PubMed:22711886 / 1748-2102 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/22711886","sourcedb":"PubMed","sourceid":"22711886","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/22711886","text":"Altogether, our results suggest that TRAF2 deficiency cooperates with BCL-2 in promoting chronic lymphocytic leukemia/small lymphocytic lymphoma in mice, possibly by specifically enforcing marginal zone B cell accumulation, increasing X-linked inhibitor of apoptosis expression, and rendering B cells independent of B cell activating factor for survival.","tracks":[{"project":"LitCoin-entities-OrganismTaxon-PD","denotations":[{"id":"T9","span":{"begin":148,"end":152},"obj":"OrganismTaxon"}],"attributes":[{"id":"A9","pred":"db_id","subj":"T9","obj":"NCBItxid:10095"},{"id":"A10","pred":"db_id","subj":"T9","obj":"NCBItxid:10088"},{"subj":"T9","pred":"source","obj":"LitCoin-entities-OrganismTaxon-PD"}]},{"project":"LitCoin-sentences","denotations":[{"id":"T18","span":{"begin":0,"end":354},"obj":"Sentence"}],"attributes":[{"subj":"T18","pred":"source","obj":"LitCoin-sentences"}]},{"project":"LitCoin-entities","denotations":[{"id":"9013","span":{"begin":37,"end":42},"obj":"GeneOrGeneProduct"},{"id":"9014","span":{"begin":70,"end":75},"obj":"GeneOrGeneProduct"},{"id":"9015","span":{"begin":89,"end":117},"obj":"DiseaseOrPhenotypicFeature"},{"id":"9016","span":{"begin":118,"end":144},"obj":"DiseaseOrPhenotypicFeature"},{"id":"9017","span":{"begin":148,"end":152},"obj":"OrganismTaxon"},{"id":"9018","span":{"begin":235,"end":266},"obj":"GeneOrGeneProduct"},{"id":"9019","span":{"begin":316,"end":340},"obj":"GeneOrGeneProduct"}],"attributes":[{"id":"A40","pred":"db_id","subj":"9013","obj":"NCBIGene:22030"},{"id":"A41","pred":"db_id","subj":"9014","obj":"NCBIGene:596"},{"id":"A42","pred":"db_id","subj":"9015","obj":"MESH:D015451"},{"id":"A43","pred":"db_id","subj":"9016","obj":"MESH:D015451"},{"id":"A44","pred":"db_id","subj":"9017","obj":"NCBITaxon:10090"},{"id":"A45","pred":"db_id","subj":"9018","obj":"NCBIGene:11798"},{"id":"A46","pred":"db_id","subj":"9019","obj":"NCBIGene:24099"},{"subj":"9013","pred":"source","obj":"LitCoin-entities"},{"subj":"9014","pred":"source","obj":"LitCoin-entities"},{"subj":"9015","pred":"source","obj":"LitCoin-entities"},{"subj":"9016","pred":"source","obj":"LitCoin-entities"},{"subj":"9017","pred":"source","obj":"LitCoin-entities"},{"subj":"9018","pred":"source","obj":"LitCoin-entities"},{"subj":"9019","pred":"source","obj":"LitCoin-entities"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}]},{"project":"LitCoin_Mondo","denotations":[{"id":"T6","span":{"begin":89,"end":144},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":109,"end":117},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":136,"end":144},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0003864"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0005059"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0005062"},{"subj":"T6","pred":"source","obj":"LitCoin_Mondo"},{"subj":"T7","pred":"source","obj":"LitCoin_Mondo"},{"subj":"T8","pred":"source","obj":"LitCoin_Mondo"}]},{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T70","span":{"begin":37,"end":42},"obj":"GeneOrGeneProduct"},{"id":"T71","span":{"begin":70,"end":75},"obj":"GeneOrGeneProduct"},{"id":"T72","span":{"begin":97,"end":108},"obj":"GeneOrGeneProduct"},{"id":"T73","span":{"begin":118,"end":123},"obj":"GeneOrGeneProduct"},{"id":"T74","span":{"begin":124,"end":135},"obj":"GeneOrGeneProduct"},{"id":"T75","span":{"begin":148,"end":152},"obj":"GeneOrGeneProduct"},{"id":"T76","span":{"begin":189,"end":197},"obj":"GeneOrGeneProduct"},{"id":"T77","span":{"begin":205,"end":209},"obj":"GeneOrGeneProduct"},{"id":"T78","span":{"begin":235,"end":266},"obj":"GeneOrGeneProduct"},{"id":"T79","span":{"begin":295,"end":300},"obj":"GeneOrGeneProduct"},{"id":"T80","span":{"begin":316,"end":340},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T70","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T71","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T72","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T73","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T74","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T75","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T76","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T77","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T78","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T79","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"},{"subj":"T80","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v0"}]},{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T40","span":{"begin":37,"end":42},"obj":"GeneOrGeneProduct"},{"id":"T41","span":{"begin":70,"end":75},"obj":"GeneOrGeneProduct"},{"id":"T42","span":{"begin":118,"end":123},"obj":"GeneOrGeneProduct"},{"id":"T43","span":{"begin":205,"end":209},"obj":"GeneOrGeneProduct"},{"id":"T44","span":{"begin":235,"end":266},"obj":"GeneOrGeneProduct"},{"id":"T45","span":{"begin":316,"end":340},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T40","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T41","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T42","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T43","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T44","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"},{"subj":"T45","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v2"}]},{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T5","span":{"begin":89,"end":117},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":118,"end":144},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A5","pred":"originalLabel","subj":"T5","obj":"D015451"},{"id":"A6","pred":"originalLabel","subj":"T6","obj":"D015451"},{"subj":"T5","pred":"source","obj":"LitCoin-Disease-MeSH"},{"subj":"T6","pred":"source","obj":"LitCoin-Disease-MeSH"}]},{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T27","span":{"begin":37,"end":42},"obj":"GeneOrGeneProduct"},{"id":"T28","span":{"begin":70,"end":75},"obj":"GeneOrGeneProduct"},{"id":"T29","span":{"begin":235,"end":266},"obj":"GeneOrGeneProduct"},{"id":"T30","span":{"begin":316,"end":340},"obj":"GeneOrGeneProduct"}],"attributes":[{"subj":"T27","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T28","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T29","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"},{"subj":"T30","pred":"source","obj":"LitCoin-GeneOrGeneProduct-v3"}]},{"project":"LitCoin_Mondo_095","denotations":[{"id":"T5","span":{"begin":89,"end":144},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0003864"},{"subj":"T5","pred":"source","obj":"LitCoin_Mondo_095"}]},{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T5","span":{"begin":89,"end":117},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":118,"end":144},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A5","pred":"ID:","subj":"T5","obj":"D015451"},{"id":"A6","pred":"ID:","subj":"T6","obj":"D015451"},{"subj":"T5","pred":"source","obj":"LitCoin-MeSH-Disease-2"},{"subj":"T6","pred":"source","obj":"LitCoin-MeSH-Disease-2"}]},{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T5","span":{"begin":89,"end":117},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":118,"end":144},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A5","pred":"#label","subj":"T5","obj":"D015451"},{"id":"A6","pred":"#label","subj":"T6","obj":"D015451"},{"subj":"T5","pred":"source","obj":"LitCoin-MONDO_bioort2019"},{"subj":"T6","pred":"source","obj":"LitCoin-MONDO_bioort2019"}]},{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T5","span":{"begin":148,"end":152},"obj":"OrganismTaxon"}],"attributes":[{"subj":"T5","pred":"source","obj":"LitCoin-NCBITaxon-2"}]},{"project":"LitCoin-training-merged","denotations":[{"id":"T30","span":{"begin":316,"end":340},"obj":"GeneOrGeneProduct"},{"id":"T29","span":{"begin":235,"end":266},"obj":"GeneOrGeneProduct"},{"id":"T28","span":{"begin":70,"end":75},"obj":"GeneOrGeneProduct"},{"id":"T27","span":{"begin":