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PubMed:20622016 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-115 Sentence denotes EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.
TextSentencer_T2 116-238 Sentence denotes Co-amplification and co-overexpression of ErbB2 and Grb7 are frequently found in various cancers, including breast cancer.
TextSentencer_T3 239-387 Sentence denotes Biochemical and functional correlations of the two molecules have identified Grb7 to be a pivotal mediator downstream of ErbB2-mediated oncogenesis.
TextSentencer_T4 388-480 Sentence denotes However, it remains largely unknown how Grb7 is involve in the ErbB2-mediated tumorigenesis.
TextSentencer_T5 481-650 Sentence denotes In this study, we show that Grb7-mediated cell proliferation and growth are essential for the tumorigenesis that occurs in ErbB2-Grb7-overexpressing breast cancer cells.
TextSentencer_T6 651-852 Sentence denotes Intrinsically, EGF-induced de novo Grb7 tyrosine phosphorylation/activation recruits and activates Ras-GTPases and subsequently promotes the phosphorylation of ERK1/2, thereby stimulating tumor growth.
TextSentencer_T7 853-1003 Sentence denotes Furthermore, we also found the anti-tumor effect could be synergized by co-treatment with Herceptin plus Grb7 knockdown in Sk-Br3 breast cancer cells.
TextSentencer_T8 1004-1250 Sentence denotes Our findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy.
T1 0-115 Sentence denotes EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.
T2 116-238 Sentence denotes Co-amplification and co-overexpression of ErbB2 and Grb7 are frequently found in various cancers, including breast cancer.
T3 239-387 Sentence denotes Biochemical and functional correlations of the two molecules have identified Grb7 to be a pivotal mediator downstream of ErbB2-mediated oncogenesis.
T4 388-480 Sentence denotes However, it remains largely unknown how Grb7 is involve in the ErbB2-mediated tumorigenesis.
T5 481-650 Sentence denotes In this study, we show that Grb7-mediated cell proliferation and growth are essential for the tumorigenesis that occurs in ErbB2-Grb7-overexpressing breast cancer cells.
T6 651-852 Sentence denotes Intrinsically, EGF-induced de novo Grb7 tyrosine phosphorylation/activation recruits and activates Ras-GTPases and subsequently promotes the phosphorylation of ERK1/2, thereby stimulating tumor growth.
T7 853-1003 Sentence denotes Furthermore, we also found the anti-tumor effect could be synergized by co-treatment with Herceptin plus Grb7 knockdown in Sk-Br3 breast cancer cells.
T8 1004-1250 Sentence denotes Our findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 158-163 gene:2064 denotes ErbB2
T1 224-237 disease:C0678222 denotes breast cancer
T2 168-172 gene:2886 denotes Grb7
T3 205-212 disease:C0006826 denotes cancers
T4 168-172 gene:2886 denotes Grb7
T5 224-237 disease:C0006142 denotes breast cancer
T6 158-163 gene:2064 denotes ErbB2
T7 224-237 disease:C0006142 denotes breast cancer
T8 158-163 gene:2064 denotes ErbB2
T9 205-212 disease:C0006826 denotes cancers
T10 168-172 gene:2886 denotes Grb7
T11 224-237 disease:C0678222 denotes breast cancer
T12 316-320 gene:2886 denotes Grb7
T13 375-386 disease:C0596263 denotes oncogenesis
T14 360-365 gene:2064 denotes ErbB2
T15 375-386 disease:C0596263 denotes oncogenesis
T16 428-432 gene:2886 denotes Grb7
T17 466-479 disease:C0596263 denotes tumorigenesis
T18 451-456 gene:2064 denotes ErbB2
T19 466-479 disease:C0596263 denotes tumorigenesis
T20 509-513 gene:2886 denotes Grb7
T21 575-588 disease:C0596263 denotes tumorigenesis
T22 604-609 gene:2064 denotes ErbB2
T23 575-588 disease:C0596263 denotes tumorigenesis
T24 1061-1065 gene:2886 denotes Grb7
T25 1075-1088 disease:C0596263 denotes tumorigenesis
T26 1212-1216 gene:2886 denotes Grb7
T27 1228-1241 disease:C0006142 denotes breast cancer
T28 1212-1216 gene:2886 denotes Grb7
T29 1228-1241 disease:C0678222 denotes breast cancer
R1 T0 T1 associated_with ErbB2,breast cancer
R2 T2 T3 associated_with Grb7,cancers
R3 T4 T5 associated_with Grb7,breast cancer
R4 T6 T7 associated_with ErbB2,breast cancer
R5 T8 T9 associated_with ErbB2,cancers
R6 T10 T11 associated_with Grb7,breast cancer
R7 T12 T13 associated_with Grb7,oncogenesis
R8 T14 T15 associated_with ErbB2,oncogenesis
R9 T16 T17 associated_with Grb7,tumorigenesis
R10 T18 T19 associated_with ErbB2,tumorigenesis
R11 T20 T21 associated_with Grb7,tumorigenesis
R12 T22 T23 associated_with ErbB2,tumorigenesis
R13 T24 T25 associated_with Grb7,tumorigenesis
R14 T26 T27 associated_with Grb7,breast cancer
R15 T28 T29 associated_with Grb7,breast cancer

