PubMed:22825334 JSON TXT

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Allie

{"project":"Allie","denotations":[{"id":"SS1_22825334_1_0","span":{"begin":108,"end":136},"obj":"expanded"},{"id":"SS2_22825334_1_0","span":{"begin":138,"end":141},"obj":"abbr"},{"id":"SS1_22825334_3_0","span":{"begin":511,"end":535},"obj":"expanded"},{"id":"SS2_22825334_3_0","span":{"begin":537,"end":541},"obj":"abbr"}],"relations":[{"id":"AE1_22825334_1_0","pred":"abbreviatedTo","subj":"SS1_22825334_1_0","obj":"SS2_22825334_1_0"},{"id":"AE1_22825334_3_0","pred":"abbreviatedTo","subj":"SS1_22825334_3_0","obj":"SS2_22825334_3_0"}],"text":"Cullin-3 protein expression levels correlate with breast cancer progression.\nCullin-3 is a component of the Cullin-Ring ubiquitin ligase (CRL) family that plays an important role in mediating protein degradation. Deregulation of Cullin-3 expression has been observed in human cancers; however, a role for Cullin-3 in tumor progression has not been previously recognized. Using the MCF10DCIS.com human breast cancer xenograft model, we show that Cullin-3 is increasingly expressed during progression from comedo ductal carcinoma in situ (DCIS) to invasive carcinomas. Cullin-3 protein is not detected in early lesions but is noticeably increased in DCIS tumors and significantly overexpressed in invasive cancers. In experimental metastasis assays, high expression of Cullin-3 was observed in the lung site. Importantly, Cullin-3 staining is detected in human breast cancer tissues, not in normal breast tissues and its expression level positively correlates with tumor stage. These data suggest that Cullin-3 may play an important role in tumor progression from DCIS to invasive cancer and may serve as a biomarker for the diagnosis of aggressive breast cancer."}

UseCases_ArguminSci_Discourse

{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T1","span":{"begin":0,"end":76},"obj":"DRI_Outcome"},{"id":"T2","span":{"begin":77,"end":212},"obj":"DRI_Challenge"},{"id":"T3","span":{"begin":213,"end":370},"obj":"DRI_Background"},{"id":"T4","span":{"begin":371,"end":566},"obj":"DRI_Outcome"},{"id":"T5","span":{"begin":567,"end":712},"obj":"DRI_Background"},{"id":"T6","span":{"begin":713,"end":806},"obj":"DRI_Background"},{"id":"T7","span":{"begin":807,"end":975},"obj":"DRI_Outcome"},{"id":"T8","span":{"begin":976,"end":1161},"obj":"DRI_Approach"}],"text":"Cullin-3 protein expression levels correlate with breast cancer progression.\nCullin-3 is a component of the Cullin-Ring ubiquitin ligase (CRL) family that plays an important role in mediating protein degradation. Deregulation of Cullin-3 expression has been observed in human cancers; however, a role for Cullin-3 in tumor progression has not been previously recognized. Using the MCF10DCIS.com human breast cancer xenograft model, we show that Cullin-3 is increasingly expressed during progression from comedo ductal carcinoma in situ (DCIS) to invasive carcinomas. Cullin-3 protein is not detected in early lesions but is noticeably increased in DCIS tumors and significantly overexpressed in invasive cancers. In experimental metastasis assays, high expression of Cullin-3 was observed in the lung site. Importantly, Cullin-3 staining is detected in human breast cancer tissues, not in normal breast tissues and its expression level positively correlates with tumor stage. These data suggest that Cullin-3 may play an important role in tumor progression from DCIS to invasive cancer and may serve as a biomarker for the diagnosis of aggressive breast cancer."}

