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PubMed:22522123 JSONTXT

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NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 149-155 OrganismTaxon denotes plants NCBItxid:3193
T2 537-542 OrganismTaxon denotes human NCBItxid:9606
T3 567-570 OrganismTaxon denotes MCF NCBItxid:11785

GlyCosmos600-CLO

Id Subject Object Predicate Lexical cue
T1 90-95 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 537-566 http://www.ebi.ac.uk/cellline#breast_cancer_cell_line denotes human breast cancer cell line
T3 567-572 http://purl.obolibrary.org/obo/CLO_0050868 denotes MCF-7
T4 910-915 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 1011-1015 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6 1247-1252 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-96 Sentence denotes Proteomic and redox-proteomic analysis of berberine-induced cytotoxicity in breast cancer cells.
TextSentencer_T2 97-237 Sentence denotes Berberine is a natural product isolated from herbal plants such as Rhizoma coptidis which has been shown to have anti-neoplastic properties.
TextSentencer_T3 238-326 Sentence denotes However, the effects of berberine on the behavior of breast cancers are largely unknown.
TextSentencer_T4 327-703 Sentence denotes To determine if berberine might be useful in the treatment of breast cancer and its cytotoxic mechanism, we analyzed the impact of berberine treatment on differential protein expression and redox regulation in human breast cancer cell line MCF-7 using lysine- and cysteine-labeling two-dimensional difference gel electrophoresis (2D-DIGE) combined with mass spectrometry (MS).
TextSentencer_T5 704-1084 Sentence denotes This study demonstrated that 96 and 22 protein features were significantly changed in protein expression and thiol reactivity, respectively and revealed that berberine-induced cytotoxicity in breast cancer cells involves dysregulation of protein folding, proteolysis, redox regulation, protein trafficking, cell signaling, electron transport, metabolism and centrosomal structure.
TextSentencer_T6 1085-1253 Sentence denotes Our work shows that this combined proteomic strategy provides a rapid method to study the molecular mechanisms of berberine-induced cytotoxicity in breast cancer cells.
TextSentencer_T7 1254-1360 Sentence denotes The identified targets may be useful for further evaluation as potential targets in breast cancer therapy.
T1 0-96 Sentence denotes Proteomic and redox-proteomic analysis of berberine-induced cytotoxicity in breast cancer cells.
T2 97-237 Sentence denotes Berberine is a natural product isolated from herbal plants such as Rhizoma coptidis which has been shown to have anti-neoplastic properties.
T3 238-326 Sentence denotes However, the effects of berberine on the behavior of breast cancers are largely unknown.
T4 327-703 Sentence denotes To determine if berberine might be useful in the treatment of breast cancer and its cytotoxic mechanism, we analyzed the impact of berberine treatment on differential protein expression and redox regulation in human breast cancer cell line MCF-7 using lysine- and cysteine-labeling two-dimensional difference gel electrophoresis (2D-DIGE) combined with mass spectrometry (MS).
T5 704-1084 Sentence denotes This study demonstrated that 96 and 22 protein features were significantly changed in protein expression and thiol reactivity, respectively and revealed that berberine-induced cytotoxicity in breast cancer cells involves dysregulation of protein folding, proteolysis, redox regulation, protein trafficking, cell signaling, electron transport, metabolism and centrosomal structure.
T6 1085-1253 Sentence denotes Our work shows that this combined proteomic strategy provides a rapid method to study the molecular mechanisms of berberine-induced cytotoxicity in breast cancer cells.
T7 1254-1360 Sentence denotes The identified targets may be useful for further evaluation as potential targets in breast cancer therapy.

GlyCosmos6-CLO

Id Subject Object Predicate Lexical cue
