PubMed:20622016
Annnotations
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-115 | Sentence | denotes | EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells. |
TextSentencer_T2 | 116-238 | Sentence | denotes | Co-amplification and co-overexpression of ErbB2 and Grb7 are frequently found in various cancers, including breast cancer. |
TextSentencer_T3 | 239-387 | Sentence | denotes | Biochemical and functional correlations of the two molecules have identified Grb7 to be a pivotal mediator downstream of ErbB2-mediated oncogenesis. |
TextSentencer_T4 | 388-480 | Sentence | denotes | However, it remains largely unknown how Grb7 is involve in the ErbB2-mediated tumorigenesis. |
TextSentencer_T5 | 481-650 | Sentence | denotes | In this study, we show that Grb7-mediated cell proliferation and growth are essential for the tumorigenesis that occurs in ErbB2-Grb7-overexpressing breast cancer cells. |
TextSentencer_T6 | 651-852 | Sentence | denotes | Intrinsically, EGF-induced de novo Grb7 tyrosine phosphorylation/activation recruits and activates Ras-GTPases and subsequently promotes the phosphorylation of ERK1/2, thereby stimulating tumor growth. |
TextSentencer_T7 | 853-1003 | Sentence | denotes | Furthermore, we also found the anti-tumor effect could be synergized by co-treatment with Herceptin plus Grb7 knockdown in Sk-Br3 breast cancer cells. |
TextSentencer_T8 | 1004-1250 | Sentence | denotes | Our findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy. |
T1 | 0-115 | Sentence | denotes | EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells. |
T2 | 116-238 | Sentence | denotes | Co-amplification and co-overexpression of ErbB2 and Grb7 are frequently found in various cancers, including breast cancer. |
T3 | 239-387 | Sentence | denotes | Biochemical and functional correlations of the two molecules have identified Grb7 to be a pivotal mediator downstream of ErbB2-mediated oncogenesis. |
T4 | 388-480 | Sentence | denotes | However, it remains largely unknown how Grb7 is involve in the ErbB2-mediated tumorigenesis. |
T5 | 481-650 | Sentence | denotes | In this study, we show that Grb7-mediated cell proliferation and growth are essential for the tumorigenesis that occurs in ErbB2-Grb7-overexpressing breast cancer cells. |
T6 | 651-852 | Sentence | denotes | Intrinsically, EGF-induced de novo Grb7 tyrosine phosphorylation/activation recruits and activates Ras-GTPases and subsequently promotes the phosphorylation of ERK1/2, thereby stimulating tumor growth. |
T7 | 853-1003 | Sentence | denotes | Furthermore, we also found the anti-tumor effect could be synergized by co-treatment with Herceptin plus Grb7 knockdown in Sk-Br3 breast cancer cells. |
T8 | 1004-1250 | Sentence | denotes | Our findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy. |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 158-163 | gene:2064 | denotes | ErbB2 |
T1 | 224-237 | disease:C0678222 | denotes | breast cancer |
T2 | 168-172 | gene:2886 | denotes | Grb7 |
T3 | 205-212 | disease:C0006826 | denotes | cancers |
T4 | 168-172 | gene:2886 | denotes | Grb7 |
T5 | 224-237 | disease:C0006142 | denotes | breast cancer |
T6 | 158-163 | gene:2064 | denotes | ErbB2 |
T7 | 224-237 | disease:C0006142 | denotes | breast cancer |
T8 | 158-163 | gene:2064 | denotes | ErbB2 |
T9 | 205-212 | disease:C0006826 | denotes | cancers |
T10 | 168-172 | gene:2886 | denotes | Grb7 |
T11 | 224-237 | disease:C0678222 | denotes | breast cancer |
T12 | 316-320 | gene:2886 | denotes | Grb7 |
T13 | 375-386 | disease:C0596263 | denotes | oncogenesis |
T14 | 360-365 | gene:2064 | denotes | ErbB2 |
T15 | 375-386 | disease:C0596263 | denotes | oncogenesis |
T16 | 428-432 | gene:2886 | denotes | Grb7 |
T17 | 466-479 | disease:C0596263 | denotes | tumorigenesis |
T18 | 451-456 | gene:2064 | denotes | ErbB2 |
T19 | 466-479 | disease:C0596263 | denotes | tumorigenesis |
T20 | 509-513 | gene:2886 | denotes | Grb7 |
T21 | 575-588 | disease:C0596263 | denotes | tumorigenesis |
T22 | 604-609 | gene:2064 | denotes | ErbB2 |
T23 | 575-588 | disease:C0596263 | denotes | tumorigenesis |
T24 | 1061-1065 | gene:2886 | denotes | Grb7 |
T25 | 1075-1088 | disease:C0596263 | denotes | tumorigenesis |
T26 | 1212-1216 | gene:2886 | denotes | Grb7 |
T27 | 1228-1241 | disease:C0006142 | denotes | breast cancer |
T28 | 1212-1216 | gene:2886 | denotes | Grb7 |
T29 | 1228-1241 | disease:C0678222 | denotes | breast cancer |
R1 | T0 | T1 | associated_with | ErbB2,breast cancer |
R2 | T2 | T3 | associated_with | Grb7,cancers |
R3 | T4 | T5 | associated_with | Grb7,breast cancer |
R4 | T6 | T7 | associated_with | ErbB2,breast cancer |
R5 | T8 | T9 | associated_with | ErbB2,cancers |
R6 | T10 | T11 | associated_with | Grb7,breast cancer |
R7 | T12 | T13 | associated_with | Grb7,oncogenesis |
R8 | T14 | T15 | associated_with | ErbB2,oncogenesis |
R9 | T16 | T17 | associated_with | Grb7,tumorigenesis |
R10 | T18 | T19 | associated_with | ErbB2,tumorigenesis |
R11 | T20 | T21 | associated_with | Grb7,tumorigenesis |
