PubMed:20622016 JSON TXT

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GlyCosmos6-UBERON

{"project":"GlyCosmos6-UBERON","denotations":[{"id":"T1","span":{"begin":95,"end":101},"obj":"Body_part"},{"id":"T2","span":{"begin":224,"end":230},"obj":"Body_part"},{"id":"T3","span":{"begin":523,"end":527},"obj":"Body_part"},{"id":"T4","span":{"begin":528,"end":541},"obj":"Body_part"},{"id":"T5","span":{"begin":630,"end":636},"obj":"Body_part"},{"id":"T6","span":{"begin":983,"end":989},"obj":"Body_part"},{"id":"T7","span":{"begin":1228,"end":1234},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_2000098"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0000310"}],"text":"EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.\nCo-amplification and co-overexpression of ErbB2 and Grb7 are frequently found in various cancers, including breast cancer. Biochemical and functional correlations of the two molecules have identified Grb7 to be a pivotal mediator downstream of ErbB2-mediated oncogenesis. However, it remains largely unknown how Grb7 is involve in the ErbB2-mediated tumorigenesis. In this study, we show that Grb7-mediated cell proliferation and growth are essential for the tumorigenesis that occurs in ErbB2-Grb7-overexpressing breast cancer cells. Intrinsically, EGF-induced de novo Grb7 tyrosine phosphorylation/activation recruits and activates Ras-GTPases and subsequently promotes the phosphorylation of ERK1/2, thereby stimulating tumor growth. Furthermore, we also found the anti-tumor effect could be synergized by co-treatment with Herceptin plus Grb7 knockdown in Sk-Br3 breast cancer cells. Our findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy."}

sentences

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":115},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":116,"end":238},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":239,"end":387},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":388,"end":480},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":481,"end":650},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":651,"end":852},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":853,"end":1003},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":1004,"end":1250},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":115},"obj":"Sentence"},{"id":"T2","span":{"begin":116,"end":238},"obj":"Sentence"},{"id":"T3","span":{"begin":239,"end":387},"obj":"Sentence"},{"id":"T4","span":{"begin":388,"end":480},"obj":"Sentence"},{"id":"T5","span":{"begin":481,"end":650},"obj":"Sentence"},{"id":"T6","span":{"begin":651,"end":852},"obj":"Sentence"},{"id":"T7","span":{"begin":853,"end":1003},"obj":"Sentence"},{"id":"T8","span":{"begin":1004,"end":1250},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.\nCo-amplification and co-overexpression of ErbB2 and Grb7 are frequently found in various cancers, including breast cancer. Biochemical and functional correlations of the two molecules have identified Grb7 to be a pivotal mediator downstream of ErbB2-mediated oncogenesis. However, it remains largely unknown how Grb7 is involve in the ErbB2-mediated tumorigenesis. In this study, we show that Grb7-mediated cell proliferation and growth are essential for the tumorigenesis that occurs in ErbB2-Grb7-overexpressing breast cancer cells. Intrinsically, EGF-induced de novo Grb7 tyrosine phosphorylation/activation recruits and activates Ras-GTPases and subsequently promotes the phosphorylation of ERK1/2, thereby stimulating tumor growth. Furthermore, we also found the anti-tumor effect could be synergized by co-treatment with Herceptin plus Grb7 knockdown in Sk-Br3 breast cancer cells. Our findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy."}

GlyCosmos6-CLO

{"project":"GlyCosmos6-CLO","denotations":[{"id":"T1","span":{"begin":43,"end":51},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T2","span":{"begin":88,"end":94},"obj":"http://purl.obolibrary.org/obo/CLO_0009034"},{"id":"T3","span":{"begin":88,"end":94},"obj":"http://purl.obolibrary.org/obo/CLO_0052100"},{"id":"T4","span":{"begin":88,"end":94},"obj":"http://purl.obolibrary.org/obo/CLO_0052101"},{"id":"T5","span":{"begin":88,"end":94},"obj":"http://purl.obolibrary.org/obo/CLO_0052102"},{"id":"T6","span":{"begin":109,"end":114},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T7","span":{"begin":523,"end":527},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T8","span":{"begin":644,"end":649},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T9","span":{"begin":716,"end":726},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T10","span":{"begin":740,"end":749},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T11","span":{"begin":976,"end":982},"obj":"http://purl.obolibrary.org/obo/CLO_0009034"},{"id":"T12","span":{"begin":976,"end":982},"obj":"http://purl.obolibrary.org/obo/CLO_0052100"},{"id":"T13","span":{"begin":976,"end":982},"obj":"http://purl.obolibrary.org/obo/CLO_0052101"},{"id":"T14","span":{"begin":976,"end":982},"obj":"http://purl.obolibrary.org/obo/CLO_0052102"},{"id":"T15","span":{"begin":997,"end":1002},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.\nCo-amplification and co-overexpression of ErbB2 and Grb7 are frequently found in various cancers, including breast cancer. Biochemical and functional correlations of the two molecules have identified Grb7 to be a pivotal mediator downstream of ErbB2-mediated oncogenesis. However, it remains largely unknown how Grb7 is involve in the ErbB2-mediated tumorigenesis. In this study, we show that Grb7-mediated cell proliferation and growth are essential for the tumorigenesis that occurs in ErbB2-Grb7-overexpressing breast cancer cells. Intrinsically, EGF-induced de novo Grb7 tyrosine phosphorylation/activation recruits and activates Ras-GTPases and subsequently promotes the phosphorylation of ERK1/2, thereby stimulating tumor growth. Furthermore, we also found the anti-tumor effect could be synergized by co-treatment with Herceptin plus Grb7 knockdown in Sk-Br3 breast cancer cells. Our findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy."}

mondo_disease

{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":95,"end":108},"obj":"Disease"},{"id":"T2","span":{"begin":224,"end":237},"obj":"Disease"},{"id":"T3","span":{"begin":630,"end":643},"obj":"Disease"},{"id":"T4","span":{"begin":839,"end":844},"obj":"Disease"},{"id":"T5","span":{"begin":889,"end":894},"obj":"Disease"},{"id":"T6","span":{"begin":983,"end":996},"obj":"Disease"},{"id":"T7","span":{"begin":1228,"end":1241},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0007254"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0007254"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0007254"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0007254"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0007254"}],"text":"EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.\nCo-amplification and co-overexpression of ErbB2 and Grb7 are frequently found in various cancers, including breast cancer. Biochemical and functional correlations of the two molecules have identified Grb7 to be a pivotal mediator downstream of ErbB2-mediated oncogenesis. However, it remains largely unknown how Grb7 is involve in the ErbB2-mediated tumorigenesis. In this study, we show that Grb7-mediated cell proliferation and growth are essential for the tumorigenesis that occurs in ErbB2-Grb7-overexpressing breast cancer cells. Intrinsically, EGF-induced de novo Grb7 tyrosine phosphorylation/activation recruits and activates Ras-GTPases and subsequently promotes the phosphorylation of ERK1/2, thereby stimulating tumor growth. Furthermore, we also found the anti-tumor effect could be synergized by co-treatment with Herceptin plus Grb7 knockdown in Sk-Br3 breast cancer cells. Our findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy."}