T1 90-95 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 537-566 http://www.ebi.ac.uk/cellline#breast_cancer_cell_line denotes human breast cancer cell line
T3 550-566 http://www.ebi.ac.uk/cellline#cancer_cell_line denotes cancer cell line
T4 557-561 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5 567-572 http://purl.obolibrary.org/obo/CLO_0050868 denotes MCF-7
T6 600-608 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeling
T7 910-915 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8 1011-1015 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T9 1247-1252 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

Allie

Id Subject Object Predicate Lexical cue
SS1_22522123_3_0 680-697 expanded denotes mass spectrometry
SS2_22522123_3_0 699-701 abbr denotes MS
AE1_22522123_3_0 SS1_22522123_3_0 SS2_22522123_3_0 abbreviatedTo mass spectrometry,MS

GlyCosmos600-FMA

Id Subject Object Predicate Lexical cue
PD-FMA-PAE-B_T1 76-82 http://purl.org/sig/ont/fma/fma9601 denotes breast
PD-FMA-PAE-B_T2 90-95 http://purl.org/sig/ont/fma/fma68646 denotes cells
PD-FMA-PAE-B_T3 291-297 http://purl.org/sig/ont/fma/fma9601 denotes breast
PD-FMA-PAE-B_T4 389-395 http://purl.org/sig/ont/fma/fma9601 denotes breast
PD-FMA-PAE-B_T5 494-501 http://purl.org/sig/ont/fma/fma67257 denotes protein
PD-FMA-PAE-B_T6 543-549 http://purl.org/sig/ont/fma/fma9601 denotes breast
PD-FMA-PAE-B_T7 557-561 http://purl.org/sig/ont/fma/fma68646 denotes cell
PD-FMA-PAE-B_T8 579-585 http://purl.org/sig/ont/fma/fma82758 denotes lysine
PD-FMA-PAE-B_T9 591-599 http://purl.org/sig/ont/fma/fma82751 denotes cysteine
PD-FMA-PAE-B_T10 743-750 http://purl.org/sig/ont/fma/fma67257 denotes protein
PD-FMA-PAE-B_T11 790-797 http://purl.org/sig/ont/fma/fma67257 denotes protein
PD-FMA-PAE-B_T12 896-902 http://purl.org/sig/ont/fma/fma9601 denotes breast
PD-FMA-PAE-B_T13 910-915 http://purl.org/sig/ont/fma/fma68646 denotes cells
PD-FMA-PAE-B_T14 942-949 http://purl.org/sig/ont/fma/fma67257 denotes protein
PD-FMA-PAE-B_T15 990-997 http://purl.org/sig/ont/fma/fma67257 denotes protein
PD-FMA-PAE-B_T16 1011-1015 http://purl.org/sig/ont/fma/fma68646 denotes cell
PD-FMA-PAE-B_T17 1062-1073 http://purl.org/sig/ont/fma/fma63837 denotes centrosomal
PD-FMA-PAE-B_T18 1233-1239 http://purl.org/sig/ont/fma/fma9601 denotes breast
PD-FMA-PAE-B_T19 1247-1252 http://purl.org/sig/ont/fma/fma68646 denotes cells
PD-FMA-PAE-B_T20 1338-1344 http://purl.org/sig/ont/fma/fma9601 denotes breast

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
PD-MONDO-B_T1 76-89 http://purl.obolibrary.org/obo/MONDO_0007254 denotes breast cancer
PD-MONDO-B_T2 83-89 http://purl.obolibrary.org/obo/MONDO_0004992 denotes cancer
PD-MONDO-B_T3 291-305 http://purl.obolibrary.org/obo/MONDO_0007254 denotes breast cancers
PD-MONDO-B_T4 389-402 http://purl.obolibrary.org/obo/MONDO_0007254 denotes breast cancer
PD-MONDO-B_T5 396-402 http://purl.obolibrary.org/obo/MONDO_0004992 denotes cancer
PD-MONDO-B_T6 543-556 http://purl.obolibrary.org/obo/MONDO_0007254 denotes breast cancer
PD-MONDO-B_T7 550-556 http://purl.obolibrary.org/obo/MONDO_0004992 denotes cancer
PD-MONDO-B_T8 896-909 http://purl.obolibrary.org/obo/MONDO_0007254 denotes breast cancer
PD-MONDO-B_T9 903-909 http://purl.obolibrary.org/obo/MONDO_0004992 denotes cancer
PD-MONDO-B_T10 1233-1246 http://purl.obolibrary.org/obo/MONDO_0007254 denotes breast cancer
PD-MONDO-B_T11 1240-1246 http://purl.obolibrary.org/obo/MONDO_0004992 denotes cancer
PD-MONDO-B_T12 1338-1351 http://purl.obolibrary.org/obo/MONDO_0007254 denotes breast cancer
PD-MONDO-B_T13 1345-1351 http://purl.obolibrary.org/obo/MONDO_0004992 denotes cancer
T1 76-89 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T2 291-305 Disease denotes breast cancers http://purl.obolibrary.org/obo/MONDO_0007254
T3 389-402 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T4 543-556 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T5 896-909 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T6 1233-1246 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T7 1338-1351 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 291-305 HP_0003002 denotes breast cancers
T2 291-305 HP_0100013 denotes breast cancers
T3 298-305 HP_0002664 denotes cancers
T4 389-402 HP_0003002 denotes breast cancer
T5 389-402 HP_0100013 denotes breast cancer
T6 396-402 HP_0002664 denotes cancer
T7 543-556 HP_0003002 denotes breast cancer
T8 543-556 HP_0100013 denotes breast cancer
T9 550-556 HP_0002664 denotes cancer
T10 896-909 HP_0003002 denotes breast cancer
T11 896-909 HP_0100013 denotes breast cancer
T12 903-909 HP_0002664 denotes cancer
T13 1233-1246 HP_0003002 denotes breast cancer
T14 1233-1246 HP_0100013 denotes breast cancer
T15 1240-1246 HP_0002664 denotes cancer
T16 1338-1351 HP_0003002 denotes breast cancer
T17 1338-1351 HP_0100013 denotes breast cancer
T18 1345-1351 HP_0002664 denotes cancer

GlyCosmos600-GlycoProteins

Id Subject Object Predicate Lexical cue
PD-GlycoProteins-B_T1 1036-1045 https://acgg.asia/db/gpdb/id/GPDB0000222 denotes transport
PD-GlycoProteins-B_T2 1036-1045 https://acgg.asia/db/gpdb/id/GPDB0001366 denotes transport
PD-GlycoProteins-B_T3 1036-1045 https://acgg.asia/db/gpdb/id/GPDB0001580 denotes transport
PD-GlycoProteins-B_T4 1036-1045 https://acgg.asia/db/gpdb/id/GPDB0001683 denotes transport
PD-GlycoProteins-B_T5 1036-1045 https://acgg.asia/db/gpdb/id/GPDB0002405 denotes transport
PD-GlycoProteins-B_T6 1036-1045 https://acgg.asia/db/gpdb/id/GPDB0002445 denotes transport
PD-GlycoProteins-B_T7 1036-1045 https://acgg.asia/db/gpdb/id/GPDB0002451 denotes transport
PD-GlycoProteins-B_T8 1036-1045 https://acgg.asia/db/gpdb/id/GPDB0002939 denotes transport
PD-GlycoProteins-B_T9 1036-1045 https://acgg.asia/db/gpdb/id/GPDB0004113 denotes transport
PD-GlycoProteins-B_T10 1036-1045 https://acgg.asia/db/gpdb/id/GPDB0004730 denotes transport
PD-GlycoProteins-B_T11 1036-1045 https://acgg.asia/db/gpdb/id/GPDB0004877 denotes transport
PD-GlycoProteins-B_T12 1036-1045 https://acgg.asia/db/gpdb/id/GPDB0005760 denotes transport
PD-GlycoProteins-B_T13 1036-1045 https://acgg.asia/db/gpdb/id/GPDB0006354 denotes transport
PD-GlycoProteins-B_T14 1036-1045 https://acgg.asia/db/gpdb/id/GPDB0006856 denotes transport
PD-GlycoProteins-B_T15 1036-1045 https://acgg.asia/db/gpdb/id/GPDB0006962 denotes transport

pubmed-enju-pas

Id Subject Object Predicate Lexical cue
EnjuParser_T0 0-9 JJ denotes Proteomic
EnjuParser_T1 10-13 CC denotes and
EnjuParser_T2 14-29 JJ denotes redox-proteomic
EnjuParser_T3 30-38 NN denotes analysis
EnjuParser_T4 39-41 IN denotes of
EnjuParser_T5 42-59 JJ denotes berberine-induced
EnjuParser_T6 60-72 NN denotes cytotoxicity
EnjuParser_T7 73-75 IN denotes in
EnjuParser_T8 76-82 NN denotes breast
EnjuParser_T9 83-89 NN denotes cancer
EnjuParser_T10 90-95 NNS denotes cells
EnjuParser_T11 97-106 NN denotes Berberine
EnjuParser_T12 107-109 VBZ denotes is
EnjuParser_T13 110-111 DT denotes a
EnjuParser_T14 112-119 JJ denotes natural
EnjuParser_T15 120-127 NN denotes product
EnjuParser_T16 128-136 VBN denotes isolated
EnjuParser_T17 137-141 IN denotes from
EnjuParser_T18 142-148 JJ denotes herbal
EnjuParser_T19 149-155 NNS denotes plants
EnjuParser_T20 156-160 JJ denotes such
EnjuParser_T21 161-163 IN denotes as
EnjuParser_T22 164-171 NN denotes Rhizoma
EnjuParser_T23 172-180 NN denotes coptidis
EnjuParser_T24 181-186 WDT denotes which
EnjuParser_T25 187-190 VBZ denotes has
EnjuParser_T26 191-195 VBN denotes been
EnjuParser_T27 196-201 VBN denotes shown
EnjuParser_T28 202-204 TO denotes to
EnjuParser_T29 205-209 VB denotes have
EnjuParser_T30 210-225 JJ denotes anti-neoplastic
EnjuParser_T31 226-236 NNS denotes properties
EnjuParser_T32 238-245 RB denotes However
EnjuParser_T33 245-246 -COMMA- denotes ,
EnjuParser_T34 247-250 DT denotes the
EnjuParser_T35 251-258 NNS denotes effects
EnjuParser_T36 259-261 IN denotes of
EnjuParser_T37 262-271 NN denotes berberine
EnjuParser_T38 272-274 IN denotes on
EnjuParser_T39 275-278 DT denotes the
EnjuParser_T40 279-287 NN denotes behavior
EnjuParser_T41 288-290 IN denotes of
EnjuParser_T42 291-297 NN denotes breast
EnjuParser_T43 298-305 NNS denotes cancers
EnjuParser_T44 306-309 VBP denotes are
EnjuParser_T45 310-317 RB denotes largely
EnjuParser_T46 318-325 JJ denotes unknown
EnjuParser_T47 327-329 TO denotes To
EnjuParser_T48 330-339 VB denotes determine
EnjuParser_T49 340-342 IN denotes if
EnjuParser_T50 343-352 NN denotes berberine
EnjuParser_T51 353-358 MD denotes might
EnjuParser_T52 359-361 VB denotes be
EnjuParser_T53 362-368 JJ denotes useful
EnjuParser_T54 369-371 IN denotes in
EnjuParser_T55 372-375 DT denotes the
EnjuParser_T56 376-385 NN denotes treatment
EnjuParser_T57 386-388 IN denotes of
EnjuParser_T58 389-395 NN denotes breast
EnjuParser_T59 396-402 NN denotes cancer
EnjuParser_T60 403-406 CC denotes and
EnjuParser_T61 407-410 PRP-DOLLAR- denotes its
EnjuParser_T62 411-420 JJ denotes cytotoxic
EnjuParser_T63 421-430 NN denotes mechanism
EnjuParser_T64 430-431 -COMMA- denotes ,
EnjuParser_T65 432-434 PRP denotes we
EnjuParser_T66 435-443 VBD denotes analyzed
EnjuParser_T67 444-447 DT denotes the
EnjuParser_T68 448-454 NN denotes impact
EnjuParser_T69 455-457 IN denotes of
EnjuParser_T70 458-467 NN denotes berberine
EnjuParser_T71 468-477 NN denotes treatment
EnjuParser_T72 478-480 IN denotes on
EnjuParser_T73 481-493 JJ denotes differential
EnjuParser_T74 494-501 NN denotes protein
EnjuParser_T75 502-512 NN denotes expression
EnjuParser_T76 513-516 CC denotes and
EnjuParser_T77 517-522 NN denotes redox
EnjuParser_T78 523-533 NN denotes regulation
EnjuParser_T79 534-536 IN denotes in
EnjuParser_T80 537-542 JJ denotes human
EnjuParser_T81 543-549 NN denotes breast
EnjuParser_T82 550-556 NN denotes cancer
EnjuParser_T83 557-561 NN denotes cell
EnjuParser_T84 562-566 NN denotes line
EnjuParser_T85 567-572 NN denotes MCF-7
EnjuParser_T86 573-578 VBG denotes using
EnjuParser_T87 579-586 NN denotes lysine-
EnjuParser_T88 587-590 CC denotes and
EnjuParser_T89 591-608 JJ denotes cysteine-labeling
EnjuParser_T90 609-624 JJ denotes two-dimensional
EnjuParser_T91 625-635 NN denotes difference
EnjuParser_T92 636-639 NN denotes gel
EnjuParser_T93 640-655 NN denotes electrophoresis
EnjuParser_T94 656-657 -LRB- denotes (
EnjuParser_T95 657-664 NN denotes 2D-DIGE
EnjuParser_T96 664-665 -RRB- denotes )
EnjuParser_T97 666-674 VBN denotes combined
EnjuParser_T98 675-679 IN denotes with
EnjuParser_T99 680-684 NN denotes mass
EnjuParser_T100 685-697 NN denotes spectrometry
EnjuParser_T101 698-699 -LRB- denotes (
EnjuParser_T102 699-701 NN denotes MS
EnjuParser_T103 701-702 -RRB- denotes )
EnjuParser_T104 704-708 DT denotes This
EnjuParser_T105 709-714 NN denotes study
EnjuParser_T106 715-727 VBD denotes demonstrated
EnjuParser_T107 728-732 IN denotes that
EnjuParser_T108 733-735 CD denotes 96
EnjuParser_T109 736-739 CC denotes and
EnjuParser_T110 740-742 CD denotes 22
EnjuParser_T111 743-750 NN denotes protein
EnjuParser_T112 751-759 NNS denotes features
EnjuParser_T113 760-764 VBD denotes were
EnjuParser_T114 765-778 RB denotes significantly
EnjuParser_T115 779-786 VBN denotes changed
EnjuParser_T116 787-789 IN denotes in
EnjuParser_T117 790-797 NN denotes protein
EnjuParser_T118 798-808 NN denotes expression
EnjuParser_T119 809-812 CC denotes and
EnjuParser_T120 813-818 NN denotes thiol
EnjuParser_T121 819-829 NN denotes reactivity
EnjuParser_T122 829-830 -COMMA- denotes ,
EnjuParser_T123 831-843 RB denotes respectively
EnjuParser_T124 844-847 CC denotes and
EnjuParser_T125 848-856 VBD denotes revealed
EnjuParser_T126 857-861 IN denotes that
EnjuParser_T127 862-879 JJ denotes berberine-induced
EnjuParser_T128 880-892 NN denotes cytotoxicity
EnjuParser_T129 893-895 IN denotes in
EnjuParser_T130 896-902 NN denotes breast
EnjuParser_T131 903-909 NN denotes cancer
EnjuParser_T132 910-915 NNS denotes cells
EnjuParser_T133 916-924 VBZ denotes involves
EnjuParser_T134 925-938 NN denotes dysregulation
EnjuParser_T135 939-941 IN denotes of
EnjuParser_T136 942-949 NN denotes protein
EnjuParser_T137 950-957 NN denotes folding
EnjuParser_T138 957-958 -COMMA- denotes ,
EnjuParser_T139 959-970 NN denotes proteolysis
EnjuParser_T140 970-971 -COMMA- denotes ,
