PubMed:2088505 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":8,"end":30},"obj":"protein"},{"id":"T2","span":{"begin":49,"end":80},"obj":"DNA"},{"id":"T3","span":{"begin":88,"end":110},"obj":"DNA"},{"id":"T4","span":{"begin":116,"end":150},"obj":"DNA"},{"id":"T5","span":{"begin":176,"end":236},"obj":"protein"},{"id":"T6","span":{"begin":316,"end":320},"obj":"protein"},{"id":"T7","span":{"begin":336,"end":342},"obj":"cell_type"},{"id":"T8","span":{"begin":472,"end":519},"obj":"protein"},{"id":"T9","span":{"begin":520,"end":525},"obj":"protein"},{"id":"T10","span":{"begin":531,"end":546},"obj":"protein"},{"id":"T11","span":{"begin":568,"end":600},"obj":"DNA"},{"id":"T12","span":{"begin":602,"end":605},"obj":"DNA"},{"id":"T13","span":{"begin":626,"end":639},"obj":"DNA"},{"id":"T14","span":{"begin":654,"end":657},"obj":"DNA"},{"id":"T15","span":{"begin":686,"end":711},"obj":"DNA"},{"id":"T16","span":{"begin":744,"end":749},"obj":"protein"},{"id":"T17","span":{"begin":767,"end":777},"obj":"protein"},{"id":"T18","span":{"begin":793,"end":803},"obj":"protein"},{"id":"T19","span":{"begin":805,"end":810},"obj":"protein"}],"text":"A novel T-cell trans-activator that recognizes a phorbol ester-inducible element of the interleukin-2 promoter.\nThe interleukin 2 (IL-2) gene promoter is recognized by several cell-type-specific and ubiquitous transcriptional regulators that integrate information transmitted by various signaling systems leading to IL-2 production and T-cell activation. Using a combination of transfection, protein-DNA binding, and in vitro transcription methods, we have discovered the novel T-cell-specific transcriptional activator TCF-1 (for T-Cell Factor-1), which recognizes a T-cell-specific response element (TCE) located within the IL-2 promoter. Although the TCE is similar in sequence to a consensus NF kappa B site, several criteria indicate that TCF-1 is distinct from NF kappa B. However, like NF kappa B, TCF-1 activity is induced by phorbol esters and other T-cell activators."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":111},"obj":"Sentence"},{"id":"S2","span":{"begin":112,"end":354},"obj":"Sentence"},{"id":"S3","span":{"begin":355,"end":640},"obj":"Sentence"},{"id":"S4","span":{"begin":641,"end":778},"obj":"Sentence"},{"id":"S5","span":{"begin":779,"end":877},"obj":"Sentence"}],"text":"A novel T-cell trans-activator that recognizes a phorbol ester-inducible element of the interleukin-2 promoter.\nThe interleukin 2 (IL-2) gene promoter is recognized by several cell-type-specific and ubiquitous transcriptional regulators that integrate information transmitted by various signaling systems leading to IL-2 production and T-cell activation. Using a combination of transfection, protein-DNA binding, and in vitro transcription methods, we have discovered the novel T-cell-specific transcriptional activator TCF-1 (for T-Cell Factor-1), which recognizes a T-cell-specific response element (TCE) located within the IL-2 promoter. Although the TCE is similar in sequence to a consensus NF kappa B site, several criteria indicate that TCF-1 is distinct from NF kappa B. However, like NF kappa B, TCF-1 activity is induced by phorbol esters and other T-cell activators."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":30},"obj":"NP"},{"id":"C2","span":{"begin":31,"end":35},"obj":"NP"},{"id":"C3","span":{"begin":84,"end":110},"obj":"NP"},{"id":"C4","span":{"begin":112,"end":150},"obj":"NP"},{"id":"C5","span":{"begin":168,"end":236},"obj":"NP"},{"id":"C6","span":{"begin":237,"end":241},"obj":"NP"},{"id":"C7","span":{"begin":468,"end":547},"obj":"NP"},{"id":"C8","span":{"begin":549,"end":554},"obj":"NP"},{"id":"C9","span":{"begin":566,"end":606},"obj":"NP"},{"id":"C10","span":{"begin":622,"end":639},"obj":"NP"},{"id":"C11","span":{"begin":650,"end":657},"obj":"NP"},{"id":"C12","span":{"begin":744,"end":749},"obj":"NP"},{"id":"C13","span":{"begin":767,"end":777},"obj":"NP"},{"id":"C14","span":{"begin":793,"end":803},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-relat","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-relat","subj":"C4","obj":"C3"},{"id":"R3","pred":"coref-relat","subj":"C6","obj":"C5"},{"id":"R4","pred":"coref-relat","subj":"C8","obj":"C7"},{"id":"R5","pred":"coref-ident","subj":"C10","obj":"C3"},{"id":"R6","pred":"coref-ident","subj":"C11","obj":"C9"},{"id":"R7","pred":"coref-ident","subj":"C12","obj":"C7"},{"id":"R8","pred":"coref-ident","subj":"C14","obj":"C13"}],"text":"A novel T-cell trans-activator that recognizes a phorbol ester-inducible element of the interleukin-2 promoter.\nThe interleukin 2 (IL-2) gene promoter is recognized by several cell-type-specific and ubiquitous transcriptional regulators that integrate information transmitted by various signaling systems leading to IL-2 production and T-cell activation. Using a combination of transfection, protein-DNA binding, and in vitro transcription methods, we have discovered the novel T-cell-specific transcriptional activator TCF-1 (for T-Cell Factor-1), which recognizes a T-cell-specific response element (TCE) located within the IL-2 promoter. Although the TCE is similar in sequence to a consensus NF kappa B site, several criteria indicate that TCF-1 is distinct from NF kappa B. However, like NF kappa B, TCF-1 activity is induced by phorbol esters and other T-cell activators."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":8,"end":30},"obj":"protein_family_or_group"},{"id":"T2","span":{"begin":49,"end":80},"obj":"DNA_domain_or_region"},{"id":"T3","span":{"begin":88,"end":101},"obj":"protein_molecule"},{"id":"T4","span":{"begin":116,"end":129},"obj":"protein_molecule"},{"id":"T5","span":{"begin":131,"end":135},"obj":"protein_molecule"},{"id":"T6","span":{"begin":316,"end":320},"obj":"protein_molecule"},{"id":"T7","span":{"begin":336,"end":342},"obj":"cell_type"},{"id":"T8","span":{"begin":378,"end":390},"obj":"other_name"},{"id":"T9","span":{"begin":417,"end":447},"obj":"other_name"},{"id":"T10","span":{"begin":472,"end":519},"obj":"protein_family_or_group"},{"id":"T11","span":{"begin":520,"end":525},"obj":"protein_molecule"},{"id":"T12","span":{"begin":531,"end":546},"obj":"protein_molecule"},{"id":"T13","span":{"begin":568,"end":600},"obj":"DNA_domain_or_region"},{"id":"T14","span":{"begin":602,"end":605},"obj":"DNA_domain_or_region"},{"id":"T15","span":{"begin":626,"end":630},"obj":"protein_molecule"},{"id":"T16","span":{"begin":654,"end":657},"obj":"DNA_domain_or_region"},{"id":"T17","span":{"begin":686,"end":695},"obj":"DNA_domain_or_region"},{"id":"T18","span":{"begin":696,"end":706},"obj":"protein_molecule"},{"id":"T19","span":{"begin":744,"end":749},"obj":"protein_molecule"},{"id":"T20","span":{"begin":767,"end":777},"obj":"protein_molecule"},{"id":"T21","span":{"begin":793,"end":803},"obj":"protein_molecule"},{"id":"T22","span":{"begin":805,"end":810},"obj":"protein_molecule"},{"id":"T23","span":{"begin":834,"end":848},"obj":"other_organic_compound"},{"id":"T24","span":{"begin":859,"end":876},"obj":"other_name"}],"text":"A novel T-cell trans-activator that recognizes a phorbol ester-inducible element of the interleukin-2 promoter.\nThe interleukin 2 (IL-2) gene promoter is recognized by several cell-type-specific and ubiquitous transcriptional regulators that integrate information transmitted by various signaling systems leading to IL-2 production and T-cell activation. Using a combination of transfection, protein-DNA binding, and in vitro transcription methods, we have discovered the novel T-cell-specific transcriptional activator TCF-1 (for T-Cell Factor-1), which recognizes a T-cell-specific response element (TCE) located within the IL-2 promoter. Although the TCE is similar in sequence to a consensus NF kappa B site, several criteria indicate that TCF-1 is distinct from NF kappa B. However, like NF kappa B, TCF-1 activity is induced by phorbol esters and other T-cell activators."}