challenge denotes Cullin-3 is a component of the Cullin-Ring ubiquitin ligase (CRL) family that plays an important role in mediating protein degradation.
T3 213-370 DRI_Background denotes Deregulation of Cullin-3 expression has been observed in human cancers; however, a role for Cullin-3 in tumor progression has not been previously recognized.
T4 371-566 DRI_Outcome denotes Using the MCF10DCIS.com human breast cancer xenograft model, we show that Cullin-3 is increasingly expressed during progression from comedo ductal carcinoma in situ (DCIS) to invasive carcinomas.
T5 567-712 DRI_Background denotes Cullin-3 protein is not detected in early lesions but is noticeably increased in DCIS tumors and significantly overexpressed in invasive cancers.
T6 713-806 DRI_Background denotes In experimental metastasis assays, high expression of Cullin-3 was observed in the lung site.
T7 807-975 DRI_Outcome denotes Importantly, Cullin-3 staining is detected in human breast cancer tissues, not in normal breast tissues and its expression level positively correlates with tumor stage.
T8 976-1161 DRI_Approach denotes These data suggest that Cullin-3 may play an important role in tumor progression from DCIS to invasive cancer and may serve as a biomarker for the diagnosis of aggressive breast cancer.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 77-212 DRI_Challenge denotes Cullin-3 is a component of the Cullin-Ring ubiquitin ligase (CRL) family that plays an important role in mediating protein degradation.
T2 213-370 DRI_Background denotes Deregulation of Cullin-3 expression has been observed in human cancers; however, a role for Cullin-3 in tumor progression has not been previously recognized.
T3 371-566 DRI_Outcome denotes Using the MCF10DCIS.com human breast cancer xenograft model, we show that Cullin-3 is increasingly expressed during progression from comedo ductal carcinoma in situ (DCIS) to invasive carcinomas.
T4 567-712 DRI_Background denotes Cullin-3 protein is not detected in early lesions but is noticeably increased in DCIS tumors and significantly overexpressed in invasive cancers.
T5 713-806 DRI_Background denotes In experimental metastasis assays, high expression of Cullin-3 was observed in the lung site.
T6 807-975 DRI_Outcome denotes Importantly, Cullin-3 staining is detected in human breast cancer tissues, not in normal breast tissues and its expression level positively correlates with tumor stage.
T7 976-1161 DRI_Approach denotes These data suggest that Cullin-3 may play an important role in tumor progression from DCIS to invasive cancer and may serve as a biomarker for the diagnosis of aggressive breast cancer.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 276-283 HP_0002664 denotes cancers
T2 317-322 HP_0002664 denotes tumor
T3 401-414 HP_0003002 denotes breast cancer
T4 401-414 HP_0100013 denotes breast cancer
T5 408-414 HP_0002664 denotes cancer
T6 653-659 HP_0002664 denotes tumors
T7 704-711 HP_0002664 denotes cancers
T8 859-872 HP_0003002 denotes breast cancer
T9 859-872 HP_0100013 denotes breast cancer
T10 866-872 HP_0002664 denotes cancer
T11 963-968 HP_0002664 denotes tumor
T12 1039-1044 HP_0002664 denotes tumor
T13 1079-1085 HP_0002664 denotes cancer
T14 1136-1146 HP_0000718 denotes aggressive
T15 1147-1160 HP_0003002 denotes breast cancer
T16 1147-1160 HP_0100013 denotes breast cancer
T17 1154-1160 HP_0002664 denotes cancer