EnjuParser_T141 972-977 NN denotes redox
EnjuParser_T142 978-988 NN denotes regulation
EnjuParser_T143 988-989 -COMMA- denotes ,
EnjuParser_T144 990-997 NN denotes protein
EnjuParser_T145 998-1009 NN denotes trafficking
EnjuParser_T146 1009-1010 -COMMA- denotes ,
EnjuParser_T147 1011-1015 NN denotes cell
EnjuParser_T148 1016-1025 NN denotes signaling
EnjuParser_T149 1025-1026 -COMMA- denotes ,
EnjuParser_T150 1027-1035 NN denotes electron
EnjuParser_T151 1036-1045 NN denotes transport
EnjuParser_T152 1045-1046 -COMMA- denotes ,
EnjuParser_T153 1047-1057 NN denotes metabolism
EnjuParser_T154 1058-1061 CC denotes and
EnjuParser_T155 1062-1073 JJ denotes centrosomal
EnjuParser_T156 1074-1083 NN denotes structure
EnjuParser_T157 1085-1088 PRP-DOLLAR- denotes Our
EnjuParser_T158 1089-1093 NN denotes work
EnjuParser_T159 1094-1099 VBZ denotes shows
EnjuParser_T160 1100-1104 IN denotes that
EnjuParser_T161 1105-1109 DT denotes this
EnjuParser_T162 1110-1118 VBN denotes combined
EnjuParser_T163 1119-1128 JJ denotes proteomic
EnjuParser_T164 1129-1137 NN denotes strategy
EnjuParser_T165 1138-1146 VBZ denotes provides
EnjuParser_T166 1147-1148 DT denotes a
EnjuParser_T167 1149-1154 JJ denotes rapid
EnjuParser_T168 1155-1161 NN denotes method
EnjuParser_T169 1162-1164 TO denotes to
EnjuParser_T170 1165-1170 VB denotes study
EnjuParser_T171 1171-1174 DT denotes the
EnjuParser_T172 1175-1184 JJ denotes molecular
EnjuParser_T173 1185-1195 NNS denotes mechanisms
EnjuParser_T174 1196-1198 IN denotes of
EnjuParser_T175 1199-1216 JJ denotes berberine-induced
EnjuParser_T176 1217-1229 NN denotes cytotoxicity
EnjuParser_T177 1230-1232 IN denotes in
EnjuParser_T178 1233-1239 NN denotes breast
EnjuParser_T179 1240-1246 NN denotes cancer
EnjuParser_T180 1247-1252 NNS denotes cells
EnjuParser_T181 1254-1257 DT denotes The
EnjuParser_T182 1258-1268 VBN denotes identified
EnjuParser_T183 1269-1276 NNS denotes targets
EnjuParser_T184 1277-1280 MD denotes may
EnjuParser_T185 1281-1283 VB denotes be
EnjuParser_T186 1284-1290 JJ denotes useful
EnjuParser_T187 1291-1294 IN denotes for
EnjuParser_T188 1295-1302 JJ denotes further
EnjuParser_T189 1303-1313 NN denotes evaluation
EnjuParser_T190 1314-1316 IN denotes as
EnjuParser_T191 1317-1326 JJ denotes potential
EnjuParser_T192 1327-1334 NNS denotes targets
EnjuParser_T193 1335-1337 IN denotes in
EnjuParser_T194 1338-1344 NN denotes breast
EnjuParser_T195 1345-1351 NN denotes cancer
EnjuParser_T196 1352-1359 NN denotes therapy
EnjuParser_R0 EnjuParser_T3 EnjuParser_T0 arg1Of analysis,Proteomic
EnjuParser_R1 EnjuParser_T0 EnjuParser_T1 arg1Of Proteomic,and
EnjuParser_R2 EnjuParser_T2 EnjuParser_T1 arg2Of redox-proteomic,and
EnjuParser_R3 EnjuParser_T3 EnjuParser_T2 arg1Of analysis,redox-proteomic
EnjuParser_R4 EnjuParser_T3 EnjuParser_T4 arg1Of analysis,of
EnjuParser_R5 EnjuParser_T6 EnjuParser_T4 arg2Of cytotoxicity,of
EnjuParser_R6 EnjuParser_T6 EnjuParser_T5 arg1Of cytotoxicity,berberine-induced
EnjuParser_R7 EnjuParser_T3 EnjuParser_T7 arg1Of analysis,in
EnjuParser_R8 EnjuParser_T10 EnjuParser_T7 arg2Of cells,in
EnjuParser_R9 EnjuParser_T10 EnjuParser_T8 arg1Of cells,breast
EnjuParser_R10 EnjuParser_T10 EnjuParser_T9 arg1Of cells,cancer
EnjuParser_R11 EnjuParser_T11 EnjuParser_T12 arg1Of Berberine,is
EnjuParser_R12 EnjuParser_T15 EnjuParser_T12 arg2Of product,is
EnjuParser_R13 EnjuParser_T15 EnjuParser_T13 arg1Of product,a
EnjuParser_R14 EnjuParser_T15 EnjuParser_T14 arg1Of product,natural
EnjuParser_R15 EnjuParser_T15 EnjuParser_T16 arg2Of product,isolated
EnjuParser_R16 EnjuParser_T16 EnjuParser_T17 arg1Of isolated,from
EnjuParser_R17 EnjuParser_T19 EnjuParser_T17 arg2Of plants,from
EnjuParser_R18 EnjuParser_T19 EnjuParser_T18 arg1Of plants,herbal
EnjuParser_R19 EnjuParser_T21 EnjuParser_T20 arg1Of as,such
EnjuParser_R20 EnjuParser_T19 EnjuParser_T21 arg1Of plants,as
EnjuParser_R21 EnjuParser_T23 EnjuParser_T21 arg2Of coptidis,as
EnjuParser_R22 EnjuParser_T23 EnjuParser_T22 arg1Of coptidis,Rhizoma
EnjuParser_R23 EnjuParser_T23 EnjuParser_T24 arg1Of coptidis,which