DisGeNET

PubmedHPO

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":205,"end":212},"obj":"HP_0002664"},{"id":"T2","span":{"begin":224,"end":237},"obj":"HP_0003002"},{"id":"T3","span":{"begin":224,"end":237},"obj":"HP_0100013"},{"id":"T4","span":{"begin":231,"end":237},"obj":"HP_0002664"},{"id":"T5","span":{"begin":630,"end":643},"obj":"HP_0003002"},{"id":"T6","span":{"begin":630,"end":643},"obj":"HP_0100013"},{"id":"T7","span":{"begin":637,"end":643},"obj":"HP_0002664"},{"id":"T8","span":{"begin":839,"end":844},"obj":"HP_0002664"},{"id":"T9","span":{"begin":889,"end":894},"obj":"HP_0002664"},{"id":"T10","span":{"begin":983,"end":996},"obj":"HP_0003002"},{"id":"T11","span":{"begin":983,"end":996},"obj":"HP_0100013"},{"id":"T12","span":{"begin":990,"end":996},"obj":"HP_0002664"},{"id":"T13","span":{"begin":1228,"end":1241},"obj":"HP_0003002"},{"id":"T14","span":{"begin":1228,"end":1241},"obj":"HP_0100013"},{"id":"T15","span":{"begin":1235,"end":1241},"obj":"HP_0002664"}],"text":"EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.\nCo-amplification and co-overexpression of ErbB2 and Grb7 are frequently found in various cancers, including breast cancer. Biochemical and functional correlations of the two molecules have identified Grb7 to be a pivotal mediator downstream of ErbB2-mediated oncogenesis. However, it remains largely unknown how Grb7 is involve in the ErbB2-mediated tumorigenesis. In this study, we show that Grb7-mediated cell proliferation and growth are essential for the tumorigenesis that occurs in ErbB2-Grb7-overexpressing breast cancer cells. Intrinsically, EGF-induced de novo Grb7 tyrosine phosphorylation/activation recruits and activates Ras-GTPases and subsequently promotes the phosphorylation of ERK1/2, thereby stimulating tumor growth. Furthermore, we also found the anti-tumor effect could be synergized by co-treatment with Herceptin plus Grb7 knockdown in Sk-Br3 breast cancer cells. Our findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy."}

DisGeNET5_gene_disease

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"20622016-0#12#16#gene2886","span":{"begin":12,"end":16},"obj":"gene2886"},{"id":"20622016-0#95#108#diseaseC0006142","span":{"begin":95,"end":108},"obj":"diseaseC0006142"},{"id":"20622016-0#95#108#diseaseC0678222","span":{"begin":95,"end":108},"obj":"diseaseC0678222"},{"id":"20622016-1#42#47#gene2064","span":{"begin":158,"end":163},"obj":"gene2064"},{"id":"20622016-1#108#121#diseaseC0006142","span":{"begin":224,"end":237},"obj":"diseaseC0006142"},{"id":"20622016-1#108#121#diseaseC0678222","span":{"begin":224,"end":237},"obj":"diseaseC0678222"},{"id":"20622016-4#123#128#gene2064","span":{"begin":604,"end":609},"obj":"gene2064"},{"id":"20622016-4#94#107#diseaseC0596263","span":{"begin":575,"end":588},"obj":"diseaseC0596263"},{"id":"20622016-7#57#61#gene2886","span":{"begin":1061,"end":1065},"obj":"gene2886"},{"id":"20622016-7#71#84#diseaseC0596263","span":{"begin":1075,"end":1088},"obj":"diseaseC0596263"}],"relations":[{"id":"12#16#gene288695#108#diseaseC0006142","pred":"associated_with","subj":"20622016-0#12#16#gene2886","obj":"20622016-0#95#108#diseaseC0006142"},{"id":"12#16#gene288695#108#diseaseC0678222","pred":"associated_with","subj":"20622016-0#12#16#gene2886","obj":"20622016-0#95#108#diseaseC0678222"},{"id":"42#47#gene2064108#121#diseaseC0006142","pred":"associated_with","subj":"20622016-1#42#47#gene2064","obj":"20622016-1#108#121#diseaseC0006142"},{"id":"42#47#gene2064108#121#diseaseC0678222","pred":"associated_with","subj":"20622016-1#42#47#gene2064","obj":"20622016-1#108#121#diseaseC0678222"},{"id":"123#128#gene206494#107#diseaseC0596263","pred":"associated_with","subj":"20622016-4#123#128#gene2064","obj":"20622016-4#94#107#diseaseC0596263"},{"id":"57#61#gene288671#84#diseaseC0596263","pred":"associated_with","subj":"20622016-7#57#61#gene2886","obj":"20622016-7#71#84#diseaseC0596263"}],"text":"EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.\nCo-amplification and co-overexpression of ErbB2 and Grb7 are frequently found in various cancers, including breast cancer. Biochemical and functional correlations of the two molecules have identified Grb7 to be a pivotal mediator downstream of ErbB2-mediated oncogenesis. However, it remains largely unknown how Grb7 is involve in the ErbB2-mediated tumorigenesis. In this study, we show that Grb7-mediated cell proliferation and growth are essential for the tumorigenesis that occurs in ErbB2-Grb7-overexpressing breast cancer cells. Intrinsically, EGF-induced de novo Grb7 tyrosine phosphorylation/activation recruits and activates Ras-GTPases and subsequently promotes the phosphorylation of ERK1/2, thereby stimulating tumor growth. Furthermore, we also found the anti-tumor effect could be synergized by co-treatment with Herceptin plus Grb7 knockdown in Sk-Br3 breast cancer cells. Our findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy."}