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 205-212 HP_0002664 denotes cancers
T2 224-237 HP_0003002 denotes breast cancer
T3 224-237 HP_0100013 denotes breast cancer
T4 231-237 HP_0002664 denotes cancer
T5 630-643 HP_0003002 denotes breast cancer
T6 630-643 HP_0100013 denotes breast cancer
T7 637-643 HP_0002664 denotes cancer
T8 839-844 HP_0002664 denotes tumor
T9 889-894 HP_0002664 denotes tumor
T10 983-996 HP_0003002 denotes breast cancer
T11 983-996 HP_0100013 denotes breast cancer
T12 990-996 HP_0002664 denotes cancer
T13 1228-1241 HP_0003002 denotes breast cancer
T14 1228-1241 HP_0100013 denotes breast cancer
T15 1235-1241 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
20622016-0#12#16#gene2886 12-16 gene2886 denotes Grb7
20622016-0#95#108#diseaseC0006142 95-108 diseaseC0006142 denotes breast cancer
20622016-0#95#108#diseaseC0678222 95-108 diseaseC0678222 denotes breast cancer
20622016-1#42#47#gene2064 158-163 gene2064 denotes ErbB2
20622016-1#108#121#diseaseC0006142 224-237 diseaseC0006142 denotes breast cancer
20622016-1#108#121#diseaseC0678222 224-237 diseaseC0678222 denotes breast cancer
20622016-4#123#128#gene2064 604-609 gene2064 denotes ErbB2
20622016-4#94#107#diseaseC0596263 575-588 diseaseC0596263 denotes tumorigenesis
20622016-7#57#61#gene2886 1061-1065 gene2886 denotes Grb7
20622016-7#71#84#diseaseC0596263 1075-1088 diseaseC0596263 denotes tumorigenesis
12#16#gene288695#108#diseaseC0006142 20622016-0#12#16#gene2886 20622016-0#95#108#diseaseC0006142 associated_with Grb7,breast cancer
12#16#gene288695#108#diseaseC0678222 20622016-0#12#16#gene2886 20622016-0#95#108#diseaseC0678222 associated_with Grb7,breast cancer
42#47#gene2064108#121#diseaseC0006142 20622016-1#42#47#gene2064 20622016-1#108#121#diseaseC0006142 associated_with ErbB2,breast cancer
42#47#gene2064108#121#diseaseC0678222 20622016-1#42#47#gene2064 20622016-1#108#121#diseaseC0678222 associated_with ErbB2,breast cancer
123#128#gene206494#107#diseaseC0596263 20622016-4#123#128#gene2064 20622016-4#94#107#diseaseC0596263 associated_with ErbB2,tumorigenesis
57#61#gene288671#84#diseaseC0596263 20622016-7#57#61#gene2886 20622016-7#71#84#diseaseC0596263 associated_with Grb7,tumorigenesis

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T719 12-16 gene:2886 denotes Grb7
T720 95-108 disease:C0006142 denotes breast cancer
T721 158-163 gene:2064 denotes ErbB2
T722 224-237 disease:C0006142 denotes breast cancer
R1 T719 T720 associated_with Grb7,breast cancer
R2 T719 T720 associated_with Grb7,breast cancer
R3 T721 T722 associated_with ErbB2,breast cancer
R4 T721 T722 associated_with ErbB2,breast cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 95-101 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 224-230 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 630-636 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 983-989 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 1228-1234 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 95-101 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 224-230 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 630-636 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 983-989 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 1228-1234 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 95-108 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T2 224-237 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T3 630-643 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T4 839-844 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T5 889-894 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T6 983-996 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T7 1228-1241 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 95-108 Phenotype denotes breast cancer HP:0003002
T2 224-237 Phenotype denotes breast cancer HP:0003002
T3 630-643 Phenotype denotes breast cancer HP:0003002
T4 839-844 Phenotype denotes tumor HP:0002664
T5 889-894 Phenotype denotes tumor HP:0002664
T6 983-996 Phenotype denotes breast cancer HP:0003002
T7 1228-1241 Phenotype denotes breast cancer HP:0003002

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 95-101 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T2 224-230 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T3 630-636 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T4 983-989 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T5 1228-1234 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 102-114 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T2 637-649 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T3 990-1002 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064