EnjuParser_R24 EnjuParser_T23 EnjuParser_T25 arg1Of coptidis,has
EnjuParser_R25 EnjuParser_T27 EnjuParser_T25 arg2Of shown,has
EnjuParser_R26 EnjuParser_T23 EnjuParser_T26 arg1Of coptidis,been
EnjuParser_R27 EnjuParser_T27 EnjuParser_T26 arg2Of shown,been
EnjuParser_R28 EnjuParser_T23 EnjuParser_T27 arg2Of coptidis,shown
EnjuParser_R29 EnjuParser_T29 EnjuParser_T27 arg3Of have,shown
EnjuParser_R30 EnjuParser_T29 EnjuParser_T28 arg1Of have,to
EnjuParser_R31 EnjuParser_T23 EnjuParser_T29 arg1Of coptidis,have
EnjuParser_R32 EnjuParser_T31 EnjuParser_T29 arg2Of properties,have
EnjuParser_R33 EnjuParser_T31 EnjuParser_T30 arg1Of properties,anti-neoplastic
EnjuParser_R34 EnjuParser_T44 EnjuParser_T32 arg1Of are,However
EnjuParser_R35 EnjuParser_T44 EnjuParser_T33 arg1Of are,","
EnjuParser_R36 EnjuParser_T35 EnjuParser_T34 arg1Of effects,the
EnjuParser_R37 EnjuParser_T35 EnjuParser_T36 arg1Of effects,of
EnjuParser_R38 EnjuParser_T37 EnjuParser_T36 arg2Of berberine,of
EnjuParser_R39 EnjuParser_T35 EnjuParser_T38 arg1Of effects,on
EnjuParser_R40 EnjuParser_T40 EnjuParser_T38 arg2Of behavior,on
EnjuParser_R41 EnjuParser_T40 EnjuParser_T39 arg1Of behavior,the
EnjuParser_R42 EnjuParser_T40 EnjuParser_T41 arg1Of behavior,of
EnjuParser_R43 EnjuParser_T43 EnjuParser_T41 arg2Of cancers,of
EnjuParser_R44 EnjuParser_T43 EnjuParser_T42 arg1Of cancers,breast
EnjuParser_R45 EnjuParser_T35 EnjuParser_T44 arg1Of effects,are
EnjuParser_R46 EnjuParser_T46 EnjuParser_T44 arg2Of unknown,are
EnjuParser_R47 EnjuParser_T46 EnjuParser_T45 arg1Of unknown,largely
EnjuParser_R48 EnjuParser_T35 EnjuParser_T46 arg1Of effects,unknown
EnjuParser_R49 EnjuParser_T48 EnjuParser_T47 arg1Of determine,To
EnjuParser_R50 EnjuParser_T66 EnjuParser_T47 modOf analyzed,To
EnjuParser_R51 EnjuParser_T65 EnjuParser_T48 arg1Of we,determine
EnjuParser_R52 EnjuParser_T52 EnjuParser_T48 arg2Of be,determine
EnjuParser_R53 EnjuParser_T52 EnjuParser_T49 arg1Of be,if
EnjuParser_R54 EnjuParser_T50 EnjuParser_T51 arg1Of berberine,might
EnjuParser_R55 EnjuParser_T52 EnjuParser_T51 arg2Of be,might
EnjuParser_R56 EnjuParser_T50 EnjuParser_T52 arg1Of berberine,be
EnjuParser_R57 EnjuParser_T53 EnjuParser_T52 arg2Of useful,be
EnjuParser_R58 EnjuParser_T50 EnjuParser_T53 arg1Of berberine,useful
EnjuParser_R59 EnjuParser_T52 EnjuParser_T54 arg1Of be,in
EnjuParser_R60 EnjuParser_T56 EnjuParser_T54 arg2Of treatment,in
EnjuParser_R61 EnjuParser_T56 EnjuParser_T55 arg1Of treatment,the
EnjuParser_R62 EnjuParser_T56 EnjuParser_T57 arg1Of treatment,of
EnjuParser_R63 EnjuParser_T60 EnjuParser_T57 arg2Of and,of
EnjuParser_R64 EnjuParser_T59 EnjuParser_T58 arg1Of cancer,breast
EnjuParser_R65 EnjuParser_T59 EnjuParser_T60 arg1Of cancer,and
EnjuParser_R66 EnjuParser_T63 EnjuParser_T60 arg2Of mechanism,and
EnjuParser_R67 EnjuParser_T63 EnjuParser_T61 arg1Of mechanism,its
EnjuParser_R68 EnjuParser_T63 EnjuParser_T62 arg1Of mechanism,cytotoxic
EnjuParser_R69 EnjuParser_T66 EnjuParser_T64 arg1Of analyzed,","
EnjuParser_R70 EnjuParser_T65 EnjuParser_T66 arg1Of we,analyzed
EnjuParser_R71 EnjuParser_T68 EnjuParser_T66 arg2Of impact,analyzed
EnjuParser_R72 EnjuParser_T68 EnjuParser_T67 arg1Of impact,the
EnjuParser_R73 EnjuParser_T68 EnjuParser_T69 arg1Of impact,of
EnjuParser_R74 EnjuParser_T71 EnjuParser_T69 arg2Of treatment,of
EnjuParser_R75 EnjuParser_T71 EnjuParser_T70 arg1Of treatment,berberine
EnjuParser_R76 EnjuParser_T68 EnjuParser_T72 arg1Of impact,on
EnjuParser_R77 EnjuParser_T76 EnjuParser_T72 arg2Of and,on
EnjuParser_R78 EnjuParser_T75 EnjuParser_T73 arg1Of expression,differential
EnjuParser_R79 EnjuParser_T75 EnjuParser_T74 arg1Of expression,protein
EnjuParser_R80 EnjuParser_T75 EnjuParser_T76 arg1Of expression,and
EnjuParser_R81 EnjuParser_T78 EnjuParser_T76 arg2Of regulation,and
EnjuParser_R82 EnjuParser_T78 EnjuParser_T77 arg1Of regulation,redox
EnjuParser_R83 EnjuParser_T76 EnjuParser_T79 arg1Of and,in
EnjuParser_R84 EnjuParser_T85 EnjuParser_T79 arg2Of MCF-7,in
EnjuParser_R85 EnjuParser_T85 EnjuParser_T80 arg1Of MCF-7,human
EnjuParser_R86 EnjuParser_T85 EnjuParser_T81 arg1Of MCF-7,breast
EnjuParser_R87 EnjuParser_T85 EnjuParser_T82 arg1Of MCF-7,cancer
EnjuParser_R88 EnjuParser_T85 EnjuParser_T83 arg1Of MCF-7,cell
EnjuParser_R89 EnjuParser_T85 EnjuParser_T84 arg1Of MCF-7,line
EnjuParser_R90 EnjuParser_T65 EnjuParser_T86 arg1Of we,using
EnjuParser_R91 EnjuParser_T88 EnjuParser_T86 arg2Of and,using
EnjuParser_R92 EnjuParser_T66 EnjuParser_T86 modOf analyzed,using
EnjuParser_R93 EnjuParser_T87 EnjuParser_T88 arg1Of lysine-,and
EnjuParser_R94 EnjuParser_T93 EnjuParser_T88 arg2Of electrophoresis,and
EnjuParser_R95 EnjuParser_T93 EnjuParser_T89 arg1Of electrophoresis,cysteine-labeling
EnjuParser_R96 EnjuParser_T93 EnjuParser_T90 arg1Of electrophoresis,two-dimensional
EnjuParser_R97 EnjuParser_T93 EnjuParser_T91 arg1Of electrophoresis,difference
EnjuParser_R98 EnjuParser_T93 EnjuParser_T92 arg1Of electrophoresis,gel
EnjuParser_R99 EnjuParser_T93 EnjuParser_T94 arg1Of electrophoresis,(
EnjuParser_R100 EnjuParser_T95 EnjuParser_T94 arg2Of 2D-DIGE,(
EnjuParser_R101 EnjuParser_T96 EnjuParser_T94 arg3Of ),(
EnjuParser_R102 EnjuParser_T93 EnjuParser_T97 arg2Of electrophoresis,combined
EnjuParser_R103 EnjuParser_T97 EnjuParser_T98 arg1Of combined,with
EnjuParser_R104 EnjuParser_T100 EnjuParser_T98 arg2Of spectrometry,with
EnjuParser_R105 EnjuParser_T100 EnjuParser_T99 arg1Of spectrometry,mass
EnjuParser_R106 EnjuParser_T100 EnjuParser_T101 arg1Of spectrometry,(
EnjuParser_R107 EnjuParser_T102 EnjuParser_T101 arg2Of MS,(
EnjuParser_R108 EnjuParser_T103 EnjuParser_T101 arg3Of ),(
EnjuParser_R109 EnjuParser_T105 EnjuParser_T104 arg1Of study,This
EnjuParser_R110 EnjuParser_T105 EnjuParser_T106 arg1Of study,demonstrated
EnjuParser_R111 EnjuParser_T124 EnjuParser_T106 arg2Of and,demonstrated
EnjuParser_R112 EnjuParser_T124 EnjuParser_T107 arg1Of and,that
EnjuParser_R113 EnjuParser_T112 EnjuParser_T108 arg1Of features,96
EnjuParser_R114 EnjuParser_T108 EnjuParser_T109 arg1Of 96,and
EnjuParser_R115 EnjuParser_T110 EnjuParser_T109 arg2Of 22,and
EnjuParser_R116 EnjuParser_T112 EnjuParser_T110 arg1Of features,22
EnjuParser_R117 EnjuParser_T112 EnjuParser_T111 arg1Of features,protein
EnjuParser_R118 EnjuParser_T112 EnjuParser_T113 arg1Of features,were
EnjuParser_R119 EnjuParser_T124 EnjuParser_T113 arg2Of and,were
EnjuParser_R120 EnjuParser_T124 EnjuParser_T114 arg1Of and,significantly
EnjuParser_R121 EnjuParser_T112 EnjuParser_T115 arg2Of features,changed
EnjuParser_R122 EnjuParser_T115 EnjuParser_T116 arg1Of changed,in
EnjuParser_R123 EnjuParser_T119 EnjuParser_T116 arg2Of and,in
EnjuParser_R124 EnjuParser_T118 EnjuParser_T117 arg1Of expression,protein
EnjuParser_R125 EnjuParser_T118 EnjuParser_T119 arg1Of expression,and
EnjuParser_R126 EnjuParser_T121 EnjuParser_T119 arg2Of reactivity,and
EnjuParser_R127 EnjuParser_T121 EnjuParser_T120 arg1Of reactivity,thiol
EnjuParser_R128 EnjuParser_T115 EnjuParser_T122 arg1Of changed,","
EnjuParser_R129 EnjuParser_T115 EnjuParser_T123 arg1Of changed,respectively
EnjuParser_R130 EnjuParser_T115 EnjuParser_T124 arg1Of changed,and
EnjuParser_R131 EnjuParser_T125 EnjuParser_T124 arg2Of revealed,and
EnjuParser_R132 EnjuParser_T112 EnjuParser_T125 arg1Of features,revealed
EnjuParser_R133 EnjuParser_T133 EnjuParser_T125 arg2Of involves,revealed
EnjuParser_R134 EnjuParser_T133 EnjuParser_T126 arg1Of involves,that
EnjuParser_R135 EnjuParser_T128 EnjuParser_T127 arg1Of cytotoxicity,berberine-induced
EnjuParser_R136 EnjuParser_T128 EnjuParser_T129 arg1Of cytotoxicity,in
EnjuParser_R137 EnjuParser_T132 EnjuParser_T129 arg2Of cells,in
EnjuParser_R138 EnjuParser_T132 EnjuParser_T130 arg1Of cells,breast
EnjuParser_R139 EnjuParser_T132 EnjuParser_T131 arg1Of cells,cancer
EnjuParser_R140 EnjuParser_T128 EnjuParser_T133 arg1Of cytotoxicity,involves
EnjuParser_R141 EnjuParser_T134 EnjuParser_T133 arg2Of dysregulation,involves
EnjuParser_R142 EnjuParser_T134 EnjuParser_T135 arg1Of dysregulation,of
EnjuParser_R143 EnjuParser_T146 EnjuParser_T135 arg2Of ",",of
EnjuParser_R144 EnjuParser_T137 EnjuParser_T136 arg1Of folding,protein
EnjuParser_R145 EnjuParser_T137 EnjuParser_T138 arg1Of folding,","