R12 | T22 | T23 | associated_with | ErbB2,tumorigenesis |
R13 | T24 | T25 | associated_with | Grb7,tumorigenesis |
R14 | T26 | T27 | associated_with | Grb7,breast cancer |
R15 | T28 | T29 | associated_with | Grb7,breast cancer |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 205-212 | HP_0002664 | denotes | cancers |
T2 | 224-237 | HP_0003002 | denotes | breast cancer |
T3 | 224-237 | HP_0100013 | denotes | breast cancer |
T4 | 231-237 | HP_0002664 | denotes | cancer |
T5 | 630-643 | HP_0003002 | denotes | breast cancer |
T6 | 630-643 | HP_0100013 | denotes | breast cancer |
T7 | 637-643 | HP_0002664 | denotes | cancer |
T8 | 839-844 | HP_0002664 | denotes | tumor |
T9 | 889-894 | HP_0002664 | denotes | tumor |
T10 | 983-996 | HP_0003002 | denotes | breast cancer |
T11 | 983-996 | HP_0100013 | denotes | breast cancer |
T12 | 990-996 | HP_0002664 | denotes | cancer |
T13 | 1228-1241 | HP_0003002 | denotes | breast cancer |
T14 | 1228-1241 | HP_0100013 | denotes | breast cancer |
T15 | 1235-1241 | HP_0002664 | denotes | cancer |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
20622016-0#12#16#gene2886 | 12-16 | gene2886 | denotes | Grb7 |
20622016-0#95#108#diseaseC0006142 | 95-108 | diseaseC0006142 | denotes | breast cancer |
20622016-0#95#108#diseaseC0678222 | 95-108 | diseaseC0678222 | denotes | breast cancer |
20622016-1#42#47#gene2064 | 158-163 | gene2064 | denotes | ErbB2 |
20622016-1#108#121#diseaseC0006142 | 224-237 | diseaseC0006142 | denotes | breast cancer |
20622016-1#108#121#diseaseC0678222 | 224-237 | diseaseC0678222 | denotes | breast cancer |
20622016-4#123#128#gene2064 | 604-609 | gene2064 | denotes | ErbB2 |
20622016-4#94#107#diseaseC0596263 | 575-588 | diseaseC0596263 | denotes | tumorigenesis |
20622016-7#57#61#gene2886 | 1061-1065 | gene2886 | denotes | Grb7 |
20622016-7#71#84#diseaseC0596263 | 1075-1088 | diseaseC0596263 | denotes | tumorigenesis |
12#16#gene288695#108#diseaseC0006142 | 20622016-0#12#16#gene2886 | 20622016-0#95#108#diseaseC0006142 | associated_with | Grb7,breast cancer |
12#16#gene288695#108#diseaseC0678222 | 20622016-0#12#16#gene2886 | 20622016-0#95#108#diseaseC0678222 | associated_with | Grb7,breast cancer |
42#47#gene2064108#121#diseaseC0006142 | 20622016-1#42#47#gene2064 | 20622016-1#108#121#diseaseC0006142 | associated_with | ErbB2,breast cancer |
42#47#gene2064108#121#diseaseC0678222 | 20622016-1#42#47#gene2064 | 20622016-1#108#121#diseaseC0678222 | associated_with | ErbB2,breast cancer |
123#128#gene206494#107#diseaseC0596263 | 20622016-4#123#128#gene2064 | 20622016-4#94#107#diseaseC0596263 | associated_with | ErbB2,tumorigenesis |
57#61#gene288671#84#diseaseC0596263 | 20622016-7#57#61#gene2886 | 20622016-7#71#84#diseaseC0596263 | associated_with | Grb7,tumorigenesis |
DisGeNet-2017-sample
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T719 | 12-16 | gene:2886 | denotes | Grb7 |
T720 | 95-108 | disease:C0006142 | denotes | breast cancer |
T721 | 158-163 | gene:2064 | denotes | ErbB2 |
T722 | 224-237 | disease:C0006142 | denotes | breast cancer |
R1 | T719 | T720 | associated_with | Grb7,breast cancer |
R2 | T719 | T720 | associated_with | Grb7,breast cancer |
R3 | T721 | T722 | associated_with | ErbB2,breast cancer |
R4 | T721 | T722 | associated_with | ErbB2,breast cancer |
UBERON-AE
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-UBERON-AE-B_T1 | 95-101 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
PD-UBERON-AE-B_T2 | 224-230 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
PD-UBERON-AE-B_T3 | 630-636 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
PD-UBERON-AE-B_T4 | 983-989 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
PD-UBERON-AE-B_T5 | 1228-1234 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
performance-test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-UBERON-AE-B_T1 | 95-101 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
PD-UBERON-AE-B_T2 | 224-230 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
PD-UBERON-AE-B_T3 | 630-636 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
PD-UBERON-AE-B_T4 | 983-989 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
PD-UBERON-AE-B_T5 | 1228-1234 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 95-108 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
T2 | 224-237 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
T3 | 630-643 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
T4 | 839-844 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
T5 | 889-894 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
T6 | 983-996 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
T7 | 1228-1241 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 95-101 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
T2 | 224-230 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
T3 | 630-636 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
T4 | 983-989 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
T5 | 1228-1234 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |