PubMed:2088505 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/2088505","sourcedb":"PubMed","sourceid":"2088505","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/2088505","text":"A novel T-cell trans-activator that recognizes a phorbol ester-inducible element of the interleukin-2 promoter.\nThe interleukin 2 (IL-2) gene promoter is recognized by several cell-type-specific and ubiquitous transcriptional regulators that integrate information transmitted by various signaling systems leading to IL-2 production and T-cell activation. Using a combination of transfection, protein-DNA binding, and in vitro transcription methods, we have discovered the novel T-cell-specific transcriptional activator TCF-1 (for T-Cell Factor-1), which recognizes a T-cell-specific response element (TCE) located within the IL-2 promoter. Although the TCE is similar in sequence to a consensus NF kappa B site, several criteria indicate that TCF-1 is distinct from NF kappa B. 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