EnjuParser_R146 EnjuParser_T139 EnjuParser_T138 arg2Of proteolysis,","
EnjuParser_R147 EnjuParser_T138 EnjuParser_T140 arg1Of ",",","
EnjuParser_R148 EnjuParser_T142 EnjuParser_T140 arg2Of regulation,","
EnjuParser_R149 EnjuParser_T142 EnjuParser_T141 arg1Of regulation,redox
EnjuParser_R150 EnjuParser_T140 EnjuParser_T143 arg1Of ",",","
EnjuParser_R151 EnjuParser_T145 EnjuParser_T143 arg2Of trafficking,","
EnjuParser_R152 EnjuParser_T145 EnjuParser_T144 arg1Of trafficking,protein
EnjuParser_R153 EnjuParser_T143 EnjuParser_T146 arg1Of ",",","
EnjuParser_R154 EnjuParser_T154 EnjuParser_T146 arg2Of and,","
EnjuParser_R155 EnjuParser_T148 EnjuParser_T147 arg1Of signaling,cell
EnjuParser_R156 EnjuParser_T148 EnjuParser_T149 arg1Of signaling,","
EnjuParser_R157 EnjuParser_T151 EnjuParser_T149 arg2Of transport,","
EnjuParser_R158 EnjuParser_T151 EnjuParser_T150 arg1Of transport,electron
EnjuParser_R159 EnjuParser_T149 EnjuParser_T152 arg1Of ",",","
EnjuParser_R160 EnjuParser_T153 EnjuParser_T152 arg2Of metabolism,","
EnjuParser_R161 EnjuParser_T152 EnjuParser_T154 arg1Of ",",and
EnjuParser_R162 EnjuParser_T156 EnjuParser_T154 arg2Of structure,and
EnjuParser_R163 EnjuParser_T156 EnjuParser_T155 arg1Of structure,centrosomal
EnjuParser_R164 EnjuParser_T158 EnjuParser_T157 arg1Of work,Our
EnjuParser_R165 EnjuParser_T158 EnjuParser_T159 arg1Of work,shows
EnjuParser_R166 EnjuParser_T165 EnjuParser_T159 arg2Of provides,shows
EnjuParser_R167 EnjuParser_T165 EnjuParser_T160 arg1Of provides,that
EnjuParser_R168 EnjuParser_T164 EnjuParser_T161 arg1Of strategy,this
EnjuParser_R169 EnjuParser_T164 EnjuParser_T162 arg2Of strategy,combined
EnjuParser_R170 EnjuParser_T164 EnjuParser_T163 arg1Of strategy,proteomic
EnjuParser_R171 EnjuParser_T164 EnjuParser_T165 arg1Of strategy,provides
EnjuParser_R172 EnjuParser_T168 EnjuParser_T165 arg2Of method,provides
EnjuParser_R173 EnjuParser_T168 EnjuParser_T166 arg1Of method,a
EnjuParser_R174 EnjuParser_T168 EnjuParser_T167 arg1Of method,rapid
EnjuParser_R175 EnjuParser_T170 EnjuParser_T169 arg1Of study,to
EnjuParser_R176 EnjuParser_T168 EnjuParser_T169 modOf method,to
EnjuParser_R177 EnjuParser_T168 EnjuParser_T170 arg1Of method,study
EnjuParser_R178 EnjuParser_T173 EnjuParser_T170 arg2Of mechanisms,study
EnjuParser_R179 EnjuParser_T173 EnjuParser_T171 arg1Of mechanisms,the
EnjuParser_R180 EnjuParser_T173 EnjuParser_T172 arg1Of mechanisms,molecular
EnjuParser_R181 EnjuParser_T173 EnjuParser_T174 arg1Of mechanisms,of
EnjuParser_R182 EnjuParser_T176 EnjuParser_T174 arg2Of cytotoxicity,of
EnjuParser_R183 EnjuParser_T176 EnjuParser_T175 arg1Of cytotoxicity,berberine-induced
EnjuParser_R184 EnjuParser_T176 EnjuParser_T177 arg1Of cytotoxicity,in
EnjuParser_R185 EnjuParser_T180 EnjuParser_T177 arg2Of cells,in
EnjuParser_R186 EnjuParser_T180 EnjuParser_T178 arg1Of cells,breast
EnjuParser_R187 EnjuParser_T180 EnjuParser_T179 arg1Of cells,cancer
EnjuParser_R188 EnjuParser_T183 EnjuParser_T181 arg1Of targets,The
EnjuParser_R189 EnjuParser_T183 EnjuParser_T182 arg2Of targets,identified
EnjuParser_R190 EnjuParser_T183 EnjuParser_T184 arg1Of targets,may
EnjuParser_R191 EnjuParser_T185 EnjuParser_T184 arg2Of be,may
EnjuParser_R192 EnjuParser_T183 EnjuParser_T185 arg1Of targets,be
EnjuParser_R193 EnjuParser_T186 EnjuParser_T185 arg2Of useful,be
EnjuParser_R194 EnjuParser_T183 EnjuParser_T186 arg1Of targets,useful
EnjuParser_R195 EnjuParser_T186 EnjuParser_T187 arg1Of useful,for
EnjuParser_R196 EnjuParser_T189 EnjuParser_T187 arg2Of evaluation,for
EnjuParser_R197 EnjuParser_T189 EnjuParser_T188 arg1Of evaluation,further
EnjuParser_R198 EnjuParser_T189 EnjuParser_T190 arg1Of evaluation,as
EnjuParser_R199 EnjuParser_T192 EnjuParser_T190 arg2Of targets,as
EnjuParser_R200 EnjuParser_T192 EnjuParser_T191 arg1Of targets,potential
EnjuParser_R201 EnjuParser_T192 EnjuParser_T193 arg1Of targets,in
EnjuParser_R202 EnjuParser_T196 EnjuParser_T193 arg2Of therapy,in
EnjuParser_R203 EnjuParser_T196 EnjuParser_T194 arg1Of therapy,breast
EnjuParser_R204 EnjuParser_T196 EnjuParser_T195 arg1Of therapy,cancer