37,"end":42},"obj":"GeneOrGeneProduct"},{"id":"T12342","span":{"begin":118,"end":144},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T79355","span":{"begin":89,"end":117},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T96215","span":{"begin":148,"end":152},"obj":"OrganismTaxon"}],"attributes":[{"id":"A6","pred":"#label","subj":"T12342","obj":"D015451"},{"id":"A5","pred":"#label","subj":"T79355","obj":"D015451"},{"subj":"T30","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T29","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T28","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T27","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T12342","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T79355","pred":"source","obj":"LitCoin-training-merged"},{"subj":"T96215","pred":"source","obj":"LitCoin-training-merged"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":37,"end":42},"obj":"gene:10010"},{"id":"T1","span":{"begin":89,"end":144},"obj":"disease:C1302547"},{"id":"T2","span":{"begin":37,"end":42},"obj":"gene:7186"},{"id":"T3","span":{"begin":89,"end":144},"obj":"disease:C1302547"},{"id":"T4","span":{"begin":70,"end":75},"obj":"gene:596"},{"id":"T5","span":{"begin":89,"end":144},"obj":"disease:C1302547"},{"id":"T6","span":{"begin":316,"end":340},"obj":"gene:10673"},{"id":"T7","span":{"begin":89,"end":144},"obj":"disease:C1302547"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"},{"subj":"T6","pred":"source","obj":"DisGeNET"},{"subj":"T7","pred":"source","obj":"DisGeNET"}]},{"project":"PubmedHPO","denotations":[{"id":"T5","span":{"begin":89,"end":117},"obj":"HP_0005550"},{"id":"T6","span":{"begin":109,"end":117},"obj":"HP_0001909"},{"id":"T7","span":{"begin":136,"end":144},"obj":"HP_0002665"},{"id":"T8","span":{"begin":235,"end":243},"obj":"HP_0001417"}],"attributes":[{"subj":"T5","pred":"source","obj":"PubmedHPO"},{"subj":"T6","pred":"source","obj":"PubmedHPO"},{"subj":"T7","pred":"source","obj":"PubmedHPO"},{"subj":"T8","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"22711886-10#37#42#gene7186","span":{"begin":37,"end":42},"obj":"gene7186"},{"id":"22711886-10#70#75#gene596","span":{"begin":70,"end":75},"obj":"gene596"},{"id":"22711886-10#316#340#gene10673","span":{"begin":316,"end":340},"obj":"gene10673"},{"id":"22711886-10#89#144#diseaseC1302547","span":{"begin":89,"end":144},"obj":"diseaseC1302547"}],"relations":[{"id":"37#42#gene718689#144#diseaseC1302547","pred":"associated_with","subj":"22711886-10#37#42#gene7186","obj":"22711886-10#89#144#diseaseC1302547"},{"id":"70#75#gene59689#144#diseaseC1302547","pred":"associated_with","subj":"22711886-10#70#75#gene596","obj":"22711886-10#89#144#diseaseC1302547"},{"id":"316#340#gene1067389#144#diseaseC1302547","pred":"associated_with","subj":"22711886-10#316#340#gene10673","obj":"22711886-10#89#144#diseaseC1302547"}],"attributes":[{"subj":"22711886-10#37#42#gene7186","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22711886-10#70#75#gene596","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22711886-10#316#340#gene10673","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"22711886-10#89#144#diseaseC1302547","pred":"source","obj":"DisGeNET5_gene_disease"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCoin-entities-OrganismTaxon-PD","color":"#93beec","default":true},{"id":"LitCoin-sentences","color":"#d8ec93"},{"id":"LitCoin-entities","color":"#e693ec"},{"id":"LitCoin_Mondo","color":"#93eccc"},{"id":"LitCoin-GeneOrGeneProduct-v0","color":"#ecb293"},{"id":"LitCoin-GeneOrGeneProduct-v2","color":"#9893ec"},{"id":"LitCoin-Disease-MeSH","color":"#a8ec93"},{"id":"LitCoin-GeneOrGeneProduct-v3","color":"#ec93c2"},{"id":"LitCoin_Mondo_095","color":"#93dcec"},{"id":"LitCoin-MeSH-Disease-2","color":"#ece293"},{"id":"LitCoin-MONDO_bioort2019","color":"#c893ec"},{"id":"LitCoin-NCBITaxon-2","color":"#93ecae"},{"id":"LitCoin-training-merged","color":"#ec9493"},{"id":"DisGeNET","color":"#93abec"},{"id":"PubmedHPO","color":"#c5ec93"},{"id":"DisGeNET5_gene_disease","color":"#ec93df"}]}]}}