PubMed:2105528 JSONTXT

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{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":95},"obj":"Sentence"},{"id":"S2","span":{"begin":96,"end":254},"obj":"Sentence"},{"id":"S3","span":{"begin":255,"end":472},"obj":"Sentence"},{"id":"S4","span":{"begin":473,"end":599},"obj":"Sentence"},{"id":"S5","span":{"begin":600,"end":766},"obj":"Sentence"}],"text":"Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif.\nActivity of the immunoglobulin heavy and kappa light chain gene enhancers depends on a complex interplay of ubiquitous and developmentally regulated proteins. Two complementary DNAs were isolated that encode proteins, denoted ITF-1 and ITF-2, that are expressed in a variety of cell types and bind the microE5/kappa 2 motif found in both heavy and kappa light chain enhancers. The complementary DNAs are the products of distinct genes, yet both ITF-1 and ITF-2 are structurally and functionally similar. The two proteins interact with one another through their putative helix-loop-helix motifs and each possesses a distinct domain that dictates transcription activation."}

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