DisGeNet-2017-sample

{"project":"DisGeNet-2017-sample","denotations":[{"id":"T719","span":{"begin":12,"end":16},"obj":"gene:2886"},{"id":"T720","span":{"begin":95,"end":108},"obj":"disease:C0006142"},{"id":"T721","span":{"begin":158,"end":163},"obj":"gene:2064"},{"id":"T722","span":{"begin":224,"end":237},"obj":"disease:C0006142"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T719","obj":"T720"},{"id":"R2","pred":"associated_with","subj":"T719","obj":"T720"},{"id":"R3","pred":"associated_with","subj":"T721","obj":"T722"},{"id":"R4","pred":"associated_with","subj":"T721","obj":"T722"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.\nCo-amplification and co-overexpression of ErbB2 and Grb7 are frequently found in various cancers, including breast cancer. Biochemical and functional correlations of the two molecules have identified Grb7 to be a pivotal mediator downstream of ErbB2-mediated oncogenesis. However, it remains largely unknown how Grb7 is involve in the ErbB2-mediated tumorigenesis. In this study, we show that Grb7-mediated cell proliferation and growth are essential for the tumorigenesis that occurs in ErbB2-Grb7-overexpressing breast cancer cells. Intrinsically, EGF-induced de novo Grb7 tyrosine phosphorylation/activation recruits and activates Ras-GTPases and subsequently promotes the phosphorylation of ERK1/2, thereby stimulating tumor growth. Furthermore, we also found the anti-tumor effect could be synergized by co-treatment with Herceptin plus Grb7 knockdown in Sk-Br3 breast cancer cells. Our findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy."}

UBERON-AE

{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":95,"end":101},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":224,"end":230},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":630,"end":636},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":983,"end":989},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":1228,"end":1234},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"}],"text":"EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.\nCo-amplification and co-overexpression of ErbB2 and Grb7 are frequently found in various cancers, including breast cancer. Biochemical and functional correlations of the two molecules have identified Grb7 to be a pivotal mediator downstream of ErbB2-mediated oncogenesis. However, it remains largely unknown how Grb7 is involve in the ErbB2-mediated tumorigenesis. In this study, we show that Grb7-mediated cell proliferation and growth are essential for the tumorigenesis that occurs in ErbB2-Grb7-overexpressing breast cancer cells. Intrinsically, EGF-induced de novo Grb7 tyrosine phosphorylation/activation recruits and activates Ras-GTPases and subsequently promotes the phosphorylation of ERK1/2, thereby stimulating tumor growth. Furthermore, we also found the anti-tumor effect could be synergized by co-treatment with Herceptin plus Grb7 knockdown in Sk-Br3 breast cancer cells. Our findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy."}

performance-test

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":95,"end":101},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":224,"end":230},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":630,"end":636},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":983,"end":989},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":1228,"end":1234},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"}],"text":"EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.\nCo-amplification and co-overexpression of ErbB2 and Grb7 are frequently found in various cancers, including breast cancer. Biochemical and functional correlations of the two molecules have identified Grb7 to be a pivotal mediator downstream of ErbB2-mediated oncogenesis. However, it remains largely unknown how Grb7 is involve in the ErbB2-mediated tumorigenesis. In this study, we show that Grb7-mediated cell proliferation and growth are essential for the tumorigenesis that occurs in ErbB2-Grb7-overexpressing breast cancer cells. Intrinsically, EGF-induced de novo Grb7 tyrosine phosphorylation/activation recruits and activates Ras-GTPases and subsequently promotes the phosphorylation of ERK1/2, thereby stimulating tumor growth. Furthermore, we also found the anti-tumor effect could be synergized by co-treatment with Herceptin plus Grb7 knockdown in Sk-Br3 breast cancer cells. Our findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy."}