PubMed_ArguminSci

{"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":77,"end":212},"obj":"DRI_Challenge"},{"id":"T2","span":{"begin":213,"end":370},"obj":"DRI_Background"},{"id":"T3","span":{"begin":371,"end":566},"obj":"DRI_Outcome"},{"id":"T4","span":{"begin":567,"end":712},"obj":"DRI_Background"},{"id":"T5","span":{"begin":713,"end":806},"obj":"DRI_Background"},{"id":"T6","span":{"begin":807,"end":975},"obj":"DRI_Outcome"},{"id":"T7","span":{"begin":976,"end":1161},"obj":"DRI_Approach"}],"text":"Cullin-3 protein expression levels correlate with breast cancer progression.\nCullin-3 is a component of the Cullin-Ring ubiquitin ligase (CRL) family that plays an important role in mediating protein degradation. Deregulation of Cullin-3 expression has been observed in human cancers; however, a role for Cullin-3 in tumor progression has not been previously recognized. Using the MCF10DCIS.com human breast cancer xenograft model, we show that Cullin-3 is increasingly expressed during progression from comedo ductal carcinoma in situ (DCIS) to invasive carcinomas. Cullin-3 protein is not detected in early lesions but is noticeably increased in DCIS tumors and significantly overexpressed in invasive cancers. In experimental metastasis assays, high expression of Cullin-3 was observed in the lung site. Importantly, Cullin-3 staining is detected in human breast cancer tissues, not in normal breast tissues and its expression level positively correlates with tumor stage. These data suggest that Cullin-3 may play an important role in tumor progression from DCIS to invasive cancer and may serve as a biomarker for the diagnosis of aggressive breast cancer."}

PubmedHPO

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":276,"end":283},"obj":"HP_0002664"},{"id":"T2","span":{"begin":317,"end":322},"obj":"HP_0002664"},{"id":"T3","span":{"begin":401,"end":414},"obj":"HP_0003002"},{"id":"T4","span":{"begin":401,"end":414},"obj":"HP_0100013"},{"id":"T5","span":{"begin":408,"end":414},"obj":"HP_0002664"},{"id":"T6","span":{"begin":653,"end":659},"obj":"HP_0002664"},{"id":"T7","span":{"begin":704,"end":711},"obj":"HP_0002664"},{"id":"T8","span":{"begin":859,"end":872},"obj":"HP_0003002"},{"id":"T9","span":{"begin":859,"end":872},"obj":"HP_0100013"},{"id":"T10","span":{"begin":866,"end":872},"obj":"HP_0002664"},{"id":"T11","span":{"begin":963,"end":968},"obj":"HP_0002664"},{"id":"T12","span":{"begin":1039,"end":1044},"obj":"HP_0002664"},{"id":"T13","span":{"begin":1079,"end":1085},"obj":"HP_0002664"},{"id":"T14","span":{"begin":1136,"end":1146},"obj":"HP_0000718"},{"id":"T15","span":{"begin":1147,"end":1160},"obj":"HP_0003002"},{"id":"T16","span":{"begin":1147,"end":1160},"obj":"HP_0100013"},{"id":"T17","span":{"begin":1154,"end":1160},"obj":"HP_0002664"}],"text":"Cullin-3 protein expression levels correlate with breast cancer progression.\nCullin-3 is a component of the Cullin-Ring ubiquitin ligase (CRL) family that plays an important role in mediating protein degradation. Deregulation of Cullin-3 expression has been observed in human cancers; however, a role for Cullin-3 in tumor progression has not been previously recognized. Using the MCF10DCIS.com human breast cancer xenograft model, we show that Cullin-3 is increasingly expressed during progression from comedo ductal carcinoma in situ (DCIS) to invasive carcinomas. Cullin-3 protein is not detected in early lesions but is noticeably increased in DCIS tumors and significantly overexpressed in invasive cancers. In experimental metastasis assays, high expression of Cullin-3 was observed in the lung site. Importantly, Cullin-3 staining is detected in human breast cancer tissues, not in normal breast tissues and its expression level positively correlates with tumor stage. These data suggest that Cullin-3 may play an important role in tumor progression from DCIS to invasive cancer and may serve as a biomarker for the diagnosis of aggressive breast cancer."}